BR112013010688A2 - anticorpos anti c-met - Google Patents

anticorpos anti c-met

Info

Publication number
BR112013010688A2
BR112013010688A2 BR112013010688A BR112013010688A BR112013010688A2 BR 112013010688 A2 BR112013010688 A2 BR 112013010688A2 BR 112013010688 A BR112013010688 A BR 112013010688A BR 112013010688 A BR112013010688 A BR 112013010688A BR 112013010688 A2 BR112013010688 A2 BR 112013010688A2
Authority
BR
Brazil
Prior art keywords
met antibodies
antibodies
met
Prior art date
Application number
BR112013010688A
Other languages
English (en)
Other versions
BR112013010688B1 (pt
Inventor
Anna Hultberg
Cristina Basilico
Els Festjens
Johannes De Haard
Michael Saunders
Natalie De Jonge
Paulo Michieli
Torsten Dreier
Original Assignee
Argen X Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argen X Bv filed Critical Argen X Bv
Priority to BR122014027420-3A priority Critical patent/BR122014027420A2/pt
Publication of BR112013010688A2 publication Critical patent/BR112013010688A2/pt
Publication of BR112013010688B1 publication Critical patent/BR112013010688B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
BR112013010688-3A 2010-11-03 2011-11-03 combinações de anticorpos c-met BR112013010688B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122014027420-3A BR122014027420A2 (pt) 2010-11-03 2011-11-03 Anticorpos anti c-met

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40986610P 2010-11-03 2010-11-03
US61/409,866 2010-11-03
PCT/EP2011/069369 WO2012059561A1 (en) 2010-11-03 2011-11-03 Anti c-met antibodies

Publications (2)

Publication Number Publication Date
BR112013010688A2 true BR112013010688A2 (pt) 2016-08-09
BR112013010688B1 BR112013010688B1 (pt) 2020-11-17

Family

ID=44906140

Family Applications (3)

Application Number Title Priority Date Filing Date
BR112013010688-3A BR112013010688B1 (pt) 2010-11-03 2011-11-03 combinações de anticorpos c-met
BR122014027420-3A BR122014027420A2 (pt) 2010-11-03 2011-11-03 Anticorpos anti c-met
BR112013010687A BR112013010687A2 (pt) 2010-11-03 2011-11-03 combinações de anticorpos c-met

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR122014027420-3A BR122014027420A2 (pt) 2010-11-03 2011-11-03 Anticorpos anti c-met
BR112013010687A BR112013010687A2 (pt) 2010-11-03 2011-11-03 combinações de anticorpos c-met

Country Status (12)

Country Link
US (7) US8637027B2 (pt)
EP (3) EP2635602B1 (pt)
JP (3) JP5857060B2 (pt)
CN (2) CN103562223B (pt)
AU (3) AU2011325098B2 (pt)
BR (3) BR112013010688B1 (pt)
CA (2) CA2816745C (pt)
DK (1) DK2635602T3 (pt)
ES (1) ES2594493T3 (pt)
IL (2) IL226112B (pt)
RU (2) RU2608644C2 (pt)
WO (2) WO2012059561A1 (pt)

