JP2013545731A5 - - Google Patents
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- Publication number
- JP2013545731A5 JP2013545731A5 JP2013535412A JP2013535412A JP2013545731A5 JP 2013545731 A5 JP2013545731 A5 JP 2013545731A5 JP 2013535412 A JP2013535412 A JP 2013535412A JP 2013535412 A JP2013535412 A JP 2013535412A JP 2013545731 A5 JP2013545731 A5 JP 2013545731A5
- Authority
- JP
- Japan
- Prior art keywords
- carbocycle
- alkyl
- symbol
- heterocycloalkyl
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 3
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 150000002923 oximes Chemical class 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- LPMXVESGRSUGHW-UHFFFAOYSA-N Acolongiflorosid K Natural products OC1C(O)C(O)C(C)OC1OC1CC2(O)CCC3C4(O)CCC(C=5COC(=O)C=5)C4(C)CC(O)C3C2(CO)C(O)C1 LPMXVESGRSUGHW-UHFFFAOYSA-N 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- LPMXVESGRSUGHW-GHYGWZAOSA-N Ouabain Natural products O([C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1)[C@H]1C[C@@H](O)[C@@]2(CO)[C@@](O)(C1)CC[C@H]1[C@]3(O)[C@@](C)([C@H](C4=CC(=O)OC4)CC3)C[C@@H](O)[C@H]21 LPMXVESGRSUGHW-GHYGWZAOSA-N 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 244000166550 Strophanthus gratus Species 0.000 claims 1
- 206010057469 Vascular stenosis Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims 1
- 229960003343 ouabain Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10189058.0 | 2010-10-27 | ||
| EP10189058 | 2010-10-27 | ||
| PCT/EP2011/068702 WO2012055894A1 (en) | 2010-10-27 | 2011-10-26 | Diterpenoid derivatives endowed of biological properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545731A JP2013545731A (ja) | 2013-12-26 |
| JP2013545731A5 true JP2013545731A5 (enExample) | 2014-12-04 |
| JP5845274B2 JP5845274B2 (ja) | 2016-01-20 |
Family
ID=43770551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535412A Expired - Fee Related JP5845274B2 (ja) | 2010-10-27 | 2011-10-26 | 生物学的特性を賦与されたジテルペノイド誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8822692B2 (enExample) |
| EP (1) | EP2632892B1 (enExample) |
| JP (1) | JP5845274B2 (enExample) |
| KR (1) | KR20130122735A (enExample) |
| CN (1) | CN103180288B (enExample) |
| AU (1) | AU2011322607A1 (enExample) |
| BR (1) | BR112013010399A2 (enExample) |
| CA (1) | CA2811854A1 (enExample) |
| CY (1) | CY1115794T1 (enExample) |
| DK (1) | DK2632892T3 (enExample) |
| EA (1) | EA021536B1 (enExample) |
| ES (1) | ES2512991T3 (enExample) |
| HR (1) | HRP20140965T1 (enExample) |
| IL (1) | IL225432A (enExample) |
| ME (1) | ME01979B (enExample) |
| MX (1) | MX2013004234A (enExample) |
| MY (1) | MY158661A (enExample) |
| NZ (1) | NZ609769A (enExample) |
| PL (1) | PL2632892T3 (enExample) |
| PT (1) | PT2632892E (enExample) |
| RS (1) | RS53619B1 (enExample) |
| SG (1) | SG189159A1 (enExample) |
| SI (1) | SI2632892T1 (enExample) |
| SM (1) | SMT201400151B (enExample) |
| WO (1) | WO2012055894A1 (enExample) |
| ZA (1) | ZA201303753B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101849399B1 (ko) | 2017-01-13 | 2018-04-17 | 가천대학교 산학협력단 | 전나무 추출물로부터 분리하여 동정한 신규한 다이테르펜 유도체 및 이의 용도 |
| CN109010931B (zh) * | 2017-06-09 | 2022-03-11 | 上海微创医疗器械（集团）有限公司 | 介入医疗器械及阿非迪霉素的应用 |
| RU2689131C1 (ru) * | 2018-11-28 | 2019-05-24 | Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" | Сульфанильные и ацетилсульфанильные производные абиетанового типа |
| CN113967212B (zh) * | 2021-10-12 | 2024-03-12 | 延边大学 | 一种歧化松香类化合物及其制备方法与应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337585A (en) * | 1961-03-10 | 1967-08-22 | Standard Oil Co | Process for making pyrrolidones and piperidones |
| JP2895097B2 (ja) * | 1989-07-20 | 1999-05-24 | 株式会社蛋白工学研究所 | 蛋白２次元結晶膜作成方法 |
| EP1036786A1 (en) * | 1999-03-16 | 2000-09-20 | Bayer Aktiengesellschaft | Rosin amine anti-fouling agents |
