JP2013545738A - c−Met抗体組合せ - Google Patents

c−Met抗体組合せ Download PDF

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JP2013545738A
JP2013545738A JP2013537139A JP2013537139A JP2013545738A JP 2013545738 A JP2013545738 A JP 2013545738A JP 2013537139 A JP2013537139 A JP 2013537139A JP 2013537139 A JP2013537139 A JP 2013537139A JP 2013545738 A JP2013545738 A JP 2013545738A
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sequence
seq
amino acid
light chain
antibody
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JP2013545738A5 (enExample
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フウルトベルグ アンナ
サウンデルス ミチャエル
デ ハアルド ジョハンネス
フェストジェンス エルス
デ ジョンゲ ナタルイエ
ミクヒエルイ パウルオ
バスイルイクオ クリストイナ
ドレイエル トルステン
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アルゲン−エックス ビー.ブイ.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013537139A 2010-11-03 2011-11-03 c−Met抗体組合せ Pending JP2013545738A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40986610P 2010-11-03 2010-11-03
US61/409,866 2010-11-03
PCT/EP2011/069372 WO2012059562A1 (en) 2010-11-03 2011-11-03 C-met antibody combinations

Publications (2)

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JP2013545738A true JP2013545738A (ja) 2013-12-26
JP2013545738A5 JP2013545738A5 (enExample) 2014-12-18

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JP2013537139A Pending JP2013545738A (ja) 2010-11-03 2011-11-03 c−Met抗体組合せ
JP2013537138A Active JP5857060B2 (ja) 2010-11-03 2011-11-03 抗c−Met抗体
JP2015177202A Pending JP2016034957A (ja) 2010-11-03 2015-09-09 抗c−Met抗体

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JP2013537138A Active JP5857060B2 (ja) 2010-11-03 2011-11-03 抗c−Met抗体
JP2015177202A Pending JP2016034957A (ja) 2010-11-03 2015-09-09 抗c−Met抗体

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US (7) US8637027B2 (enExample)
EP (3) EP2635602B1 (enExample)
JP (3) JP2013545738A (enExample)
CN (2) CN103562223B (enExample)
AU (3) AU2011325098B2 (enExample)
BR (3) BR112013010688B1 (enExample)
CA (2) CA2816745C (enExample)
DK (1) DK2635602T3 (enExample)
ES (1) ES2594493T3 (enExample)
IL (2) IL226112B (enExample)
RU (2) RU2013125457A (enExample)
WO (2) WO2012059561A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017534259A (ja) * 2014-09-16 2017-11-24 シムフォゲン・アクティーゼルスカブSymphogen A/S 抗met抗体および組成物
JP2019531725A (ja) * 2016-09-23 2019-11-07 エルスター セラピューティクス, インコーポレイテッド ラムダ及びカッパ軽鎖を含む多重特異性抗体分子

