JP2012180360A5 - - Google Patents
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- Publication number
- JP2012180360A5 JP2012180360A5 JP2012098050A JP2012098050A JP2012180360A5 JP 2012180360 A5 JP2012180360 A5 JP 2012180360A5 JP 2012098050 A JP2012098050 A JP 2012098050A JP 2012098050 A JP2012098050 A JP 2012098050A JP 2012180360 A5 JP2012180360 A5 JP 2012180360A5
- Authority
- JP
- Japan
- Prior art keywords
- piperidino
- chlorophenyl
- pyridyl
- methoxy
- butanoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 4
- 229940077388 benzenesulfonate Drugs 0.000 claims 4
- YWGDOWXRIALTES-NRFANRHFSA-N bepotastine Chemical compound C1CN(CCCC(=O)O)CCC1O[C@H](C=1N=CC=CC=1)C1=CC=C(Cl)C=C1 YWGDOWXRIALTES-NRFANRHFSA-N 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- ASNHGEVAWNWCRQ-UHFFFAOYSA-N 4-(hydroxymethyl)oxolane-2,3,4-triol Chemical compound OCC1(O)COC(O)C1O ASNHGEVAWNWCRQ-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims 1
- 229940092714 benzenesulfonic acid Drugs 0.000 claims 1
- YWGDOWXRIALTES-UHFFFAOYSA-N bepotastine Chemical compound C1CN(CCCC(=O)O)CCC1OC(C=1N=CC=CC=1)C1=CC=C(Cl)C=C1 YWGDOWXRIALTES-UHFFFAOYSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012098050A JP5518928B2 (ja) | 1996-12-26 | 2012-04-23 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1996347895 | 1996-12-26 | ||
| JP34789596 | 1996-12-26 | ||
| JP2012098050A JP5518928B2 (ja) | 1996-12-26 | 2012-04-23 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010264019A Division JP5360605B2 (ja) | 1996-12-26 | 2010-11-26 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013201621A Division JP2014012732A (ja) | 1996-12-26 | 2013-09-27 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012180360A JP2012180360A (ja) | 2012-09-20 |
| JP2012180360A5 true JP2012180360A5 (enExample) | 2013-11-14 |
| JP5518928B2 JP5518928B2 (ja) | 2014-06-11 |
Family
ID=18393337
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP35078497A Expired - Lifetime JP3107784B2 (ja) | 1996-12-26 | 1997-12-19 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2000032961A Expired - Lifetime JP4562229B2 (ja) | 1996-12-26 | 2000-02-10 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2007000109A Expired - Lifetime JP4704362B2 (ja) | 1996-12-26 | 2007-01-04 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2010264019A Expired - Lifetime JP5360605B2 (ja) | 1996-12-26 | 2010-11-26 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2012098050A Expired - Lifetime JP5518928B2 (ja) | 1996-12-26 | 2012-04-23 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2013201621A Withdrawn JP2014012732A (ja) | 1996-12-26 | 2013-09-27 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2014077266A Withdrawn JP2014169294A (ja) | 1996-12-26 | 2014-04-03 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2015137803A Withdrawn JP2016006059A (ja) | 1996-12-26 | 2015-07-09 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2016170684A Pending JP2017014270A (ja) | 1996-12-26 | 2016-09-01 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP35078497A Expired - Lifetime JP3107784B2 (ja) | 1996-12-26 | 1997-12-19 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2000032961A Expired - Lifetime JP4562229B2 (ja) | 1996-12-26 | 2000-02-10 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2007000109A Expired - Lifetime JP4704362B2 (ja) | 1996-12-26 | 2007-01-04 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2010264019A