DK3199951T3 - Arginin-vasopressin-prohormon som prædiktiv biomarkør for diabetes - Google Patents

Arginin-vasopressin-prohormon som prædiktiv biomarkør for diabetes Download PDF

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Publication number
DK3199951T3
DK3199951T3 DK16205552.9T DK16205552T DK3199951T3 DK 3199951 T3 DK3199951 T3 DK 3199951T3 DK 16205552 T DK16205552 T DK 16205552T DK 3199951 T3 DK3199951 T3 DK 3199951T3
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DK
Denmark
Prior art keywords
prohormon
biomarket
vasopressin
predictive
arginine
Prior art date
Application number
DK16205552.9T
Other languages
English (en)
Inventor
Joachim Struck
Andreas Bergmann
Olle Melander
Christopher Newton-Cheh
Thomas J Wang
Original Assignee
Brahms Gmbh
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brahms Gmbh, Massachusetts Gen Hospital filed Critical Brahms Gmbh
Application granted granted Critical
Publication of DK3199951T3 publication Critical patent/DK3199951T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/16Oxytocins; Vasopressins; Related peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2410/00Assays, e.g. immunoassays or enzyme assays, involving peptides of less than 20 animo acids
    • G01N2410/04Oxytocins; Vasopressins; Related peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK16205552.9T 2008-10-31 2009-10-29 Arginin-vasopressin-prohormon som prædiktiv biomarkør for diabetes DK3199951T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08168096 2008-10-31
EP09744978.9A EP2356463B1 (en) 2008-10-31 2009-10-29 Arginine vasopressin pro-hormone as predictive biomarker for diabetes

Publications (1)

Publication Number Publication Date
DK3199951T3 true DK3199951T3 (da) 2020-02-24

Family

ID=40445457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16205552.9T DK3199951T3 (da) 2008-10-31 2009-10-29 Arginin-vasopressin-prohormon som prædiktiv biomarkør for diabetes

Country Status (7)

Country Link
US (2) US9116153B2 (da)
EP (2) EP3199951B1 (da)
JP (2) JP5785086B2 (da)
CN (3) CN102317788A (da)
DK (1) DK3199951T3 (da)
ES (2) ES2772930T3 (da)
WO (1) WO2010049179A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10316583A1 (de) * 2003-04-10 2004-10-28 B.R.A.H.M.S Aktiengesellschaft Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2016394A4 (en) 2006-04-04 2013-04-24 Singulex Inc METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES
DE102006060112A1 (de) * 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
EP2440936A4 (en) 2009-06-08 2013-03-13 Singulex Inc GROUPS OF HIGHLY SENSITIVE BIOMARKERS
US20130149386A1 (en) * 2011-12-07 2013-06-13 Region Nordjylland Cd36 as biomarker for steatosis
EP2861767A4 (en) * 2012-06-15 2016-07-27 Nuclea Biotechnologies Inc PREDICTIVE MARKERS FOR CANCER AND METAL CHANGE SYNDROME
JP6196034B2 (ja) 2012-12-20 2017-09-13 ライオン株式会社 高血糖リスク判定用マーカーペプチドおよびその用途
CN103266089A (zh) * 2013-05-09 2013-08-28 南京医科大学第一附属医院 抗人和肽素单克隆抗体mcco1及其应用
US20160097781A1 (en) * 2014-10-01 2016-04-07 Sphingotec Gmbh Method for stratifying a female subject for hormone replacement therapy
CN113238063A (zh) * 2021-05-31 2021-08-10 迈克生物股份有限公司 Gdf15评估代谢综合征患者进展为心血管疾病的应用
CN113248590B (zh) * 2021-06-24 2021-09-10 天津奇云诺德生物医学有限公司 一种NT-proBNP蛋白抗原决定簇多肽及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606016D0 (en) * 1996-03-22 1996-05-22 Smithkline Beecham Plc Novel use
WO2004006860A2 (en) * 2002-07-16 2004-01-22 Woomera Therapeutics, Inc. Compositions and uses thereof for identifying and targeting provasopressin-expressing cancer cells
WO2005033327A2 (en) 2003-09-29 2005-04-14 Biosite Incorporated Methods and compositions for the diagnosis of sepsis
EP1628136A1 (en) * 2004-08-19 2006-02-22 B.R.A.H.M.S. Aktiengesellschaft Method of diagnosis of disease using copeptin
WO2007044860A2 (en) * 2005-10-11 2007-04-19 Tethys Bioscience, Inc. Diabetes-associated markers and methods of use thereof
EP2092340B1 (en) * 2006-10-18 2014-07-09 Axela Inc. Measuring multiple analytes over a broad range of concentrations using optical diffraction
DK2084543T3 (da) * 2006-10-26 2018-01-22 Brahms Gmbh Risikostratificering af akut koronarsyndrom ved hjælp af fragmenter/delpeptider af provasopressin, især copeptin eller neurophysin II
WO2008128352A1 (en) * 2007-04-19 2008-10-30 Axela, Inc. Methods and compositions for signal amplification

Also Published As

Publication number Publication date
CN106153943B (zh) 2019-02-15
EP3199951B1 (en) 2019-11-20
JP5785086B2 (ja) 2015-09-24
JP2012507020A (ja) 2012-03-22
EP2356463B1 (en) 2017-08-30
ES2645688T3 (es) 2017-12-07
JP6055005B2 (ja) 2016-12-27
US20110318766A1 (en) 2011-12-29
EP2356463A1 (en) 2011-08-17
ES2772930T3 (es) 2020-07-08
CN102317788A (zh) 2012-01-11
US20150293127A1 (en) 2015-10-15
EP3199951A1 (en) 2017-08-02
US9116153B2 (en) 2015-08-25
JP2015135338A (ja) 2015-07-27
WO2010049179A1 (en) 2010-05-06
US9952229B2 (en) 2018-04-24
CN106153943A (zh) 2016-11-23
CN103713137A (zh) 2014-04-09

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