JP2014503575A - 超常磁性のナノ粒子を用いて、興味対象生成物のリポソームからの放出をモニターする方法 - Google Patents

超常磁性のナノ粒子を用いて、興味対象生成物のリポソームからの放出をモニターする方法 Download PDF

Info

Publication number
JP2014503575A
JP2014503575A JP2013550906A JP2013550906A JP2014503575A JP 2014503575 A JP2014503575 A JP 2014503575A JP 2013550906 A JP2013550906 A JP 2013550906A JP 2013550906 A JP2013550906 A JP 2013550906A JP 2014503575 A JP2014503575 A JP 2014503575A
Authority
JP
Japan
Prior art keywords
liposome
nanoparticles
heating
liposomes
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013550906A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014503575A5 (https=
Inventor
アニエス・ポティエ
ローラン・レヴィ
マリー−エディス・メイル
マテュー・ジェルマン
シリル・ロアンザト
クリ・ムーナン
ピエール・スミルノフ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Nanobiotix SA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Nanobiotix SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Nanobiotix SA filed Critical Centre National de la Recherche Scientifique CNRS
Publication of JP2014503575A publication Critical patent/JP2014503575A/ja
Publication of JP2014503575A5 publication Critical patent/JP2014503575A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Signal Processing (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
JP2013550906A 2011-01-31 2012-01-31 超常磁性のナノ粒子を用いて、興味対象生成物のリポソームからの放出をモニターする方法 Pending JP2014503575A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161437831P 2011-01-31 2011-01-31
EP11305097.5 2011-01-31
US61/437,831 2011-01-31
EP11305097 2011-01-31
PCT/EP2012/051510 WO2012104277A2 (en) 2011-01-31 2012-01-31 Method of monitoring the release from liposomes of a product of interest using superparamagnetic nanoparticles.

Publications (2)

Publication Number Publication Date
JP2014503575A true JP2014503575A (ja) 2014-02-13
JP2014503575A5 JP2014503575A5 (https=) 2015-03-12

Family

ID=44146997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013550906A Pending JP2014503575A (ja) 2011-01-31 2012-01-31 超常磁性のナノ粒子を用いて、興味対象生成物のリポソームからの放出をモニターする方法

Country Status (4)

Country Link
US (2) US20140227343A1 (https=)
EP (1) EP2670393B8 (https=)
JP (1) JP2014503575A (https=)
WO (1) WO2012104277A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018532279A (ja) * 2015-08-28 2018-11-01 湖南博海新材料股▲ふん▼有限公司Ｈｕｎａｎ Ｂｏｈａｉ Ｎｅｗ Ｍａｔｅｒｉａｌｓ Ｃｏ．，Ｌｔｄ ナノ磁気レオロジカル流体及びその製造設備並びに方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012104275A2 (en) 2011-01-31 2012-08-09 Nanobiotix Nanoparticles delivery systems, preparation and uses thereof
EA029635B1 (ru) 2011-12-16 2018-04-30 Нанобиотикс Применение наночастицы, включающей металлический материал, покрытый материалом оксида гафния, в онкологии и композиция, ее содержащая
RU2014133467A (ru) 2012-02-17 2016-04-10 Селшн Корпорейшн Термочувствительные составы в виде наночастиц и способ их получения
WO2014191569A1 (en) 2013-05-30 2014-12-04 Nanobiotix Pharmaceutical composition, preparation and uses thereof
KR20150026613A (ko) * 2013-09-03 2015-03-11 삼성전자주식회사 소수성 물질 및 조영제를 포함하는 리포좀 및 그의 용도
ES2543362B1 (es) * 2014-01-15 2016-06-06 Soluciones Nanotecnológicas, Sl Composiciones que contienen liposomas, ácidos grasos poliinsaturados omega-3 de cadena larga y nanopartículas superparamagnéticas y su uso en el tratamiento de tumores malignos
SG11201704143YA (en) * 2014-11-25 2017-06-29 Nanobiotix Pharmaceutical composition, preparation and uses thereof
UA123665C2 (uk) 2014-11-25 2021-05-12 Кюрадігм Сас Фармацевтична композиція, її одержання і застосування
ES2774365T3 (es) 2014-11-25 2020-07-20 Curadigm Sas Composición farmacéutica, preparación y usos de la misma
EP3229776B1 (en) 2014-11-25 2023-06-28 Curadigm Sas Pharmaceutical composition combining at least two distinct nanoparticles and a pharmaceutical compound, preparation and uses thereof
EP3223796B1 (en) 2014-11-25 2021-07-21 Curadigm Sas Pharmaceutical compositions, preparation and uses thereof
UA124572C2 (uk) 2015-05-28 2021-10-13 Нанобіотікс Наночастинки для застосування як терапевтичної вакцини

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001527534A (ja) * 1997-03-07 2001-12-25 マックス−デルブルック−セントラム フュア モレクラーレ メディシン 特異的磁気体、その製造方法及び使用
JP2006051732A (ja) * 2004-08-13 2006-02-23 Panakku Kogyo Kk 成形品から熱可塑性樹脂を回収する方法及び成形品
WO2008033031A2 (en) * 2006-09-12 2008-03-20 Epitarget As Mri trackable drug delivery particles, uses and methods thereof
US20090004258A1 (en) * 2007-06-27 2009-01-01 National Health Research Institutes Drug Release from Thermosensitive Liposomes by Applying an Alternative Magnetic Field