Expired - Lifetime JP5360605B2 (ja) | 1996-12-26 | 2010-11-26 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013201621A Withdrawn JP2014012732A (ja) | 1996-12-26 | 2013-09-27 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2014077266A Withdrawn JP2014169294A (ja) | 1996-12-26 | 2014-04-03 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2015137803A Withdrawn JP2016006059A (ja) | 1996-12-26 | 2015-07-09 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JP2016170684A Pending JP2017014270A (ja) | 1996-12-26 | 2016-09-01 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (9) | JP3107784B2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3107784B2 (ja) * | 1996-12-26 | 2000-11-13 | 宇部興産株式会社 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| EP1525884B1 (en) * | 2002-07-31 | 2011-10-12 | Senju Pharmaceutical Co., Ltd. | Aqueous liquid preparations and light-stabilized aqueous liquid preparations |
| CA2496623C (en) | 2002-08-29 | 2008-02-12 | Taisho Pharmaceutical Co., Ltd. | Benzenesulfonate salts of 4-fluoro-2-cyanopyrrolidine derivatives |
| KR100879409B1 (ko) * | 2007-06-11 | 2009-01-19 | 한미약품 주식회사 | (ｓ)-베포타스틴의 제조방법 및 이에 사용되는 중간체 |
| KR20090061972A (ko) * | 2007-12-12 | 2009-06-17 | 한미약품 주식회사 | 베포타스틴 ｐ-톨루엔술폰산염의 결정형, 이의 제조방법 및이를 포함하는 약학 조성물 |
| KR101132949B1 (ko) | 2009-09-08 | 2012-04-10 | 경희대학교 산학협력단 | 베포타스틴 살리실산염, 이의 제조방법 및 이를 유효성분으로 포함하는 항히스타민 또는 항알레르기용 약학적 조성물 |
| JP2011195500A (ja) * | 2010-03-19 | 2011-10-06 | Tokuyama Corp | （ｓ）−４−［４−［（４−クロロフェニル）（２−ピリジル）メトキシ］ピペリジノ］ブタン酸一ベンゼンスルホン酸塩の製造方法 |
| JP5641802B2 (ja) * | 2010-07-26 | 2014-12-17 | 株式会社トクヤマ | （ｓ）−４−〔（４−クロロフェニル）（２−ピリジル）メトキシ〕ピペリジンのジアステレオマー塩の製造方法 |
| KR101232233B1 (ko) | 2010-12-08 | 2013-02-12 | (주)팜스웰바이오 | (ｓ)-베포타스틴의 제조 방법 |
| JP2012240982A (ja) * | 2011-05-23 | 2012-12-10 | Toray Fine Chemicals Co Ltd | 光学活性ピペリジン誘導体のベンゼンスルホン酸塩の製造方法 |
| KR101717599B1 (ko) | 2015-05-11 | 2017-03-17 | 한국화학연구원 | 신규한 광학분할제 및 이를 이용한 (rs)-베포타스틴의 광학분할방법 |
| CN111116556B (zh) * | 2019-12-26 | 2021-11-02 | 北京鑫开元医药科技有限公司 | 一种(r)-2-[(4-氯苯基)(4-哌啶氧基)甲基]吡啶的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0225465A (ja) * | 1988-07-15 | 1990-01-26 | Ube Ind Ltd | ピペリジン誘導体、その製造方法並びにそれを含む抗ヒスタミン剤 |
| JP2624372B2 (ja) * | 1990-11-15 | 1997-06-25 | 宇部興産株式会社 | ジアリールメトキシピペリジン誘導体 |
| JP2787973B2 (ja) * | 1993-05-28 | 1998-08-20 | 宇部興産株式会社 | ピペリジン中間体の精製法 |
| JPH08333339A (ja) * | 1995-06-08 | 1996-12-17 | Fujisawa Pharmaceut Co Ltd | 光学活性なピペリジン酢酸誘導体の製造法 |
| JP3107784B2 (ja) * | 1996-12-26 | 2000-11-13 | 宇部興産株式会社 | 光学活性ピペリジン誘導体の酸付加塩及びその製法 |
| JPH10182635A (ja) * | 1996-12-26 | 1998-07-07 | Ube Ind Ltd | 光学活性ピペリジン誘導体及びその製造方法 |
-
1997
- 1997-12-19 JP JP35078497A patent/JP3107784B2/ja not_active Expired - Lifetime
-
2000
- 2000-02-10 JP JP2000032961A patent/JP4562229B2/ja not_active Expired - Lifetime
-
2007
- 2007-01-04 JP JP2007000109A patent/JP4704362B2/ja not_active Expired - Lifetime
-
2010
- 2010-11-26 JP JP2010264019A patent/JP5360605B2/ja not_active Expired - Lifetime
-
2012
- 2012-04-23 JP JP2012098050A patent/JP5518928B2/ja not_active Expired - Lifetime
-
2013
- 2013-09-27 JP JP2013201621A patent/JP2014012732A/ja not_active Withdrawn
-
2014
- 2014-04-03 JP JP2014077266A patent/JP2014169294A/ja not_active Withdrawn
-
2015
- 2015-07-09 JP JP2015137803A patent/JP2016006059A/ja not_active Withdrawn
-
2016
- 2016-09-01 JP JP2016170684A patent/JP2017014270A/ja active Pending
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