JP2015502740A5 - - Google Patents
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- JP2015502740A5 JP2015502740A5 JP2014537335A JP2014537335A JP2015502740A5 JP 2015502740 A5 JP2015502740 A5 JP 2015502740A5 JP 2014537335 A JP2014537335 A JP 2014537335A JP 2014537335 A JP2014537335 A JP 2014537335A JP 2015502740 A5 JP2015502740 A5 JP 2015502740A5
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- Prior art keywords
- sample
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- antibody
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- Prior art date
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- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 68
- 208000011231 Crohn disease Diseases 0.000 claims 27
- 238000000034 method Methods 0.000 claims 26
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims 19
- 239000003550 marker Substances 0.000 claims 14
- 238000002965 ELISA Methods 0.000 claims 12
- 238000007637 random forest analysis Methods 0.000 claims 9
- 238000007619 statistical method Methods 0.000 claims 9
- 206010009900 Colitis ulcerative Diseases 0.000 claims 8
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 8
- 238000003066 decision tree Methods 0.000 claims 5
- 230000002068 genetic effect Effects 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 102100031758 Extracellular matrix protein 1 Human genes 0.000 claims 4
- 101000866526 Homo sapiens Extracellular matrix protein 1 Proteins 0.000 claims 4
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 4
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
- 230000000405 serological effect Effects 0.000 claims 4
- 102100040355 Autophagy-related protein 16-1 Human genes 0.000 claims 3
- 102100027890 Homeobox protein Nkx-2.3 Human genes 0.000 claims 3
- 101000964092 Homo sapiens Autophagy-related protein 16-1 Proteins 0.000 claims 3
- 101000632181 Homo sapiens Homeobox protein Nkx-2.3 Proteins 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 230000035945 sensitivity Effects 0.000 claims 3
- 108010040721 Flagellin Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 102100031051 Cysteine and glycine-rich protein 1 Human genes 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 108091006374 cAMP receptor proteins Proteins 0.000 claims 1
- 238000003205 genotyping method Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550293P | 2011-10-21 | 2011-10-21 | |
| US61/550,293 | 2011-10-21 | ||
| US201161553853P | 2011-10-31 | 2011-10-31 | |
| US61/553,853 | 2011-10-31 | ||
| US201161567096P | 2011-12-05 | 2011-12-05 | |
| US61/567,096 | 2011-12-05 | ||
| US201161570271P | 2011-12-13 | 2011-12-13 | |
| US61/570,271 | 2011-12-13 | ||
| PCT/US2012/061202 WO2013059732A1 (en) | 2011-10-21 | 2012-10-19 | Methods for improving inflammatory bowel disease diagnosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015502740A JP2015502740A (ja) | 2015-01-29 |
| JP2015502740A5 true JP2015502740A5 (enExample) | 2015-12-10 |
Family
ID=48141435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537335A Pending JP2015502740A (ja) | 2011-10-21 | 2012-10-19 | 炎症性腸疾患の診断を改善するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8715943B2 (enExample) |
| EP (1) | EP2769321B1 (enExample) |
| JP (1) | JP2015502740A (enExample) |
| AU (1) | AU2012325798B2 (enExample) |
| CA (1) | CA2852954A1 (enExample) |
| IL (1) | IL232167A0 (enExample) |
| MX (1) | MX352274B (enExample) |
| SG (1) | SG11201401536QA (enExample) |
| WO (1) | WO2013059732A1 (enExample) |
