JP2014240408A5 - - Google Patents
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- Publication number
- JP2014240408A5 JP2014240408A5 JP2014158170A JP2014158170A JP2014240408A5 JP 2014240408 A5 JP2014240408 A5 JP 2014240408A5 JP 2014158170 A JP2014158170 A JP 2014158170A JP 2014158170 A JP2014158170 A JP 2014158170A JP 2014240408 A5 JP2014240408 A5 JP 2014240408A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- eosinophilic
- prednisone
- treatment
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010065563 Eosinophilic bronchitis Diseases 0.000 claims description 8
- 210000003979 eosinophil Anatomy 0.000 claims description 5
- 150000003431 steroids Chemical class 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 10
- 229960004618 prednisone Drugs 0.000 claims 10
- 102000000743 Interleukin-5 Human genes 0.000 claims 7
- 108010002616 Interleukin-5 Proteins 0.000 claims 7
- 230000003472 neutralizing effect Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 4
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 208000015768 polyposis Diseases 0.000 claims 2
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 208000028185 Angioedema Diseases 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 208000006968 Helminthiasis Diseases 0.000 claims 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 1
- 208000016300 Idiopathic chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 206010028594 Myocardial fibrosis Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 241000243981 Onchocerca Species 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 201000009323 chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 206010057271 eosinophilic colitis Diseases 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 201000001561 eosinophilic gastritis Diseases 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 208000037916 non-allergic rhinitis Diseases 0.000 claims 1
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4036308P | 2008-03-28 | 2008-03-28 | |
| US61/040,363 | 2008-03-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502090A Division JP5917143B2 (ja) | 2008-03-28 | 2009-03-27 | 処置方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016214438A Division JP6457463B2 (ja) | 2008-03-28 | 2016-11-01 | 処置方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014240408A JP2014240408A (ja) | 2014-12-25 |
| JP2014240408A5 true JP2014240408A5 (cg-RX-API-DMAC7.html) | 2016-02-18 |
| JP6069267B2 JP6069267B2 (ja) | 2017-02-01 |
Family
ID=41114741
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502090A Active JP5917143B2 (ja) | 2008-03-28 | 2009-03-27 | 処置方法 |
| JP2014158170A Active JP6069267B2 (ja) | 2008-03-28 | 2014-08-01 | 処置方法 |
| JP2016214438A Active JP6457463B2 (ja) | 2008-03-28 | 2016-11-01 | 処置方法 |
| JP2018238018A Pending JP2019065029A (ja) | 2008-03-28 | 2018-12-20 | 処置方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502090A Active JP5917143B2 (ja) | 2008-03-28 | 2009-03-27 | 処置方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016214438A Active JP6457463B2 (ja) | 2008-03-28 | 2016-11-01 | 処置方法 |
| JP2018238018A Pending JP2019065029A (ja) | 2008-03-28 | 2018-12-20 | 処置方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9834600B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2274009B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP5917143B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100134702A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102026660A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009228163B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0910854A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2719786A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201071137A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2441945T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL208354A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010010667A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009120927A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201006648B (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010521496A (ja) | 2007-03-14 | 2010-06-24 | ノップ ニューロサイエンシーズ、インク． | キラル精製置換ベンゾチアゾールジアミンの合成 |
| JP5917143B2 (ja) | 2008-03-28 | 2016-05-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 処置方法 |
| CA2734491A1 (en) | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| AU2012352180A1 (en) | 2011-12-16 | 2014-07-31 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015006708A1 (en) | 2013-07-12 | 2015-01-15 | Knopp Biosciences Llc | Treating elevated levels of eosinophils and/or basophils |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| EP3038467B1 (en) | 2013-08-13 | 2020-07-29 | Knopp Biosciences LLC | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| ES2871556T3 (es) | 2013-08-13 | 2021-10-29 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de la urticaria crónica |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| ES2811124T3 (es) * | 2014-09-08 | 2021-03-10 | Cephalon Inc | Uso de reslizumab para tratar el asma eosinofílica moderada a grave |