| UA74145C2 (uk) * | 1999-04-30 | 2005-11-15 | Пфайзер Продактс Інк. | Модулятори глюкокортикоїдного рецептора |
| WO2000073253A1 (en) * | 1999-05-14 | 2000-12-07 | Nereus Pharmaceuticals, Inc. | NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS |
| CA2445330A1 (en) | 2001-04-25 | 2002-11-07 | Tanabe Seiyaku Co., Ltd. | Potassium channel opener |
| US6831101B2 (en) * | 2001-06-14 | 2004-12-14 | Chemokine Therapeutics Corporation | Tricyclic rantes receptor ligands |
| US20040033986A1 (en) * | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
| US7456222B2 (en) * | 2002-05-17 | 2008-11-25 | Sequella, Inc. | Anti tubercular drug: compositions and methods |
| JP2005239649A (ja) * | 2004-02-27 | 2005-09-08 | Arakawa Chem Ind Co Ltd | １３−ヒドロキシポドカルパ−８，１１，１３−トリエン系化合物の製造方法 |
| WO2005084141A2 (en) | 2004-03-03 | 2005-09-15 | Korea Research Institute Of Bioscience And Biotechnology | Novel abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease |
| MXPA06014578A (es) * | 2004-06-24 | 2007-03-23 | Galapagos Nv | Metodos y composiciones para promover homeostasis osea. |
| EP1853578A1 (en) * | 2005-02-15 | 2007-11-14 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-beta agonists |
| EP1912932B1 (en) * | 2005-07-21 | 2012-05-02 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-a modulators; syntheses of such modulators and methods of using such modulators |
| US20100305068A1 (en) * | 2006-11-09 | 2010-12-02 | Foldrx Pharmaceuticals, Inc. | Compounds and methods for modulating protein trafficking |
| TW200902637A (en) * | 2007-05-09 | 2009-01-16 | Clariant Int Ltd | Pentamethine cyanine azo complex dye compounds for optical data recording |
| CN101730706B (zh) * | 2007-05-11 | 2015-04-15 | 生物科技研究有限公司 | 具有神经保护和增强记忆活性的受体拮抗剂 |
| US20110218143A1 (en) * | 2007-11-20 | 2011-09-08 | University Of Florida Research Foundation | Compositions and methods for tissue repair |
| JP2010053042A (ja) | 2008-08-26 | 2010-03-11 | Univ Of Tokyo | カリウムチャネル調節薬 |
-
2011
- 2011-10-26 ME MEP-2014-121A patent/ME01979B/me unknown
- 2011-10-26 MX MX2013004234A patent/MX2013004234A/es unknown
- 2011-10-26 WO PCT/EP2011/068702 patent/WO2012055894A1/en not_active Ceased
- 2011-10-26 PL PL11776414T patent/PL2632892T3/pl unknown
- 2011-10-26 CN CN201180051740.2A patent/CN103180288B/zh not_active Expired - Fee Related
- 2011-10-26 PT PT117764142T patent/PT2632892E/pt unknown
- 2011-10-26 KR KR1020137009747A patent/KR20130122735A/ko not_active Withdrawn
- 2011-10-26 ES ES11776414.2T patent/ES2512991T3/es active Active
- 2011-10-26 EA EA201390615A patent/EA021536B1/ru not_active IP Right Cessation
- 2011-10-26 SI SI201130277T patent/SI2632892T1/sl unknown
- 2011-10-26 CA CA2811854A patent/CA2811854A1/en not_active Abandoned
- 2011-10-26 DK DK11776414.2T patent/DK2632892T3/da active
- 2011-10-26 HR HRP20140965AT patent/HRP20140965T1/hr unknown
- 2011-10-26 BR BR112013010399A patent/BR112013010399A2/pt not_active IP Right Cessation
- 2011-10-26 NZ NZ609769A patent/NZ609769A/en not_active IP Right Cessation
- 2011-10-26 MY MYPI2013001334A patent/MY158661A/en unknown
- 2011-10-26 JP JP2013535412A patent/JP5845274B2/ja not_active Expired - Fee Related
- 2011-10-26 SG SG2013023395A patent/SG189159A1/en unknown
- 2011-10-26 RS RS20140541A patent/RS53619B1/sr unknown
- 2011-10-26 EP EP11776414.2A patent/EP2632892B1/en active Active
- 2011-10-26 AU AU2011322607A patent/AU2011322607A1/en not_active Abandoned
-
2013
- 2013-03-21 IL IL225432A patent/IL225432A/en not_active IP Right Cessation
- 2013-05-23 ZA ZA2013/03753A patent/ZA201303753B/en unknown
- 2013-07-26 US US13/951,736 patent/US8822692B2/en not_active Expired - Fee Related
-
2014
- 2014-10-15 CY CY20141100840T patent/CY1115794T1/el unknown
- 2014-10-17 SM SM201400151T patent/SMT201400151B/xx unknown