JP2017501152A5 - - Google Patents
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- Publication number
- JP2017501152A5 JP2017501152A5 JP2016539182A JP2016539182A JP2017501152A5 JP 2017501152 A5 JP2017501152 A5 JP 2017501152A5 JP 2016539182 A JP2016539182 A JP 2016539182A JP 2016539182 A JP2016539182 A JP 2016539182A JP 2017501152 A5 JP2017501152 A5 JP 2017501152A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cys
- solution
- radioactive tracer
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 239000000700 radioactive tracer Substances 0.000 claims 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- 239000000243 solution Substances 0.000 claims 12
- 239000003960 organic solvent Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims 4
- 239000012156 elution solvent Substances 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229940124553 radioprotectant Drugs 0.000 claims 3
- 238000001044 reversed-phase solid-phase extraction Methods 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 101800005149 Peptide B Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 238000004140 cleaning Methods 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108010091748 peptide A Proteins 0.000 claims 2
- 108010005636 polypeptide C Proteins 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- 230000003537 radioprotector Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YYLQUHNPNCGKJQ-NHYDCYSISA-N (3R)-3-hydroxy-L-aspartic acid Chemical compound OC(=O)[C@@H](N)[C@@H](O)C(O)=O YYLQUHNPNCGKJQ-NHYDCYSISA-N 0.000 claims 1
- 108010062877 Bacteriocins Proteins 0.000 claims 1
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229960004050 aminobenzoic acid Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 239000012738 dissolution medium Substances 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229960005219 gentisic acid Drugs 0.000 claims 1
- 239000000718 radiation-protective agent Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1322451.4A GB201322451D0 (en) | 2013-12-18 | 2013-12-18 | Purification method and compositions |
| GB1322451.4 | 2013-12-18 | ||
| PCT/EP2014/078608 WO2015091881A1 (en) | 2013-12-18 | 2014-12-18 | Purification method and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019108641A Division JP2019196356A (ja) | 2013-12-18 | 2019-06-11 | 精製方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501152A JP2017501152A (ja) | 2017-01-12 |
| JP2017501152A5 true JP2017501152A5 (enExample) | 2017-12-28 |
| JP6842920B2 JP6842920B2 (ja) | 2021-03-17 |
Family
ID=50071048
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539182A Active JP6842920B2 (ja) | 2013-12-18 | 2014-12-18 | 精製方法及び組成物 |
| JP2019108641A Withdrawn JP2019196356A (ja) | 2013-12-18 | 2019-06-11 | 精製方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019108641A Withdrawn JP2019196356A (ja) | 2013-12-18 | 2019-06-11 | 精製方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20160303262A1 (enExample) |
| EP (1) | EP3083526B1 (enExample) |
| JP (2) | JP6842920B2 (enExample) |
| CN (1) | CN105849067B (enExample) |
| ES (1) | ES2750624T3 (enExample) |
| GB (1) | GB201322451D0 (enExample) |
| WO (1) | WO2015091881A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120165650A1 (en) * | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| US20210350946A1 (en) * | 2019-10-25 | 2021-11-11 | ITM Isotopen Technologien München AG | System and method of recovering a parent radionuclide from a radionuclide generator |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101636183B (zh) * | 2007-02-13 | 2014-03-19 | 日本医事物理股份有限公司 | 放射性诊断显像剂的制备方法 |
| GB201013808D0 (en) * | 2010-08-18 | 2010-09-29 | Ge Healthcare Ltd | Peptide radiotracer compositions |
| EP3395373B1 (en) * | 2010-12-01 | 2022-10-19 | GE Healthcare Limited | Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging |
| GB201020314D0 (en) * | 2010-12-01 | 2011-01-12 | Ge Healthcare Ltd | Apoptosis pet imaging agents |
| US20130295010A1 (en) * | 2010-12-22 | 2013-11-07 | Duncan Hiscock | Her2 binding peptides labelled with a 18f - containing organosilicon compound |
| GB201202420D0 (en) * | 2012-02-13 | 2012-03-28 | Ge Healthcare Ltd | Radiotracer compositions |
| GB201209082D0 (en) * | 2012-05-24 | 2012-07-04 | Ge Healthcare Ltd | Purification method |
-
2013
- 2013-12-18 GB GBGB1322451.4A patent/GB201322451D0/en not_active Ceased
-
2014
- 2014-12-18 US US15/102,511 patent/US20160303262A1/en not_active Abandoned
- 2014-12-18 ES ES14815726T patent/ES2750624T3/es active Active
- 2014-12-18 CN CN201480069376.6A patent/CN105849067B/zh active Active
- 2014-12-18 EP EP14815726.6A patent/EP3083526B1/en active Active
- 2014-12-18 JP JP2016539182A patent/JP6842920B2/ja active Active
- 2014-12-18 WO PCT/EP2014/078608 patent/WO2015091881A1/en not_active Ceased
-
2019
- 2019-06-11 JP JP2019108641A patent/JP2019196356A/ja not_active Withdrawn
-
2021
- 2021-05-07 US US17/314,158 patent/US20210330824A1/en not_active Abandoned
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