JP2013545731A5 - - Google Patents
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- Publication number
- JP2013545731A5 JP2013545731A5 JP2013535412A JP2013535412A JP2013545731A5 JP 2013545731 A5 JP2013545731 A5 JP 2013545731A5 JP 2013535412 A JP2013535412 A JP 2013535412A JP 2013535412 A JP2013535412 A JP 2013535412A JP 2013545731 A5 JP2013545731 A5 JP 2013545731A5
- Authority
- JP
- Japan
- Prior art keywords
- carbocycle
- alkyl
- symbol
- heterocycloalkyl
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 3
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 150000002923 oximes Chemical class 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- LPMXVESGRSUGHW-UHFFFAOYSA-N Acolongiflorosid K Natural products OC1C(O)C(O)C(C)OC1OC1CC2(O)CCC3C4(O)CCC(C=5COC(=O)C=5)C4(C)CC(O)C3C2(CO)C(O)C1 LPMXVESGRSUGHW-UHFFFAOYSA-N 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- LPMXVESGRSUGHW-GHYGWZAOSA-N Ouabain Natural products O([C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1)[C@H]1C[C@@H](O)[C@@]2(CO)[C@@](O)(C1)CC[C@H]1[C@]3(O)[C@@](C)([C@H](C4=CC(=O)OC4)CC3)C[C@@H](O)[C@H]21 LPMXVESGRSUGHW-GHYGWZAOSA-N 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 244000166550 Strophanthus gratus Species 0.000 claims 1
- 206010057469 Vascular stenosis Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims 1
- 229960003343 ouabain Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10189058 | 2010-10-27 | ||
| EP10189058.0 | 2010-10-27 | ||
| PCT/EP2011/068702 WO2012055894A1 (en) | 2010-10-27 | 2011-10-26 | Diterpenoid derivatives endowed of biological properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545731A JP2013545731A (ja) | 2013-12-26 |
| JP2013545731A5 true JP2013545731A5 (enExample) | 2014-12-04 |
| JP5845274B2 JP5845274B2 (ja) | 2016-01-20 |
Family
ID=43770551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535412A Expired - Fee Related JP5845274B2 (ja) | 2010-10-27 | 2011-10-26 | 生物学的特性を賦与されたジテルペノイド誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8822692B2 (enExample) |
| EP (1) | EP2632892B1 (enExample) |
| JP (1) | JP5845274B2 (enExample) |
| KR (1) | KR20130122735A (enExample) |
| CN (1) | CN103180288B (enExample) |
| AU (1) | AU2011322607A1 (enExample) |
| BR (1) | BR112013010399A2 (enExample) |
| CA (1) | CA2811854A1 (enExample) |
| CY (1) | CY1115794T1 (enExample) |
| DK (1) | DK2632892T3 (enExample) |
| EA (1) | EA021536B1 (enExample) |
| ES (1) | ES2512991T3 (enExample) |
| HR (1) | HRP20140965T1 (enExample) |
| IL (1) | IL225432A (enExample) |
| ME (1) | ME01979B (enExample) |
| MX (1) | MX2013004234A (enExample) |
| MY (1) | MY158661A (enExample) |
| NZ (1) | NZ609769A (enExample) |
| PL (1) | PL2632892T3 (enExample) |
| PT (1) | PT2632892E (enExample) |
| RS (1) | RS53619B1 (enExample) |
| SG (1) | SG189159A1 (enExample) |
| SI (1) | SI2632892T1 (enExample) |
| SM (1) | SMT201400151B (enExample) |
| WO (1) | WO2012055894A1 (enExample) |
| ZA (1) | ZA201303753B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101849399B1 (ko) | 2017-01-13 | 2018-04-17 | 가천대학교 산학협력단 | 전나무 추출물로부터 분리하여 동정한 신규한 다이테르펜 유도체 및 이의 용도 |
| CN109010931B (zh) * | 2017-06-09 | 2022-03-11 | 上海微创医疗器械（集团）有限公司 | 介入医疗器械及阿非迪霉素的应用 |
| RU2689131C1 (ru) * | 2018-11-28 | 2019-05-24 | Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" | Сульфанильные и ацетилсульфанильные производные абиетанового типа |
| CN113967212B (zh) * | 2021-10-12 | 2024-03-12 | 延边大学 | 一种歧化松香类化合物及其制备方法与应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337585A (en) * | 1961-03-10 | 1967-08-22 | Standard Oil Co | Process for making pyrrolidones and piperidones |
| JP2895097B2 (ja) * | 1989-07-20 | 1999-05-24 | 株式会社蛋白工学研究所 | 蛋白２次元結晶膜作成方法 |
| EP1036786A1 (en) * | 1999-03-16 | 2000-09-20 | Bayer Aktiengesellschaft | Rosin amine anti-fouling agents |
