JP2014500883A5 - - Google Patents
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- Publication number
- JP2014500883A5 JP2014500883A5 JP2013541350A JP2013541350A JP2014500883A5 JP 2014500883 A5 JP2014500883 A5 JP 2014500883A5 JP 2013541350 A JP2013541350 A JP 2013541350A JP 2013541350 A JP2013541350 A JP 2013541350A JP 2014500883 A5 JP2014500883 A5 JP 2014500883A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- peptide
- cys
- compound
- btm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000005647 linker group Chemical group 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- -1 aminooxy compound Chemical class 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 238000009833 condensation Methods 0.000 claims 3
- 230000005494 condensation Effects 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
- 101800005149 Peptide B Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001728 carbonyl compounds Chemical class 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108010091748 peptide A Proteins 0.000 claims 2
- 108010005636 polypeptide C Proteins 0.000 claims 2
- 238000000163 radioactive labelling Methods 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- YYLQUHNPNCGKJQ-NHYDCYSISA-N (3R)-3-hydroxy-L-aspartic acid Chemical compound OC(=O)[C@@H](N)[C@@H](O)C(O)=O YYLQUHNPNCGKJQ-NHYDCYSISA-N 0.000 claims 1
- 108010062877 Bacteriocins Proteins 0.000 claims 1
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1020314.9A GB201020314D0 (en) | 2010-12-01 | 2010-12-01 | Apoptosis pet imaging agents |
| GB1020314.9 | 2010-12-01 | ||
| US201161476805P | 2011-04-19 | 2011-04-19 | |
| GBGB1106593.5A GB201106593D0 (en) | 2011-04-19 | 2011-04-19 | Radioconjugation method |
| GB1106593.5 | 2011-04-19 | ||
| US61/476,805 | 2011-04-19 | ||
| PCT/EP2011/071506 WO2012072736A2 (en) | 2010-12-01 | 2011-12-01 | Radioconjugation method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500883A JP2014500883A (ja) | 2014-01-16 |
| JP2014500883A5 true JP2014500883A5 (enExample) | 2015-01-22 |
| JP6231882B2 JP6231882B2 (ja) | 2017-11-15 |
Family
ID=45063153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541350A Active JP6231882B2 (ja) | 2010-12-01 | 2011-12-01 | 放射性コンジュゲーション方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9493504B2 (enExample) |
| EP (2) | EP3395373B1 (enExample) |
| JP (1) | JP6231882B2 (enExample) |
| KR (1) | KR20130119957A (enExample) |
| CN (2) | CN104984372B (enExample) |
| AU (1) | AU2011334881A1 (enExample) |
| BR (1) | BR112013013283A2 (enExample) |
| CA (1) | CA2819347A1 (enExample) |
| ES (2) | ES2675102T3 (enExample) |
| MX (1) | MX2013006202A (enExample) |
| RU (1) | RU2013122649A (enExample) |
| WO (1) | WO2012072736A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3395373B1 (en) * | 2010-12-01 | 2022-10-19 | GE Healthcare Limited | Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging |
| GB201314936D0 (en) * | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| GB201322451D0 (en) * | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Purification method and compositions |
| CA3085407A1 (en) * | 2018-01-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Radiolabelled oligonucleotides and process for their preparation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040662A2 (en) | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
| GB0305704D0 (en) * | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| EP1713508A2 (en) * | 2004-01-29 | 2006-10-25 | Biosynexus Incorporated | Use of amino-oxy functional groups in the preparation of vaccine conjugates |
| GB0420344D0 (en) | 2004-09-14 | 2004-10-13 | Amersham Plc | Diagnostic compounds |
| GB0420365D0 (en) | 2004-09-14 | 2004-10-13 | Hammersmith Imanet Ltd | Radiolabelled insulin |
| EP2125039A2 (en) | 2006-12-18 | 2009-12-02 | GE Healthcare AS | Synthesis of a radiofluorinated peptide using photolabile protecting groups |
| EP2114464A2 (en) * | 2006-12-28 | 2009-11-11 | GE Healthcare AS | Radiofluorination methods |
| US8545809B2 (en) * | 2007-01-11 | 2013-10-01 | Immunomedics, Inc. | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules |
| US20080274046A1 (en) * | 2007-02-20 | 2008-11-06 | Christian Prenant | Radiolabelling |
| GB0803477D0 (en) * | 2008-02-26 | 2008-04-02 | Ge Healthcare As | Therapy selection method |
| EP3395373B1 (en) * | 2010-12-01 | 2022-10-19 | GE Healthcare Limited | Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging |
-
2011
- 2011-12-01 EP EP18167523.2A patent/EP3395373B1/en active Active
- 2011-12-01 JP JP2013541350A patent/JP6231882B2/ja active Active
- 2011-12-01 BR BR112013013283A patent/BR112013013283A2/pt not_active IP Right Cessation
- 2011-12-01 MX MX2013006202A patent/MX2013006202A/es unknown
- 2011-12-01 WO PCT/EP2011/071506 patent/WO2012072736A2/en not_active Ceased
- 2011-12-01 EP EP11788862.8A patent/EP2646060B1/en active Active
- 2011-12-01 ES ES11788862.8T patent/ES2675102T3/es active Active
- 2011-12-01 RU RU2013122649/04A patent/RU2013122649A/ru not_active Application Discontinuation
- 2011-12-01 AU AU2011334881A patent/AU2011334881A1/en not_active Abandoned
- 2011-12-01 US US13/991,340 patent/US9493504B2/en active Active
- 2011-12-01 KR KR1020137016889A patent/KR20130119957A/ko not_active Withdrawn
- 2011-12-01 CA CA2819347A patent/CA2819347A1/en not_active Abandoned
- 2011-12-01 ES ES18167523T patent/ES2929507T3/es active Active
- 2011-12-01 CN CN201510440109.1A patent/CN104984372B/zh active Active
- 2011-12-01 CN CN201180057989.4A patent/CN103269725B/zh active Active
-
2016
- 2016-11-01 US US15/340,743 patent/US20170044080A1/en not_active Abandoned
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