JP2013545738A - ｃ−Ｍｅｔ抗体組合せ - Google Patents

ｃ−Ｍｅｔ抗体組合せ Download PDF

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JP2013545738A
JP2013545738A JP2013537139A JP2013537139A JP2013545738A JP 2013545738 A JP2013545738 A JP 2013545738A JP 2013537139 A JP2013537139 A JP 2013537139A JP 2013537139 A JP2013537139 A JP 2013537139A JP 2013545738 A JP2013545738 A JP 2013545738A
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sequence
seq
amino acid
light chain
antibody
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JP2013537139A
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JP2013545738A5 (enExample
Inventor
フウルトベルグ アンナ
サウンデルス ミチャエル
デ ハアルド ジョハンネス
フェストジェンス エルス
デ ジョンゲ ナタルイエ
ミクヒエルイ パウルオ
バスイルイクオ クリストイナ
ドレイエル トルステン
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アルゲン−エックス ビー．ブイ．
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Publication of JP2013545738A5 publication Critical patent/JP2013545738A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013537139A 2010-11-03 2011-11-03 ｃ−Ｍｅｔ抗体組合せ Pending JP2013545738A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40986610P 2010-11-03 2010-11-03
US61/409,866 2010-11-03
PCT/EP2011/069372 WO2012059562A1 (en) 2010-11-03 2011-11-03 C-met antibody combinations

Publications (2)

Publication Number Publication Date
JP2013545738A true JP2013545738A (ja) 2013-12-26
JP2013545738A5 JP2013545738A5 (enExample) 2014-12-18

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Family Applications (3)

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JP2013537139A Pending JP2013545738A (ja) 2010-11-03 2011-11-03 ｃ−Ｍｅｔ抗体組合せ
JP2013537138A Active JP5857060B2 (ja) 2010-11-03 2011-11-03 抗ｃ−Ｍｅｔ抗体
JP2015177202A Pending JP2016034957A (ja) 2010-11-03 2015-09-09 抗ｃ−Ｍｅｔ抗体

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JP2013537138A Active JP5857060B2 (ja) 2010-11-03 2011-11-03 抗ｃ−Ｍｅｔ抗体
JP2015177202A Pending JP2016034957A (ja) 2010-11-03 2015-09-09 抗ｃ−Ｍｅｔ抗体

Country Status (12)

Country Link
US (7) US8637027B2 (enExample)
EP (3) EP2635603B1 (enExample)
JP (3) JP2013545738A (enExample)
CN (2) CN103562223B (enExample)
AU (3) AU2011325097B2 (enExample)
BR (3) BR122014027420A2 (enExample)
CA (2) CA2816745C (enExample)
DK (1) DK2635602T3 (enExample)
ES (1) ES2594493T3 (enExample)
IL (2) IL226112B (enExample)
RU (2) RU2013125457A (enExample)
WO (2) WO2012059562A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017534259A (ja) * 2014-09-16 2017-11-24 シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ 抗ｍｅｔ抗体および組成物
JP2019531725A (ja) * 2016-09-23 2019-11-07 エルスター セラピューティクス， インコーポレイテッド ラムダ及びカッパ軽鎖を含む多重特異性抗体分子

