JP2013545761A5 - - Google Patents

Info

Publication number

JP2013545761A5

JP2013545761A5 JP2013541060A JP2013541060A JP2013545761A5 JP 2013545761 A5 JP2013545761 A5 JP 2013545761A5 JP 2013541060 A JP2013541060 A JP 2013541060A JP 2013541060 A JP2013541060 A JP 2013541060A JP 2013545761 A5 JP2013545761 A5 JP 2013545761A5

Authority

JP

Japan

Prior art keywords

seq

vaccine

vaccine formulation

composition

polypeptide

Prior art date

2011-11-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229960005486 vaccine Drugs 0.000 claims description 106
• 239000012634 fragment Substances 0.000 claims description 86
• 239000000203 mixture Substances 0.000 claims description 78
• 229920001184 polypeptide Polymers 0.000 claims description 66
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 66
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 66
• 238000009472 formulation Methods 0.000 claims description 56
• 230000002163 immunogen Effects 0.000 claims description 54
• 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 37
• 208000015181 infectious disease Diseases 0.000 claims description 16
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 16
• 229930182490 saponin Natural products 0.000 claims description 16
• 150000007949 saponins Chemical class 0.000 claims description 16
• 125000000539 amino acid group Chemical group 0.000 claims description 15
• 239000002671 adjuvant Substances 0.000 claims description 14
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 12
• 239000003937 drug carrier Substances 0.000 claims description 12
• 230000003902 lesion Effects 0.000 claims description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 10
• 239000000427 antigen Substances 0.000 claims description 8
• 102000036639 antigens Human genes 0.000 claims description 8
• 108091007433 antigens Proteins 0.000 claims description 8
• 210000003918 fraction a Anatomy 0.000 claims description 8
• 210000000540 fraction c Anatomy 0.000 claims description 8
• 208000024891 symptom Diseases 0.000 claims description 8
• 230000005867 T cell response Effects 0.000 claims description 6
• 102000039446 nucleic acids Human genes 0.000 claims description 6
• 108020004707 nucleic acids Proteins 0.000 claims description 6
• 150000007523 nucleic acids Chemical class 0.000 claims description 6
• 239000002773 nucleotide Substances 0.000 claims description 6
• 125000003729 nucleotide group Chemical group 0.000 claims description 6
• 239000002245 particle Substances 0.000 claims description 6
• PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 claims description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
• 108010076504 Protein Sorting Signals Proteins 0.000 claims description 2
• 235000012000 cholesterol Nutrition 0.000 claims description 2
• 108020001507 fusion proteins Proteins 0.000 claims description 2
• 102000037865 fusion proteins Human genes 0.000 claims description 2
• 230000002401 inhibitory effect Effects 0.000 claims description 2
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 2
• 239000013612 plasmid Substances 0.000 claims description 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 238000000034 method Methods 0.000 description 17
• 108090000623 proteins and genes Proteins 0.000 description 8
• 150000001413 amino acids Chemical class 0.000 description 6
• 102000004169 proteins and genes Human genes 0.000 description 6
• 101150027427 ICP4 gene Proteins 0.000 description 3
• 230000004071 biological effect Effects 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 125000003275 alpha amino acid group Chemical group 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1