CN105849067B - 纯化方法和组合物 - Google Patents

纯化方法和组合物 Download PDF

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Publication number
CN105849067B
CN105849067B CN201480069376.6A CN201480069376A CN105849067B CN 105849067 B CN105849067 B CN 105849067B CN 201480069376 A CN201480069376 A CN 201480069376A CN 105849067 B CN105849067 B CN 105849067B
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Prior art keywords
peptide
cys
radioactive tracer
gly
thr
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CN201480069376.6A
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English (en)
Chinese (zh)
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CN105849067A (zh
Inventor
T.恩格尔
A.R.迈耶尔
I.A.卡恩
R.J.奈尔内
G.麦克罗比
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GE Healthcare Ltd
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GE Healthcare Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201480069376.6A 2013-12-18 2014-12-18 纯化方法和组合物 Active CN105849067B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1322451.4A GB201322451D0 (en) 2013-12-18 2013-12-18 Purification method and compositions
GB1322451.4 2013-12-18
PCT/EP2014/078608 WO2015091881A1 (en) 2013-12-18 2014-12-18 Purification method and compositions

Publications (2)

Publication Number Publication Date
CN105849067A CN105849067A (zh) 2016-08-10
CN105849067B true CN105849067B (zh) 2018-04-17

Family

ID=50071048

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480069376.6A Active CN105849067B (zh) 2013-12-18 2014-12-18 纯化方法和组合物

Country Status (7)

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US (2) US20160303262A1 (enExample)
EP (1) EP3083526B1 (enExample)
JP (2) JP6842920B2 (enExample)
CN (1) CN105849067B (enExample)
ES (1) ES2750624T3 (enExample)
GB (1) GB201322451D0 (enExample)
WO (1) WO2015091881A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120165650A1 (en) * 2010-12-22 2012-06-28 General Electric Company Her2 binders
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
US20210350946A1 (en) * 2019-10-25 2021-11-11 ITM Isotopen Technologien München AG System and method of recovering a parent radionuclide from a radionuclide generator

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012072728A1 (en) * 2010-12-01 2012-06-07 Ge Healthcare Limited Apoptosis pet imaging agents
CN103153350A (zh) * 2010-08-18 2013-06-12 通用电气健康护理有限公司 肽放射性示踪剂组合物
CN103269725A (zh) * 2010-12-01 2013-08-28 通用电气健康护理有限公司 放射性缀合法
CN103402550A (zh) * 2010-12-22 2013-11-20 通用电气健康护理有限公司 用含有18f的有机硅化合物标记的her2结合肽
WO2013174909A1 (en) * 2012-05-24 2013-11-28 Ge Healthcare Limited Purification of [18f] - fluciclatide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101636183B (zh) * 2007-02-13 2014-03-19 日本医事物理股份有限公司 放射性诊断显像剂的制备方法
GB201202420D0 (en) * 2012-02-13 2012-03-28 Ge Healthcare Ltd Radiotracer compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153350A (zh) * 2010-08-18 2013-06-12 通用电气健康护理有限公司 肽放射性示踪剂组合物
WO2012072728A1 (en) * 2010-12-01 2012-06-07 Ge Healthcare Limited Apoptosis pet imaging agents
CN103269725A (zh) * 2010-12-01 2013-08-28 通用电气健康护理有限公司 放射性缀合法
CN103402550A (zh) * 2010-12-22 2013-11-20 通用电气健康护理有限公司 用含有18f的有机硅化合物标记的her2结合肽
WO2013174909A1 (en) * 2012-05-24 2013-11-28 Ge Healthcare Limited Purification of [18f] - fluciclatide

Also Published As

Publication number Publication date
CN105849067A (zh) 2016-08-10
EP3083526B1 (en) 2019-08-07
GB201322451D0 (en) 2014-02-05
WO2015091881A1 (en) 2015-06-25
ES2750624T3 (es) 2020-03-26
HK1226050B (zh) 2017-09-22
EP3083526A1 (en) 2016-10-26
US20160303262A1 (en) 2016-10-20
US20210330824A1 (en) 2021-10-28
JP6842920B2 (ja) 2021-03-17
JP2019196356A (ja) 2019-11-14
JP2017501152A (ja) 2017-01-12

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