JP2014005302A5 - - Google Patents
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- JP2014005302A5 JP2014005302A5 JP2013212550A JP2013212550A JP2014005302A5 JP 2014005302 A5 JP2014005302 A5 JP 2014005302A5 JP 2013212550 A JP2013212550 A JP 2013212550A JP 2013212550 A JP2013212550 A JP 2013212550A JP 2014005302 A5 JP2014005302 A5 JP 2014005302A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- tablet
- microns
- amount
- mannitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000001913 cellulose Substances 0.000 claims 16
- 239000000546 pharmaceutical excipient Substances 0.000 claims 13
- 239000002245 particle Substances 0.000 claims 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 10
- 229930195725 Mannitol Natural products 0.000 claims 10
- 229920002678 cellulose Polymers 0.000 claims 10
- 235000010980 cellulose Nutrition 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000000594 mannitol Substances 0.000 claims 10
- 229960001855 mannitol Drugs 0.000 claims 10
- 235000010355 mannitol Nutrition 0.000 claims 10
- -1 3,4-Dimethylphenyl Chemical group 0.000 claims 8
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 239000005913 Maltodextrin Substances 0.000 claims 6
- 229920002774 Maltodextrin Polymers 0.000 claims 6
- 229920000881 Modified starch Polymers 0.000 claims 6
- 229920002472 Starch Polymers 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000000832 lactitol Substances 0.000 claims 6
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 6
- 229960003451 lactitol Drugs 0.000 claims 6
- 235000010448 lactitol Nutrition 0.000 claims 6
- 229940035034 maltodextrin Drugs 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229920003124 powdered cellulose Polymers 0.000 claims 6
- 235000019814 powdered cellulose Nutrition 0.000 claims 6
- 239000000600 sorbitol Substances 0.000 claims 6
- 229960002920 sorbitol Drugs 0.000 claims 6
- 235000010356 sorbitol Nutrition 0.000 claims 6
- 239000008107 starch Substances 0.000 claims 6
- 229940032147 starch Drugs 0.000 claims 6
- 235000019698 starch Nutrition 0.000 claims 6
- 206010043554 thrombocytopenia Diseases 0.000 claims 5
- 239000011230 binding agent Substances 0.000 claims 4
- 239000007884 disintegrant Substances 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- PYTBSUAIKFVNEG-UHFFFAOYSA-N C(O)CN.C(O)CN.C1(=CC(=CC=C1)C(=O)O)C1=CC=CC=C1 Chemical compound C(O)CN.C(O)CN.C1(=CC(=CC=C1)C(=O)O)C1=CC=CC=C1 PYTBSUAIKFVNEG-UHFFFAOYSA-N 0.000 claims 3
- ZJWUEJOPKFYFQD-UHFFFAOYSA-N 2-hydroxy-3-phenylbenzoic acid Chemical compound OC(=O)C1=CC=CC(C=2C=CC=CC=2)=C1O ZJWUEJOPKFYFQD-UHFFFAOYSA-N 0.000 claims 2
- 239000007888 film coating Substances 0.000 claims 2
- 238000009501 film coating Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- SVOQIEJWJCQGDQ-UHFFFAOYSA-N 3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid Chemical compound CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C SVOQIEJWJCQGDQ-UHFFFAOYSA-N 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91576107P | 2007-05-03 | 2007-05-03 | |
| US60/915,761 | 2007-05-03 | ||
| US94773107P | 2007-07-03 | 2007-07-03 | |
| US60/947,731 | 2007-07-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507380A Division JP5419866B2 (ja) | 2007-05-03 | 2007-08-01 | 新たな医薬組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015083393A Division JP6144713B2 (ja) | 2007-05-03 | 2015-04-15 | 新たな医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014005302A JP2014005302A (ja) | 2014-01-16 |
| JP2014005302A5 true JP2014005302A5 (OSRAM) | 2014-06-19 |
