JP2014504270A5 - - Google Patents
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- Publication number
- JP2014504270A5 JP2014504270A5 JP2013537908A JP2013537908A JP2014504270A5 JP 2014504270 A5 JP2014504270 A5 JP 2014504270A5 JP 2013537908 A JP2013537908 A JP 2013537908A JP 2013537908 A JP2013537908 A JP 2013537908A JP 2014504270 A5 JP2014504270 A5 JP 2014504270A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- receptor
- fusion protein
- integrin
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41135010P | 2010-11-08 | 2010-11-08 | |
| US61/411,350 | 2010-11-08 | ||
| PCT/US2011/059599 WO2012064658A1 (en) | 2010-11-08 | 2011-11-07 | Fusion proteins comprising an engineered knottin peptide and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017079525A Division JP6535361B2 (ja) | 2010-11-08 | 2017-04-13 | 改変ノッチンペプチドを含む融合タンパク質及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504270A JP2014504270A (ja) | 2014-02-20 |
| JP2014504270A5 true JP2014504270A5 (cg-RX-API-DMAC10.html) | 2014-12-25 |
| JP6170435B2 JP6170435B2 (ja) | 2017-07-26 |
Family
ID=46051256
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537908A Expired - Fee Related JP6170435B2 (ja) | 2010-11-08 | 2011-11-07 | 改変ノッチンペプチドを含む融合タンパク質及びその使用 |
| JP2017079525A Expired - Fee Related JP6535361B2 (ja) | 2010-11-08 | 2017-04-13 | 改変ノッチンペプチドを含む融合タンパク質及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017079525A Expired - Fee Related JP6535361B2 (ja) | 2010-11-08 | 2017-04-13 | 改変ノッチンペプチドを含む融合タンパク質及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10844106B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3604549A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP6170435B2 (cg-RX-API-DMAC10.html) |
| AU (3) | AU2011326164B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2817197C (cg-RX-API-DMAC10.html) |
| DK (1) | DK2638173T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2012064658A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008045252A2 (en) * | 2006-10-04 | 2008-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered integrin binding peptides |
| CA2817197C (en) * | 2010-11-08 | 2020-08-04 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| WO2013078250A2 (en) | 2011-11-22 | 2013-05-30 | The Board Of Trustees Of The Leland Stanford Junior University | Cystine knot peptides that bind alpha-v-beta-6 integrin |
| US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| US9587001B2 (en) | 2012-10-19 | 2017-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Conjugated knottin mini-proteins containing non-natural amino acids |
| SG11201504600UA (en) * | 2012-12-10 | 2015-07-30 | Hutchinson Fred Cancer Res | Methods for screening |
| US9822347B2 (en) | 2012-12-14 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Modified AXL peptides and their use in inhibition of AXL signaling in anti-metastatic therapy |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| EP3180018B1 (en) * | 2014-08-12 | 2019-07-24 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein |
| WO2016025647A1 (en) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| EP3313427A4 (en) * | 2015-06-26 | 2018-12-26 | Fred Hutchinson Cancer Research Center | Therapeutic peptides and methods of use thereof |
| CA2994865A1 (en) | 2015-09-09 | 2017-03-16 | Fred Hutchinson Cancer Research Center | Cartilage-homing peptides |
| TWI799366B (zh) * | 2015-09-15 | 2023-04-21 | 美商建南德克公司 | 胱胺酸結骨架平臺 |
| WO2017118761A1 (en) * | 2016-01-08 | 2017-07-13 | Iontas Ltd | Binding members with altered diversity scaffold domains |
| WO2017139570A1 (en) * | 2016-02-12 | 2017-08-17 | Massachusetts Intitute Of Technology | Synergistic tumor treatment with il-2, an integrin-binding-fc fusion protein, and a cancer vaccinne |
| US10765625B2 (en) | 2016-03-15 | 2020-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Knottin-drug conjugates and methods of using the same |
| WO2018044234A1 (en) * | 2016-08-31 | 2018-03-08 | Nanyang Technological University | Cysteine-rich polypeptides and conjugates and methods of using the same |
| US10350266B2 (en) | 2017-01-10 | 2019-07-16 | Nodus Therapeutics, Inc. | Method of treating cancer with a multiple integrin binding Fc fusion protein |
| EP3568150A4 (en) | 2017-01-10 | 2020-12-02 | Xcella Biosciences, Inc. | POLYTHERAPY FOR TUMOR TREATMENT WITH INTEGRIN-BOUND FC FUSION PROTEIN AND IMMUNE MODULATOR |
| CA3049262A1 (en) | 2017-01-18 | 2018-07-26 | Fred Hutchinson Cancer Research Center | Peptide compositions and methods of use thereof for disrupting tead interactions |
| CN110475565A (zh) | 2017-03-16 | 2019-11-19 | 光明之火生物科学公司 | 软骨归巢肽缀合物及其使用方法 |
| WO2018232122A1 (en) | 2017-06-15 | 2018-12-20 | Blaze Bioscience, Inc. | Renal-homing peptide conjugates and methods of use thereof |
| GB201711208D0 (en) | 2017-07-12 | 2017-08-23 | Iontas Ltd | Ion channel inhibitors |
| AU2018307752A1 (en) | 2017-07-24 | 2020-03-12 | Rutgers, The State University Of New Jersey | Phosphatidylserine targeting fusion molecules and methods for their use |
| JP7386161B2 (ja) | 2017-12-19 | 2023-11-24 | ブレイズ バイオサイエンス， インコーポレイテッド | 腫瘍ホーミング及び細胞透過性ペプチド免疫抗がん剤複合体、ならびにそれらの使用方法 |
