JP2013540748A5 - - Google Patents
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- JP2013540748A5 JP2013540748A5 JP2013529362A JP2013529362A JP2013540748A5 JP 2013540748 A5 JP2013540748 A5 JP 2013540748A5 JP 2013529362 A JP2013529362 A JP 2013529362A JP 2013529362 A JP2013529362 A JP 2013529362A JP 2013540748 A5 JP2013540748 A5 JP 2013540748A5
- Authority
- JP
- Japan
- Prior art keywords
- adenosine receptor
- receptor agonist
- selective
- use according
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003379 purinergic P1 receptor agonist Substances 0.000 claims description 69
- -1 2- (2-methylphenyl) ethyl Chemical group 0.000 claims description 67
- 101150007969 ADORA1 gene Proteins 0.000 claims description 56
- 229940122614 Adenosine receptor agonist Drugs 0.000 claims description 54
- 101150051188 Adora2a gene Proteins 0.000 claims description 50
- 239000003814 drug Substances 0.000 claims description 40
- 229940124597 therapeutic agent Drugs 0.000 claims description 39
- 239000003795 chemical substances by application Substances 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 23
- 230000008499 blood brain barrier function Effects 0.000 claims description 17
- 210000001218 blood-brain barrier Anatomy 0.000 claims description 17
- 230000035699 permeability Effects 0.000 claims description 15
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- 239000000556 agonist Substances 0.000 claims description 12
- 230000001225 therapeutic effect Effects 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
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- 239000002465 adenosine A2a receptor agonist Substances 0.000 claims description 8
- NVGGIHKSKVAPEY-XKLVTHTNSA-N (2r,3r,4s,5r)-2-(6-amino-2-oct-1-ynylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C12=NC(C#CCCCCCC)=NC(N)=C2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NVGGIHKSKVAPEY-XKLVTHTNSA-N 0.000 claims description 6
- 229940122086 Adenosine A2a receptor agonist Drugs 0.000 claims description 6
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| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| CN116359519B (zh) * | 2023-05-29 | 2023-09-15 | 中国人民解放军军事科学院军事医学研究院 | CLDN5蛋白、Cldn5基因及其修饰在抑郁障碍诊断和/或治疗中的应用 |
| CN117298087A (zh) * | 2023-10-17 | 2023-12-29 | 张岳峰 | 促血液药物颅内转运合剂及其应用 |
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|---|---|---|---|---|
| US5260210A (en) * | 1989-09-27 | 1993-11-09 | Rubin Lee L | Blood-brain barrier model |
| US5236908A (en) * | 1991-06-07 | 1993-08-17 | Gensia Pharmaceuticals, Inc. | Methods of treating injury to the central nervous system |
| GB9323884D0 (en) * | 1993-11-19 | 1994-01-05 | Eisai London Res Lab Ltd | Physiological modulation |
| MXPA02001882A (es) * | 1999-08-23 | 2002-08-20 | Univ Tulane | Modulacion del transportador de leptina a traves de la barrera hemato-encefalica. |
| US6586413B2 (en) * | 1999-11-05 | 2003-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
| WO2001042451A2 (en) * | 1999-12-08 | 2001-06-14 | Genset | FULL-LENGTH HUMAN cDNAs ENCODING POTENTIALLY SECRETED PROTEINS |
| GB0120124D0 (en) * | 2001-05-04 | 2001-10-10 | Aventis Pharm Prod Inc | Effect of timing and duration of administration of amp 579 on reperfusion injury in rabbit heart |
| CN1791669A (zh) * | 2002-06-20 | 2006-06-21 | 惠氏公司 | 用于预测血脑屏障通透性的方法和组合物 |
| US20070032450A1 (en) * | 2005-08-02 | 2007-02-08 | Rieger Jayson M | New compositions and methods for the treatment of inflammation |
| US20070265223A1 (en) * | 2006-03-10 | 2007-11-15 | Ikaria, Inc. | Compositions and methods of enhancing survivability and reducing injury of cells, tissues, organs, and organisms under hypoxic or ischemic conditions |
| WO2007137303A2 (en) * | 2006-05-24 | 2007-11-29 | Myelin Repair Foundation, Inc. | Permeability of blood-brain barrier |
| UY31631A1 (es) * | 2008-02-06 | 2009-09-30 | Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones | |
| CN102014959B (zh) * | 2008-03-10 | 2016-01-20 | 康奈尔大学 | 血脑屏障通透性的调节 |
| WO2011057199A1 (en) * | 2009-11-06 | 2011-05-12 | Adenios, Inc. | Compositions for treating cns disorders |
-
2011
- 2011-09-16 US US13/823,266 patent/US20130224110A1/en not_active Abandoned
- 2011-09-16 JP JP2013529362A patent/JP2013540748A/ja active Pending
- 2011-09-16 WO PCT/US2011/051935 patent/WO2012037457A1/en not_active Ceased
- 2011-09-16 EP EP11826017.3A patent/EP2616538A4/en not_active Withdrawn
- 2011-09-16 CN CN201180054987XA patent/CN103221535A/zh active Pending
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