JP2013541588A5 - - Google Patents
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- Publication number
- JP2013541588A5 JP2013541588A5 JP2013537811A JP2013537811A JP2013541588A5 JP 2013541588 A5 JP2013541588 A5 JP 2013541588A5 JP 2013537811 A JP2013537811 A JP 2013537811A JP 2013537811 A JP2013537811 A JP 2013537811A JP 2013541588 A5 JP2013541588 A5 JP 2013541588A5
- Authority
- JP
- Japan
- Prior art keywords
- degrees
- pyrrolo
- pyrimidin
- aminomethyl
- piperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- PWPNYABQEOGNNC-UHFFFAOYSA-N [3-[[4-(aminomethyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] n,n-dimethylcarbamate Chemical compound CN(C)C(=O)OC1=CC=CC(NC(=O)C2(CN)CCN(CC2)C=2C=3C(C)=CNC=3N=CN=2)=C1 PWPNYABQEOGNNC-UHFFFAOYSA-N 0.000 claims 10
- 238000000034 method Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 238000002844 melting Methods 0.000 claims 3
- 230000008018 melting Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 238000001228 spectrum Methods 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 1
- CMDTUAMBRMMOON-UHFFFAOYSA-N [3-[[4-(aminomethyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] n,n-dimethylcarbamate;benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.CN(C)C(=O)OC1=CC=CC(NC(=O)C2(CN)CCN(CC2)C=2C=3C(C)=CNC=3N=CN=2)=C1 CMDTUAMBRMMOON-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 239000012296 anti-solvent Substances 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- -1 sulfonic acid monohydrate Chemical class 0.000 claims 1
- 230000004304 visual acuity Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41060210P | 2010-11-05 | 2010-11-05 | |
| US61/410,602 | 2010-11-05 | ||
| PCT/US2011/059086 WO2012061565A1 (en) | 2010-11-05 | 2011-11-03 | Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013541588A JP2013541588A (ja) | 2013-11-14 |
| JP2013541588A5 true JP2013541588A5 (enExample) | 2014-12-04 |
Family
ID=45002136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537811A Pending JP2013541588A (ja) | 2010-11-05 | 2011-11-03 | ３−（４−（アミノメチル）−１−（５−メチル−７Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）ピペリジン−４−カルボキサミド）フェニルジメチルカルバメートの固体形態 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8735408B2 (enExample) |
| EP (1) | EP2635584A1 (enExample) |
| JP (1) | JP2013541588A (enExample) |
| KR (1) | KR20140003433A (enExample) |
| CN (1) | CN103298815A (enExample) |
| AR (1) | AR083756A1 (enExample) |
| AU (1) | AU2011323371A1 (enExample) |
| BR (1) | BR112013011094A2 (enExample) |
| CA (1) | CA2817112A1 (enExample) |
| IL (1) | IL225884A0 (enExample) |
| MX (1) | MX2013004923A (enExample) |
| RU (1) | RU2013125755A (enExample) |
| SG (1) | SG190098A1 (enExample) |
| TW (1) | TW201302754A (enExample) |
| WO (1) | WO2012061565A1 (enExample) |
| ZA (1) | ZA201302996B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015150337A1 (en) | 2014-04-01 | 2015-10-08 | Amakem Nv | Lim kinase inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI439457B (zh) * | 2007-09-28 | 2014-06-01 | Lexicon Pharmaceuticals Inc | （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法 |
| KR101706391B1 (ko) * | 2008-04-21 | 2017-02-13 | 렉시컨 파마슈티컬스 인코퍼레이티드 | Ｌｉｍｋ2 억제제, 그를 포함하는 조성물 및 그의 사용 방법 |
-
2011
- 2011-11-01 TW TW100139812A patent/TW201302754A/zh unknown
- 2011-11-03 US US13/288,321 patent/US8735408B2/en active Active
- 2011-11-03 RU RU2013125755/04A patent/RU2013125755A/ru not_active Application Discontinuation
- 2011-11-03 JP JP2013537811A patent/JP2013541588A/ja active Pending
- 2011-11-03 KR KR1020137014386A patent/KR20140003433A/ko not_active Withdrawn
- 2011-11-03 MX MX2013004923A patent/MX2013004923A/es not_active Application Discontinuation
- 2011-11-03 WO PCT/US2011/059086 patent/WO2012061565A1/en not_active Ceased
- 2011-11-03 SG SG2013033618A patent/SG190098A1/en unknown
- 2011-11-03 AU AU2011323371A patent/AU2011323371A1/en not_active Abandoned
- 2011-11-03 CN CN2011800533551A patent/CN103298815A/zh active Pending
- 2011-11-03 CA CA2817112A patent/CA2817112A1/en not_active Abandoned
- 2011-11-03 EP EP11785536.1A patent/EP2635584A1/en not_active Withdrawn
- 2011-11-03 BR BR112013011094A patent/BR112013011094A2/pt not_active IP Right Cessation
- 2011-11-04 AR ARP110104111A patent/AR083756A1/es unknown
-
2013
- 2013-04-22 IL IL225884A patent/IL225884A0/en unknown
- 2013-04-24 ZA ZA2013/02996A patent/ZA201302996B/en unknown
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