JP5606438B2 - 抗血管新生療法を受容可能な被験体の同定 - Google Patents
抗血管新生療法を受容可能な被験体の同定 Download PDFInfo
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| GB201409479D0 (en) | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| MX382902B (es) | 2014-10-31 | 2025-03-13 | Oncomed Pharm Inc | Inhibidor de la vía noth en combinación con un agente inmunoterapéutico para usarse en el tratamiento de cáncer. |
| WO2017053705A1 (en) | 2015-09-23 | 2017-03-30 | Oncomed Pharmaceuticals, Inc. | Methods and compositions for treatment of cancer |
Family Cites Families (23)
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| US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
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| EP1238986B1 (en) | 1992-10-28 | 2008-06-25 | Genentech, Inc. | Use of Vascular endothelial cell growth factor antagonists |
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| WO2000054770A1 (en) * | 1999-03-15 | 2000-09-21 | Boston Life Sciences, Inc. | Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis |
| US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| AU2001238493A1 (en) * | 2000-02-17 | 2001-08-27 | Millennium Pharmaceuticals, Inc | Methods and compositions for the identification, assessment, prevention and therapy of human cancers |
| US7632647B2 (en) | 2001-04-13 | 2009-12-15 | Biosite Incorporated | Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes |
| DE60233301D1 (de) | 2001-05-04 | 2009-09-24 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
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| JP4838794B2 (ja) * | 2004-06-15 | 2011-12-14 | エフ．ホフマン−ラ ロシュ アーゲー | 心臓毒性医薬の結果として心血管合併症に罹患するリスクを診断するための心臓ホルモンの使用 |
| US7939267B2 (en) * | 2004-11-04 | 2011-05-10 | Laboratory Corporation Of America Holdings | Detection of activation of endothelial cells as surrogate marker for angiogenesis |
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| EP1887361A1 (en) * | 2006-08-07 | 2008-02-13 | Bio-Rad Pasteur | Method for the prediction of vascular events |
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| WO2008063932A2 (en) | 2006-11-10 | 2008-05-29 | Genentech, Inc. | Method for treating age-related macular degeneration |
| JP5306218B2 (ja) * | 2006-11-21 | 2013-10-02 | エフ．ホフマン−ラ ロシュ アーゲー | トロポニンＴおよびＮＴ−ｐｒｏＢＮＰの検出に基づく慢性動脈疾患での診断および治療的アプローチの最適化のための手段および方法 |
| EP2324358A1 (en) | 2008-07-23 | 2011-05-25 | F. Hoffmann-La Roche AG | Monitoring anti-angiogenesis therapy |
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| US20110113864A1 (en) | 2011-05-19 |
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| WO2010010153A1 (en) | 2010-01-28 |
| EP2321651B1 (en) | 2017-08-23 |
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