|
EP1648511A1
(en)
*
|
2003-07-29 |
2006-04-26 |
Morphotek, Inc. |
Antibodies and methods for generating genetically altered antibodies with enhanced effector function
|
|
EP3101034A1
(en)
|
2004-02-12 |
2016-12-07 |
Morphotek, Inc. |
Monoclonal antibodies that specifically bind to folate receptor alpha
|
|
EP1861425B1
(en)
|
2005-03-10 |
2012-05-16 |
Morphotek, Inc. |
Anti-mesothelin antibodies
|
|
CA2607444C
(en)
|
2005-04-22 |
2015-03-10 |
Morphotek, Inc. |
Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
|
|
KR100694508B1
(ko)
*
|
2005-05-24 |
2007-03-13 |
울산대학교 산학협력단 |
Hbbk4항체를 포함하는 암 질환 치료용 약학조성물및 이를 이용한 암의 면역치료 방법
|
|
US7943133B2
(en)
|
2006-02-02 |
2011-05-17 |
Boston Biocom Llc |
Mesothelin antibody protein fusions and methods of use
|
|
US7795411B2
(en)
|
2006-10-05 |
2010-09-14 |
Fred Hutchinson Cancer Research Center |
Vectors for expressing in vivo biotinylated recombinant proteins
|
|
CN111518218A
(zh)
*
|
2006-11-02 |
2020-08-11 |
阿塞勒隆制药公司 |
Alk1受体和配体拮抗剂及其用途
|
|
ES2526355T3
(es)
|
2007-10-01 |
2015-01-09 |
Bristol-Myers Squibb Company |
Anticuerpos humanos que se adhieren a mesotelina, y usos de los mismos
|
|
MX2010005603A
(es)
|
2007-11-26 |
2010-08-02 |
Bayer Schering Pharma Ag |
Anticuerpos antimesotelina y usos de los mismos.
|
|
CA2718321A1
(en)
*
|
2008-03-27 |
2009-10-01 |
Dimiter S. Dimitrov |
Human anti-mesothelin monoclonal antibodies
|
|
JP2010014691A
(ja)
*
|
2008-06-20 |
2010-01-21 |
Igaku Seibutsugaku Kenkyusho:Kk |
腹水中のメソテリン及び/又は巨核球増強因子を検出するための方法、キット、試薬及び装置
|
|
EP2411416A1
(en)
*
|
2009-03-24 |
2012-02-01 |
The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services |
Anti-mesothelin antibodies
|
|
AR076284A1
(es)
*
|
2009-04-29 |
2011-06-01 |
Bayer Schering Pharma Ag |
Inmunoconjugados de antimesotelina y usos de los mismos
|
|
HUE036157T2
(hu)
*
|
2010-03-30 |
2018-06-28 |
Janssen Biotech Inc |
Humanizált IL-25 ellenanyagok
|
|
BR112013014527A2
(pt)
|
2010-12-20 |
2017-03-07 |
Genentech Inc |
anticorpo isolado, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, uso do imunoconjugado, método para tratamento de um indivíduo que tem um câncer positivo para mesotelina, para inibição de proliferação de uma célula positiva para mesotelina, para detecção de mesotelina humana em uma amostra biológica e para detectar um câncer positivo para mesotelina
|
|
US10233240B1
(en)
*
|
2011-04-18 |
2019-03-19 |
The Regents Of The University Of California |
Methods for treating cholestatic liver fibrosis
|
|
SG194787A1
(en)
|
2011-05-06 |
2013-12-30 |
Us Gov Health & Human Serv |
Recombinant immunotoxin targeting mesothelin
|
|
SG11201404354UA
(en)
*
|
2012-02-17 |
2014-10-30 |
Seattle Genetics Inc |
ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER
|
|
WO2013142300A2
(en)
*
|
2012-03-20 |
2013-09-26 |
Biogen Idec Ma Inc. |
Jcv neutralizing antibodies
|
|
ES2731757T3
(es)
|
2012-03-20 |
2019-11-18 |
Biogen Ma Inc |
Anticuerpos neutralizantes de JCV
|
|
EP2828290B1
(en)
|
2012-03-23 |
2018-08-15 |
The United States of America, represented by the Secretary, Department of Health and Human Services |
Anti-mesothelin chimeric antigen receptors
|
|
WO2014004549A2
(en)
|
2012-06-27 |
2014-01-03 |
Amgen Inc. |
Anti-mesothelin binding proteins
|
|
EP3327037B1
(en)
*
|
2012-08-21 |
2019-10-09 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Mesothelin domain-specific monoclonal antibodies and use thereof
|
|
PT3221356T
(pt)
|
2014-11-20 |
2020-10-29 |