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| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| NZ595471A (en) | 2009-04-14 | 2014-01-31 | Nestec Sa | Inflammatory bowel disease prognostics |
| WO2015067913A1 (en) | 2013-11-07 | 2015-05-14 | Diagnodus Limited | Biomarkers |
| WO2012154987A1 (en) | 2011-05-10 | 2012-11-15 | Nestec Sa | Methods of disease activity profiling for personalized therapy management |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| WO2014182689A1 (en) * | 2013-05-06 | 2014-11-13 | Yacyshyn Bruce R | Method of using biomarkers in predicting inflammatory bowel disease |
| CN105358713B (zh) | 2013-05-17 | 2020-02-28 | 雪松-西奈医学中心 | 与克罗恩病相关的tnfsf15和dcr3的变体 |
| SG11201509371XA (en) * | 2013-05-24 | 2015-12-30 | Nestec Sa | Pathway specific markers for diagnosing irritable bowel syndrome |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| US11568982B1 (en) | 2014-02-17 | 2023-01-31 | Health at Scale Corporation | System to improve the logistics of clinical care by selectively matching patients to providers |
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| CN104131102B (zh) * | 2014-08-07 | 2016-06-15 | 马飞 | 一种判断nsclc患者对吉非替尼治疗反应性的试剂盒 |
| US11809501B2 (en) * | 2014-08-28 | 2023-11-07 | Ebay Inc. | Systems, apparatuses, and methods for providing a ranking based recommendation |
| JP2018504584A (ja) * | 2014-12-02 | 2018-02-15 | ネステク ソシエテ アノニム | 過敏性腸疾患患者を治療するためのベドリズマブの投与計画を確立する方法 |
| AU2016209478B2 (en) | 2015-01-20 | 2019-03-07 | Nantomics, Llc | Systems and methods for response prediction to chemotherapy in high grade bladder cancer |
| JP6356359B2 (ja) * | 2015-03-03 | 2018-07-11 | ナントミクス，エルエルシー | アンサンブルに基づいたリサーチ・レコメンデーションシステムおよび方法 |
| US11037070B2 (en) * | 2015-04-29 | 2021-06-15 | Siemens Healthcare Gmbh | Diagnostic test planning using machine learning techniques |
| JP2019508395A (ja) | 2016-02-02 | 2019-03-28 | マキシマス ダイアグノスティック テクノロジーズ エルエルシー | 炎症性腸疾患の処置を改善するための腸管バリア機能の評価 |
| US11946927B2 (en) | 2016-03-14 | 2024-04-02 | Musidora Biotechnology Llc | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
| US10295527B2 (en) | 2016-03-14 | 2019-05-21 | Bruce Yacyshyn | Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis |
| KR20180127416A (ko) | 2016-03-17 | 2018-11-28 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| CN109476698B (zh) * | 2016-05-20 | 2023-10-17 | 西达-赛奈医疗中心 | 基于基因的炎性肠病诊断 |
| JP7111322B2 (ja) | 2016-12-02 | 2022-08-02 | 国立大学法人 東京大学 | 線維化関連分子に対する抗体およびその医療応用 |
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| US11162943B2 (en) | 2017-05-31 | 2021-11-02 | Prometheus Biosciences Inc. | Methods for assessing mucosal healing in Crohn's disease patients |
| EP3728642A4 (en) * | 2017-12-18 | 2021-09-15 | Personal Genome Diagnostics Inc. | AUTOMATIC LEARNING SYSTEM AND SOMATIC MUTATION DISCOVERY PROCESS |
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| WO2020009949A1 (en) | 2018-07-05 | 2020-01-09 | Boston Scientific Scimed, Inc. | Devices, systems, and methods for determining inflammation and/or fibrosis |
| AU2019325238A1 (en) * | 2018-08-21 | 2021-03-18 | Bruce R. Yacyshyn | Process and system for identifying individuals having a high risk of inflammatory bowel disease and a method of treatment |
| CA3121167A1 (en) * | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Methods of stratifying and treating a sub-population of inflammatory bowel disease patients |
| CA3121162A1 (en) | 2018-11-29 | 2020-06-04 | Cedars-Sinai Medical Center | Rnaset2 compositions and methods of treatment therewith |