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EP2143441A1 (en) * 2008-07-08 2010-01-13 Pierre Fabre Medicament Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer
AU2011325098B2 (en) 2010-11-03 2016-07-14 Argen-X N.V. c-Met antibody combinations
KR20130036993A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 c-Met의 SEMA 도메인 내의 에피토프에 특이적으로 결합하는 항체
AU2012351751B2 (en) * 2011-10-19 2017-09-07 Novimmune S.A. Methods of purifying antibodies
US9926364B2 (en) 2011-11-03 2018-03-27 Argen-X N.V. Chimeric human-llama antigens and methods of use
AU2012340826A1 (en) 2011-11-21 2014-05-29 Genentech, Inc. Purification of anti-c-met antibodies
EP2785741A1 (en) * 2011-12-02 2014-10-08 Cancer Research Technology Limited Antibodies against hgf - receptor and uses
EP2807189B1 (en) 2012-01-23 2019-03-20 Ablynx N.V. Sequences directed against hepatocyte growth factor (hgf) and polypeptides comprising the same for the treatment of cancers and/or tumors
US9931400B2 (en) 2012-09-12 2018-04-03 Samsung Electronics Co., Ltd. Method of combination therapy for prevention or treatment of c-Met or angiogenesis factor induced diseases
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US9535055B2 (en) * 2013-03-28 2017-01-03 Samsung Electronics Co., Ltd. Marker for determining effects of anti-c-Met antibody and method of determining effects of anti-c-Met antibody using the marker
EP2786765B1 (en) 2013-04-01 2018-10-03 Samsung Electronics Co., Ltd. Composition for combination therapy comprising an anti-C-met antibody and a FGFR inhibitor
KR102139607B1 (ko) * 2013-04-01 2020-07-30 삼성전자주식회사 항 c-Met 항체 및 FGFR 저해제를 포함하는 병용 투여용 약학 조성물
US10214593B2 (en) 2013-04-02 2019-02-26 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-c-MET antibody
KR102060540B1 (ko) 2013-04-03 2019-12-31 삼성전자주식회사 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물
JP6491642B2 (ja) * 2013-04-30 2019-03-27 エージェンシー フォー サイエンス, テクノロジー アンド リサーチ mAb2抗Met抗体
KR102186363B1 (ko) * 2013-09-06 2020-12-04 삼성전자주식회사 c-Met 저해제 및 베타-카테닌 저해제를 포함하는 병용 투여용 약학 조성물
KR102192591B1 (ko) * 2013-09-09 2020-12-18 삼성전자주식회사 c-Met 저해제 및 c-Myc 저해제를 포함하는 병용 투여용 약학 조성물
EP3176269B1 (en) * 2014-07-29 2020-12-02 Wellmarker Bio Co., Ltd. Inhibitors of met and igsf1 for treating cancer
US20180057595A1 (en) * 2015-03-16 2018-03-01 Celldex Therapeutics, Inc. Anti-MET Antibodies and Methods of Use Thereof
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
WO2018221969A1 (en) * 2017-05-30 2018-12-06 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-met antibody and use thereof
KR102078292B1 (ko) * 2017-05-30 2020-02-19 주식회사 종근당 신규한 항 c-Met 항체 및 이의 용도
CA3070100A1 (en) * 2017-07-17 2019-01-24 Janssen Biotech, Inc. Antigen binding regions against fibronectin type iii domains and methods of using the same
CN109771642B (zh) 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017534259A (ja) * 2014-09-16 2017-11-24 シムフォゲン・アクティーゼルスカブSymphogen A/S 抗met抗体および組成物
JP2019531725A (ja) * 2016-09-23 2019-11-07 エルスター セラピューティクス, インコーポレイテッド ラムダ及びカッパ軽鎖を含む多重特異性抗体分子
JP7274413B2 (ja) 2016-09-23 2023-05-16 マレンゴ・セラピューティクス,インコーポレーテッド ラムダ及びカッパ軽鎖を含む多重特異性抗体分子
US12421323B2 (en) 2016-09-23 2025-09-23 Marengo Therapeutics, Inc. Multispecific antibody molecules comprising lambda and kappa light chains

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CA2816919A1 (en) 2012-05-10
EP2635602A1 (en) 2013-09-11
ES2594493T3 (es) 2016-12-20
WO2012059562A1 (en) 2012-05-10
BR112013010687A2 (pt) 2016-08-02
US8637027B2 (en) 2014-01-28
US9884917B2 (en) 2018-02-06
US10676535B2 (en) 2020-06-09
JP2016034957A (ja) 2016-03-17
AU2011325097A1 (en) 2013-05-02
EP2635603A1 (en) 2013-09-11
AU2011325098A1 (en) 2013-05-09
BR112013010688A2 (pt) 2016-08-09
BR112013010688B1 (pt) 2020-11-17
IL226112A0 (en) 2013-06-27
US20140205606A1 (en) 2014-07-24
US20180215833A1 (en) 2018-08-02
RU2013125457A (ru) 2014-12-10
CA2816745A1 (en) 2012-05-10
CN103562223A (zh) 2014-02-05
CN103764678A (zh) 2014-04-30
JP2013545455A (ja) 2013-12-26
CN103562223B (zh) 2017-02-22
DK2635602T3 (en) 2016-10-10
AU2015210420B2 (en) 2017-08-03
US20120148607A1 (en) 2012-06-14
RU2608644C2 (ru) 2017-01-23
US9631027B2 (en) 2017-04-25
US20120156206A1 (en) 2012-06-21
EP3165538A1 (en) 2017-05-10
US9688773B2 (en) 2017-06-27
RU2013125459A (ru) 2014-12-10
WO2012059561A1 (en) 2012-05-10
EP2635603B1 (en) 2016-03-23
JP5857060B2 (ja) 2016-02-10
US9688774B2 (en) 2017-06-27
AU2011325098B2 (en) 2016-07-14
US20170349667A1 (en) 2017-12-07
US20150376292A1 (en) 2015-12-31
AU2011325097B2 (en) 2015-05-21
EP2635602B1 (en) 2016-09-07
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IL226113A0 (en) 2013-06-27
US20150376291A1 (en) 2015-12-31
BR122014027420A2 (pt) 2019-08-20
IL226112B (en) 2019-05-30
AU2015210420A1 (en) 2015-09-03

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