| JP5735078B2 JP5735078B2 (ja) | 2015-06-17 |
Family
ID=39343460
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507380A Active JP5419866B2 (ja) | 2007-05-03 | 2007-08-01 | 新たな医薬組成物 |
| JP2013212550A Active JP5735078B2 (ja) | 2007-05-03 | 2013-10-10 | 新たな医薬組成物 |
| JP2015083393A Active JP6144713B2 (ja) | 2007-05-03 | 2015-04-15 | 新たな医薬組成物 |
| JP2017074555A Active JP6560289B2 (ja) | 2007-05-03 | 2017-04-04 | 新たな医薬組成物 |
| JP2019073452A Pending JP2019123747A (ja) | 2007-05-03 | 2019-04-08 | 新たな医薬組成物 |
| JP2021051850A Pending JP2021100968A (ja) | 2007-05-03 | 2021-03-25 | 新たな医薬組成物 |
| JP2022178573A Pending JP2023011888A (ja) | 2007-05-03 | 2022-11-08 | 新たな医薬組成物 |
| JP2024196745A Active JP7642148B2 (ja) | 2007-05-03 | 2024-11-11 | 新たな医薬組成物 |
| JP2024196746A Active JP7642149B2 (ja) | 2007-05-03 | 2024-11-11 | 新たな医薬組成物 |
| JP2025027513A Pending JP2025081605A (ja) | 2007-05-03 | 2025-02-25 | 新たな医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507380A Active JP5419866B2 (ja) | 2007-05-03 | 2007-08-01 | 新たな医薬組成物 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015083393A Active JP6144713B2 (ja) | 2007-05-03 | 2015-04-15 | 新たな医薬組成物 |
| JP2017074555A Active JP6560289B2 (ja) | 2007-05-03 | 2017-04-04 | 新たな医薬組成物 |
| JP2019073452A Pending JP2019123747A (ja) | 2007-05-03 | 2019-04-08 | 新たな医薬組成物 |
| JP2021051850A Pending JP2021100968A (ja) | 2007-05-03 | 2021-03-25 | 新たな医薬組成物 |
| JP2022178573A Pending JP2023011888A (ja) | 2007-05-03 | 2022-11-08 | 新たな医薬組成物 |
| JP2024196745A Active JP7642148B2 (ja) | 2007-05-03 | 2024-11-11 | 新たな医薬組成物 |
| JP2024196746A Active JP7642149B2 (ja) | 2007-05-03 | 2024-11-11 | 新たな医薬組成物 |
| JP2025027513A Pending JP2025081605A (ja) | 2007-05-03 | 2025-02-25 | 新たな医薬組成物 |
Country Status (35)
| Country | Link |
|---|---|
| US (15) | US20100129352A1 (OSRAM) |
| EP (5) | EP4218732B1 (OSRAM) |
| JP (10) | JP5419866B2 (OSRAM) |
| KR (3) | KR101632851B1 (OSRAM) |
| CN (3) | CN101686930A (OSRAM) |
| AR (1) | AR059656A1 (OSRAM) |
| AU (1) | AU2007352608C1 (OSRAM) |
| BR (1) | BRPI0721651B8 (OSRAM) |
| CA (1) | CA2685831C (OSRAM) |
| CL (1) | CL2007002242A1 (OSRAM) |
| CO (1) | CO6260058A2 (OSRAM) |
| CR (1) | CR11143A (OSRAM) |
| CY (1) | CY1117284T1 (OSRAM) |
| DK (3) | DK2152237T3 (OSRAM) |
| DO (1) | DOP2009000253A (OSRAM) |
| EA (2) | EA034294B1 (OSRAM) |
| EC (1) | ECSP077628A (OSRAM) |
| ES (3) | ES2981985T3 (OSRAM) |
| FI (2) | FI3090730T3 (OSRAM) |
| HR (3) | HRP20250383T3 (OSRAM) |
| HU (3) | HUE072202T2 (OSRAM) |
| IL (3) | IL238840B2 (OSRAM) |
| JO (1) | JO3643B1 (OSRAM) |
| LT (2) | LT3090730T (OSRAM) |
| MA (1) | MA30236B1 (OSRAM) |
| MX (1) | MX2009011881A (OSRAM) |
| MY (1) | MY158072A (OSRAM) |
| NZ (1) | NZ580888A (OSRAM) |
| PE (3) | PE20151953A1 (OSRAM) |
| PL (3) | PL4218732T3 (OSRAM) |
| PT (3) | PT2152237E (OSRAM) |
| SI (3) | SI4218732T1 (OSRAM) |
| TW (2) | TWI439267B (OSRAM) |
| WO (1) | WO2008136843A1 (OSRAM) |
| ZA (1) | ZA200907710B (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
| US20120149749A1 (en) * | 2008-10-16 | 2012-06-14 | Michael Arning | Method of treating thrombocytopenia |
| EP2414336A1 (en) | 2009-04-01 | 2012-02-08 | Pliva Hrvatska D.O.O. | Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof |
| CA2763768A1 (en) * | 2009-05-29 | 2010-12-02 | Glaxosmithkline Llc | Methods of administration of thrombopoietin agonist compounds |
| TWI505828B (zh) * | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產（第二）有限公司 | 新穎醫藥組成物 |
| WO2012121958A2 (en) * | 2011-03-08 | 2012-09-13 | Glaxosmithkline Llc | Combination |
