JP2014503198A - 組換え酵素および他のタンパク質のタンパク質発現および分泌を改善する新規シグナル配列 - Google Patents
組換え酵素および他のタンパク質のタンパク質発現および分泌を改善する新規シグナル配列 Download PDFInfo
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
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| PCT/US2011/061862 WO2012071422A2 (en) | 2010-11-22 | 2011-11-22 | Novel signal sequences to improve protein expressions and secretion of recombinant enzymes and other proteins |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021505135A (ja) * | 2017-11-30 | 2021-02-18 | アミカス セラピューティックス インコーポレイテッド | Ｃｄｋｌ５発現変異体及びｃｄｋｌ５融合タンパク質 |
| JP2021521851A (ja) * | 2018-04-30 | 2021-08-30 | アミカス セラピューティックス インコーポレイテッド | 遺伝子治療構築物及び使用方法 |
| JP2022530833A (ja) * | 2019-04-30 | 2022-07-01 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ポンペ病の治療のために有用な組成物 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3164492T3 (pl) * | 2014-07-03 | 2020-04-30 | F. Hoffmann-La Roche Ag | Układy ekspresji polipeptydu |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| KR102760654B1 (ko) | 2017-06-07 | 2025-02-04 | 리제너론 파마슈티칼스 인코포레이티드 | 효소 내재화를 위한 조성물 및 방법 |
| MA51796A (fr) | 2018-02-07 | 2020-12-16 | Regeneron Pharma | Procédés et compositions pour l'administration de protéines thérapeutiques |
| US12252544B2 (en) | 2018-05-17 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Anti-CD63 antibodies, conjugates, and uses thereof |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| WO2020077114A2 (en) | 2018-10-10 | 2020-04-16 | Amicus Therapeutics, Inc. | Disulfide bond stabilized polypeptide compositions and methods of use |
| EP3870600A1 (en) | 2018-10-24 | 2021-09-01 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| JP2022514863A (ja) * | 2018-12-19 | 2022-02-16 | ヴェルサメブ アーゲー | タンパク質をコードするｒｎａ |
| KR20210149251A (ko) | 2019-03-08 | 2021-12-08 | 옵시디안 테라퓨틱스, 인크. | 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법 |
| WO2020252404A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| JP2022537670A (ja) | 2019-06-12 | 2022-08-29 | オブシディアン セラピューティクス， インコーポレイテッド | Ｃａ２の組成物および調整可能な制御方法 |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| CN112342247B (zh) * | 2020-11-10 | 2022-03-11 | 江苏科技大学 | 一种提高家蚕细胞表达外源蛋白分泌率的方法 |
| MX2023006445A (es) | 2020-12-01 | 2023-08-10 | Univ Pennsylvania | Composiciones y usos de estas para el tratamiento del síndrome de angelman. |
| WO2023086939A1 (en) | 2021-11-12 | 2023-05-19 | Amicus Therapeutics, Inc. | Compositions and methods for treating mucopolysaccharidosis iiia |
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| JP2007528212A (ja) * | 2003-11-06 | 2007-10-11 | ジェネンコー・インターナショナル・インク | 糸状菌におけるプロテアーゼ抑制剤及びその変異体の発現 |
| JP2009533364A (ja) * | 2006-04-11 | 2009-09-17 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 治療用ポリペプチドのインビボでの回収を増大させる方法 |
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- 2011-11-22 JP JP2013541026A patent/JP2014503198A/ja not_active Withdrawn
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| JP2002530426A (ja) * | 1998-11-24 | 2002-09-17 | ブリストル−マイヤーズ スクイブ カンパニー | ７０ｋＤ熱ショック蛋白による化合物の細胞内標的輸送 |
| JP2007528212A (ja) * | 2003-11-06 | 2007-10-11 | ジェネンコー・インターナショナル・インク | 糸状菌におけるプロテアーゼ抑制剤及びその変異体の発現 |
| JP2009533364A (ja) * | 2006-04-11 | 2009-09-17 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 治療用ポリペプチドのインビボでの回収を増大させる方法 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021505135A (ja) * | 2017-11-30 | 2021-02-18 | アミカス セラピューティックス インコーポレイテッド | Ｃｄｋｌ５発現変異体及びｃｄｋｌ５融合タンパク質 |
| JP2021521851A (ja) * | 2018-04-30 | 2021-08-30 | アミカス セラピューティックス インコーポレイテッド | 遺伝子治療構築物及び使用方法 |
| JP7749322B2 (ja) | 2018-04-30 | 2025-10-06 | アミカス セラピューティックス インコーポレイテッド | 遺伝子治療構築物及び使用方法 |
| JP2022530833A (ja) * | 2019-04-30 | 2022-07-01 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ポンペ病の治療のために有用な組成物 |
| JP7585233B2 (ja) | 2019-04-30 | 2024-11-18 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ポンペ病の治療のために有用な組成物 |
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| CY1121049T1 (el) | 2019-12-11 |
| WO2012071422A3 (en) | 2012-08-02 |
| EP2643468A2 (en) | 2013-10-02 |
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| US9279007B2 (en) | 2016-03-08 |
| DK3461905T3 (da) | 2020-11-02 |
| CA2818689A1 (en) | 2012-05-31 |
| CN103328649B (zh) | 2016-06-22 |
| US20140045216A1 (en) | 2014-02-13 |
| ES2829199T3 (es) | 2021-05-31 |
| BR112013012671A2 (pt) | 2016-10-11 |
| LT2643468T (lt) | 2018-09-10 |
| EP2643468B1 (en) | 2018-07-04 |
| HRP20181315T1 (hr) | 2018-10-19 |
| PL2643468T3 (pl) | 2018-11-30 |
| HUE039070T2 (hu) | 2018-12-28 |
| BR112013012671B1 (pt) | 2022-03-03 |
| ES2687415T3 (es) | 2018-10-25 |
| KR20190060888A (ko) | 2019-06-03 |
| PT2643468T (pt) | 2018-10-11 |
| SI2643468T1 (sl) | 2018-10-30 |
| CA2818689C (en) | 2021-09-21 |
| WO2012071422A2 (en) | 2012-05-31 |
| CN103328649A (zh) | 2013-09-25 |
| KR101984318B1 (ko) | 2019-05-31 |
| RS57601B1 (sr) | 2018-11-30 |
| SMT201800466T1 (it) | 2018-11-09 |
| DK2643468T3 (en) | 2018-09-24 |
| KR20130121878A (ko) | 2013-11-06 |
| EP3461905B1 (en) | 2020-08-05 |
| EP2643468A4 (en) | 2014-12-24 |
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