JP2011528797A5 - - Google Patents
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- Publication number
- JP2011528797A5 JP2011528797A5 JP2011519175A JP2011519175A JP2011528797A5 JP 2011528797 A5 JP2011528797 A5 JP 2011528797A5 JP 2011519175 A JP2011519175 A JP 2011519175A JP 2011519175 A JP2011519175 A JP 2011519175A JP 2011528797 A5 JP2011528797 A5 JP 2011528797A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- subject
- cardiac troponin
- angiogenic therapy
- reference amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004903 Troponin Human genes 0.000 claims 19
- 108090001027 Troponin Proteins 0.000 claims 19
- 230000000747 cardiac effect Effects 0.000 claims 18
- 238000011122 anti-angiogenic therapy Methods 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 10
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 10
- 239000005557 antagonist Substances 0.000 claims 10
- 108020001621 Natriuretic Peptide Proteins 0.000 claims 8
- 102000004571 Natriuretic peptide Human genes 0.000 claims 8
- 239000000692 natriuretic peptide Substances 0.000 claims 8
- 102400001263 NT-proBNP Human genes 0.000 claims 2
- 102000004987 Troponin T Human genes 0.000 claims 2
- 108090001108 Troponin T Proteins 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000007211 cardiovascular event Effects 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08161014.9 | 2008-07-23 | ||
| EP08161014 | 2008-07-23 | ||
| PCT/EP2009/059505 WO2010010153A1 (en) | 2008-07-23 | 2009-07-23 | Identification of subjects being susceptible to anti-angiogenesis therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528797A JP2011528797A (ja) | 2011-11-24 |
| JP2011528797A5 true JP2011528797A5 (enExample) | 2012-01-12 |
| JP5606438B2 JP5606438B2 (ja) | 2014-10-15 |
Family
ID=40162929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519175A Active JP5606438B2 (ja) | 2008-07-23 | 2009-07-23 | 抗血管新生療法を受容可能な被験体の同定 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9983213B2 (enExample) |
| EP (1) | EP2321651B1 (enExample) |
| JP (1) | JP5606438B2 (enExample) |
| ES (1) | ES2644723T3 (enExample) |
| WO (1) | WO2010010153A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| BR112013031019A2 (pt) * | 2011-06-02 | 2017-03-21 | Almac Diagnostics Ltd | teste diagnóstico molecular para câncer |
| HRP20190044T1 (hr) | 2011-09-23 | 2019-02-22 | Oncomed Pharmaceuticals, Inc. | Agensi koji vežu vegf/dll4 i njihove uporabe |
| AU2013337811A1 (en) * | 2012-10-31 | 2015-05-14 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
| US11091809B2 (en) | 2012-12-03 | 2021-08-17 | Almac Diagnostic Services Limited | Molecular diagnostic test for cancer |
| GB201409479D0 (en) | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| MX382902B (es) | 2014-10-31 | 2025-03-13 | Oncomed Pharm Inc | Inhibidor de la vía noth en combinación con un agente inmunoterapéutico para usarse en el tratamiento de cáncer. |
| WO2017053705A1 (en) | 2015-09-23 | 2017-03-30 | Oncomed Pharmaceuticals, Inc. | Methods and compositions for treatment of cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| EP1238986B1 (en) | 1992-10-28 | 2008-06-25 | Genentech, Inc. | Use of Vascular endothelial cell growth factor antagonists |
| ES2236634T3 (es) | 1997-04-07 | 2005-07-16 | Genentech, Inc. | Anticuerpos anti-vegf. |
| US20020032315A1 (en) * | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| WO2000054770A1 (en) * | 1999-03-15 | 2000-09-21 | Boston Life Sciences, Inc. | Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis |
| US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| AU2001238493A1 (en) * | 2000-02-17 | 2001-08-27 | Millennium Pharmaceuticals, Inc | Methods and compositions for the identification, assessment, prevention and therapy of human cancers |
| US7632647B2 (en) | 2001-04-13 | 2009-12-15 | Biosite Incorporated | Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes |
| DE60233301D1 (de) | 2001-05-04 | 2009-09-24 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
| RS20150135A1 (sr) | 2003-05-30 | 2015-08-31 | Genentech Inc. | Tretman sa anti-vegf antitelima |
| WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| JP4838794B2 (ja) * | 2004-06-15 | 2011-12-14 | エフ．ホフマン−ラ ロシュ アーゲー | 心臓毒性医薬の結果として心血管合併症に罹患するリスクを診断するための心臓ホルモンの使用 |
| US7939267B2 (en) * | 2004-11-04 | 2011-05-10 | Laboratory Corporation Of America Holdings | Detection of activation of endothelial cells as surrogate marker for angiogenesis |
| WO2006077265A1 (en) * | 2005-01-24 | 2006-07-27 | F. Hoffmann-La Roche Ag | The use of bnp-type peptides and anp-type peptides for assessing the risk of suffering from a cardiovascular complication as a consequence of volume overload |
| MX2008001966A (es) * | 2005-08-12 | 2008-03-26 | Regeneron Pharma | Tratamiento de enfermedades mediante administracion subcutanea de un antagonista vegf. |
| EP2016394A4 (en) | 2006-04-04 | 2013-04-24 | Singulex Inc | METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES |
| EP1887361A1 (en) * | 2006-08-07 | 2008-02-13 | Bio-Rad Pasteur | Method for the prediction of vascular events |
| EP1890154B1 (en) | 2006-08-16 | 2012-07-04 | F. Hoffmann-La Roche AG | Cardiac troponin as an indicator of advanced coronary artery disease |
| WO2008063932A2 (en) | 2006-11-10 | 2008-05-29 | Genentech, Inc. | Method for treating age-related macular degeneration |
| JP5306218B2 (ja) * | 2006-11-21 | 2013-10-02 | エフ．ホフマン−ラ ロシュ アーゲー | トロポニンＴおよびＮＴ−ｐｒｏＢＮＰの検出に基づく慢性動脈疾患での診断および治療的アプローチの最適化のための手段および方法 |
| EP2324358A1 (en) | 2008-07-23 | 2011-05-25 | F. Hoffmann-La Roche AG | Monitoring anti-angiogenesis therapy |
-
2009
- 2009-07-23 EP EP09800069.8A patent/EP2321651B1/en active Active
- 2009-07-23 JP JP2011519175A patent/JP5606438B2/ja active Active
- 2009-07-23 WO PCT/EP2009/059505 patent/WO2010010153A1/en not_active Ceased
- 2009-07-23 ES ES09800069.8T patent/ES2644723T3/es active Active
-
2011
- 2011-01-20 US US13/010,183 patent/US9983213B2/en active Active
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