JP2014239679A5 - - Google Patents
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- JP2014239679A5 JP2014239679A5 JP2014103465A JP2014103465A JP2014239679A5 JP 2014239679 A5 JP2014239679 A5 JP 2014239679A5 JP 2014103465 A JP2014103465 A JP 2014103465A JP 2014103465 A JP2014103465 A JP 2014103465A JP 2014239679 A5 JP2014239679 A5 JP 2014239679A5
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- JP
- Japan
- Prior art keywords
- self
- reporter gene
- sequence
- nucleic acid
- reporter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108700008625 Reporter Genes Proteins 0.000 claims 34
- 230000014509 gene expression Effects 0.000 claims 27
- 239000013598 vector Substances 0.000 claims 27
- 150000007523 nucleic acids Chemical class 0.000 claims 25
- 238000000034 method Methods 0.000 claims 18
- 125000000524 functional group Chemical group 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 230000000977 initiatory effect Effects 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 230000010076 replication Effects 0.000 claims 9
- 101710195674 Replication initiator protein Proteins 0.000 claims 8
- 230000001973 epigenetic effect Effects 0.000 claims 8
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 7
- 230000005030 transcription termination Effects 0.000 claims 7
- 230000004913 activation Effects 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 101710088839 Replication initiation protein Proteins 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 230000003362 replicative effect Effects 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 1
- 108060001084 Luciferase Proteins 0.000 claims 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 1
- 108010093894 Xanthine oxidase Proteins 0.000 claims 1
- 238000003149 assay kit Methods 0.000 claims 1
- 108010005774 beta-Galactosidase Proteins 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 108091005948 blue fluorescent proteins Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 108010054624 red fluorescent protein Proteins 0.000 claims 1
- 108700014832 replication initiator Proteins 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014103465A JP2014239679A (ja) | 2013-05-17 | 2014-05-19 | 細胞のエピジェネティックな情報を得る方法、細胞の特性を判定する方法、薬剤感受性を判断するまたは薬剤若しくは免疫療法剤の種類を選択する方法、疾患の診断方法、並びに自己複製ベクター、アッセイキットおよび分析装置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013105481 | 2013-05-17 | ||
| JP2013105481 | 2013-05-17 | ||
| JP2014103465A JP2014239679A (ja) | 2013-05-17 | 2014-05-19 | 細胞のエピジェネティックな情報を得る方法、細胞の特性を判定する方法、薬剤感受性を判断するまたは薬剤若しくは免疫療法剤の種類を選択する方法、疾患の診断方法、並びに自己複製ベクター、アッセイキットおよび分析装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014239679A JP2014239679A (ja) | 2014-12-25 |
| JP2014239679A5 true JP2014239679A5 (enExample) | 2017-03-09 |
Family
ID=51898518
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517155A Active JP6140277B2 (ja) | 2013-05-17 | 2014-05-19 | 細胞のエピジェネティックな情報を得る方法、細胞の特性を判定する方法、薬剤感受性を判断するまたは薬剤若しくは免疫療法剤の種類を選択する方法、疾患の診断方法、並びに自己複製ベクター、アッセイキットおよび分析装置 |
| JP2014103465A Pending JP2014239679A (ja) | 2013-05-17 | 2014-05-19 | 細胞のエピジェネティックな情報を得る方法、細胞の特性を判定する方法、薬剤感受性を判断するまたは薬剤若しくは免疫療法剤の種類を選択する方法、疾患の診断方法、並びに自己複製ベクター、アッセイキットおよび分析装置 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517155A Active JP6140277B2 (ja) | 2013-05-17 | 2014-05-19 | 細胞のエピジェネティックな情報を得る方法、細胞の特性を判定する方法、薬剤感受性を判断するまたは薬剤若しくは免疫療法剤の種類を選択する方法、疾患の診断方法、並びに自己複製ベクター、アッセイキットおよび分析装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160153057A1 (enExample) |
| EP (1) | EP2998408B1 (enExample) |
| JP (2) | JP6140277B2 (enExample) |
| CN (1) | CN105308188B (enExample) |
| WO (1) | WO2014185549A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2998408B1 (en) * | 2013-05-17 | 2020-01-08 | Toshiba Medical Systems Corporation | Method for obtaining epigenetic cell information, method for determining cell characteristics, method for assessing drug sensitivity or selecting drug or immunotherapeutic agent variety, disease diagnosis method, self-replicating vector, assay kit, and analysis device |
| US20180245057A1 (en) * | 2015-09-01 | 2018-08-30 | Dana-Farber Cancer Institute, Inc. | Systems and methods for selection of grna targeting strands for cas9 localization |
| JP6723011B2 (ja) * | 2016-01-19 | 2020-07-15 | キヤノンメディカルシステムズ株式会社 | 被検細胞の細胞特性を評価するためのレポーターベクター、アッセイキット、方法および装置 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5243829B2 (ja) | 2008-03-27 | 2013-07-24 | シスメックス株式会社 | メチル化ｄｎａの解析方法 |
| JP5716153B2 (ja) | 2010-09-14 | 2015-05-13 | 独立行政法人産業技術総合研究所 | 時計遺伝子のｄｎａメチル化による概日リズム制御機構のレポーターアッセイ系 |
| JP5703086B2 (ja) | 2011-03-28 | 2015-04-15 | 株式会社東芝 | 細胞外に金属化合物結合能を提示するレポーターベクター |
| CN102286524B (zh) * | 2011-08-08 | 2014-04-23 | 安徽农业大学 | 一种植物转化载体及其构建方法和应用 |
| JP5863338B2 (ja) * | 2011-08-25 | 2016-02-16 | 株式会社東芝 | プラスミド型ベクター、遺伝子プロモーター活性の検出方法、及びアッセイキット |
| EP2998408B1 (en) * | 2013-05-17 | 2020-01-08 | Toshiba Medical Systems Corporation | Method for obtaining epigenetic cell information, method for determining cell characteristics, method for assessing drug sensitivity or selecting drug or immunotherapeutic agent variety, disease diagnosis method, self-replicating vector, assay kit, and analysis device |
-
2014
- 2014-05-19 EP EP14797267.3A patent/EP2998408B1/en active Active
- 2014-05-19 WO PCT/JP2014/063214 patent/WO2014185549A1/ja not_active Ceased
- 2014-05-19 JP JP2015517155A patent/JP6140277B2/ja active Active
- 2014-05-19 CN CN201480028611.5A patent/CN105308188B/zh active Active
- 2014-05-19 JP JP2014103465A patent/JP2014239679A/ja active Pending
-
2015
- 2015-11-17 US US14/943,766 patent/US20160153057A1/en not_active Abandoned
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