Hoffmann La Roche |
Moléculas de ligação ao antigénio biespecíficas ativadoras das células t contra folr1 e cd3
|
|
DK3221357T3
(da)
|
2014-11-20 |
2020-08-10 |
Hoffmann La Roche |
Fælles letkæder og fremgangsmåder til anvendelse
|
|
WO2016126608A1
(en)
|
2015-02-02 |
2016-08-11 |
Novartis Ag |
Car-expressing cells against multiple tumor antigens and uses thereof
|
|
PL3298033T5
(pl)
|
2015-05-18 |
2023-10-30 |
TCR2 Therapeutics Inc. |
Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
|
|
WO2017032293A1
(zh)
*
|
2015-08-21 |
2017-03-02 |
科济生物医药(上海)有限公司 |
抗间皮素全人抗体以及靶向间皮素的免疫效应细胞
|
|
KR101782487B1
(ko)
*
|
2015-09-24 |
2017-09-27 |
재단법인 목암생명과학연구소 |
신규 항-메소텔린 항체 및 이를 포함하는 조성물
|
|
JP2018536389A
(ja)
*
|
2015-10-02 |
2018-12-13 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
メソテリンとcd3に結合する二重特異性細胞活性化抗原結合分子
|
|
MX389194B
(es)
*
|
2015-10-06 |
2025-03-20 |
Univ Minnesota |
Compuestos terapéuticos y métodos.
|
|
RU2018127657A
(ru)
|
2015-12-30 |
2020-01-31 |
Новартис Аг |
Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью
|
|
KR20180118175A
(ko)
|
2016-03-04 |
2018-10-30 |
노파르티스 아게 |
다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도
|
|
JP7015244B2
(ja)
|
2016-03-22 |
2022-02-02 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
プロテアーゼ活性化t細胞二重特異性分子
|
|
WO2017162587A1
(en)
*
|
2016-03-22 |
2017-09-28 |
F. Hoffmann-La Roche Ag |
Protease-activated t cell bispecific molecules
|
|
EP3432924A1
(en)
|
2016-03-23 |
2019-01-30 |
Novartis AG |
Cell secreted minibodies and uses thereof
|
|
CN109715808A
(zh)
|
2016-04-15 |
2019-05-03 |
诺华股份有限公司 |
用于选择性蛋白质表达的组合物和方法
|
|
JP7160683B2
(ja)
*
|
2016-04-29 |
2022-10-25 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
術後癒着の予防及び治療のための方法及び組成物
|
|
BR112018074453A2
(pt)
*
|
2016-05-27 |
2019-03-19 |
Abbvie Biotherapeutics Inc. |
proteínas de ligação biespecíficas ligando uma protéina imunomoduladora e um antígeno tumoral
|
|
SG11201811184UA
(en)
|
2016-06-20 |
2019-01-30 |
F Star Beta Ltd |
Lag -3 binding members
|
|
GB201612520D0
(en)
|
2016-07-19 |
2016-08-31 |
F-Star Beta Ltd |
Binding molecules
|
|
BR112019002035A2
(pt)
|
2016-08-01 |
2019-05-14 |
Novartis Ag |
tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2
|
|
CA3032498A1
(en)
|
2016-08-02 |
2018-02-08 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
WO2018067993A1
(en)
|
2016-10-07 |
2018-04-12 |
TCR2 Therapeutics Inc. |
Compositions and methods for t-cell receptors reprogramming using fusion proteins
|
|
JP7291396B2
(ja)
|
2016-11-22 |
2023-06-15 |
ティーシーアール2 セラピューティクス インク. |
融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法
|
|
EP4649966A3
(en)
|
2016-12-01 |
2026-02-18 |
Regeneron Pharmaceuticals, Inc. |
Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
|
|
ES2912408T3
(es)
|
2017-01-26 |
2022-05-25 |
Novartis Ag |
Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos
|
|
WO2018232020A1
(en)
|
2017-06-13 |
2018-12-20 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
EP3728316B1
(en)
|
2017-12-19 |
2025-02-26 |
invoX Pharma Limited |
Fc binding fragments comprising a pd-l1 antigen-binding site
|
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
|
EP3788369A1
(en)
|
2018-05-01 |
2021-03-10 |
Novartis Ag |
Biomarkers for evaluating car-t cells to predict clinical outcome
|
|
EP3801769A1
(en)
|
2018-05-25 |
2021-04-14 |
Novartis AG |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
WO2019237035A1
(en)
|
2018-06-08 |
2019-12-12 |
Intellia Therapeutics, Inc. |
