JP6842920B2 - 精製方法及び組成物 - Google Patents

精製方法及び組成物 Download PDF

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Publication number
JP6842920B2
JP6842920B2 JP2016539182A JP2016539182A JP6842920B2 JP 6842920 B2 JP6842920 B2 JP 6842920B2 JP 2016539182 A JP2016539182 A JP 2016539182A JP 2016539182 A JP2016539182 A JP 2016539182A JP 6842920 B2 JP6842920 B2 JP 6842920B2
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Japan
Prior art keywords
peptide
solution
cys
radioactive tracer
gly
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JP2016539182A
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English (en)
Japanese (ja)
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JP2017501152A (ja
JP2017501152A5 (enExample
Inventor
エンゲル，トルグリム
メイジャー，アンドレアス・リチャード
カーン，イミティアス・アハメド
ナイルネ，ロバート・ジェイムズ
マクロビー，グラエム
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of JP2017501152A5 publication Critical patent/JP2017501152A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2016539182A 2013-12-18 2014-12-18 精製方法及び組成物 Active JP6842920B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1322451.4A GB201322451D0 (en) 2013-12-18 2013-12-18 Purification method and compositions
GB1322451.4 2013-12-18
PCT/EP2014/078608 WO2015091881A1 (en) 2013-12-18 2014-12-18 Purification method and compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019108641A Division JP2019196356A (ja) 2013-12-18 2019-06-11 精製方法及び組成物

Publications (3)

Publication Number Publication Date
JP2017501152A JP2017501152A (ja) 2017-01-12
JP2017501152A5 JP2017501152A5 (enExample) 2017-12-28
JP6842920B2 true JP6842920B2 (ja) 2021-03-17

Family

ID=50071048

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016539182A Active JP6842920B2 (ja) 2013-12-18 2014-12-18 精製方法及び組成物
JP2019108641A Withdrawn JP2019196356A (ja) 2013-12-18 2019-06-11 精製方法及び組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019108641A Withdrawn JP2019196356A (ja) 2013-12-18 2019-06-11 精製方法及び組成物

Country Status (7)

Country Link
US (2) US20160303262A1 (enExample)
EP (1) EP3083526B1 (enExample)
JP (2) JP6842920B2 (enExample)
CN (1) CN105849067B (enExample)
ES (1) ES2750624T3 (enExample)
GB (1) GB201322451D0 (enExample)
WO (1) WO2015091881A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120165650A1 (en) * 2010-12-22 2012-06-28 General Electric Company Her2 binders
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
US20210350946A1 (en) * 2019-10-25 2021-11-11 ITM Isotopen Technologien München AG System and method of recovering a parent radionuclide from a radionuclide generator

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101636183B (zh) * 2007-02-13 2014-03-19 日本医事物理股份有限公司 放射性诊断显像剂的制备方法
GB201013808D0 (en) * 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
EP3395373B1 (en) * 2010-12-01 2022-10-19 GE Healthcare Limited Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging
GB201020314D0 (en) * 2010-12-01 2011-01-12 Ge Healthcare Ltd Apoptosis pet imaging agents
US20130295010A1 (en) * 2010-12-22 2013-11-07 Duncan Hiscock Her2 binding peptides labelled with a 18f - containing organosilicon compound
GB201202420D0 (en) * 2012-02-13 2012-03-28 Ge Healthcare Ltd Radiotracer compositions
GB201209082D0 (en) * 2012-05-24 2012-07-04 Ge Healthcare Ltd Purification method

Also Published As

Publication number Publication date
CN105849067A (zh) 2016-08-10
EP3083526B1 (en) 2019-08-07
GB201322451D0 (en) 2014-02-05
WO2015091881A1 (en) 2015-06-25
ES2750624T3 (es) 2020-03-26
HK1226050B (zh) 2017-09-22
EP3083526A1 (en) 2016-10-26
CN105849067B (zh) 2018-04-17
US20160303262A1 (en) 2016-10-20
US20210330824A1 (en) 2021-10-28
JP2019196356A (ja) 2019-11-14
JP2017501152A (ja) 2017-01-12

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