| EP2925728A4 (en) * | 2012-11-27 | 2016-11-02 | Glaxosmithkline Llc | COMBINATION |
| WO2015029074A2 (en) * | 2013-09-02 | 2015-03-05 | Hetero Research Foundation | Compositions of eltrombopag |
| KR101545268B1 (ko) | 2015-02-05 | 2015-08-20 | 보령제약 주식회사 | 정제 및 이의 제조방법 |
| WO2016126012A1 (en) * | 2015-02-05 | 2016-08-11 | Boryung Pharmaceutical Co., Ltd | Tablet and method of preparing the same |
| WO2017042839A1 (en) | 2015-09-08 | 2017-03-16 | Actavis Group Ptc Ehf. | Novel eltrombopag salt and preparation thereof |
| CA3008036A1 (en) * | 2016-01-22 | 2017-07-27 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising bicyclo-substituted pyrazolon azo derivative or salt thereof and preparation method thereof |
| CN106361719A (zh) * | 2016-08-25 | 2017-02-01 | 浙江万晟药业有限公司 | 一种艾曲泊帕液体胶囊及其制备方法 |
| CN107913411B (zh) * | 2016-10-11 | 2023-08-25 | 广东东阳光药业股份有限公司 | 艾曲泊帕包合物及其制剂和制备方法 |
| WO2018078644A1 (en) * | 2016-10-24 | 2018-05-03 | Hetero Labs Limited | Orally disintegrating tablets of eltrombopag |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| US20180280861A1 (en) * | 2017-03-30 | 2018-10-04 | JMAC Resources, Inc. | Mixer Truck Water Spray Bar |
| EP3395331B1 (en) | 2017-04-26 | 2019-08-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising eltrombopag olamine |
| CN107468662A (zh) * | 2017-10-10 | 2017-12-15 | 甘宜玲 | 一种治疗消化不良的药物片剂及其制备方法 |
| CN107898784B (zh) * | 2017-11-01 | 2020-09-18 | 天津国际生物医药联合研究院 | 艾曲波帕乙醇胺在抗结核分枝杆菌感染中的应用 |
| CN109893503A (zh) * | 2017-12-11 | 2019-06-18 | 武汉武药科技有限公司 | 一种艾曲泊帕口服混悬液及其制备方法 |
| EP3409272B1 (en) | 2018-03-07 | 2020-06-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical composition comprising eltrombopag olamine, reducing sugar, and polymeric binder |
| US20210308104A1 (en) * | 2018-08-02 | 2021-10-07 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Pharmaceutical composition comprising eltrombopag olamine |
| CN110327330A (zh) * | 2019-08-08 | 2019-10-15 | 上海中医药大学 | 艾曲波帕在制备抗癌血管生成药物及抗癌药物组合物中的应用 |
| WO2021055820A1 (en) | 2019-09-20 | 2021-03-25 | Novartis Ag | 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid and its salts formulation |
| TR201917244A1 (tr) | 2019-11-07 | 2021-05-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Eltrombopag olami̇n i̇çeren kapsül |
| AU2020397233A1 (en) | 2019-12-06 | 2022-06-30 | Synthon B.V. | Pharmaceutical composition comprising eltrombopag bis(monoethanolamine) |
| EP4069203A1 (en) | 2019-12-06 | 2022-10-12 | Synthon B.V. | Pharmaceutical composition comprising eltrombopag bis(monoethanolamine) |
| WO2021123832A1 (en) | 2019-12-20 | 2021-06-24 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
| US20220079883A1 (en) * | 2020-09-14 | 2022-03-17 | Actavis Laboratories Fl, Inc. | Eltrombopag choline dosage forms |
| TR202014694A1 (tr) * | 2020-09-16 | 2022-03-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Eltrombopag olami̇n i̇çeren bi̇r kati oral farmasöri̇k formülasyon |
| EP4014970A1 (en) | 2020-12-21 | 2022-06-22 | Genepharm S.A. | A solid oral composition of eltrombopag olamine |
| WO2022195545A1 (en) | 2021-03-18 | 2022-09-22 | Novartis Ag | Novel pharmaceutical formulations |
| WO2022201087A1 (en) | 2021-03-25 | 2022-09-29 | Novartis Ag | 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid and its salts formulation |
| EP4436554A1 (en) | 2021-12-15 | 2024-10-02 | Galenicum Health SLU | Pharmaceutical compositions comprising eltrombopag |
| CN115919789A (zh) * | 2022-12-08 | 2023-04-07 | 山东新时代药业有限公司 | 一种艾曲泊帕乙醇胺片及其制备方法 |
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