JP2014505594A5 - - Google Patents
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- JP2014505594A5 JP2014505594A5 JP2013552712A JP2013552712A JP2014505594A5 JP 2014505594 A5 JP2014505594 A5 JP 2014505594A5 JP 2013552712 A JP2013552712 A JP 2013552712A JP 2013552712 A JP2013552712 A JP 2013552712A JP 2014505594 A5 JP2014505594 A5 JP 2014505594A5
- Authority
- JP
- Japan
- Prior art keywords
- microfluidic channel
- microfluidic
- droplet
- inlet
- cross
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000007788 liquid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440198P | 2011-02-07 | 2011-02-07 | |
| US61/440,198 | 2011-02-07 | ||
| PCT/US2012/023961 WO2012109138A1 (en) | 2011-02-07 | 2012-02-06 | Systems and methods for splitting droplets |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148580A Division JP2016224057A (ja) | 2011-02-07 | 2016-07-28 | 液滴を分裂させるためのシステムおよび方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014505594A JP2014505594A (ja) | 2014-03-06 |
| JP2014505594A5 true JP2014505594A5 (enExample) | 2015-03-26 |
Family
ID=45774321
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552712A Pending JP2014505594A (ja) | 2011-02-07 | 2012-02-06 | 液滴を分裂させるためのシステムおよび方法 |
| JP2016148580A Pending JP2016224057A (ja) | 2011-02-07 | 2016-07-28 | 液滴を分裂させるためのシステムおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148580A Pending JP2016224057A (ja) | 2011-02-07 | 2016-07-28 | 液滴を分裂させるためのシステムおよび方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20140026968A1 (enExample) |
| EP (1) | EP2673088A1 (enExample) |
| JP (2) | JP2014505594A (enExample) |
| KR (1) | KR20140063507A (enExample) |
| CN (2) | CN105689030A (enExample) |
| BR (1) | BR112013019880A2 (enExample) |
| WO (1) | WO2012109138A1 (enExample) |
Families Citing this family (36)
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| PL229042B1 (pl) * | 2011-09-30 | 2018-06-29 | Inst Chemii Fizycznej Polskiej Akademii Nauk | Sposób dzielenia kropel w złączu mikroprzepływowym i układ do dzielenia kropel w złączu mikroprzepływowym |
| US9475013B2 (en) | 2012-02-08 | 2016-10-25 | President And Fellows Of Harvard College | Droplet formation using fluid breakup |
| DE102012217487A1 (de) * | 2012-09-26 | 2014-04-17 | Agilent Technologies, Inc. - A Delaware Corporation - | Fluidschnittstelle zwischen Fluidleitungen unterschiedlicher Querschnitte |
| EP2964390B1 (en) * | 2013-03-06 | 2018-12-26 | President and Fellows of Harvard College | Use of devices for forming relatively monodisperse droplets |
| CN103285946A (zh) * | 2013-05-27 | 2013-09-11 | 苏州扬清芯片科技有限公司 | 一种生物芯片及其操控方法 |
| CN103285947A (zh) * | 2013-05-27 | 2013-09-11 | 苏州扬清芯片科技有限公司 | 一种液滴微流控芯片及其操控方法 |
| WO2015112985A1 (en) * | 2014-01-24 | 2015-07-30 | The Johns Hopkins University | System and device for high throughput generation of combinatorial droplets and methods of use |
| CN105478177A (zh) * | 2014-09-18 | 2016-04-13 | 苏州贝和医疗科技有限公司 | 一种用于数字pcr的液滴生成装置及方法 |
| US10178027B2 (en) * | 2016-01-27 | 2019-01-08 | Oracle International Corporation | System and method for supporting inter subnet partitions in a high performance computing environment |
| US10171353B2 (en) * | 2016-03-04 | 2019-01-01 | Oracle International Corporation | System and method for supporting dual-port virtual router in a high performance computing environment |
| CA3020913C (en) * | 2016-04-15 | 2024-01-02 | President And Fellows Of Harvard College | Systems and methods for the collection of droplets and/or other entities |
| US10143129B2 (en) * | 2017-02-27 | 2018-12-04 | Cnh Industrial Canada, Ltd. | Flow splitter for distributing agricultural products and related system |
