CY1115794T1 - Παραγωγα διτερπενοειδων που διαθετουν βιολογικες ιδιοτητες - Google Patents
Παραγωγα διτερπενοειδων που διαθετουν βιολογικες ιδιοτητεςInfo
- Publication number
- CY1115794T1 CY1115794T1 CY20141100840T CY141100840T CY1115794T1 CY 1115794 T1 CY1115794 T1 CY 1115794T1 CY 20141100840 T CY20141100840 T CY 20141100840T CY 141100840 T CY141100840 T CY 141100840T CY 1115794 T1 CY1115794 T1 CY 1115794T1
- Authority
- CY
- Cyprus
- Prior art keywords
- derperenoid
- producers
- biological properties
- dipterenoid
- arteriectomy
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/31—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by at least three rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
- C07C217/10—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/54—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά νέα παράγωγα διτερπενοειδών τύπου (I), μεθόδους για την παρασκευή τους, και φαρμακευτικές συνθέσεις που τα περιέχουν, για τη θεραπευτική αγωγή καρδιαγγειακών διαταραχών, της ακράτειας ούρων, του άσθματος, της νόσου Αλτσχάιμερ και/ή για την πρόληψη αγγειακών βλαβών που οφείλονται σε απόφραξη ως αποτέλεσμα αρτηριοτομής και/ή αγγειοπλαστικής, και για την πρόληψη βλάβης σε όργανα υπερτασικών ασθενών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10189058 | 2010-10-27 | ||
EP11776414.2A EP2632892B1 (en) | 2010-10-27 | 2011-10-26 | Diterpenoid derivatives endowed of biological properties |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115794T1 true CY1115794T1 (el) | 2017-01-25 |
Family
ID=43770551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100840T CY1115794T1 (el) | 2010-10-27 | 2014-10-15 | Παραγωγα διτερπενοειδων που διαθετουν βιολογικες ιδιοτητες |
Country Status (27)
Country | Link |
---|---|
US (1) | US8822692B2 (el) |
EP (1) | EP2632892B1 (el) |
JP (1) | JP5845274B2 (el) |
KR (1) | KR20130122735A (el) |
CN (1) | CN103180288B (el) |
AU (1) | AU2011322607A1 (el) |
BR (1) | BR112013010399A2 (el) |
CA (1) | CA2811854A1 (el) |
CY (1) | CY1115794T1 (el) |
DK (1) | DK2632892T3 (el) |
EA (1) | EA021536B1 (el) |
ES (1) | ES2512991T3 (el) |
HK (1) | HK1186170A1 (el) |
HR (1) | HRP20140965T1 (el) |
IL (1) | IL225432A (el) |
ME (1) | ME01979B (el) |
MX (1) | MX2013004234A (el) |
MY (1) | MY158661A (el) |
NZ (1) | NZ609769A (el) |
PL (1) | PL2632892T3 (el) |
PT (1) | PT2632892E (el) |
RS (1) | RS53619B1 (el) |
SG (1) | SG189159A1 (el) |
SI (1) | SI2632892T1 (el) |
SM (1) | SMT201400151B (el) |
WO (1) | WO2012055894A1 (el) |
ZA (1) | ZA201303753B (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101849399B1 (ko) | 2017-01-13 | 2018-04-17 | 가천대학교 산학협력단 | 전나무 추출물로부터 분리하여 동정한 신규한 다이테르펜 유도체 및 이의 용도 |
CN109010931B (zh) * | 2017-06-09 | 2022-03-11 | 上海微创医疗器械(集团)有限公司 | 介入医疗器械及阿非迪霉素的应用 |
RU2689131C1 (ru) * | 2018-11-28 | 2019-05-24 | Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" | Сульфанильные и ацетилсульфанильные производные абиетанового типа |
CN113967212B (zh) * | 2021-10-12 | 2024-03-12 | 延边大学 | 一种歧化松香类化合物及其制备方法与应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US3337585A (en) * | 1961-03-10 | 1967-08-22 | Standard Oil Co | Process for making pyrrolidones and piperidones |
JP2895097B2 (ja) * | 1989-07-20 | 1999-05-24 | 株式会社蛋白工学研究所 | 蛋白2次元結晶膜作成方法 |
EP1036786A1 (en) * | 1999-03-16 | 2000-09-20 | Bayer Aktiengesellschaft | Rosin amine anti-fouling agents |
MXPA01011018A (es) * | 1999-04-30 | 2002-05-06 | Pfizer Prod Inc | Moduladores del receptor glucocorticoide. |
NZ515675A (en) * | 1999-05-14 | 2004-06-25 | Nereus Pharmaceuticals Inc | Novel interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators |
CA2445330A1 (en) | 2001-04-25 | 2002-11-07 | Tanabe Seiyaku Co., Ltd. | Potassium channel opener |
US6831101B2 (en) * | 2001-06-14 | 2004-12-14 | Chemokine Therapeutics Corporation | Tricyclic rantes receptor ligands |
US20040033986A1 (en) * | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
US7456222B2 (en) * | 2002-05-17 | 2008-11-25 | Sequella, Inc. | Anti tubercular drug: compositions and methods |
JP2005239649A (ja) * | 2004-02-27 | 2005-09-08 | Arakawa Chem Ind Co Ltd | 13−ヒドロキシポドカルパ−8,11,13−トリエン系化合物の製造方法 |
JP4777970B2 (ja) * | 2004-03-03 | 2011-09-21 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 新規なアビエタンジテルペノイド系化合物、及び榧抽出物、またはそれから分離したアビエタンジテルペノイド系化合物またはテルペノイド系化合物を有効成分とする心臓循環系疾患の予防及び治療用組成物 |