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EP2143441A1 (en) 2008-07-08 2010-01-13 Pierre Fabre Medicament Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer
AU2011325098B2 (en) 2010-11-03 2016-07-14 Argen-X N.V. c-Met antibody combinations
KR20130036993A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 c-Met의 SEMA 도메인 내의 에피토프에 특이적으로 결합하는 항체
PT2768857T (pt) * 2011-10-19 2020-01-27 Novimmune Sa Métodos para purificar anticorpos
EP2773660A2 (en) * 2011-11-03 2014-09-10 Argen-X B.V. Chimeric human-camel antigens and their use
US20130129718A1 (en) 2011-11-21 2013-05-23 Genentech, Inc. Purification of anti-c-met antibodies
WO2013079973A1 (en) * 2011-12-02 2013-06-06 Di Cara Danielle Marie Antibodies against hgf - receptor and uses
EP2807189B1 (en) 2012-01-23 2019-03-20 Ablynx N.V. Sequences directed against hepatocyte growth factor (hgf) and polypeptides comprising the same for the treatment of cancers and/or tumors
US9931400B2 (en) 2012-09-12 2018-04-03 Samsung Electronics Co., Ltd. Method of combination therapy for prevention or treatment of c-Met or angiogenesis factor induced diseases
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US9535055B2 (en) * 2013-03-28 2017-01-03 Samsung Electronics Co., Ltd. Marker for determining effects of anti-c-Met antibody and method of determining effects of anti-c-Met antibody using the marker
EP2786765B1 (en) * 2013-04-01 2018-10-03 Samsung Electronics Co., Ltd. Composition for combination therapy comprising an anti-C-met antibody and a FGFR inhibitor
KR102139607B1 (ko) * 2013-04-01 2020-07-30 삼성전자주식회사 항 c-Met 항체 및 FGFR 저해제를 포함하는 병용 투여용 약학 조성물
US10214593B2 (en) 2013-04-02 2019-02-26 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-c-MET antibody
KR102060540B1 (ko) 2013-04-03 2019-12-31 삼성전자주식회사 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물
EP2992019B1 (en) * 2013-04-30 2019-03-06 Agency For Science, Technology And Research Mab 2 anti-met antibody
KR102186363B1 (ko) * 2013-09-06 2020-12-04 삼성전자주식회사 c-Met 저해제 및 베타-카테닌 저해제를 포함하는 병용 투여용 약학 조성물
KR102192591B1 (ko) * 2013-09-09 2020-12-18 삼성전자주식회사 c-Met 저해제 및 c-Myc 저해제를 포함하는 병용 투여용 약학 조성물
ES2898343T3 (es) * 2014-07-29 2022-03-07 Wellmarker Bio Co Ltd Inhibidores de MET e IGSF1 para el tratamiento de cáncer de estómago y de pulmón
WO2016042412A1 (en) * 2014-09-16 2016-03-24 Symphogen A/S Anti-met antibodies and compositions
US20180057595A1 (en) 2015-03-16 2018-03-01 Celldex Therapeutics, Inc. Anti-MET Antibodies and Methods of Use Thereof
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
WO2018057955A1 (en) * 2016-09-23 2018-03-29 Elstar Therapeutics, Inc. Multispecific antibody molecules comprising lambda and kappa light chains
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
WO2018221969A1 (en) * 2017-05-30 2018-12-06 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-met antibody and use thereof
AU2018278730B2 (en) 2017-05-30 2021-02-04 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-Met antibody and use thereof
CN111093696B (zh) * 2017-07-17 2023-10-27 詹森生物科技公司 抗iii型纤连蛋白结构域的抗原结合区及其使用方法
CN109771642B (zh) * 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
WO2020068752A1 (en) * 2018-09-27 2020-04-02 Celgene Corporation SIRPα BINDING PROTEINS AND METHODS OF USE THEREOF
US11591390B2 (en) 2018-09-27 2023-02-28 Celgene Corporation SIRP-α binding proteins and methods of use thereof
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WO2023034569A1 (en) * 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-cmet antibodies and their uses

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Also Published As

Publication number Publication date
US9688773B2 (en) 2017-06-27
JP2013545455A (ja) 2013-12-26
EP2635603B1 (en) 2016-03-23
IL226113A0 (en) 2013-06-27
EP2635602A1 (en) 2013-09-11
CA2816745A1 (en) 2012-05-10
US9884917B2 (en) 2018-02-06
EP2635602B1 (en) 2016-09-07
US20170349667A1 (en) 2017-12-07
CA2816919A1 (en) 2012-05-10
JP2016034957A (ja) 2016-03-17
WO2012059562A1 (en) 2012-05-10
US20150376292A1 (en) 2015-12-31
BR122014027420A2 (pt) 2019-08-20
US20120148607A1 (en) 2012-06-14
CN103764678A (zh) 2014-04-30
US20150376291A1 (en) 2015-12-31
CN103562223B (zh) 2017-02-22
DK2635602T3 (en) 2016-10-10
BR112013010687A2 (pt) 2016-08-02
AU2011325097B2 (en) 2015-05-21
EP3165538A1 (en) 2017-05-10
ES2594493T3 (es) 2016-12-20
RU2013125459A (ru) 2014-12-10
AU2015210420A1 (en) 2015-09-03
CA2816745C (en) 2019-03-12
RU2013125457A (ru) 2014-12-10
AU2015210420B2 (en) 2017-08-03
AU2011325098B2 (en) 2016-07-14
AU2011325098A1 (en) 2013-05-09
US10676535B2 (en) 2020-06-09
WO2012059561A1 (en) 2012-05-10
US20140205606A1 (en) 2014-07-24
CN103562223A (zh) 2014-02-05
US20180215833A1 (en) 2018-08-02
AU2011325097A1 (en) 2013-05-02
EP2635603A1 (en) 2013-09-11
RU2608644C2 (ru) 2017-01-23
IL226112A0 (en) 2013-06-27
US9688774B2 (en) 2017-06-27
JP2013545738A (ja) 2013-12-26
JP5857060B2 (ja) 2016-02-10
US9631027B2 (en) 2017-04-25
US8637027B2 (en) 2014-01-28
BR112013010688B1 (pt) 2020-11-17
IL226112B (en) 2019-05-30
US20120156206A1 (en) 2012-06-21

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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Owner name: ARGEN-X BV (NL)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: ARGEN-X N.V. (NL)

B25D Requested change of name of applicant approved

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B25A Requested transfer of rights approved

Owner name: ARGENX BVBA (BE)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/11/2011, OBSERVADAS AS CONDICOES LEGAIS.