JP2011528797A5 - - Google Patents
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- Publication number
- JP2011528797A5 JP2011528797A5 JP2011519175A JP2011519175A JP2011528797A5 JP 2011528797 A5 JP2011528797 A5 JP 2011528797A5 JP 2011519175 A JP2011519175 A JP 2011519175A JP 2011519175 A JP2011519175 A JP 2011519175A JP 2011528797 A5 JP2011528797 A5 JP 2011528797A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- subject
- cardiac troponin
- angiogenic therapy
- reference amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004903 Troponin Human genes 0.000 claims 19
- 108090001027 Troponin Proteins 0.000 claims 19
- 230000000747 cardiac effect Effects 0.000 claims 18
- 238000011122 anti-angiogenic therapy Methods 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 10
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 10
- 239000005557 antagonist Substances 0.000 claims 10
- 108020001621 Natriuretic Peptide Proteins 0.000 claims 8
- 102000004571 Natriuretic peptide Human genes 0.000 claims 8
- 239000000692 natriuretic peptide Substances 0.000 claims 8
- 102400001263 NT-proBNP Human genes 0.000 claims 2
- 102000004987 Troponin T Human genes 0.000 claims 2
- 108090001108 Troponin T Proteins 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000007211 cardiovascular event Effects 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08161014.9 | 2008-07-23 | ||
| EP08161014 | 2008-07-23 | ||
| PCT/EP2009/059505 WO2010010153A1 (en) | 2008-07-23 | 2009-07-23 | Identification of subjects being susceptible to anti-angiogenesis therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528797A JP2011528797A (ja) | 2011-11-24 |
| JP2011528797A5 true JP2011528797A5 (enExample) | 2012-01-12 |
| JP5606438B2 JP5606438B2 (ja) | 2014-10-15 |
Family
ID=40162929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519175A Active JP5606438B2 (ja) | 2008-07-23 | 2009-07-23 | 抗血管新生療法を受容可能な被験体の同定 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9983213B2 (enExample) |
| EP (1) | EP2321651B1 (enExample) |
| JP (1) | JP5606438B2 (enExample) |
| ES (1) | ES2644723T3 (enExample) |
| WO (1) | WO2010010153A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883145B2 (en) | 2009-10-16 | 2014-11-11 | Oncomed Pharmaceuticals, Inc. | Methods of treatment with DLL4 antagonists and an anti-hypertensive agent |
| EA025926B1 (ru) * | 2011-06-02 | 2017-02-28 | Олмак Дайэгностикс Лимитед | Молекулярно-диагностический тест на рак |
| JP6170496B2 (ja) | 2011-09-23 | 2017-07-26 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｖｅｇｆ／ｄｌｌ４結合剤およびその使用 |
| JP6371294B2 (ja) * | 2012-10-31 | 2018-08-08 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｄｌｌ４アンタゴニストによる処置の方法およびモニタリング |
| AU2013353839A1 (en) | 2012-12-03 | 2015-06-18 | Almac Diagnostics Limited | Molecular diagnostic test for cancer |
| GB201409479D0 (en) | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| WO2016070051A2 (en) | 2014-10-31 | 2016-05-06 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| EP3353204B1 (en) | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| EP0666868B2 (en) | 1992-10-28 | 2006-06-14 | Genentech, Inc. | Use of anti-VEGF antibodies for the treatment of cancer |
| KR100870353B1 (ko) | 1997-04-07 | 2008-11-25 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
| US20020032315A1 (en) * | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| CA2367611A1 (en) * | 1999-03-15 | 2000-09-21 | Richard M. Thorn | Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis |
| US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| AU2001238493A1 (en) * | 2000-02-17 | 2001-08-27 | Millennium Pharmaceuticals, Inc | Methods and compositions for the identification, assessment, prevention and therapy of human cancers |
| US7632647B2 (en) | 2001-04-13 | 2009-12-15 | Biosite Incorporated | Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes |
| DE60233301D1 (de) | 2001-05-04 | 2009-09-24 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
| KR20160014775A (ko) | 2003-05-30 | 2016-02-11 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체를 사용한 치료 |
| WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| CA2567738C (en) * | 2004-06-15 | 2010-12-21 | F. Hoffmann-La Roche Ag | The use of cardiac hormones for diagnosing the risk of suffering from a cardiovascular complication as a consequence of cardiotoxic medication |
| US7939267B2 (en) * | 2004-11-04 | 2011-05-10 | Laboratory Corporation Of America Holdings | Detection of activation of endothelial cells as surrogate marker for angiogenesis |
| DE602006003411D1 (de) * | 2005-01-24 | 2008-12-11 | Roche Diagnostics Gmbh | Verwendung von Herzhormonen zur Diagnose des Kardiovaskuläre Risikos als folge einer Verabreichung von Entzündungshemmern |
| CN101237880B (zh) * | 2005-08-12 | 2011-09-21 | 瑞泽恩制药公司 | 通过vegf拮抗剂的皮下给药治疗疾病 |
| CA3086149A1 (en) | 2006-04-04 | 2007-10-11 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| EP1887361A1 (en) * | 2006-08-07 | 2008-02-13 | Bio-Rad Pasteur | Method for the prediction of vascular events |
| EP1890154B1 (en) | 2006-08-16 | 2012-07-04 | F. Hoffmann-La Roche AG | Cardiac troponin as an indicator of advanced coronary artery disease |
| WO2008063932A2 (en) | 2006-11-10 | 2008-05-29 | Genentech, Inc. | Method for treating age-related macular degeneration |
| WO2008061978A2 (en) * | 2006-11-21 | 2008-05-29 | Roche Diagnostics Gmbh | Means and methods for optimization of diagnostic and therapeutic approaches in chronic artery disease based on the detection of troponin t and nt-probnp |
| EP2324358A1 (en) | 2008-07-23 | 2011-05-25 | F. Hoffmann-La Roche AG | Monitoring anti-angiogenesis therapy |
-
2009
- 2009-07-23 JP JP2011519175A patent/JP5606438B2/ja active Active
- 2009-07-23 ES ES09800069.8T patent/ES2644723T3/es active Active
- 2009-07-23 WO PCT/EP2009/059505 patent/WO2010010153A1/en not_active Ceased
- 2009-07-23 EP EP09800069.8A patent/EP2321651B1/en active Active
-
2011
- 2011-01-20 US US13/010,183 patent/US9983213B2/en active Active
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