JP2013545087A5 - - Google Patents
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- JP2013545087A5 JP2013545087A5 JP2013534031A JP2013534031A JP2013545087A5 JP 2013545087 A5 JP2013545087 A5 JP 2013545087A5 JP 2013534031 A JP2013534031 A JP 2013534031A JP 2013534031 A JP2013534031 A JP 2013534031A JP 2013545087 A5 JP2013545087 A5 JP 2013545087A5
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- Japan
- Prior art keywords
- patient
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- biomarkers
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39300910P | 2010-10-14 | 2010-10-14 | |
| US61/393,009 | 2010-10-14 | ||
| US201161436956P | 2011-01-27 | 2011-01-27 | |
| US201161436955P | 2011-01-27 | 2011-01-27 | |
| US61/436,955 | 2011-01-27 | ||
| US61/436,956 | 2011-01-27 | ||
| PCT/US2011/056338 WO2012051519A2 (en) | 2010-10-14 | 2011-10-14 | Biomarkers of brain injury |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545087A JP2013545087A (ja) | 2013-12-19 |
| JP2013545087A5 true JP2013545087A5 (https=) | 2014-12-04 |
| JP6071886B2 JP6071886B2 (ja) | 2017-02-01 |
Family
ID=45938999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013534031A Active JP6071886B2 (ja) | 2010-10-14 | 2011-10-14 | 脳損傷のバイオマーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9746481B2 (https=) |
| EP (1) | EP2628013B1 (https=) |
| JP (1) | JP6071886B2 (https=) |
| IL (1) | IL225731B (https=) |
| WO (1) | WO2012051519A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| US12601749B2 (en) | 2008-08-11 | 2026-04-14 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| HK1206425A1 (en) | 2012-03-13 | 2016-01-08 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| US9378551B2 (en) * | 2013-01-03 | 2016-06-28 | Siemens Aktiengesellschaft | Method and system for lesion candidate detection |
| US10534003B2 (en) | 2013-07-17 | 2020-01-14 | The Johns Hopkins University | Multi-protein biomarker assay for brain injury detection and outcome |
| JP6312302B2 (ja) * | 2014-01-06 | 2018-04-18 | 公益財団法人ヒューマンサイエンス振興財団 | 脳梗塞の診断マーカー |
| EP2896702A1 (en) * | 2014-01-16 | 2015-07-22 | University College Cork, National University Of Irland Cork | A method of identifying a neonate at risk of having or developing hypoxic-ischaemic encephalopathy (HIE) |
| US10238664B2 (en) * | 2014-07-09 | 2019-03-26 | Duke University | Compositions and methods for the repair of myelin |
| WO2016055148A2 (en) * | 2014-10-06 | 2016-04-14 | Université De Genève | Markers and their use in brain injury |
| US12422442B2 (en) | 2014-10-06 | 2025-09-23 | Universite De Geneve | Markers and their use in brain injury |
| US20180024145A1 (en) | 2015-02-05 | 2018-01-25 | Immunarray USA, Inc. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| CN107864671A (zh) | 2015-05-05 | 2018-03-30 | 加利福尼亚大学董事会 | 星形细胞创伤节和神经创伤生物标志物 |
| CN110383068A (zh) * | 2016-10-03 | 2019-10-25 | 雅培实验室 | 评估患者样品中uch-l1状态的改进方法 |
| US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
| EP3559670A1 (en) * | 2016-12-23 | 2019-10-30 | Pangratz-Führer, Susanne | Alpha-b crystallin in the diagnosis of neonatal brain damage |
| CN106645755B (zh) * | 2016-12-30 | 2018-09-25 | 深圳大学 | 一种ad生物标记物及其检测方法 |
| EP4537847A3 (en) | 2017-01-13 | 2025-07-30 | Duke University | Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders |
| CA3261113A1 (en) | 2017-03-23 | 2025-10-27 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1 |
