JP2014098049A5 - - Google Patents
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- Publication number
- JP2014098049A5 JP2014098049A5 JP2014040226A JP2014040226A JP2014098049A5 JP 2014098049 A5 JP2014098049 A5 JP 2014098049A5 JP 2014040226 A JP2014040226 A JP 2014040226A JP 2014040226 A JP2014040226 A JP 2014040226A JP 2014098049 A5 JP2014098049 A5 JP 2014098049A5
- Authority
- JP
- Japan
- Prior art keywords
- peaks
- furan
- acetyl
- dione
- diffraction pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004519 manufacturing process Methods 0.000 claims 11
- 239000013078 crystal Substances 0.000 claims 9
- DPHUWDIXHNQOSY-UHFFFAOYSA-N napabucasin Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1OC(C(=O)C)=C2 DPHUWDIXHNQOSY-UHFFFAOYSA-N 0.000 claims 9
- 238000002441 X-ray diffraction Methods 0.000 claims 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- ALOLHIXWHIWOHM-UHFFFAOYSA-N 2-acetyl-2,3,4,9-tetrahydronaphtho[2,3-b]furan-4,9-dione Natural products O=C1C2=CC=CC=C2C(=O)C2=C1OC(C(=O)C)C2 ALOLHIXWHIWOHM-UHFFFAOYSA-N 0.000 claims 2
- AGHIQBRPBAHPMV-UHFFFAOYSA-N 3-bromobut-3-en-2-one Chemical compound CC(=O)C(Br)=C AGHIQBRPBAHPMV-UHFFFAOYSA-N 0.000 claims 2
- CSFWPUWCSPOLJW-UHFFFAOYSA-N lawsone Chemical compound C1=CC=C2C(=O)C(O)=CC(=O)C2=C1 CSFWPUWCSPOLJW-UHFFFAOYSA-N 0.000 claims 2
- KUJTUBMARVZCNB-UHFFFAOYSA-N 1-(4,9-dihydrobenzo[f][1]benzofuran-2-yl)ethanone Chemical compound C(C)(=O)C1=CC2=C(O1)CC1=CC=CC=C1C2 KUJTUBMARVZCNB-UHFFFAOYSA-N 0.000 claims 1
- DRSZTATWOSZRAK-UHFFFAOYSA-N 3,4-dibromobutan-2-one Chemical compound CC(=O)C(Br)CBr DRSZTATWOSZRAK-UHFFFAOYSA-N 0.000 claims 1
- -1 3-bromo-3,4-dibromobutan-2-one Chemical compound 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31588610P | 2010-03-19 | 2010-03-19 | |
| US31589010P | 2010-03-19 | 2010-03-19 | |
| US61/315,886 | 2010-03-19 | ||
| US61/315,890 | 2010-03-19 | ||
| US32581410P | 2010-04-19 | 2010-04-19 | |
| US61/325,814 | 2010-04-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500246A Division JP5602935B2 (ja) | 2010-03-19 | 2011-03-21 | がん幹細胞を標的とするための新規の化合物および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014098049A JP2014098049A (ja) | 2014-05-29 |
| JP2014098049A5 true JP2014098049A5 (enExample) | 2014-11-27 |
Family
ID=50940329
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014040227A Withdrawn JP2014098050A (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2014040226A Withdrawn JP2014098049A (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2014040225A Expired - Fee Related JP5993390B2 (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015035285A Pending JP2015098489A (ja) | 2010-03-19 | 2015-02-25 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015179115A Expired - Fee Related JP6246169B2 (ja) | 2010-03-19 | 2015-09-11 | がん幹細胞を標的とするための新規の方法 |
| JP2016194176A Withdrawn JP2016222723A (ja) | 2010-03-19 | 2016-09-30 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2017199380A Withdrawn JP2018002744A (ja) | 2010-03-19 | 2017-10-13 | がん幹細胞を標的とするための新規の方法 |
| JP2018081329A Withdrawn JP2018115209A (ja) | 2010-03-19 | 2018-04-20 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020014705A Withdrawn JP2020063308A (ja) | 2010-03-19 | 2020-01-31 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020082479A Pending JP2020114888A (ja) | 2010-03-19 | 2020-05-08 | がん幹細胞を標的とするための新規の方法 |
