JP2014500867A5 - - Google Patents

Download PDF

Info

Publication number
JP2014500867A5
JP2014500867A5 JP2013537678A JP2013537678A JP2014500867A5 JP 2014500867 A5 JP2014500867 A5 JP 2014500867A5 JP 2013537678 A JP2013537678 A JP 2013537678A JP 2013537678 A JP2013537678 A JP 2013537678A JP 2014500867 A5 JP2014500867 A5 JP 2014500867A5
Authority
JP
Japan
Prior art keywords
peptide
active substance
composition
seq
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013537678A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014500867A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/054967 external-priority patent/WO2012064429A2/en
Publication of JP2014500867A publication Critical patent/JP2014500867A/ja
Publication of JP2014500867A5 publication Critical patent/JP2014500867A5/ja
Pending legal-status Critical Current

Links

JP2013537678A 2010-11-09 2011-10-05 皮膚浸透性および細胞侵入性（ｓｐａｃｅ）ペプチドとその使用法 Pending JP2014500867A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41188410P 2010-11-09 2010-11-09
US61/411,884 2010-11-09
US201161527574P 2011-08-25 2011-08-25
US61/527,574 2011-08-25
US201161528036P 2011-08-26 2011-08-26
US61/528,036 2011-08-26
PCT/US2011/054967 WO2012064429A2 (en) 2010-11-09 2011-10-05 Skin permeating and cell entering (space) peptides and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2014500867A JP2014500867A (ja) 2014-01-16
JP2014500867A5 true JP2014500867A5 (enExample) 2014-11-20

Family

ID=46051476

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537678A Pending JP2014500867A (ja) 2010-11-09 2011-10-05 皮膚浸透性および細胞侵入性（ｓｐａｃｅ）ペプチドとその使用法

Country Status (8)