Compositions and methods for immunooncology
|
|
EP3806889A4
(en)
*
|
2018-06-18 |
2022-07-13 |
Anwita Biosciences, Inc. |
CYTOKI FUSION PROTEINS AND USES THEREOF
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
PT3820569T
(pt)
|
2018-07-12 |
2025-01-14 |
Invox Pharma Ltd |
Moléculas de anticorpo que se ligam a pd-l1 e cd137
|
|
GB201811403D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
Antibody molecules
|
|
GB201811408D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
CD137 Binding Molecules
|
|
GB201811415D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
Anti-Mesothelin Anti bodies
|
|
GB201811404D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
Anti-CD137 Antibodies
|
|
GB201811410D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
OX40 Binding molecules
|
|
GB201811450D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Delta Ltd |
Mesothelin and CD137 binding molecules
|
|
ES3044118T3
(en)
|
2018-07-12 |
2025-11-26 |
Invox Pharma Ltd |
Antibody molecules that bind cd137 and ox40
|
|
KR20210069048A
(ko)
|
2018-08-30 |
2021-06-10 |
티씨알2 테라퓨틱스 인크. |
융합 단백질을 이용하는 tcr 재프로그래밍을 위한 조성물 및 방법
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
CN112912400B
(zh)
|
2018-10-19 |
2025-05-30 |
明尼苏达大学董事会 |
Nk接合子分子及其使用方法
|
|
WO2020092631A1
(en)
*
|
2018-10-31 |
2020-05-07 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for detecting and treating cancers characterized by expression of mesothelin
|
|
KR20210106437A
(ko)
|
2018-12-20 |
2021-08-30 |
노파르티스 아게 |
3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물
|
|
CN109705219B
(zh)
*
|
2019-01-08 |
2020-11-13 |
上海霖科生物科技有限公司 |
与间皮素结合的单克隆抗体及其制备方法
|
|
CA3123519A1
(en)
|
2019-02-15 |
2020-08-20 |
Novartis Ag |
Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
CN113490528B
(zh)
|
2019-02-15 |
2024-12-03 |
诺华股份有限公司 |
3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途
|
|
KR20220035908A
(ko)
*
|
2019-06-19 |
2022-03-22 |
실버백 테라퓨틱스, 인크. |
항-메소텔린 항체 및 이의 면역접합체
|
|
US11827709B2
(en)
|
2019-12-05 |
2023-11-28 |
Seagen Inc. |
Anti-AVB6 antibodies and antibody-drug conjugates
|
|
IL293640A
(en)
|
2019-12-20 |
2022-08-01 |
Amgen Inc |
CD40 antagonistic mesothelin-targeted multispecific antibody constructs for the treatment of solid tumors
|
|
BR112022011902A2
(pt)
|
2019-12-20 |
2022-09-06 |
Novartis Ag |
Terapias de combinação
|
|
JP2023529211A
(ja)
|
2020-06-11 |
2023-07-07 |
ノバルティス アーゲー |
Zbtb32阻害剤及びその使用
|
|
KR20230027056A
(ko)
|
2020-06-23 |
2023-02-27 |
노파르티스 아게 |
3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법
|
|
JP7819176B2
(ja)
|
2020-08-03 |
2026-02-24 |
ノバルティス アーゲー |
ヘテロアリール置換3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体及びその使用
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
TW202321296A
(zh)
|
2021-10-06 |
2023-06-01 |
美商鏈接免疫療法公司 |
抗間皮素抗原結合分子及其用途
|
|
WO2023214325A1
(en)
|
2022-05-05 |
2023-11-09 |
Novartis Ag |
Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
|
|
WO2024102954A1
(en)
|
2022-11-10 |
2024-05-16 |
Massachusetts Institute Of Technology |
Activation induced clipping system (aics)
|
|
AU2024260837A1
(en)
|
2023-04-25 |
2025-10-16 |
Arsenal Biosciences, Inc. |
Novel receptors for transcription regulation
|
|
PE20252789A1
(es)
|
2023-05-24 |
2025-12-22 |
Kumquat Biosciences Inc |
Compuestos heterociclicos y usos de estos
|
|
WO2025235862A1
(en)
|
2024-05-10 |
2025-11-13 |
Inndura Therapeutics Inc. |
A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a
|