| JP2021197732A Pending JP2022020002A (ja) | 2010-03-19 | 2021-12-06 | がん幹細胞を標的とするための新規の化合物および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014040227A Withdrawn JP2014098050A (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014040225A Expired - Fee Related JP5993390B2 (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015035285A Pending JP2015098489A (ja) | 2010-03-19 | 2015-02-25 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015179115A Expired - Fee Related JP6246169B2 (ja) | 2010-03-19 | 2015-09-11 | がん幹細胞を標的とするための新規の方法 |
| JP2016194176A Withdrawn JP2016222723A (ja) | 2010-03-19 | 2016-09-30 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2017199380A Withdrawn JP2018002744A (ja) | 2010-03-19 | 2017-10-13 | がん幹細胞を標的とするための新規の方法 |
| JP2018081329A Withdrawn JP2018115209A (ja) | 2010-03-19 | 2018-04-20 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020014705A Withdrawn JP2020063308A (ja) | 2010-03-19 | 2020-01-31 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020082479A Pending JP2020114888A (ja) | 2010-03-19 | 2020-05-08 | がん幹細胞を標的とするための新規の方法 |
| JP2021197732A Pending JP2022020002A (ja) | 2010-03-19 | 2021-12-06 | がん幹細胞を標的とするための新規の化合物および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP3108750B1 (enExample) |
| JP (11) | JP2014098050A (enExample) |
| CN (3) | CN104016951B (enExample) |
| CA (3) | CA2959951A1 (enExample) |
| DK (1) | DK3108750T3 (enExample) |
| ES (1) | ES2689928T3 (enExample) |
| HU (1) | HUE066482T2 (enExample) |
| NZ (2) | NZ701237A (enExample) |
| PT (1) | PT2547205T (enExample) |
| RU (2) | RU2657750C1 (enExample) |
| SG (3) | SG10201502079VA (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3067054B1 (en) | 2007-09-10 | 2020-12-30 | Boston Biomedical, Inc. | Novel compositions and methods for cancer treatment |
| CN104016951B (zh) * | 2010-03-19 | 2016-07-13 | 北京强新生物科技有限公司 | 靶向癌症干细胞的化合物和组合物 |
| AU2011227023B2 (en) * | 2010-03-19 | 2015-05-28 | Boston Biomedical, Inc. | Novel methods for targeting cancer stem cells |
| MX2015014181A (es) | 2013-04-09 | 2016-05-24 | Boston Biomedical Inc | 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer. |
| JP2018521979A (ja) * | 2015-06-03 | 2018-08-09 | ボストン バイオメディカル， インコーポレイテッド | 癌の治療に使用するための癌幹細胞性阻害剤および免疫療法剤を含む組成物 |
| GB201515387D0 (en) * | 2015-08-28 | 2015-10-14 | Amazentis Sa | Compositions |
| GB201515391D0 (en) * | 2015-08-28 | 2015-10-14 | Amazentis Sa | Compositions |
| JP6751658B2 (ja) | 2016-11-15 | 2020-09-09 | クラリオン株式会社 | 音声認識装置、音声認識システム |
| JP7106563B2 (ja) | 2016-11-29 | 2022-07-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | ナフトフラン誘導体、その調製、および使用方法 |
| US10646464B2 (en) | 2017-05-17 | 2020-05-12 | Boston Biomedical, Inc. | Methods for treating cancer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61205257A (ja) * | 1985-03-08 | 1986-09-11 | Ishihara Sangyo Kaisha Ltd | ベンゾイルウレア系化合物、その製法及びそれを含有する抗ガン剤 |
| EP0945131A1 (de) * | 1998-03-27 | 1999-09-29 | Boehringer Ingelheim Pharma KG | Perorale Wirkstoff-Suspension |
| JP2003525862A (ja) * | 1999-01-27 | 2003-09-02 | ザ ユニヴァーシティー オブ サウス フロリダ | ヒト癌の治療のためのｓｔａｔ３シグナル伝達の阻害 |
| EP1551392A4 (en) * | 2002-09-17 | 2006-09-20 | Arqule Inc | NEW LAPACHO COMPOUNDS AND APPLICATION METHOD THEREFOR |
| TWI335913B (en) * | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| WO2006087919A1 (ja) * | 2005-01-28 | 2006-08-24 | Takeda Pharmaceutical Company Limited | 難水溶性物質含有微細化組成物 |
