CN107311969B - 靶向癌症干细胞的新的化合物和组合物 - Google Patents

靶向癌症干细胞的新的化合物和组合物 Download PDF

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CN107311969B
CN107311969B CN201710613672.3A CN201710613672A CN107311969B CN 107311969 B CN107311969 B CN 107311969B CN 201710613672 A CN201710613672 A CN 201710613672A CN 107311969 B CN107311969 B CN 107311969B
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compound
polymorph
furan
naphtho
cancer
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CN107311969A (zh
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李嘉强
D.勒格特
李有志
李微
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1Globe Biomedical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

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  • Pregnancy & Childbirth (AREA)
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  • Hematology (AREA)
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CN201710613672.3A 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物 Active CN107311969B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31588610P 2010-03-19 2010-03-19
US31589010P 2010-03-19 2010-03-19
US61/315,890 2010-03-19
US61/315,886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
CN2011800231072A CN103002890A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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CN107311969B true CN107311969B (zh) 2022-01-28

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CN201710613672.3A Active CN107311969B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
CN201410101861.9A Active CN104016951B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的化合物和组合物
CN201710134235.3A Pending CN106860443A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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CN201710134235.3A Pending CN106860443A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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EP (2) EP3108750B1 (enExample)
JP (11) JP2014098049A (enExample)
CN (3) CN107311969B (enExample)
CA (3) CA2993363A1 (enExample)
DK (1) DK3108750T3 (enExample)
ES (1) ES2689928T3 (enExample)
HU (1) HUE066482T2 (enExample)
NZ (2) NZ712826A (enExample)
PT (1) PT2547205T (enExample)
RU (2) RU2015142279A (enExample)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE027443T2 (en) 2007-09-10 2016-10-28 Boston Biomedical Inc A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors
SG10201704745UA (en) * 2010-03-19 2017-07-28 Boston Biomedical Inc Novel compounds and compositions for targeting cancer stem cells
CN103025159A (zh) * 2010-03-19 2013-04-03 波士顿生物医学公司 靶向癌症干细胞的新方法
JP6433085B2 (ja) 2013-04-09 2018-12-05 ボストン バイオメディカル, インコーポレイテッド がんの処置に使用するための2−アセチルナフト[2,3−b]フラン−4,9−ジオン
EA201792623A1 (ru) * 2015-06-03 2018-04-30 Бостон Биомедикал, Инк. Композиции, содержащие ингибитор стволовости рака и иммунотерапевтический агент, для применения в лечении рака
GB201515391D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
GB201515387D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
JP6751658B2 (ja) 2016-11-15 2020-09-09 クラリオン株式会社 音声認識装置、音声認識システム
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
WO2018213424A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61205257A (ja) * 1985-03-08 1986-09-11 Ishihara Sangyo Kaisha Ltd ベンゾイルウレア系化合物、その製法及びそれを含有する抗ガン剤
EP0945131A1 (de) * 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Perorale Wirkstoff-Suspension
EP1146869A2 (en) * 1999-01-27 2001-10-24 University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US20060142271A1 (en) * 2002-09-17 2006-06-29 Klaus Muller Novel lapacho compounds and methods of use thereof
AR042052A1 (es) * 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
JP5288791B2 (ja) * 2005-01-28 2013-09-11 武田薬品工業株式会社 難水溶性物質含有微細化組成物
JP2006290871A (ja) * 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
AR058676A1 (es) * 2005-09-30 2008-02-20 Smithkline Beecham Corp Composicion farmaceutica que contiene (s) -(-)-n-( alfa- etilbencil) -3- hidroxi- 2- fenilquinolina-4-carboxamida ( talnetant), povidona , manitol y tensioactivo, procedimiento para prepararla y forma de dosificacion que la comprende
EP1860126A1 (en) * 2006-05-26 2007-11-28 INEOS Manufacturing Belgium NV Polyolefin powder
HUE027443T2 (en) * 2007-09-10 2016-10-28 Boston Biomedical Inc A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors
JP5719770B2 (ja) * 2008-07-08 2015-05-20 ベータ・ファーマ・インコーポレイテッドBeta Pharma, Inc. 塩酸イコチニブ、合成物、結晶学的形態、併用薬及びその用途
SG10201704745UA (en) * 2010-03-19 2017-07-28 Boston Biomedical Inc Novel compounds and compositions for targeting cancer stem cells
CN103002890A (zh) * 2010-03-19 2013-03-27 波士顿生物医学公司 靶向癌症干细胞的新的化合物和组合物
CN103025159A (zh) * 2010-03-19 2013-04-03 波士顿生物医学公司 靶向癌症干细胞的新方法

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Publication number Publication date
CN107311969A (zh) 2017-11-03
JP2020114888A (ja) 2020-07-30
EP3295796A1 (en) 2018-03-21
NZ712826A (en) 2017-03-31
JP6246169B2 (ja) 2017-12-13
JP2020063308A (ja) 2020-04-23
CA2959931A1 (en) 2011-09-22
CA2993363A1 (en) 2011-09-22
NZ701237A (en) 2016-04-29
JP2022020002A (ja) 2022-01-27
PT2547205T (pt) 2024-05-27
JP2018115209A (ja) 2018-07-26
EP3108750A1 (en) 2016-12-28
HUE066482T2 (hu) 2024-08-28
JP2018002744A (ja) 2018-01-11
SG10201704745UA (en) 2017-07-28
CN104016951B (zh) 2016-07-13
JP2014098048A (ja) 2014-05-29
DK3108750T3 (en) 2018-10-22
JP2015232037A (ja) 2015-12-24
JP2014098049A (ja) 2014-05-29
JP2015098489A (ja) 2015-05-28
CN106860443A (zh) 2017-06-20
EP3108750B1 (en) 2018-07-04
ES2689928T3 (es) 2018-11-16
SG10201706265PA (en) 2017-08-30
RU2657750C1 (ru) 2018-06-15
JP2014098050A (ja) 2014-05-29
JP5993390B2 (ja) 2016-09-14
SG10201502079VA (en) 2015-06-29
JP2016222723A (ja) 2016-12-28
CA2959951A1 (en) 2011-09-22
CN104016951A (zh) 2014-09-03
RU2015142279A3 (enExample) 2019-02-26
RU2015142279A (ru) 2018-12-28

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