ES2675102T3 - Método de radioconjugación - Google Patents
Método de radioconjugación Download PDFInfo
- Publication number
- ES2675102T3 ES2675102T3 ES11788862.8T ES11788862T ES2675102T3 ES 2675102 T3 ES2675102 T3 ES 2675102T3 ES 11788862 T ES11788862 T ES 11788862T ES 2675102 T3 ES2675102 T3 ES 2675102T3
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- gly
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB1020314.9A GB201020314D0 (en) | 2010-12-01 | 2010-12-01 | Apoptosis pet imaging agents |
| GB201020314 | 2010-12-01 | ||
| US201161476805P | 2011-04-19 | 2011-04-19 | |
| GB201106593 | 2011-04-19 | ||
| US201161476805P | 2011-04-19 | ||
| GBGB1106593.5A GB201106593D0 (en) | 2011-04-19 | 2011-04-19 | Radioconjugation method |
| PCT/EP2011/071506 WO2012072736A2 (en) | 2010-12-01 | 2011-12-01 | Radioconjugation method |
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|---|---|
| ES2675102T3 true ES2675102T3 (es) | 2018-07-06 |
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| ES18167523T Active ES2929507T3 (es) | 2010-12-01 | 2011-12-01 | Método para marcar una molécula directora biológica mediante conjugación con un radioisótopo adecuado para formación de imágenes por PET o SPECT |
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| ES18167523T Active ES2929507T3 (es) | 2010-12-01 | 2011-12-01 | Método para marcar una molécula directora biológica mediante conjugación con un radioisótopo adecuado para formación de imágenes por PET o SPECT |
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| Country | Link |
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| EP (2) | EP3395373B1 (enExample) |
| JP (1) | JP6231882B2 (enExample) |
| KR (1) | KR20130119957A (enExample) |
| CN (2) | CN104984372B (enExample) |
| AU (1) | AU2011334881A1 (enExample) |
| BR (1) | BR112013013283A2 (enExample) |
| CA (1) | CA2819347A1 (enExample) |
| ES (2) | ES2675102T3 (enExample) |
| MX (1) | MX2013006202A (enExample) |
| RU (1) | RU2013122649A (enExample) |
| WO (1) | WO2012072736A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3395373B1 (en) * | 2010-12-01 | 2022-10-19 | GE Healthcare Limited | Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging |
| GB201314936D0 (en) * | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| GB201322451D0 (en) * | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Purification method and compositions |
| CA3085407A1 (en) * | 2018-01-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Radiolabelled oligonucleotides and process for their preparation |
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| WO1996040662A2 (en) | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
| GB0305704D0 (en) * | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| EP1713508A2 (en) * | 2004-01-29 | 2006-10-25 | Biosynexus Incorporated | Use of amino-oxy functional groups in the preparation of vaccine conjugates |
| GB0420344D0 (en) | 2004-09-14 | 2004-10-13 | Amersham Plc | Diagnostic compounds |
| GB0420365D0 (en) | 2004-09-14 | 2004-10-13 | Hammersmith Imanet Ltd | Radiolabelled insulin |
| EP2125039A2 (en) | 2006-12-18 | 2009-12-02 | GE Healthcare AS | Synthesis of a radiofluorinated peptide using photolabile protecting groups |
| EP2114464A2 (en) * | 2006-12-28 | 2009-11-11 | GE Healthcare AS | Radiofluorination methods |
| US8545809B2 (en) * | 2007-01-11 | 2013-10-01 | Immunomedics, Inc. | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules |
| US20080274046A1 (en) * | 2007-02-20 | 2008-11-06 | Christian Prenant | Radiolabelling |
| GB0803477D0 (en) * | 2008-02-26 | 2008-04-02 | Ge Healthcare As | Therapy selection method |
| EP3395373B1 (en) * | 2010-12-01 | 2022-10-19 | GE Healthcare Limited | Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging |
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- 2011-12-01 JP JP2013541350A patent/JP6231882B2/ja active Active
- 2011-12-01 BR BR112013013283A patent/BR112013013283A2/pt not_active IP Right Cessation
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2929507T3 (es) | 2022-11-29 |
| RU2013122649A (ru) | 2015-01-10 |
| US9493504B2 (en) | 2016-11-15 |
| JP6231882B2 (ja) | 2017-11-15 |
| JP2014500883A (ja) | 2014-01-16 |
| EP3395373B1 (en) | 2022-10-19 |
| CN104984372B (zh) | 2018-11-09 |
| CN104984372A (zh) | 2015-10-21 |
| EP3395373A1 (en) | 2018-10-31 |
| MX2013006202A (es) | 2013-07-29 |
| AU2011334881A1 (en) | 2013-06-06 |
| CN103269725A (zh) | 2013-08-28 |
| EP2646060A2 (en) | 2013-10-09 |
| WO2012072736A2 (en) | 2012-06-07 |
| CN103269725B (zh) | 2015-09-23 |
| CA2819347A1 (en) | 2012-06-07 |
| WO2012072736A3 (en) | 2012-10-18 |
| US20170044080A1 (en) | 2017-02-16 |
| KR20130119957A (ko) | 2013-11-01 |
| BR112013013283A2 (pt) | 2016-11-22 |
| EP2646060B1 (en) | 2018-05-30 |
| US20130259803A1 (en) | 2013-10-03 |
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