| JP2006290871A (ja) * | 2005-03-16 | 2006-10-26 | Taheebo Japan Kk | 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法 |
| AR058676A1 (es) * | 2005-09-30 | 2008-02-20 | Smithkline Beecham Corp | Composicion farmaceutica que contiene (s) -(-)-n-( alfa- etilbencil) -3- hidroxi- 2- fenilquinolina-4-carboxamida ( talnetant), povidona , manitol y tensioactivo, procedimiento para prepararla y forma de dosificacion que la comprende |
| EP1860126A1 (en) * | 2006-05-26 | 2007-11-28 | INEOS Manufacturing Belgium NV | Polyolefin powder |
| EP3067054B1 (en) * | 2007-09-10 | 2020-12-30 | Boston Biomedical, Inc. | Novel compositions and methods for cancer treatment |
| CN104530061B (zh) * | 2008-07-08 | 2017-05-10 | 贝达药业股份有限公司 | 埃克替尼盐酸盐晶型、药物组合物和用途 |
| AU2011227023B2 (en) * | 2010-03-19 | 2015-05-28 | Boston Biomedical, Inc. | Novel methods for targeting cancer stem cells |
| CN104016951B (zh) * | 2010-03-19 | 2016-07-13 | 北京强新生物科技有限公司 | 靶向癌症干细胞的化合物和组合物 |
| BR112012023661A2 (pt) * | 2010-03-19 | 2020-11-24 | Boston Biomedical, Inc. | novos compostos e novas composições direcionadas a células-tronco cancerosas |
-
2011
- 2011-03-21 CN CN201410101861.9A patent/CN104016951B/zh active Active
- 2011-03-21 SG SG10201502079VA patent/SG10201502079VA/en unknown
- 2011-03-21 NZ NZ701237A patent/NZ701237A/en not_active IP Right Cessation
- 2011-03-21 RU RU2016123004A patent/RU2657750C1/ru active
- 2011-03-21 HU HUE11757135A patent/HUE066482T2/hu unknown
- 2011-03-21 CN CN201710613672.3A patent/CN107311969B/zh active Active
- 2011-03-21 PT PT117571356T patent/PT2547205T/pt unknown
- 2011-03-21 EP EP16182813.2A patent/EP3108750B1/en active Active
- 2011-03-21 RU RU2015142279A patent/RU2015142279A/ru not_active Application Discontinuation
- 2011-03-21 SG SG10201704745UA patent/SG10201704745UA/en unknown
- 2011-03-21 CA CA2959951A patent/CA2959951A1/en not_active Abandoned
- 2011-03-21 SG SG10201706265PA patent/SG10201706265PA/en unknown
- 2011-03-21 CN CN201710134235.3A patent/CN106860443A/zh active Pending
- 2011-03-21 ES ES16182813.2T patent/ES2689928T3/es active Active
- 2011-03-21 EP EP17196754.0A patent/EP3295796A1/en active Pending
- 2011-03-21 CA CA2959931A patent/CA2959931A1/en not_active Abandoned
- 2011-03-21 DK DK16182813.2T patent/DK3108750T3/en active
- 2011-03-21 CA CA2993363A patent/CA2993363A1/en not_active Abandoned
- 2011-03-21 NZ NZ712826A patent/NZ712826A/en unknown
-
2014
- 2014-03-03 JP JP2014040227A patent/JP2014098050A/ja not_active Withdrawn
- 2014-03-03 JP JP2014040226A patent/JP2014098049A/ja not_active Withdrawn
- 2014-03-03 JP JP2014040225A patent/JP5993390B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-25 JP JP2015035285A patent/JP2015098489A/ja active Pending
- 2015-09-11 JP JP2015179115A patent/JP6246169B2/ja not_active Expired - Fee Related
-
2016
- 2016-09-30 JP JP2016194176A patent/JP2016222723A/ja not_active Withdrawn
-
2017
- 2017-10-13 JP JP2017199380A patent/JP2018002744A/ja not_active Withdrawn
-
2018
- 2018-04-20 JP JP2018081329A patent/JP2018115209A/ja not_active Withdrawn
-
2020
- 2020-01-31 JP JP2020014705A patent/JP2020063308A/ja not_active Withdrawn
- 2020-05-08 JP JP2020082479A patent/JP2020114888A/ja active Pending
-
2021
- 2021-12-06 JP JP2021197732A patent/JP2022020002A/ja active Pending
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