Country Link
US (4) US8518871B2 (enExample)
EP (1) EP2638162B1 (enExample)
JP (1) JP2014500867A (enExample)
KR (1) KR20130139254A (enExample)
CN (1) CN103201386A (enExample)
AU (1) AU2011326732B2 (enExample)
CA (1) CA2811113A1 (enExample)
WO (1) WO2012064429A2 (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3431485B2 (en) 2010-10-01 2024-09-04 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
CA2811113A1 (en) 2010-11-09 2012-05-18 The Regents Of The University Of California Skin permeating and cell entering (space) peptides and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
WO2013112488A2 (en) * 2012-01-23 2013-08-01 Kythera Biopharmaceuticals, Inc. Dermal filling compositions and methods
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
HK1209658A1 (en) 2012-05-01 2016-04-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
AU2013262972A1 (en) * 2012-05-16 2014-12-11 Aadigen, Llc Multi-target modulation for treating fibrosis and inflammatory conditions
KR101329411B1 (ko) 2012-05-31 2013-11-14 주식회사 엘지생활건강 피부투과성 펩타이드
CA2892529C (en) 2012-11-26 2023-04-25 Moderna Therapeutics, Inc. Terminally modified rna
CN103897043A (zh) * 2012-12-28 2014-07-02 天津药物研究院 一种穿膜多肽连接拉帕替尼的制备及应用
US20140227174A1 (en) * 2013-02-11 2014-08-14 The Regents Of The University Of California Skin permeating and cell entering (space) peptides and methods of use therefor
WO2014123543A2 (en) * 2013-02-11 2014-08-14 Convoy Therapeutics Skin permeating and cell entering (space) peptides and methods of use therefor
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US9642895B2 (en) 2013-08-12 2017-05-09 3M Innovative Properties Company Peptides for enhancing transdermal delivery
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
KR101608131B1 (ko) * 2013-11-14 2016-03-31 주식회사 엘지생활건강 인간 성장호르몬의 융합단백질을 포함하는 피부개선용 화장료 조성물
US9321821B2 (en) 2013-11-14 2016-04-26 Lg Household & Health Care Ltd. Cosmetic composition for improving skin conditions comprising fusion protein
WO2016033314A1 (en) * 2014-08-27 2016-03-03 The Regents Of The University Of California Skin penetrating peptides (spps) and methods of use therefor
EP3197920B1 (en) 2014-09-25 2021-01-13 Nanyang Technological University Targeting of melanocytes for delivering therapeutic or diagnostic agents using protein nanocages
WO2016071814A1 (en) 2014-11-04 2016-05-12 Università Degli Studi Di Milano A promoter for cutaneous absorption of active ingredients having peptidic structure
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
CN108350030B (zh) * 2015-09-10 2022-12-13 汉阳大学校产学协力团 皮肤可渗透肽及其使用方法
WO2017043920A1 (ko) * 2015-09-10 2017-03-16 한양대학교 산학협력단 피부 투과성 펩티드 및 그 이용방법
US20180251495A1 (en) * 2015-09-15 2018-09-06 The Regents Of The University Of California Skin-Penetrating Peptides and Compositions and Methods of Use Thereof
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
CA3002786C (en) * 2015-10-30 2021-09-07 Bonac Corporation Composition stably containing single-stranded nucleic acid molecule that suppresses expression of tgf-.beta.1 gene
WO2017082690A1 (ko) * 2015-11-12 2017-05-18 주식회사 펩트론 미백, 피부 탄력, 주름 개선 및 상처치유 활성을 갖는 다기능성 피부투과 펩타이드
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
CN105504066A (zh) * 2016-01-16 2016-04-20 广州市科玮生物技术有限公司 一种融合蛋白在化妆品中的应用
WO2017127834A1 (en) * 2016-01-23 2017-07-27 Sand Bruce J Enhanced transdermal delivery of active agents
CA3087881A1 (en) 2017-01-17 2018-07-26 Michael David FORREST Therapeutic inhibitors of the reverse mode of atp synthase
KR20200042440A (ko) * 2017-04-17 2020-04-23 앰퍼샌드 바이오파마슈티컬스, 엘엘씨 고형종양, 과다색소침착 및 통풍의 전이를 억제하기 위한 완충제의 비경구 비전신적 투여
KR102083976B1 (ko) * 2017-12-18 2020-03-03 주식회사 엘지생활건강 혈관내피세포 성장인자의 융합 단백질을 포함하는 피부개선용 화장료 조성물
KR102083978B1 (ko) * 2017-12-18 2020-03-03 주식회사 엘지생활건강 혈소판유래 성장인자 a서브유닛의 융합 단백질을 포함하는 피부개선용 화장료 조성물
US12337000B2 (en) 2017-07-13 2025-06-24 Michael David FORREST Therapeutic modulators of the reverse mode of ATP synthase
GB2566516A (en) 2017-09-15 2019-03-20 Univ Oxford Innovation Ltd Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria
JP2020534285A (ja) 2017-09-15 2020-11-26 アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 投与および処置の方法
US10905738B2 (en) 2018-07-05 2021-02-02 Biozeus Desenvolvimento De Produtos Biofarmacêuticos Synthetic peptides, prodrugs, pharmaceutical compositions and uses
BR112021020951A2 (pt) 2019-04-19 2021-12-14 Fount Bio Inc Dispensação e retenção de agentes ativos dentro da pele
WO2020232394A1 (en) 2019-05-16 2020-11-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
WO2021113410A1 (en) * 2019-12-02 2021-06-10 Ampersand Biopharmaceuticals, Inc. Transdermal penetrant formulations for vitamins, minerals and supplements
KR102301572B1 (ko) * 2020-02-06 2021-09-10 인천대학교 산학협력단 신규한 핵산 분자 전달용 조성물 및 그 용도
CN113943778A (zh) * 2020-07-17 2022-01-18 通用电气医疗集团股份有限公司 用于核酸检测的分子探针及其制备方法和用途
CN111803652B (zh) * 2020-08-04 2021-09-14 南通康是美生物科技有限公司 治疗痤疮的化合物在制备治疗痤疮的药物组合物或化妆品组合物中的用途
EP4281034A1 (en) 2021-01-24 2023-11-29 Forrest, Michael, David Inhibitors of atp synthase - cosmetic and therapeutic uses
CN114315960B (zh) * 2021-12-31 2022-10-14 深圳市维琪医药研发有限公司 一种经修饰的肽及其美容组合物或药用组合物和用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH624011A5 (enExample) 1977-08-05 1981-07-15 Battelle Memorial Institute
US5077057A (en) 1989-04-05 1991-12-31 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
US6083539A (en) 1994-12-16 2000-07-04 Sakuma Ebisu Kabushiki Kaisha Buckwheat starch syrup, method for preparing the same, and foods containing the same
US6747137B1 (en) * 1998-02-13 2004-06-08 Genome Therapeutics Corporation Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics
US20090070897A1 (en) 2006-01-12 2009-03-12 Goldman Barry S Genes and uses for plant improvement
JP4596391B2 (ja) * 2005-02-10 2010-12-08 国立大学法人大阪大学 細胞透過性ペプチド
WO2007035474A2 (en) 2005-09-15 2007-03-29 Novomed Technologies, Inc. (Shanghai) Transdermal delivery peptides and method of use thereof
US7659252B2 (en) 2005-09-15 2010-02-09 Novomed Technologies, Inc. (Shanghai) Transdermal delivery peptides and method of use thereof
JP2007143454A (ja) * 2005-11-25 2007-06-14 Toray Ind Inc 細胞膜通過性ペプチド
AU2006325030B2 (en) * 2005-12-16 2012-07-26 Cellectis Cell penetrating peptide conjugates for delivering nucleic acids into cells
GB0606415D0 (en) 2006-03-31 2006-05-10 Univ Southampton Topical drug delivery
US20080213377A1 (en) 2006-12-08 2008-09-04 Bhatia Sangeeta N Delivery of Nanoparticles and/or Agents to Cells
JP2008200011A (ja) * 2007-02-22 2008-09-04 Toray Ind Inc 細胞内移行性ペプチド、それを含有する医薬組成物及びその使用方法
AU2008295509A1 (en) 2007-08-29 2009-03-12 Tufts University Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits
US20090233993A1 (en) * 2008-03-06 2009-09-17 Burnham Institute For Medical Research Compositions and methods for inhibiting gsk3 activity and uses thereof
US20110212028A1 (en) * 2008-09-16 2011-09-01 Kariem Ahmed Chemically modified cell-penetrating peptides for improved delivery of gene modulating compounds
US8389481B2 (en) * 2008-11-12 2013-03-05 University Of Medicine And Dentistry Of New Jersey Glutamate-enhanced cell-penetrating peptides and methods of using same
CN101812439B (zh) * 2009-02-25 2012-07-04 张舒羽 一种透皮结构域及其衍生的具有透皮作用的融合蛋白和其制备方法
WO2010123971A2 (en) * 2009-04-22 2010-10-28 Board Of Regents, The University Of Texas System Hydrogels for combinatorial delivery of immune-modulating biomolecules
JP2012525146A (ja) 2009-04-28 2012-10-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 細胞透過のための過剰に荷電されたタンパク質
CA2811113A1 (en) * 2010-11-09 2012-05-18 The Regents Of The University Of California Skin permeating and cell entering (space) peptides and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids

Similar Documents

Publication Publication Date Title
JP2014500867A5 (enExample)
He et al. Synthetic charge-invertible polymer for rapid and complete implantation of layer-by-layer microneedle drug films for enhanced transdermal vaccination
Davis The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic
Zhao et al. Integrin-targeting peptides for the design of functional cell-responsive biomaterials
Versluis et al. In situ modification of plain liposomes with lipidated coiled coil forming peptides induces membrane fusion
Er et al. Amino acids, peptides, and proteins: implications for nanotechnological applications in biosensing and drug/gene delivery
Liu et al. Arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo
Rothbard et al. Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells
Zhou et al. Antibacterial polypeptide-grafted chitosan-based nanocapsules as an “armed” carrier of anticancer and antiepileptic drugs
Robison et al. Polyarginine interacts more strongly and cooperatively than polylysine with phospholipid bilayers
Behr Synthetic gene transfer vectors II: back to the future.
Saurer et al. Layer-by-layer assembly of DNA-and protein-containing films on microneedles for drug delivery to the skin
Xu et al. Recruiting T‐cells toward the brain for enhanced glioblastoma immunotherapeutic efficacy by co‐delivery of cytokines and immune checkpoint antibodies with macrophage‐membrane‐camouflaged nanovesicles
Wender et al. Dendrimeric molecular transporters: synthesis and evaluation of tunable polyguanidino dendrimers that facilitate cellular uptake
US9642895B2 (en) Peptides for enhancing transdermal delivery
CN104271149B (zh) 经皮递送装置
Han et al. Zwitterlation mitigates protein bioactivity loss in vitro over PEGylation
Wahlich et al. Nanomedicines for the Delivery of Biologics
JP2009526754A5 (enExample)
JP2006523453A5 (enExample)
Medrano-Bosch et al. Nanoparticles to target and treat macrophages: the Ockham’s concept?
Zhang et al. Novel pharmaceutical strategies for enhancing skin penetration of biomacromolecules
Menger et al. Migration of poly-L-lysine through a lipid bilayer
Srivatsav et al. The emerging world of membrane vesicles: functional relevance, theranostic avenues and tools for investigating membrane function
Li et al. Tumor-targeted liposomal drug delivery mediated by a diseleno bond-stabilized cyclic peptide