JP2013543850A5 - - Google Patents
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- Publication number
- JP2013543850A5 JP2013543850A5 JP2013538047A JP2013538047A JP2013543850A5 JP 2013543850 A5 JP2013543850 A5 JP 2013543850A5 JP 2013538047 A JP2013538047 A JP 2013538047A JP 2013538047 A JP2013538047 A JP 2013538047A JP 2013543850 A5 JP2013543850 A5 JP 2013543850A5
- Authority
- JP
- Japan
- Prior art keywords
- prolyl
- group
- methyl
- leucyl
- amidinophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C([C@](CCC1)*1C(O*(*)*)=O)=O)N Chemical compound C*(C([C@](CCC1)*1C(O*(*)*)=O)=O)N 0.000 description 7
- UZEKTDVGUQCDBI-UHFFFAOYSA-N CC(C)NC(N)=N Chemical compound CC(C)NC(N)=N UZEKTDVGUQCDBI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010535094.4A CN102464701B (zh) | 2010-11-08 | 2010-11-08 | 一类新型化合物、其制备方法及用途 |
| CN201010535094.4 | 2010-11-08 | ||
| PCT/CN2011/081811 WO2012062187A1 (zh) | 2010-11-08 | 2011-11-04 | 作为凝血酶抑制剂的脯氨酰胺衍生物、其制备方法及应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013543850A JP2013543850A (ja) | 2013-12-09 |
| JP2013543850A5 true JP2013543850A5 (enExample) | 2014-12-11 |
| JP6219720B2 JP6219720B2 (ja) | 2017-10-25 |
Family
ID=46050404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538047A Active JP6219720B2 (ja) | 2010-11-08 | 2011-11-04 | 新規な化合物、その製造方法および用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9434760B2 (enExample) |
| EP (3) | EP2639230A4 (enExample) |
| JP (1) | JP6219720B2 (enExample) |
| CN (1) | CN102464701B (enExample) |
| WO (1) | WO2012062187A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103833827B (zh) * | 2012-11-27 | 2016-08-03 | 上海医药工业研究院 | 一种酰胺类化合物、其药物组合物、制备方法及应用 |
| AU2016342027B2 (en) * | 2015-10-23 | 2021-05-13 | Navitor Pharmaceuticals, Inc. | Modulators of Sestrin-GATOR2 interaction and uses thereof |
| CN116370448A (zh) | 2017-04-26 | 2023-07-04 | 纳维托制药有限公司 | Sestrin-gator2相互作用的调节剂及其用途 |
| SG11202010069SA (en) * | 2018-04-26 | 2020-11-27 | Zeria Pharmaceutical Co Ltd | Dipeptide and pharmaceutical composition containing same |
| EP3870158A4 (en) | 2018-10-24 | 2022-08-10 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
| CN113195515B (zh) * | 2018-10-29 | 2024-11-15 | 丽珠医药集团股份有限公司 | 新的二肽类化合物及其用途 |
| JP7693644B2 (ja) * | 2019-07-08 | 2025-06-17 | リゾルート，インコーポレイティド | 血漿カリクレイン阻害薬の調製プロセス |
| WO2021087432A1 (en) | 2019-11-01 | 2021-05-06 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mtorc1 modulator |
| EP4667482A1 (en) * | 2023-02-16 | 2025-12-24 | Zhejiang Huahai Pharmaceutical Co., Ltd. | Salt of dipeptide compound, preparation method therefor, and use thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101653A (en) | 1974-11-08 | 1978-07-18 | Mitsubishi Chemical Industries Limited | N2 -arylsulfonyl-argininamides and the pharmaceutically acceptable salts thereof |
| CA1161431A (en) * | 1979-05-11 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives |
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| JP3840668B2 (ja) * | 1994-01-27 | 2006-11-01 | 三菱化学株式会社 | プロリンアミド誘導体 |
| CA2140598C (en) * | 1994-01-27 | 2010-03-09 | Masahiro Ohshima | Prolineamide derivatives |
| IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| PL321759A1 (en) * | 1995-02-17 | 1997-12-22 | Basf Ag | Novel thrombosin inhibitors |
| EP0858262B1 (en) | 1995-10-24 | 2002-12-04 | Merck & Co., Inc. | Thrombin inhibitors |
| FI105274B (fi) | 1996-03-15 | 2000-07-14 | Upm Kymmene Oy | Menetelmä ei-hormonivaikutteisten, tyydyttymättömien kasvisteroidien hydraamiseksi ja käytetyn katalyytin regenerointi |
| AU751111B2 (en) * | 1998-01-26 | 2002-08-08 | Basf Aktiengesellschaft | Thrombin inhibitors |
| SK14232001A3 (sk) * | 1999-04-09 | 2002-06-04 | Basf Aktiengesellschaft | Nízkomolekulové inhibítory komplementárnych proteáz |
| DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
| JP2004518688A (ja) * | 2001-01-30 | 2004-06-24 | ブリストル−マイヤーズ スクイブ カンパニー | ファクターＸａ阻害剤のスルホンアミドラクタムおよびその方法 |
| AU2007334402B2 (en) * | 2006-12-14 | 2014-02-13 | Exelixis, Inc. | Methods of using MEK inhibitors |
-
2010
- 2010-11-08 CN CN201010535094.4A patent/CN102464701B/zh active Active
-
2011
- 2011-11-04 EP EP11839747.0A patent/EP2639230A4/en active Pending
- 2011-11-04 US US13/884,196 patent/US9434760B2/en active Active
- 2011-11-04 EP EP14183844.1A patent/EP2824097A1/en not_active Withdrawn
- 2011-11-04 EP EP18208270.1A patent/EP3466961B1/en active Active
- 2011-11-04 WO PCT/CN2011/081811 patent/WO2012062187A1/zh not_active Ceased
- 2011-11-04 JP JP2013538047A patent/JP6219720B2/ja active Active
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