| JP2022513178A (ja) | 2018-10-09 | 2022-02-07 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 受容体アンタゴニストとしての操作された線維芽細胞増殖因子多様体 |
| WO2020154032A1 (en) | 2019-01-23 | 2020-07-30 | Massachusetts Institute Of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
| CN113661240B (zh) * | 2019-04-02 | 2024-11-05 | 伊莱利利公司 | 选择和检测结合肽的方法 |
| KR20220002271A (ko) * | 2019-04-29 | 2022-01-06 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 간세포 성장인자의 조작된 이량체 단편을 이용한 안구 치료 방법 |
| AU2020277470A1 (en) * | 2019-05-22 | 2022-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Drug conjugates and methods of using same |
| CA3156165A1 (en) * | 2019-09-30 | 2021-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Knottin-immunostimulant conjugates and related compositions and methods |
| US20230211001A1 (en) * | 2020-07-30 | 2023-07-06 | The Board Of Trustees Of The Leland Stanford Junior University | Lysosomal Targeting Molecules Comprising Knottin Peptides And Related Compositions And Methods |
| MX2020012914A (es) * | 2020-11-27 | 2022-05-30 | Centro De Investig Cientifica Y De Educacion Superior De Ensenada Baja California Cicese | Proteina andamio para la generacion de proteinas quimericas de union a antigeno. |
| WO2025255080A1 (en) * | 2024-06-04 | 2025-12-11 | The Children's Hospital Of Philadelphia | Hypoxia inducible high-fidelity circuit |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5468634A (en) * | 1991-06-24 | 1995-11-21 | The University Of North Carolina At Chapel Hill | Axl oncogene |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6303749B1 (en) * | 1999-01-29 | 2001-10-16 | Amgen Inc. | Agouti and agouti-related peptide analogs |
| DE10053224A1 (de) * | 2000-10-26 | 2002-05-08 | Univ Goettingen Georg August | Verfahren zur Exposition von Peptiden und Polypeptiden auf der Zelloberfläche von Bakterien |
| US20040132634A1 (en) | 2001-01-31 | 2004-07-08 | Frank Sicheri | Compositions and methods for regulating the kinase domain of receptor tyrosine kinases |
| GB0110430D0 (en) | 2001-04-27 | 2001-06-20 | Medical Res Council | Protein variants and uses thereof |
| EP1737971B1 (en) | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
| AU2005277641A1 (en) * | 2004-08-16 | 2006-03-02 | Medimmune, Llc | Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity |
| US7674881B2 (en) | 2005-10-07 | 2010-03-09 | The University Of Chicago | Convergent synthesis of proteins by kinetically controlled ligation |
| US7666622B2 (en) * | 2005-10-19 | 2010-02-23 | Regeneron Pharmaceuticals, Inc. | Monomeric self-associating fusion polypeptides and therapeutic uses thereof |
| WO2008045252A2 (en) * | 2006-10-04 | 2008-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered integrin binding peptides |
| EP1958957A1 (en) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprising a knottin protein moiety |
| EP2170395A1 (en) * | 2007-07-02 | 2010-04-07 | Wyeth LLC | Modulators of axl for use in treating bone disorders |
| CN101952312A (zh) | 2007-07-31 | 2011-01-19 | 米迪缪尼有限公司 | 多特异性表位结合蛋白及其应用 |
| US10457719B2 (en) * | 2007-09-18 | 2019-10-29 | The Jackson Laboratory | Antibodies and FC fusion protein modifications with enhanced persistence or pharmacokinetic stability in vivo and methods of use thereof |
| WO2009061853A2 (en) * | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Mutant interleukin-2 (il-2) polypeptides |
| US8394924B2 (en) | 2008-10-23 | 2013-03-12 | Massachusetts Institute Of Technology | Directed engagement of activating Fc receptors |
| US8329826B2 (en) | 2008-11-06 | 2012-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Surface modification of interpenetrating polymer networks |
| US8778888B2 (en) | 2009-11-06 | 2014-07-15 | The Board Of Trustees Of The Leland Stanford Junior University | Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use |
| CA3056999A1 (en) | 2010-01-22 | 2011-07-28 | Amato J. Giaccia | Inhibition of axl signaling in anti-metastatic therapy |
| CA2817197C (en) * | 2010-11-08 | 2020-08-04 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| US10350266B2 (en) * | 2017-01-10 | 2019-07-16 | Nodus Therapeutics, Inc. | Method of treating cancer with a multiple integrin binding Fc fusion protein |
-
2011
- 2011-11-07 CA CA2817197A patent/CA2817197C/en active Active
- 2011-11-07 AU AU2011326164A patent/AU2011326164B2/en not_active Ceased
- 2011-11-07 JP JP2013537908A patent/JP6170435B2/ja not_active Expired - Fee Related
- 2011-11-07 US US13/883,216 patent/US10844106B2/en active Active
- 2011-11-07 WO PCT/US2011/059599 patent/WO2012064658A1/en not_active Ceased
- 2011-11-07 EP EP19180924.3A patent/EP3604549A1/en not_active Withdrawn
- 2011-11-07 EP EP11839687.8A patent/EP2638173B1/en active Active
- 2011-11-07 DK DK11839687.8T patent/DK2638173T3/da active
-
2016
- 2016-08-04 AU AU2016210712A patent/AU2016210712B2/en not_active Ceased
-
2017
- 2017-04-13 JP JP2017079525A patent/JP6535361B2/ja not_active Expired - Fee Related
-
2018
- 2018-01-24 AU AU2018200587A patent/AU2018200587B2/en not_active Ceased
-
2020
- 2020-10-08 US US17/066,167 patent/US11498952B2/en active Active
-
2022
- 2022-11-14 US US18/055,297 patent/US12240882B2/en active Active
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