RU2013122649A - Способ радиоактивного коньюгирования - Google Patents
Способ радиоактивного коньюгирования Download PDFInfo
- Publication number
- RU2013122649A RU2013122649A RU2013122649/04A RU2013122649A RU2013122649A RU 2013122649 A RU2013122649 A RU 2013122649A RU 2013122649/04 A RU2013122649/04 A RU 2013122649/04A RU 2013122649 A RU2013122649 A RU 2013122649A RU 2013122649 A RU2013122649 A RU 2013122649A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- peptide
- cys
- radioisotope
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 16
- 230000021615 conjugation Effects 0.000 title 1
- 230000002285 radioactive effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- -1 aminooxy compound Chemical class 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 238000002372 labelling Methods 0.000 claims 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 101800005149 Peptide B Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001728 carbonyl compounds Chemical class 0.000 claims 2
- 238000009833 condensation Methods 0.000 claims 2
- 230000005494 condensation Effects 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 108010091748 peptide A Proteins 0.000 claims 2
- 108010005636 polypeptide C Proteins 0.000 claims 2
- 238000002600 positron emission tomography Methods 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 2
- YYLQUHNPNCGKJQ-NHYDCYSISA-N (3R)-3-hydroxy-L-aspartic acid Chemical compound OC(=O)[C@@H](N)[C@@H](O)C(O)=O YYLQUHNPNCGKJQ-NHYDCYSISA-N 0.000 claims 1
- 108010062877 Bacteriocins Proteins 0.000 claims 1
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1020314.9A GB201020314D0 (en) | 2010-12-01 | 2010-12-01 | Apoptosis pet imaging agents |
| GB1020314.9 | 2010-12-01 | ||
| US201161476805P | 2011-04-19 | 2011-04-19 | |
| GBGB1106593.5A GB201106593D0 (en) | 2011-04-19 | 2011-04-19 | Radioconjugation method |
| GB1106593.5 | 2011-04-19 | ||
| US61/476,805 | 2011-04-19 | ||
| PCT/EP2011/071506 WO2012072736A2 (en) | 2010-12-01 | 2011-12-01 | Radioconjugation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013122649A true RU2013122649A (ru) | 2015-01-10 |
Family
ID=45063153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013122649/04A RU2013122649A (ru) | 2010-12-01 | 2011-12-01 | Способ радиоактивного коньюгирования |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9493504B2 (enExample) |
| EP (2) | EP3395373B1 (enExample) |
| JP (1) | JP6231882B2 (enExample) |
| KR (1) | KR20130119957A (enExample) |
| CN (2) | CN104984372B (enExample) |
| AU (1) | AU2011334881A1 (enExample) |
| BR (1) | BR112013013283A2 (enExample) |
| CA (1) | CA2819347A1 (enExample) |
| ES (2) | ES2675102T3 (enExample) |
| MX (1) | MX2013006202A (enExample) |
| RU (1) | RU2013122649A (enExample) |
| WO (1) | WO2012072736A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3395373B1 (en) * | 2010-12-01 | 2022-10-19 | GE Healthcare Limited | Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging |
| GB201314936D0 (en) * | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| GB201322451D0 (en) * | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Purification method and compositions |
| CA3085407A1 (en) * | 2018-01-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Radiolabelled oligonucleotides and process for their preparation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040662A2 (en) | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
| GB0305704D0 (en) * | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| EP1713508A2 (en) * | 2004-01-29 | 2006-10-25 | Biosynexus Incorporated | Use of amino-oxy functional groups in the preparation of vaccine conjugates |
| GB0420344D0 (en) | 2004-09-14 | 2004-10-13 | Amersham Plc | Diagnostic compounds |
| GB0420365D0 (en) | 2004-09-14 | 2004-10-13 | Hammersmith Imanet Ltd | Radiolabelled insulin |
| EP2125039A2 (en) | 2006-12-18 | 2009-12-02 | GE Healthcare AS | Synthesis of a radiofluorinated peptide using photolabile protecting groups |
| EP2114464A2 (en) * | 2006-12-28 | 2009-11-11 | GE Healthcare AS | Radiofluorination methods |
| US8545809B2 (en) * | 2007-01-11 | 2013-10-01 | Immunomedics, Inc. | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules |
| US20080274046A1 (en) * | 2007-02-20 | 2008-11-06 | Christian Prenant | Radiolabelling |
| GB0803477D0 (en) * | 2008-02-26 | 2008-04-02 | Ge Healthcare As | Therapy selection method |
| EP3395373B1 (en) * | 2010-12-01 | 2022-10-19 | GE Healthcare Limited | Method for labelling a biological targeting molecule via conjugation with a radioisotope suitable for pet or spect imaging |
-
2011
- 2011-12-01 EP EP18167523.2A patent/EP3395373B1/en active Active
- 2011-12-01 JP JP2013541350A patent/JP6231882B2/ja active Active
- 2011-12-01 BR BR112013013283A patent/BR112013013283A2/pt not_active IP Right Cessation
- 2011-12-01 MX MX2013006202A patent/MX2013006202A/es unknown
- 2011-12-01 WO PCT/EP2011/071506 patent/WO2012072736A2/en not_active Ceased
- 2011-12-01 EP EP11788862.8A patent/EP2646060B1/en active Active
- 2011-12-01 ES ES11788862.8T patent/ES2675102T3/es active Active
- 2011-12-01 RU RU2013122649/04A patent/RU2013122649A/ru not_active Application Discontinuation
- 2011-12-01 AU AU2011334881A patent/AU2011334881A1/en not_active Abandoned
- 2011-12-01 US US13/991,340 patent/US9493504B2/en active Active
- 2011-12-01 KR KR1020137016889A patent/KR20130119957A/ko not_active Withdrawn
- 2011-12-01 CA CA2819347A patent/CA2819347A1/en not_active Abandoned
- 2011-12-01 ES ES18167523T patent/ES2929507T3/es active Active
- 2011-12-01 CN CN201510440109.1A patent/CN104984372B/zh active Active
- 2011-12-01 CN CN201180057989.4A patent/CN103269725B/zh active Active
-
2016
- 2016-11-01 US US15/340,743 patent/US20170044080A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2929507T3 (es) | 2022-11-29 |
| US9493504B2 (en) | 2016-11-15 |
| JP6231882B2 (ja) | 2017-11-15 |
| JP2014500883A (ja) | 2014-01-16 |
| EP3395373B1 (en) | 2022-10-19 |
| CN104984372B (zh) | 2018-11-09 |
| CN104984372A (zh) | 2015-10-21 |
| EP3395373A1 (en) | 2018-10-31 |
| MX2013006202A (es) | 2013-07-29 |
| AU2011334881A1 (en) | 2013-06-06 |
| CN103269725A (zh) | 2013-08-28 |
| EP2646060A2 (en) | 2013-10-09 |
| WO2012072736A2 (en) | 2012-06-07 |
| CN103269725B (zh) | 2015-09-23 |
| CA2819347A1 (en) | 2012-06-07 |
| WO2012072736A3 (en) | 2012-10-18 |
| US20170044080A1 (en) | 2017-02-16 |
| ES2675102T3 (es) | 2018-07-06 |
| KR20130119957A (ko) | 2013-11-01 |
| BR112013013283A2 (pt) | 2016-11-22 |
| EP2646060B1 (en) | 2018-05-30 |
| US20130259803A1 (en) | 2013-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20141202 |