| WO2018191531A1 (en) | 2017-04-15 | 2018-10-18 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
| ES3053676T3 (en) | 2017-04-28 | 2026-01-23 | Abbott Lab | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
| WO2018217792A1 (en) | 2017-05-23 | 2018-11-29 | Immunarray USA, Inc. | Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma |
| US10866251B2 (en) | 2017-05-25 | 2020-12-15 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
| JP7269182B2 (ja) | 2017-05-30 | 2023-05-08 | アボット・ラボラトリーズ | 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法 |
| US11169159B2 (en) | 2017-07-03 | 2021-11-09 | Abbott Laboratories | Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood |
| WO2019112863A1 (en) * | 2017-12-06 | 2019-06-13 | FloTBI Inc. | Assay and point of care device utilizing saliva for diagnosis and treatment of neurological conditions affected brain health |
| JP7379165B2 (ja) | 2017-12-09 | 2023-11-14 | アボット・ラボラトリーズ | Ｇｆａｐとｕｃｈ－ｌ１との組合せを使用する、ヒト対象における外傷性脳損傷を診断及び査定する一助となるための方法 |
| EP3721233A2 (en) | 2017-12-09 | 2020-10-14 | Abbott Laboratories | Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1) |
| CN111699391A (zh) | 2017-12-29 | 2020-09-22 | 雅培实验室 | 用于诊断和评估创伤性脑损伤的新型生物标志物和方法 |
| CN108872589B (zh) * | 2018-01-03 | 2021-09-03 | 深圳市人民医院 | 脑梗死外周血标志物及其应用 |
| EP3779452B1 (en) * | 2018-03-30 | 2023-05-03 | National Center of Neurology and Psychiatry | Neonatal hypoxic-ischemic encephalopathy severity determining method and prognosis predicting method |
| EP3880067A4 (en) * | 2018-11-14 | 2022-08-10 | Mark Evans | METHOD AND DEVICE FOR REDUCING THE RISK OF NEONATAL NEUROLOGICAL INJURY |
| US20220016221A1 (en) * | 2018-12-05 | 2022-01-20 | Ipsen Biopharm Limited | Treatment of symptoms of traumatic brain injury |
| CN110261617B (zh) * | 2019-05-14 | 2022-07-01 | 深圳市人民医院 | 脑出血外周血标志物及其应用 |
| CN110907422B (zh) * | 2019-12-16 | 2021-07-06 | 吉林大学 | 基于Ti3C2的凝血酶适体传感器及其制备方法 |
| WO2021234607A1 (en) * | 2020-05-20 | 2021-11-25 | St. Jude Children's Research Hospital | Detection of alzheimer's disease using specific biomarkers |
| US20230250480A1 (en) * | 2020-07-09 | 2023-08-10 | University Of Florida Research Foundation, Incorporated | Biofluid-based protein and mirna biomarkers for neonatal hypoxic-ischemic encephalopathy |
| EP3982123A1 (en) * | 2020-10-08 | 2022-04-13 | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca | Markers and their use in brain injury |
| US12582345B2 (en) * | 2021-02-01 | 2026-03-24 | The University Of Chicago | Systems and methods for identifying progression of hypoxic-ischemic brain injury |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3234412A (en) * | 1961-07-21 | 1966-02-08 | Babcock & Wilcox Co | Thermionic conversion nuclear reactor |
| SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| ES2259800T3 (es) | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| EP0700521B1 (en) | 1993-05-28 | 2003-06-04 | Baylor College Of Medicine | Method and mass spectrometer for desorption and ionization of analytes |
| US5866434A (en) | 1994-12-08 | 1999-02-02 | Meso Scale Technology | Graphitic nanotubes in luminescence assays |
| JPH11502617A (ja) | 1995-03-10 | 1999-03-02 | メソ スケール テクノロジーズ，エルエルシー | 多重アレイの多重特異的な電気化学発光試験 |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| US6413783B1 (en) | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
| CA2323638A1 (en) | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US6780606B1 (en) | 1999-02-26 | 2004-08-24 | Synx Pharma, Inc. | Method for diagnosing and distinguishing stroke and diagnostic devices for use therein |