EP1758651A2 (en) * | 2004-06-24 | 2007-03-07 | Galapagos N.V. | Lxr agonists to promote bone homeostasis |
US8093302B2 (en) * | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
WO2007015757A2 (en) * | 2005-07-21 | 2007-02-08 | Nereus Pharmaceuticals, Inc. | Interleukin-1 and tumor necrosis factor-a modulators; syntheses of such modulators and methods of using such modulators |
WO2008058269A2 (en) * | 2006-11-09 | 2008-05-15 | Foldrx Pharmaceuticals, Inc. | Compounds and methods for modulating protein trafficking |
US20100093983A1 (en) * | 2007-05-09 | 2010-04-15 | Klein Cedric | Use of indolimium diazamethine cations for optical data recording |
CN104844678B (zh) * | 2007-05-11 | 2018-02-09 | 香港科技大学 | 具有神经保护和增强记忆活性的受体调节剂 |
WO2009067245A2 (en) * | 2007-11-20 | 2009-05-28 | University Of Florida Research Foundation, Inc. | Compositions and methods for tissue repair |
JP2010053042A (ja) | 2008-08-26 | 2010-03-11 | Univ Of Tokyo | カリウムチャネル調節薬 |
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2011
- 2011-10-26 EP EP11776414.2A patent/EP2632892B1/en active Active
- 2011-10-26 MY MYPI2013001334A patent/MY158661A/en unknown
- 2011-10-26 PT PT117764142T patent/PT2632892E/pt unknown
- 2011-10-26 NZ NZ609769A patent/NZ609769A/en not_active IP Right Cessation
- 2011-10-26 AU AU2011322607A patent/AU2011322607A1/en not_active Abandoned
- 2011-10-26 PL PL11776414T patent/PL2632892T3/pl unknown
- 2011-10-26 ME MEP-2014-121A patent/ME01979B/me unknown
- 2011-10-26 WO PCT/EP2011/068702 patent/WO2012055894A1/en active Application Filing
- 2011-10-26 SI SI201130277T patent/SI2632892T1/sl unknown
- 2011-10-26 KR KR1020137009747A patent/KR20130122735A/ko not_active Application Discontinuation
- 2011-10-26 RS RS20140541A patent/RS53619B1/en unknown
- 2011-10-26 CN CN201180051740.2A patent/CN103180288B/zh not_active Expired - Fee Related
- 2011-10-26 MX MX2013004234A patent/MX2013004234A/es unknown
- 2011-10-26 JP JP2013535412A patent/JP5845274B2/ja not_active Expired - Fee Related
- 2011-10-26 BR BR112013010399A patent/BR112013010399A2/pt not_active IP Right Cessation
- 2011-10-26 CA CA2811854A patent/CA2811854A1/en not_active Abandoned
- 2011-10-26 SG SG2013023395A patent/SG189159A1/en unknown
- 2011-10-26 EA EA201390615A patent/EA021536B1/ru not_active IP Right Cessation
- 2011-10-26 ES ES11776414.2T patent/ES2512991T3/es active Active
- 2011-10-26 DK DK11776414.2T patent/DK2632892T3/da active
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2013
- 2013-03-21 IL IL225432A patent/IL225432A/en not_active IP Right Cessation
- 2013-05-23 ZA ZA2013/03753A patent/ZA201303753B/en unknown
- 2013-07-26 US US13/951,736 patent/US8822692B2/en not_active Expired - Fee Related
- 2013-12-04 HK HK13113479.8A patent/HK1186170A1/xx not_active IP Right Cessation
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2014
- 2014-10-07 HR HRP20140965AT patent/HRP20140965T1/hr unknown
- 2014-10-15 CY CY20141100840T patent/CY1115794T1/el unknown
- 2014-10-17 SM SM201400151T patent/SMT201400151B/xx unknown
Also Published As
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RS53619B1 (en) | 2015-04-30 |
JP5845274B2 (ja) | 2016-01-20 |
ZA201303753B (en) | 2014-01-29 |
CN103180288B (zh) | 2015-03-25 |
ES2512991T3 (es) | 2014-10-24 |
IL225432A (en) | 2015-05-31 |
MY158661A (en) | 2016-10-31 |
SMT201400151B (it) | 2015-01-15 |
SI2632892T1 (sl) | 2014-11-28 |
SG189159A1 (en) | 2013-05-31 |
EP2632892B1 (en) | 2014-07-30 |
PT2632892E (pt) | 2014-10-24 |
EA201390615A1 (ru) | 2013-08-30 |
MX2013004234A (es) | 2013-08-21 |
IL225432A0 (en) | 2013-06-27 |
DK2632892T3 (da) | 2014-10-27 |
EP2632892A1 (en) | 2013-09-04 |
HRP20140965T1 (hr) | 2014-11-21 |
US8822692B2 (en) | 2014-09-02 |
JP2013545731A (ja) | 2013-12-26 |
AU2011322607A1 (en) | 2013-04-11 |
BR112013010399A2 (pt) | 2017-07-25 |
EA021536B1 (ru) | 2015-07-30 |
HK1186170A1 (en) | 2014-03-07 |
ME01979B (me) | 2015-05-20 |
KR20130122735A (ko) | 2013-11-08 |
NZ609769A (en) | 2015-02-27 |
US20130310423A1 (en) | 2013-11-21 |
PL2632892T3 (pl) | 2014-12-31 |
CA2811854A1 (en) | 2012-05-03 |
CN103180288A (zh) | 2013-06-26 |
WO2012055894A1 (en) | 2012-05-03 |
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