JP2012507020A5 - - Google Patents

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Publication number

JP2012507020A5

JP2012507020A5 JP2011533626A JP2011533626A JP2012507020A5 JP 2012507020 A5 JP2012507020 A5 JP 2012507020A5 JP 2011533626 A JP2011533626 A JP 2011533626A JP 2011533626 A JP2011533626 A JP 2011533626A JP 2012507020 A5 JP2012507020 A5 JP 2012507020A5

Authority

JP

Japan

Prior art keywords

subject

assay

fragment

metabolic syndrome

copeptin

Prior art date

2009-10-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 238000003556 assay Methods 0.000 claims 24
• 239000012634 fragment Substances 0.000 claims 23
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 18
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 18
• 238000000034 method Methods 0.000 claims 16
• 239000000523 sample Substances 0.000 claims 14
• 206010012601 diabetes mellitus Diseases 0.000 claims 13
• 102400000060 Copeptin Human genes 0.000 claims 9
• 101800000115 Copeptin Proteins 0.000 claims 9
• KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 9
• 102400000059 Arg-vasopressin Human genes 0.000 claims 7
• 101800001144 Arg-vasopressin Proteins 0.000 claims 7
• 238000004458 analytical method Methods 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• 238000003018 immunoassay Methods 0.000 claims 4
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
• 239000008103 glucose Substances 0.000 claims 3
• 101800000407 Brain natriuretic peptide 32 Proteins 0.000 claims 2
• 101800004490 Endothelin-1 Proteins 0.000 claims 2
• 102100034296 Natriuretic peptides A Human genes 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 239000002243 precursor Substances 0.000 claims 2
• 108010091794 preprovasopressin Proteins 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• 102400000687 Big endothelin-1 Human genes 0.000 claims 1
• 101800001398 Big endothelin-1 Proteins 0.000 claims 1
• 108010008126 C-terminal proendothelin-1 Proteins 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 102000012192 Cystatin C Human genes 0.000 claims 1
• 108010061642 Cystatin C Proteins 0.000 claims 1
• 102400000686 Endothelin-1 Human genes 0.000 claims 1
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 1
• 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 1
• 101000852968 Homo sapiens Interleukin-1 receptor-like 1 Proteins 0.000 claims 1
• 101000585365 Homo sapiens Sulfotransferase 2A1 Proteins 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 238000008214 LDL Cholesterol Methods 0.000 claims 1
• 102400001263 NT-proBNP Human genes 0.000 claims 1
• -1 NT-proET-1 Proteins 0.000 claims 1
• 101710187800 Natriuretic peptides A Proteins 0.000 claims 1
• 102100036836 Natriuretic peptides B Human genes 0.000 claims 1
• 101710187802 Natriuretic peptides B Proteins 0.000 claims 1
• 102400001018 Proadrenomedullin N-20 terminal peptide Human genes 0.000 claims 1
• 101800000795 Proadrenomedullin N-20 terminal peptide Proteins 0.000 claims 1
• 108010048233 Procalcitonin Proteins 0.000 claims 1
• 102100029867 Sulfotransferase 2A1 Human genes 0.000 claims 1
• GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 claims 1
• 108010004977 Vasopressins Proteins 0.000 claims 1
• 102000002852 Vasopressins Human genes 0.000 claims 1
• 230000003276 anti-hypertensive effect Effects 0.000 claims 1
• HZZGDPLAJHVHSP-GKHTVLBPSA-N big endothelin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CSSC1)C1=CN=CN1 HZZGDPLAJHVHSP-GKHTVLBPSA-N 0.000 claims 1
• 238000004364 calculation method Methods 0.000 claims 1
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
• 235000012000 cholesterol Nutrition 0.000 claims 1
• 230000035487 diastolic blood pressure Effects 0.000 claims 1
• 238000006073 displacement reaction Methods 0.000 claims 1
• 239000000284 extract Substances 0.000 claims 1
• 238000007689 inspection Methods 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• PIRWNASAJNPKHT-SHZATDIYSA-N pamp Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C1=CC=CC=C1 PIRWNASAJNPKHT-SHZATDIYSA-N 0.000 claims 1
• 230000036470 plasma concentration Effects 0.000 claims 1
• 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims 1
• 108010012004 proadrenomedullin Proteins 0.000 claims 1
• 102000034567 proadrenomedullin Human genes 0.000 claims 1
• CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 claims 1
• 108010072272 proendothelin 1 Proteins 0.000 claims 1
• 210000003296 saliva Anatomy 0.000 claims 1
• 230000000391 smoking effect Effects 0.000 claims 1
• 230000035488 systolic blood pressure Effects 0.000 claims 1
• 150000003626 triacylglycerols Chemical class 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1
• 229960003726 vasopressin Drugs 0.000 claims 1