| US10408852B2 (en) | 2017-04-26 | 2019-09-10 | Lawrence Livermore National Security, Llc | Automated control of microfluidic devices based on machine learning |
| CN107323090B (zh) * | 2017-07-27 | 2019-01-18 | 京东方科技集团股份有限公司 | 一种打印喷头、打印设备及打印方法 |
| CN107754960B (zh) * | 2017-10-26 | 2019-09-03 | 北京工业大学 | 基于附加流量实现双乳液滴非对称分裂的微流控芯片 |
| DE102018203047A1 (de) * | 2018-03-01 | 2019-09-05 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung |
| CN112399882B (zh) | 2018-04-16 | 2023-08-01 | 派特恩生物技术有限公司 | 用于形成二维微滴阵列的方法和设备 |
| CN108956558B (zh) * | 2018-05-24 | 2023-09-15 | 深圳市帝迈生物技术有限公司 | 一种微流控芯片和免疫荧光分析仪 |
| US11703427B2 (en) | 2018-06-25 | 2023-07-18 | 10X Genomics, Inc. | Methods and systems for cell and bead processing |
| US10486155B1 (en) * | 2018-10-22 | 2019-11-26 | Klaris Corporation | Vacuum-loaded, droplet-generating microfluidic chips and related methods |
| CN109289951B (zh) * | 2018-10-29 | 2021-01-05 | 深圳先进技术研究院 | 液滴分裂微流控芯片及应用 |
| JP6761153B1 (ja) * | 2019-03-20 | 2020-09-23 | 京セラ株式会社 | 粒子計測デバイスならびに粒子分離計測デバイスおよび粒子分離計測装置 |
| CN111821927B (zh) * | 2019-04-17 | 2021-12-07 | 北京大学 | 一种制备微/纳结构材料的方法及装置 |
| CN112108192B (zh) * | 2019-06-19 | 2022-03-22 | 中国科学院大连化学物理研究所 | 一种微流控芯片及其应用 |
| EP3763438A1 (en) * | 2019-07-12 | 2021-01-13 | Curiosity Diagnostics sp. z o.o | Microfluidic chip, production process and uses |
| CN110449195A (zh) * | 2019-09-05 | 2019-11-15 | 北京工业大学 | 一种提高液滴在不对称通道分裂均匀度的装置 |
| CN110643488A (zh) * | 2019-09-27 | 2020-01-03 | 晶准生物医学(深圳)有限公司 | 微流控液滴操纵分割装置及其操纵分割方法 |
| WO2021168768A1 (zh) * | 2020-02-28 | 2021-09-02 | 京东方科技集团股份有限公司 | 一种微流控芯片和微流控系统 |
| CN111537398B (zh) * | 2020-05-29 | 2021-10-15 | 河南农业大学 | 一种控制液滴撞击形态、接触时间及液滴可控分裂的方法 |
| CN116171200A (zh) * | 2020-09-02 | 2023-05-26 | 10X基因组学有限公司 | 用于高通量液滴形成的装置、系统和方法 |
| EP4180123A1 (en) * | 2021-11-12 | 2023-05-17 | Ecole Polytechnique Fédérale de Lausanne (EPFL) EPFL-TTO | Microfluidic device for sample encapsulation and method for operation thereof |
| CN114534811B (zh) * | 2022-02-28 | 2024-10-18 | 上海天马微电子有限公司 | 微流控装置及其制作方法 |
| CN115254217B (zh) * | 2022-07-27 | 2023-12-01 | 领航基因科技(杭州)有限公司 | 液滴制备装置及方法 |
| CN117205975A (zh) * | 2022-10-20 | 2023-12-12 | 中国科学技术大学 | 一种基于约束圆的微流控芯片分叉结构及通用设计方法 |
| CN118892767A (zh) * | 2024-07-16 | 2024-11-05 | 四川大学 | 并行多级分裂倍增微流控装置及单分散双重乳液的高通量制备方法 |
| CN119657247B (zh) * | 2025-01-20 | 2025-10-10 | 中国工程物理研究院激光聚变研究中心 | 一种基于液滴分裂制备单固核固水油液滴的方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2422804A (en) | 1946-01-26 | 1947-06-24 | Walter H Schroeder | Kite |
| US5862808A (en) | 1997-08-26 | 1999-01-26 | Cigar Savor Enterprises Llc | Cigar punch |
| WO2001088525A1 (en) * | 2000-05-12 | 2001-11-22 | University Of Cincinnati | Structurally programmable microfluidic systems |
| US7901939B2 (en) * | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
| JP2006507921A (ja) * | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| US20060078893A1 (en) * | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| WO2004091763A2 (en) * | 2003-04-10 | 2004-10-28 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| WO2004103565A2 (de) * | 2003-05-19 | 2004-12-02 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung und verfahren zur strukturierung von flüssigkeiten und zum zudosieren von reaktionsflüssigkeiten zu in separationsmedium eingebetteten flüssigkeitskompartimenten |
| EP2662136A3 (en) * | 2003-08-27 | 2013-12-25 | President and Fellows of Harvard College | Method for handling and mixing droplets |
| US20050221339A1 (en) * | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7655470B2 (en) * | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