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US8444976B2 (en) 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
EP2143441A1 (en) 2008-07-08 2010-01-13 Pierre Fabre Medicament Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer
BR122014027420A2 (pt) 2010-11-03 2019-08-20 Argenx Bvba Anticorpos anti c-met
KR20130036993A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 ｃ-Ｍｅｔ의 ＳＥＭＡ 도메인 내의 에피토프에 특이적으로 결합하는 항체
ES2767135T3 (es) * 2011-10-19 2020-06-16 Novimmune Sa Métodos para purificar anticuerpos
WO2013064700A2 (en) 2011-11-03 2013-05-10 Argen-X B.V. Chimeric polypeptides and methods of use
MX2014005885A (es) 2011-11-21 2014-09-04 Genentech Inc Purificacion de anticuerpos anti-c-met.
WO2013079973A1 (en) * 2011-12-02 2013-06-06 Di Cara Danielle Marie Antibodies against hgf - receptor and uses
AU2013201422B2 (en) 2012-01-23 2015-04-09 Ablynx Nv Sequences directed against hepatocyte growth factor (HFG) and polypeptides comprising the same for the treatment of cancers and/or tumors
EP2708556B1 (en) * 2012-09-12 2018-11-07 Samsung Electronics Co., Ltd Pharmaceutical composition for the use in a combination therapy for prevention or treatment of c-met or angiogenesis factor induced diseases
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US9535055B2 (en) * 2013-03-28 2017-01-03 Samsung Electronics Co., Ltd. Marker for determining effects of anti-c-Met antibody and method of determining effects of anti-c-Met antibody using the marker
KR102139607B1 (ko) * 2013-04-01 2020-07-30 삼성전자주식회사 항 c-Met 항체 및 FGFR 저해제를 포함하는 병용 투여용 약학 조성물
EP2786765B1 (en) * 2013-04-01 2018-10-03 Samsung Electronics Co., Ltd. Composition for combination therapy comprising an anti-C-met antibody and a FGFR inhibitor
US10214593B2 (en) 2013-04-02 2019-02-26 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-c-MET antibody
KR102060540B1 (ko) 2013-04-03 2019-12-31 삼성전자주식회사 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물
JP6491642B2 (ja) * 2013-04-30 2019-03-27 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ ｍＡｂ２抗Ｍｅｔ抗体
KR102186363B1 (ko) * 2013-09-06 2020-12-04 삼성전자주식회사 c-Met 저해제 및 베타-카테닌 저해제를 포함하는 병용 투여용 약학 조성물
KR102192591B1 (ko) * 2013-09-09 2020-12-18 삼성전자주식회사 c-Met 저해제 및 c-Myc 저해제를 포함하는 병용 투여용 약학 조성물
KR101811731B1 (ko) * 2014-07-29 2018-01-25 재단법인 아산사회복지재단 Met 저해제에 대한 감수성 예측용 신규한 바이오 마커 및 이의 용도
WO2016149265A1 (en) * 2015-03-16 2016-09-22 Kolltan Pharmaceuticals, Inc. Anti-met antibodies and methods of use thereof
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TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
AU2018278730B2 (en) * 2017-05-30 2021-02-04 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-Met antibody and use thereof
WO2018221969A1 (en) * 2017-05-30 2018-12-06 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-met antibody and use thereof
JP7280238B2 (ja) * 2017-07-17 2023-05-23 ヤンセン バイオテツク，インコーポレーテツド フィブロネクチンｉｉｉ型ドメインに対する抗原結合領域及びその使用方法
CN109771642B (zh) * 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
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TW202028237A (zh) * 2018-09-27 2020-08-01 美商西建公司 SIRPα結合蛋白及其使用方法
JP7750828B2 (ja) 2019-09-16 2025-10-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 免疫ｐｅｔ撮像のための放射標識されたｍｅｔ結合タンパク質
CN115297889A (zh) 2020-09-01 2022-11-04 荣昌生物制药(烟台)股份有限公司 抗c-Met抗体药物偶联物及其应用
BR112023020801A2 (pt) 2021-04-08 2023-12-12 Byondis Bv Anticorpo ou fragmento de ligação ao antígeno, conjugado anticorpo-fármaco, composição farmacêutica, e, combinação de um anticorpo ou fragmento de ligação ao antígeno, um conjugado anticorpo-fármaco ou uma composição farmacêutica
WO2023034569A1 (en) * 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-cmet antibodies and their uses
IL324556A (en) 2023-05-19 2026-01-01 Servier Lab Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
JP2017534259A (ja) * 2014-09-16 2017-11-24 シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ 抗ｍｅｔ抗体および組成物
JP2019531725A (ja) * 2016-09-23 2019-11-07 エルスター セラピューティクス， インコーポレイテッド ラムダ及びカッパ軽鎖を含む多重特異性抗体分子
JP7274413B2 (ja) 2016-09-23 2023-05-16 マレンゴ・セラピューティクス，インコーポレーテッド ラムダ及びカッパ軽鎖を含む多重特異性抗体分子
US12421323B2 (en) 2016-09-23 2025-09-23 Marengo Therapeutics, Inc. Multispecific antibody molecules comprising lambda and kappa light chains

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JP2013545455A (ja) 2013-12-26
CN103562223B (zh) 2017-02-22
BR112013010687A2 (pt) 2016-08-02
EP2635603B1 (en) 2016-03-23
US8637027B2 (en) 2014-01-28
RU2013125457A (ru) 2014-12-10
EP3165538A1 (en) 2017-05-10
AU2015210420B2 (en) 2017-08-03
WO2012059562A1 (en) 2012-05-10
CA2816919A1 (en) 2012-05-10
US20120148607A1 (en) 2012-06-14
DK2635602T3 (en) 2016-10-10
CA2816745C (en) 2019-03-12
RU2013125459A (ru) 2014-12-10
AU2011325097B2 (en) 2015-05-21
JP5857060B2 (ja) 2016-02-10
US20150376291A1 (en) 2015-12-31
RU2608644C2 (ru) 2017-01-23
US9884917B2 (en) 2018-02-06
US9631027B2 (en) 2017-04-25
JP2016034957A (ja) 2016-03-17
CN103562223A (zh) 2014-02-05
EP2635602B1 (en) 2016-09-07
WO2012059561A1 (en) 2012-05-10
BR112013010688A2 (pt) 2016-08-09
IL226112A0 (en) 2013-06-27
IL226113A0 (en) 2013-06-27
EP2635602A1 (en) 2013-09-11
CA2816745A1 (en) 2012-05-10
US20180215833A1 (en) 2018-08-02
US20140205606A1 (en) 2014-07-24
CN103764678A (zh) 2014-04-30
US20120156206A1 (en) 2012-06-21
US9688773B2 (en) 2017-06-27
AU2011325098A1 (en) 2013-05-09
BR122014027420A2 (pt) 2019-08-20
US20150376292A1 (en) 2015-12-31
ES2594493T3 (es) 2016-12-20
US9688774B2 (en) 2017-06-27
IL226112B (en) 2019-05-30
US10676535B2 (en) 2020-06-09
US20170349667A1 (en) 2017-12-07
AU2011325098B2 (en) 2016-07-14
AU2015210420A1 (en) 2015-09-03
BR112013010688B1 (pt) 2020-11-17
AU2011325097A1 (en) 2013-05-02
EP2635603A1 (en) 2013-09-11

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