| WO2020117795A1 (en) * | 2018-12-04 | 2020-06-11 | Prometheus Biosciences, Inc. | Assessment and monitoring of mucosal healing in children and adults with crohn's disease |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| CA3137728A1 (en) * | 2019-04-23 | 2020-10-29 | Cedars-Sinai Medical Center | Methods and systems for assessing inflammatory disease with deep learning |
| WO2020232262A1 (en) * | 2019-05-16 | 2020-11-19 | Procisedx Inc. | Assay detection methods for vcam-1 and calprotectin |
| CN110373457B (zh) * | 2019-06-20 | 2023-03-14 | 镇江市第一人民医院 | 一种用于溃疡性结肠炎诊断的mRNA标志物及其应用 |
| CN111417124A (zh) * | 2019-06-28 | 2020-07-14 | 西南交通大学 | 在认知无线网络环境下频谱感知的方法 |
| CN115605615A (zh) * | 2020-03-06 | 2023-01-13 | 美国控股实验室公司（Us） | 用于血红蛋白a(hba)检测和基因分型的测定 |
| US11610679B1 (en) * | 2020-04-20 | 2023-03-21 | Health at Scale Corporation | Prediction and prevention of medical events using machine-learning algorithms |
| WO2021247548A1 (en) * | 2020-06-03 | 2021-12-09 | Cedars-Sinai Medical Center | Treatments for a sub-population of inflammatory bowel disease patients |
| US12094582B1 (en) | 2020-08-11 | 2024-09-17 | Health at Scale Corporation | Intelligent healthcare data fabric system |
| US12080428B1 (en) | 2020-09-10 | 2024-09-03 | Health at Scale Corporation | Machine intelligence-based prioritization of non-emergent procedures and visits |
| WO2022061346A1 (en) * | 2020-09-16 | 2022-03-24 | Northwestern University | Classification of functional lumen imaging probe data |
| WO2022076372A1 (en) * | 2020-10-05 | 2022-04-14 | Cedars-Sinai Medical Center | Methods and systems for stratifying inflammatory bowel disease patients |
| EP4256345B1 (en) * | 2020-12-04 | 2026-03-04 | Icahn School of Medicine at Mount Sinai | Methods for dynamic immunohistochemistry profiling of autism spectrum disorder |
| US20240044916A1 (en) * | 2020-12-11 | 2024-02-08 | Icahn School Of Medicine At Mount Sinai | Methods of monitoring inflammatory bowel diseases |
| JP7655721B2 (ja) * | 2020-12-18 | 2025-04-02 | 花王株式会社 | 疲労マーカー及びそれを用いた疲労の検出方法 |
| JP7655720B2 (ja) * | 2020-12-18 | 2025-04-02 | 花王株式会社 | ストレスマーカー及びそれを用いた慢性ストレスレベルの検出方法 |
| MX2023009621A (es) | 2021-02-17 | 2023-10-31 | Prometheus Biosciences Inc | Anticuerpos anti-cd30l y usos de estos. |
| US20240404053A1 (en) * | 2021-09-22 | 2024-12-05 | Janssen Research & Development, Llc | Automatic Estimation of Ulcerative Colitis Severity from Endoscopy Videos USING ORDINAL MULTI-INSTANCE LEARNING |
| US20250149178A1 (en) * | 2022-01-28 | 2025-05-08 | University Of Southern California | Identifying non-disease patients using a disease related assay and analysis in the liquid biopsy |
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| JP2013511988A (ja) * | 2009-11-25 | 2013-04-11 | ネステク ソシエテ アノニム | 過敏性腸症候群診断用の新規なゲノムバイオマーカー |
| JP2013528389A (ja) | 2010-06-04 | 2013-07-11 | ネステク ソシエテ アノニム | 炎症性腸疾患の診断を改善させる方法 |
-
2012
- 2012-10-19 EP EP12841790.4A patent/EP2769321B1/en active Active
- 2012-10-19 JP JP2014537335A patent/JP2015502740A/ja active Pending
- 2012-10-19 MX MX2014004712A patent/MX352274B/es active IP Right Grant
- 2012-10-19 SG SG11201401536QA patent/SG11201401536QA/en unknown
- 2012-10-19 CA CA2852954A patent/CA2852954A1/en not_active Abandoned
- 2012-10-19 WO PCT/US2012/061202 patent/WO2013059732A1/en not_active Ceased
- 2012-10-19 AU AU2012325798A patent/AU2012325798B2/en not_active Ceased
-
2013
- 2013-03-15 US US13/840,779 patent/US8715943B2/en active Active
-
2014
- 2014-03-28 US US14/229,715 patent/US20150072879A1/en not_active Abandoned
- 2014-04-22 IL IL232167A patent/IL232167A0/en unknown
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