JP2014159478A5 - - Google Patents
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- JP2014159478A5 JP2014159478A5 JP2014111127A JP2014111127A JP2014159478A5 JP 2014159478 A5 JP2014159478 A5 JP 2014159478A5 JP 2014111127 A JP2014111127 A JP 2014111127A JP 2014111127 A JP2014111127 A JP 2014111127A JP 2014159478 A5 JP2014159478 A5 JP 2014159478A5
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- Prior art keywords
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- acid sequence
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- Prior art date
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- 238000000034 method Methods 0.000 claims 29
- 241001465754 Metazoa Species 0.000 claims 12
- 150000001413 amino acids Chemical group 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 102000018511 hepcidin Human genes 0.000 claims 6
- 108060003558 hepcidin Proteins 0.000 claims 6
- 229940066919 hepcidin Drugs 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 206010022971 Iron Deficiencies Diseases 0.000 claims 4
- 206010065973 Iron Overload Diseases 0.000 claims 4
- 208000017667 Chronic Disease Diseases 0.000 claims 2
- 102000001554 Hemoglobins Human genes 0.000 claims 2
- 108010054147 Hemoglobins Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 2
- 239000013060 biological fluid Substances 0.000 claims 2
- 238000005534 hematocrit Methods 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 1
- 208000018565 Hemochromatosis Diseases 0.000 claims 1
- 201000000361 Hemochromatosis type 2 Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000036696 Microcytic anaemia Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000009361 bacterial endocarditis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 201000007119 infective endocarditis Diseases 0.000 claims 1
- 201000003453 lung abscess Diseases 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65347905P | 2005-02-16 | 2005-02-16 | |
| US60/653,479 | 2005-02-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011264338A Division JP5852426B2 (ja) | 2005-02-16 | 2011-12-02 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016183644A Division JP6250764B2 (ja) | 2005-02-16 | 2016-09-21 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014159478A JP2014159478A (ja) | 2014-09-04 |
| JP2014159478A5 true JP2014159478A5 (OSRAM) | 2014-11-13 |
| JP6073833B2 JP6073833B2 (ja) | 2017-02-01 |
Family
ID=36917026
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007556264A Expired - Fee Related JP5063366B2 (ja) | 2005-02-16 | 2006-02-16 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
| JP2011264338A Expired - Fee Related JP5852426B2 (ja) | 2005-02-16 | 2011-12-02 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
| JP2014111127A Expired - Fee Related JP6073833B2 (ja) | 2005-02-16 | 2014-05-29 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
| JP2016183644A Expired - Fee Related JP6250764B2 (ja) | 2005-02-16 | 2016-09-21 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007556264A Expired - Fee Related JP5063366B2 (ja) | 2005-02-16 | 2006-02-16 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
| JP2011264338A Expired - Fee Related JP5852426B2 (ja) | 2005-02-16 | 2011-12-02 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016183644A Expired - Fee Related JP6250764B2 (ja) | 2005-02-16 | 2016-09-21 | ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US7968091B2 (OSRAM) |
| EP (3) | EP1858541B1 (OSRAM) |
| JP (4) | JP5063366B2 (OSRAM) |
| CA (1) | CA2597925A1 (OSRAM) |
| ES (2) | ES2392096T3 (OSRAM) |
| HK (1) | HK1218875A1 (OSRAM) |
| WO (1) | WO2006088972A2 (OSRAM) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1355666B1 (en) | 2000-12-22 | 2012-06-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (RGM) and its modulators |
| DE60231804D1 (de) | 2001-05-25 | 2009-05-14 | Inst Nat Sante Rech Med | Verwendung von hepcidin zur herstellung eines arzneimittels zur behandlung von eisenhomöostase störungen |
| EP2314617B1 (en) | 2004-07-23 | 2015-06-24 | Acceleron Pharma Inc. | ActRII receptor polypeptides |
| US7968091B2 (en) * | 2005-02-16 | 2011-06-28 | The General Hospital Corporation | Methods and compositions to regulate iron metabolism |
| US20070099245A1 (en) * | 2005-09-29 | 2007-05-03 | Boris Gorovits | Assays for neutralizing antibodies |
| WO2007039256A2 (de) | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| EA201692543A1 (ru) | 2005-11-23 | 2017-08-31 | Акселерон Фарма Инк. | Антагонисты активина-actriia и их применение для стимулирования роста кости |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| EP2124999B1 (en) | 2006-12-18 | 2012-10-03 | Acceleron Pharma, Inc. | Activin-actrii antagonists and uses for treating anemia |
| MX354099B (es) | 2007-02-01 | 2018-02-13 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
| TWI432449B (zh) | 2007-02-02 | 2014-04-01 | Acceleron Pharma Inc | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| KR20160129095A (ko) | 2007-02-09 | 2016-11-08 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| US8895002B2 (en) | 2007-04-09 | 2014-11-25 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
| CA2699936A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| PT2340031T (pt) | 2008-08-14 | 2019-07-25 | Acceleron Pharma Inc | Armadilhas de gdf para uso no tratamento de anemia |