| WO2000056934A1 (en) | 1999-03-24 | 2000-09-28 | Packard Bioscience Company | Continuous porous matrix arrays |
| WO2001031580A2 (en) | 1999-10-27 | 2001-05-03 | Biowulf Technologies, Llc | Methods and devices for identifying patterns in biological systems |
| US6925389B2 (en) | 2000-07-18 | 2005-08-02 | Correlogic Systems, Inc., | Process for discriminating between biological states based on hidden patterns from biological data |
| US20020164576A1 (en) | 2000-09-22 | 2002-11-07 | Pedersen Finn Skou | Methods for diagnosis and treatment of diseases associated with altered expression of Nrf2 |
| WO2002024867A2 (en) | 2000-09-22 | 2002-03-28 | University Of Aarhus | Novel compositions and methods for lymphoma and leukemia |
| AU2002245043B2 (en) | 2000-11-16 | 2006-10-26 | Bio-Rad Laboratories, Inc. | Method for analyzing mass spectra |
| US7113896B2 (en) | 2001-05-11 | 2006-09-26 | Zhen Zhang | System and methods for processing biological expression data |
| US6884591B2 (en) | 2001-06-25 | 2005-04-26 | The Cleveland Clinic Foundation | Peripheral marker of blood brain barrier permeability |
| US7144708B2 (en) | 2001-06-25 | 2006-12-05 | The Cleveland Clinic Foundation | Markers of blood barrier disruption and methods of using same |
| DK1412725T3 (en) | 2001-06-29 | 2019-03-25 | Meso Scale Technologies Llc | Multi-well plates for LUMINESCENSE TEST MEASUREMENTS |
| EP1412487B1 (en) | 2001-07-30 | 2010-06-16 | Meso Scale Technologies LLC | Assay electrodes having immobilized lipid/protein layers and methods of making and using the same |
| DE60233949D1 (de) | 2001-08-20 | 2009-11-19 | Biosite Inc | Diagnostische marker für schlaganfall und hirntrauma sowie verfahren zur verwendung davon |
| WO2003023380A1 (en) | 2001-09-10 | 2003-03-20 | Meso Scale Technologies, Llc | Assay buffer, compositions containing the same, and methods of using the same |
| AU2002341621A1 (en) | 2001-09-10 | 2003-03-24 | Meso Scale Technologies, Llc | Methods, reagents, kits and apparatus for protein function analysis |
| US20070098728A1 (en) | 2001-09-24 | 2007-05-03 | Pedersen Finn S | Novel compositions and methods in cancer |
| EP1456668B1 (en) | 2001-12-05 | 2007-05-02 | Sense Proteomic Limited | Protein arrays for allelic variants and uses thereof |
| US20020193950A1 (en) | 2002-02-25 | 2002-12-19 | Gavin Edward J. | Method for analyzing mass spectra |
| US7036946B1 (en) | 2002-09-13 | 2006-05-02 | Rockwell Collins, Inc. | LCD backlight with UV light-emitting diodes and planar reactive element |
| CA2772050C (en) | 2002-12-26 | 2016-09-06 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
| EP1519194A1 (en) | 2003-09-24 | 2005-03-30 | Roche Diagnostics GmbH | Use of gfap for identification of intracerebral hemorrhage |
| US7981362B2 (en) | 2003-11-04 | 2011-07-19 | Meso Scale Technologies, Llc | Modular assay plates, reader systems and methods for test measurements |
| US20140303041A1 (en) | 2004-04-15 | 2014-10-09 | University Of Florida Research Foundation Inc. | In vitro diagnostic devices for nervous system injury and other neural disorders |
| ES2367311T3 (es) | 2004-04-15 | 2011-11-02 | University Of Florida Research Foundation, Inc. | Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales. |
| US7396654B2 (en) * | 2004-04-15 | 2008-07-08 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for traumatic brain injury |