| AU776608B2 (en) * | 1999-04-30 | 2004-09-16 | Pfizer Products Inc. | Glucocorticoid receptor modulators |
| ATE449754T1 (de) * | 1999-05-14 | 2009-12-15 | Nereus Pharmaceuticals Inc | Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren |
| JP3973561B2 (ja) * | 2001-04-25 | 2007-09-12 | 田辺製薬株式会社 | カリウムチャネル開口薬 |
| US6831101B2 (en) * | 2001-06-14 | 2004-12-14 | Chemokine Therapeutics Corporation | Tricyclic rantes receptor ligands |
| US7456222B2 (en) * | 2002-05-17 | 2008-11-25 | Sequella, Inc. | Anti tubercular drug: compositions and methods |
| US20040033986A1 (en) * | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
| JP2005239649A (ja) * | 2004-02-27 | 2005-09-08 | Arakawa Chem Ind Co Ltd | １３−ヒドロキシポドカルパ−８，１１，１３−トリエン系化合物の製造方法 |
| JP4777970B2 (ja) * | 2004-03-03 | 2011-09-21 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 新規なアビエタンジテルペノイド系化合物、及び榧抽出物、またはそれから分離したアビエタンジテルペノイド系化合物またはテルペノイド系化合物を有効成分とする心臓循環系疾患の予防及び治療用組成物 |
| US20060014231A1 (en) * | 2004-06-24 | 2006-01-19 | Luc Van Rompaey | Methods and compositions to promote bone homeostasis |
| US8093302B2 (en) * | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
| US7893299B2 (en) * | 2005-07-21 | 2011-02-22 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-αmodulators; syntheses of such modulators and methods of using such modulators |
| WO2008058269A2 (en) * | 2006-11-09 | 2008-05-15 | Foldrx Pharmaceuticals, Inc. | Compounds and methods for modulating protein trafficking |
| EP2147433A2 (en) * | 2007-05-09 | 2010-01-27 | Clariant Finance (BVI) Limited | Use of indolinium diazamethine cations for optical data recording |
| CN104844678B (zh) * | 2007-05-11 | 2018-02-09 | 香港科技大学 | 具有神经保护和增强记忆活性的受体调节剂 |
| WO2009067245A2 (en) * | 2007-11-20 | 2009-05-28 | University Of Florida Research Foundation, Inc. | Compositions and methods for tissue repair |
| JP2010053042A (ja) * | 2008-08-26 | 2010-03-11 | Univ Of Tokyo | カリウムチャネル調節薬 |
-
2011
- 2011-10-26 MY MYPI2013001334A patent/MY158661A/en unknown
- 2011-10-26 PT PT117764142T patent/PT2632892E/pt unknown
- 2011-10-26 EA EA201390615A patent/EA021536B1/ru not_active IP Right Cessation
- 2011-10-26 BR BR112013010399A patent/BR112013010399A2/pt not_active IP Right Cessation
- 2011-10-26 KR KR1020137009747A patent/KR20130122735A/ko not_active Withdrawn
- 2011-10-26 EP EP11776414.2A patent/EP2632892B1/en active Active
- 2011-10-26 AU AU2011322607A patent/AU2011322607A1/en not_active Abandoned
- 2011-10-26 PL PL11776414T patent/PL2632892T3/pl unknown
- 2011-10-26 SI SI201130277T patent/SI2632892T1/sl unknown
- 2011-10-26 DK DK11776414.2T patent/DK2632892T3/da active
- 2011-10-26 CN CN201180051740.2A patent/CN103180288B/zh not_active Expired - Fee Related
- 2011-10-26 NZ NZ609769A patent/NZ609769A/en not_active IP Right Cessation
- 2011-10-26 CA CA2811854A patent/CA2811854A1/en not_active Abandoned
- 2011-10-26 ME MEP-2014-121A patent/ME01979B/me unknown
- 2011-10-26 MX MX2013004234A patent/MX2013004234A/es unknown
- 2011-10-26 ES ES11776414.2T patent/ES2512991T3/es active Active
- 2011-10-26 JP JP2013535412A patent/JP5845274B2/ja not_active Expired - Fee Related
- 2011-10-26 RS RS20140541A patent/RS53619B1/sr unknown
- 2011-10-26 WO PCT/EP2011/068702 patent/WO2012055894A1/en not_active Ceased
- 2011-10-26 HR HRP20140965AT patent/HRP20140965T1/hr unknown
- 2011-10-26 SG SG2013023395A patent/SG189159A1/en unknown
-
2013
- 2013-03-21 IL IL225432A patent/IL225432A/en not_active IP Right Cessation
- 2013-05-23 ZA ZA2013/03753A patent/ZA201303753B/en unknown
- 2013-07-26 US US13/951,736 patent/US8822692B2/en not_active Expired - Fee Related
-
2014
- 2014-10-15 CY CY20141100840T patent/CY1115794T1/el unknown
- 2014-10-17 SM SM201400151T patent/SMT201400151B/xx unknown