| AU2016311385C1 (en) | 2015-08-24 | 2019-08-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Biopharmaceutical compositions |
| MX2019014105A (es) | 2017-05-26 | 2020-02-07 | Glaxosmithkline Ip Dev Ltd | Composiciones biofarmaceuticas y metodos relacionados. |
| KR20230067604A (ko) * | 2020-08-05 | 2023-05-16 | 아레테이아 테라퓨틱스, 인코포레이티드 | 중등도 내지 중증 천식의 치료를 위한 덱스프라미펙솔의 용도 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8800397D0 (en) | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
| EP0441891A1 (en) | 1988-11-03 | 1991-08-21 | Schering Corporation | Method of preventing or reducing eosinophilia |
| US5096704A (en) | 1988-11-03 | 1992-03-17 | Schering Corporation | Method of treating eosinophilia |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0533006A1 (en) | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimaeric interleukin 5-receptor/immunoglobulin polypeptides |
| US5910573A (en) | 1992-01-23 | 1999-06-08 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Monomeric and dimeric antibody-fragment fusion proteins |
| AR248044A1 (es) | 1992-02-06 | 1995-05-31 | Schering Corp | Una secuencia de adn que codifica anticuerpos monoclonales humanizados contra interleuquinas humanas, metodo de obtencion y de seleccion de dichos anticuerpos, vector recombinante y celula huesped. |
| JPH06141885A (ja) | 1992-11-05 | 1994-05-24 | Chemo Sero Therapeut Res Inst | モノクローナル抗体 |
| WO1995014040A1 (en) | 1993-11-19 | 1995-05-26 | Baylor College Of Medicine | Monoclonal antibodies specific for human interleukin-5 |
| GB9412230D0 (en) | 1994-06-17 | 1994-08-10 | Celltech Ltd | Interleukin-5 specific recombiant antibodies |
| US7399837B2 (en) | 1995-12-22 | 2008-07-15 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| US5683892A (en) | 1994-12-23 | 1997-11-04 | Smithkline Beecham Corporation | DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| AU708951B2 (en) * | 1994-12-23 | 1999-08-19 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| US5783184A (en) | 1994-12-23 | 1998-07-21 | Smithkline Beecham Corporation | Method for treatment and diagnosis of IL-5 mediated disorders |
| US6248723B1 (en) | 1997-06-10 | 2001-06-19 | National Jewish Medical And Research Center | Method for treatment of inflammatory disease |
| AP2000001805A0 (en) | 1997-10-22 | 2000-06-30 | Jens Ponikau | Use of antifungal agents for the topical treatment of fungus-induced mucositis. |
| WO2001012646A1 (en) | 1999-08-19 | 2001-02-22 | Smithkline Beecham Corporation | Sialoadhesin factor-1 agonist and antagonist antibodies |
| US20030017169A1 (en) | 2000-12-29 | 2003-01-23 | Sidney Pestka | Controlled release systems for polymers |
| CN1326879C (zh) | 2002-03-29 | 2007-07-18 | 先灵公司 | 人源抗白细胞介素5单克隆抗体及其制备方法和包含这些抗体的组合物 |
| US7339507B1 (en) * | 2006-09-13 | 2008-03-04 | Jiun-In Guo | Device for video decoding |
| EP2097438B1 (en) | 2006-12-11 | 2015-08-26 | Bracco Imaging S.p.A | Fibrin binding peptide conjugates for diagnostic and therapeutic applications |
| SI2152290T1 (sl) | 2007-04-30 | 2014-09-30 | Glaxosmithkline Llc | Postopki za dajanje anti-IL-5 protiteles |
| US20090035216A1 (en) | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
| JP5917143B2 (ja) | 2008-03-28 | 2016-05-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 処置方法 |
| US8926631B2 (en) | 2010-08-06 | 2015-01-06 | MoMelan Technologies, Inc. | Methods for preparing a skin graft without culturing or use of biologics |
| WO2012109429A2 (en) | 2011-02-09 | 2012-08-16 | Glaxosmithkline Llc | Lyophilized formulations |
-
2009
- 2009-03-27 JP JP2011502090A patent/JP5917143B2/ja active Active
- 2009-03-27 WO PCT/US2009/038509 patent/WO2009120927A2/en not_active Ceased
- 2009-03-27 AU AU2009228163A patent/AU2009228163B2/en not_active Ceased
- 2009-03-27 EP EP09725345.4A patent/EP2274009B1/en not_active Revoked
- 2009-03-27 CN CN2009801176573A patent/CN102026660A/zh active Pending
- 2009-03-27 BR BRPI0910854A patent/BRPI0910854A2/pt not_active IP Right Cessation
- 2009-03-27 KR KR1020107024046A patent/KR20100134702A/ko not_active Withdrawn
- 2009-03-27 CA CA2719786A patent/CA2719786A1/en not_active Abandoned
- 2009-03-27 ES ES09725345.4T patent/ES2441945T3/es active Active
- 2009-03-27 US US12/935,038 patent/US9834600B2/en active Active
- 2009-03-27 MX MX2010010667A patent/MX2010010667A/es not_active Application Discontinuation
- 2009-03-27 EA EA201071137A patent/EA201071137A1/ru unknown
-
2010
- 2010-09-16 ZA ZA2010/06648A patent/ZA201006648B/en unknown
- 2010-09-21 IL IL208354A patent/IL208354A0/en unknown
-
2014
- 2014-08-01 JP JP2014158170A patent/JP6069267B2/ja active Active
-
2016
- 2016-11-01 JP JP2016214438A patent/JP6457463B2/ja active Active
-
2017
- 2017-11-06 US US15/804,104 patent/US20180057582A1/en not_active Abandoned
-
2018
- 2018-12-20 JP JP2018238018A patent/JP2019065029A/ja active Pending
-
2019
- 2019-09-19 US US16/575,903 patent/US11325972B2/en active Active