| US8318167B2 (en) * | 2008-11-13 | 2012-11-27 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation of BMP-6 |
| US20110293526A1 (en) * | 2008-11-20 | 2011-12-01 | University Of Southern California | Compositions and methods to modulate hair growth |
| US8138142B2 (en) | 2009-01-13 | 2012-03-20 | Acceleron Pharma Inc. | Methods for increasing adiponectin in a patient in need thereof |
| CN102482339B (zh) | 2009-06-08 | 2015-06-17 | 阿塞勒隆制药公司 | 用于增加产热脂肪细胞的方法 |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| WO2011063018A1 (en) | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| CA2780069C (en) * | 2009-12-08 | 2018-07-17 | Abbott Gmbh & Co. Kg | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
| US20120121576A1 (en) | 2010-11-08 | 2012-05-17 | Jasbir Seehra | Actriia binding agents and uses thereof |
| CN103649126B (zh) | 2011-01-19 | 2016-11-09 | 菲卢马克斯制药公司 | 用于调节铁稳态的组合物及其使用方法 |
| US9636398B2 (en) | 2011-12-14 | 2017-05-02 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
| WO2013090635A2 (en) | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
| MX391536B (es) | 2012-01-27 | 2025-03-21 | Abbvie Deutschland | Composicion y metodo para el diagnostico y tratamiento de enfermedades asociadas con la degeneracion de neuritas. |
| JP6501362B2 (ja) * | 2012-11-01 | 2019-04-17 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | エリスロフェロンおよびｅｒｆｅポリペプチドならびに鉄代謝を調節する方法 |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
| AR093620A1 (es) | 2012-12-17 | 2015-06-10 | Lilly Co Eli | Anticuerpos bmp-6 |
| WO2014147246A1 (en) * | 2013-03-21 | 2014-09-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression |
| US20150330990A1 (en) * | 2013-06-13 | 2015-11-19 | Biodesy, Inc. | Method of screening candidate biochemical entities targeting a target biochemical entity |
| BR112016029226A2 (pt) | 2014-06-13 | 2017-10-17 | Acceleron Pharma Inc | métodos e composições para o tratamento de úlceras |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| FI3227675T3 (fi) | 2014-12-03 | 2023-05-25 | Celgene Corp | Aktiviini-actrii-antagonisteja ja niiden käyttöjä myelodysplastisen oireyhtymän hoitamiseksi |
| UY36449A (es) | 2014-12-19 | 2016-07-29 | Novartis Ag | Composiciones y métodos para anticuerpos dirigidos a bmp6 |
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| US11124766B2 (en) * | 2015-06-12 | 2021-09-21 | Emory University | Growth and survival compositions for cells capable of producing antibodies and methods related thereto |
| ES3028883T3 (en) | 2015-08-31 | 2025-06-20 | Nat Res Council Canada | Tgf-beta-receptor ectodomain fusion molecules and uses thereof |
| HRP20251038T1 (hr) * | 2015-10-23 | 2025-11-07 | Vifor (International) Ag | Novi inhibitori feroportina |
| US11458148B2 (en) | 2016-02-22 | 2022-10-04 | Brigham Young University | Method and compositions for the treatment of anemia through the inhibition of furin |
| CN110381988A (zh) | 2016-06-15 | 2019-10-25 | 诺华股份有限公司 | 使用骨形态发生蛋白6(bmp6)的抑制剂治疗疾病的方法 |
| EP3589663A4 (en) | 2017-03-02 | 2020-10-21 | National Research Council of Canada | TGF-ß RECEPTOR ECTODOMAIN FUSION MOLECULES AND THEIR USES |
| US11125757B2 (en) | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
| EP3870181B1 (en) | 2018-10-26 | 2024-08-14 | Keros Therapeutics, Inc. | Crystal forms of an alk2 inhibitor |
| EP4041243A4 (en) * | 2019-09-27 | 2023-10-18 | Disc Medicine, Inc. | METHODS OF TREATMENT OF ANEMIA OF CHRONIC DISEASE |
| KR20220088699A (ko) | 2019-09-27 | 2022-06-28 | 디스크 메디슨, 인크. | 골수섬유증 및 관련 상태의 치료 방법 |
| JP2023528223A (ja) | 2020-05-13 | 2023-07-04 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体 |
| WO2022098821A1 (en) * | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating lymphopenia |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
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| CA2549477A1 (en) | 2005-06-29 | 2006-12-29 | The Regents Of The University Of California | Competitive regulation of hepcidin mrna by soluble and cell-associated hemojuvelin |
-
2006
- 2006-02-16 US US11/884,509 patent/US7968091B2/en active Active
- 2006-02-16 WO PCT/US2006/005367 patent/WO2006088972A2/en not_active Ceased
- 2006-02-16 JP JP2007556264A patent/JP5063366B2/ja not_active Expired - Fee Related
- 2006-02-16 EP EP06735151A patent/EP1858541B1/en not_active Revoked
- 2006-02-16 ES ES06735151T patent/ES2392096T3/es active Active
- 2006-02-16 CA CA002597925A patent/CA2597925A1/en not_active Abandoned
- 2006-02-16 EP EP10196139.9A patent/EP2335719B1/en active Active
- 2006-02-16 EP EP15173396.1A patent/EP2954903A1/en not_active Withdrawn
- 2006-02-16 ES ES10196139.9T patent/ES2547866T3/es active Active
-
2011
- 2011-06-28 US US13/171,438 patent/US8293236B2/en not_active Expired - Fee Related
- 2011-12-02 JP JP2011264338A patent/JP5852426B2/ja not_active Expired - Fee Related
-
2012
- 2012-02-28 US US13/407,502 patent/US8637023B2/en active Active
- 2012-10-18 US US13/654,623 patent/US8865168B2/en active Active
-
2014
- 2014-05-29 JP JP2014111127A patent/JP6073833B2/ja not_active Expired - Fee Related
- 2014-07-16 US US14/332,716 patent/US9556251B2/en not_active Expired - Fee Related
-
2016
- 2016-06-16 HK HK16106934.8A patent/HK1218875A1/en unknown
- 2016-09-21 JP JP2016183644A patent/JP6250764B2/ja not_active Expired - Fee Related
- 2016-12-12 US US15/375,491 patent/US20170183411A1/en not_active Abandoned
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