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| US7776583B2 (en) | 2004-06-03 | 2010-08-17 | Meso Scale Technologies, Llc | Methods and apparatuses for conducting assays |
| EP2514837B1 (en) * | 2004-06-25 | 2016-02-10 | Washington University | Markers for brain damage |
| US20060257943A1 (en) | 2005-01-25 | 2006-11-16 | Cis Biotech, Inc. | Ischemic biomarkers and their use to predict adverse neurological events from surgery |
| US7884260B2 (en) | 2005-06-14 | 2011-02-08 | University Of Chicago | Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination |
| GB2428240A (en) * | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
| WO2007123976A2 (en) | 2006-04-18 | 2007-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody profiling for determination of patient responsiveness |
| WO2007136617A2 (en) | 2006-05-18 | 2007-11-29 | Walter Reed Army Institute Of Research (Wrair) | Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury |
| WO2008046509A1 (en) | 2006-10-16 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Ltbp2 as a biomarker, therapeutic and diagnostic target |
| WO2008097618A1 (en) | 2007-02-06 | 2008-08-14 | University Of Florida Research Foundation, Inc. | Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury |
| EP2015196A1 (en) | 2007-06-28 | 2009-01-14 | Siemens Aktiengesellschaft | Programmer interface for manufacturing execution system |
| WO2009143519A2 (en) | 2008-05-23 | 2009-11-26 | The Johns Hopkins University | Biomarkers for myocardial ischemia |
| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| US20140342381A1 (en) | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| JP5781436B2 (ja) | 2008-08-11 | 2015-09-24 | バンヤン・バイオマーカーズ・インコーポレーテッド | 神経学的状態のバイオマーカー検出方法およびアッセイ |
| US20170315136A9 (en) | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| AU2010291933B2 (en) | 2009-09-14 | 2016-09-08 | Banyan Biomarkers, Inc. | Micro-RNA, autoantibody and protein markers for diagnosis of neuronal injury |
| GB201008541D0 (en) * | 2010-05-21 | 2010-07-07 | Univ Geneve | Diagnostic methods |
| US8663911B2 (en) | 2011-01-28 | 2014-03-04 | Cyrex Laboratories, Llc | Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto |
| US20140141458A1 (en) | 2011-05-12 | 2014-05-22 | The Johns Hopkins University | Assay reagents for a neurogranin diagnostic kit |
| WO2012170998A1 (en) | 2011-06-10 | 2012-12-13 | Cornell University | Immobilized protein system for rapid and enhanced multiplexed diagnostics |
| US20150119273A1 (en) | 2012-05-16 | 2015-04-30 | Trustees Of Boston University | Chronic Traumatic Encephalopathy in Blast-Exposed Individuals |
| WO2014194329A1 (en) | 2013-05-31 | 2014-12-04 | Banyan Biomarkers, Inc. | NEURAL SPECIFIC S100β FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION |
| WO2015066211A1 (en) | 2013-10-29 | 2015-05-07 | Banyan Biomarkers, Inc. | Uch-l1 isoforms, assays and devices for detection of a neurological condition |
-
2011
- 2011-10-14 WO PCT/US2011/056338 patent/WO2012051519A2/en not_active Ceased
- 2011-10-14 US US13/879,470 patent/US9746481B2/en active Active
- 2011-10-14 JP JP2013534031A patent/JP6071886B2/ja active Active
- 2011-10-14 EP EP11833480.4A patent/EP2628013B1/en active Active
-
2013
- 2013-04-11 IL IL225731A patent/IL225731B/en active IP Right Grant
-
2014
- 2014-10-27 US US14/524,217 patent/US20150051115A1/en not_active Abandoned
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