| US7968287B2 (en) * | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| EP1861194A2 (en) | 2005-03-04 | 2007-12-05 | The President and Fellows of Harvard College | Method and apparatus for forming multiple emulsions |
| FR2890578B3 (fr) * | 2005-09-09 | 2007-11-30 | Rhodia Chimie Sa | Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation |
| CN101300352B (zh) * | 2005-09-01 | 2013-03-20 | 佳能美国生命科学公司 | 检测、分析和鉴定基因组dna的方法和分子诊断装置 |
| TWI296711B (en) * | 2005-10-11 | 2008-05-11 | Ind Tech Res Inst | Biochip with microchannels |
| ATE416508T1 (de) | 2005-10-24 | 2008-12-15 | Conergy Ag | Wechselrichter |
| RU2008127327A (ru) | 2005-12-06 | 2010-01-20 | Ибара-Удилайт Ко., Лтд. (Jp) | Комплексное соединение палладия и раствор для обеспечения каталитических свойств, содержащий его |
| US7811603B2 (en) * | 2006-05-09 | 2010-10-12 | The Regents Of The University Of California | Microfluidic device for forming monodisperse lipoplexes |
| EP2021113A2 (en) * | 2006-05-11 | 2009-02-11 | Raindance Technologies, Inc. | Microfluidic devices |
| WO2008063135A1 (en) * | 2006-11-24 | 2008-05-29 | Agency For Science, Technology And Research | Apparatus for processing a sample in a liquid droplet and method of using the same |
| US7776927B2 (en) | 2007-03-28 | 2010-08-17 | President And Fellows Of Harvard College | Emulsions and techniques for formation |
| US8883291B2 (en) | 2007-08-07 | 2014-11-11 | President And Fellows Of Harvard College | Metal oxide coating on surfaces |
| US8802027B2 (en) | 2008-03-28 | 2014-08-12 | President And Fellows Of Harvard College | Surfaces, including microfluidic channels, with controlled wetting properties |
| EP2286125B1 (en) | 2008-05-16 | 2015-07-08 | President and Fellows of Harvard College | Valves and other flow control in fluidic systems including microfluidic systems |
| WO2009152363A2 (en) | 2008-06-11 | 2009-12-17 | David Stansberry | Universal variable transmission line hanger |
| JP5553428B2 (ja) * | 2008-08-27 | 2014-07-16 | Nsマテリアルズ株式会社 | ペプチドポリマーの製造方法 |
| EP2340435A1 (en) * | 2008-10-08 | 2011-07-06 | Université de Strasbourg | Microfluidic devices for reliable on-chip incubation of droplets in delay lines |
| WO2010104604A1 (en) | 2009-03-13 | 2010-09-16 | President And Fellows Of Harvard College | Method for the controlled creation of emulsions, including multiple emulsions |
| US9625454B2 (en) * | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| JP4973721B2 (ja) * | 2009-12-07 | 2012-07-11 | 東ソー株式会社 | 微小粒子構造体およびそれを用いた微小粒子の製造方法 |
| TWI499552B (zh) * | 2012-12-07 | 2015-09-11 | Univ Nat Cheng Kung | 液滴產生方法及裝置 |
| US20140161686A1 (en) * | 2012-12-10 | 2014-06-12 | Advanced Liquid Logic, Inc. | System and method of dispensing liquids in a microfluidic device |
| US11141730B2 (en) * | 2013-06-14 | 2021-10-12 | President And Fellows Of Harvard College | Coalescence of droplets |
| CN105765055A (zh) * | 2013-08-27 | 2016-07-13 | 基纽拜奥股份有限公司 | 微流体装置和其使用方法 |
-
2012
- 2012-02-06 CN CN201610085021.7A patent/CN105689030A/zh active Pending
- 2012-02-06 JP JP2013552712A patent/JP2014505594A/ja active Pending
- 2012-02-06 US US13/979,984 patent/US20140026968A1/en not_active Abandoned
- 2012-02-06 BR BR112013019880A patent/BR112013019880A2/pt not_active IP Right Cessation
- 2012-02-06 CN CN201280007426.9A patent/CN103347612B/zh not_active Expired - Fee Related
- 2012-02-06 WO PCT/US2012/023961 patent/WO2012109138A1/en not_active Ceased
- 2012-02-06 EP EP12706734.6A patent/EP2673088A1/en not_active Withdrawn
- 2012-02-06 KR KR1020137023593A patent/KR20140063507A/ko not_active Withdrawn
-
2016
- 2016-07-28 JP JP2016148580A patent/JP2016224057A/ja active Pending
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