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395619A (en) * 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
DE19716732C2 (de) 1997-03-07 1999-03-25 Max Delbrueck Centrum Spezifische Magnetosomen, Verfahren zu ihrer Herstellung und ihre Verwendung
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
US6200598B1 (en) * 1998-06-18 2001-03-13 Duke University Temperature-sensitive liposomal formulation
US7769423B2 (en) * 2002-09-11 2010-08-03 Duke University MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting
WO2006051732A1 (ja) 2004-11-10 2006-05-18 Konica Minolta Medical & Graphic, Inc. 被覆磁性粒子含有製剤およびその製造方法、並びに診断治療システム
NO20064315L (no) * 2006-09-22 2008-03-24 Epitarget As T1 MRI-sporbare medikamentavleveringspartikler and anvendelse derav
EP2067485A1 (en) * 2007-12-07 2009-06-10 Koninklijke Philips Electronics N.V. Drug carrier providing MRI contrast enhancement
EP2340051B1 (en) * 2008-09-10 2015-11-11 Koninklijke Philips N.V. Drug carrier providing mri contrast enhancement
WO2012104275A2 (en) 2011-01-31 2012-08-09 Nanobiotix Nanoparticles delivery systems, preparation and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001527534A (ja) * 1997-03-07 2001-12-25 マックス−デルブルック−セントラム フュア モレクラーレ メディシン 特異的磁気体、その製造方法及び使用
JP2006051732A (ja) * 2004-08-13 2006-02-23 Panakku Kogyo Kk 成形品から熱可塑性樹脂を回収する方法及び成形品
WO2008033031A2 (en) * 2006-09-12 2008-03-20 Epitarget As Mri trackable drug delivery particles, uses and methods thereof
US20090004258A1 (en) * 2007-06-27 2009-01-01 National Health Research Institutes Drug Release from Thermosensitive Liposomes by Applying an Alternative Magnetic Field

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018532279A (ja) * 2015-08-28 2018-11-01 湖南博海新材料股▲ふん▼有限公司Ｈｕｎａｎ Ｂｏｈａｉ Ｎｅｗ Ｍａｔｅｒｉａｌｓ Ｃｏ．，Ｌｔｄ ナノ磁気レオロジカル流体及びその製造設備並びに方法
US10896776B2 (en) 2015-08-28 2021-01-19 Hunan Bohai New Materials Co., Ltd. Nano magneto-rheological fluid and preparation method and device thereof

Also Published As

Publication number Publication date
EP2670393A2 (en) 2013-12-11
EP2670393B8 (en) 2016-10-05
US20160038616A1 (en) 2016-02-11
US10064962B2 (en) 2018-09-04
EP2670393B1 (en) 2016-08-10
US20140227343A1 (en) 2014-08-14
WO2012104277A2 (en) 2012-08-09
WO2012104277A3 (en) 2012-10-26

Similar Documents

Publication Publication Date Title
US10064962B2 (en) Method of monitoring the release from liposomes of a product of interest using superparamagnetic nanoparticles
JP6158714B2 (ja) ナノ粒子デリバリーシステム、その製造および使用
US5411730A (en) Magnetic microparticles
Lorenzato et al. MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image‐guided local drug delivery
Terreno et al. Paramagnetic liposomes as innovative contrast agents for magnetic resonance (MR) molecular imaging applications
US20090004258A1 (en) Drug Release from Thermosensitive Liposomes by Applying an Alternative Magnetic Field
US20100247445A1 (en) Polymeric drug carrier for image-guided delivery
Carvalho et al. Enhanced contrast efficiency in MRI by PEGylated magnetoliposomes loaded with PEGylated SPION: Effect of SPION coating and micro-environment
Feshitan et al. Theranostic Gd (III)-lipid microbubbles for MRI-guided focused ultrasound surgery
Millart et al. Superparamagnetic lipid-based hybrid nanosystems for drug delivery
US20100254913A1 (en) Non-spherical contrast agents for cest mri based on bulk magnetic susceptibility effect
WO2008033031A2 (en) Mri trackable drug delivery particles, uses and methods thereof
US20100158817A1 (en) T1 mri trackable drug delivery particles, uses and methods thereof
Lorenzato et al. MRI monitoring of nanocarrier accumulation and release using Gadolinium‐SPIO co‐labelled thermosensitive liposomes
Meincke et al. Iron oxide-loaded liposomes for MR imaging
Wang et al. Magnetic vortex iron oxide nanorings coated with mesoporous silica as smart diagnostic and therapeutic nanoagents: Negative MRI-guided tumor magnetothermal-chemotherapy
Tripepi Design and testing of" smart" probes for multimodal molecular imaging applications
Lopes et al. Magnetoliposomes Containing Multicore Nanoparticles and a New Thienopyridine Antitumor Compound for Chemo/Thermotherapy
Kuo Biomimetic nanostructures for theranostic applications
Fernandes Image-guided drug delivery using Fe-deferoxamine loaded temperature-sensitive liposomes
Medina et al. Bochra Chahid, Luce Vander Elst c, Julien Flament d, Fawzi Boumezbeur d

Legal Events

Date Code Title Description
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20140326

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150119

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150119

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20151224

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160119

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20160218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160414

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160913

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170425