JP2013539795A - Egfr発動性がんの細胞増殖の阻害方法 - Google Patents
Egfr発動性がんの細胞増殖の阻害方法 Download PDFInfo
- Publication number
- JP2013539795A JP2013539795A JP2013534053A JP2013534053A JP2013539795A JP 2013539795 A JP2013539795 A JP 2013539795A JP 2013534053 A JP2013534053 A JP 2013534053A JP 2013534053 A JP2013534053 A JP 2013534053A JP 2013539795 A JP2013539795 A JP 2013539795A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- atoms
- substituted
- unsubstituted
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c(nc1Nc2ccccc2)ncc1Cl Chemical compound *c(nc1Nc2ccccc2)ncc1Cl 0.000 description 2
- LZAIDNSADNOUIN-UHFFFAOYSA-N COc1cc(P(C)(C)=O)ccc1Nc(nc1Nc2ccccc2)ncc1Cl Chemical compound COc1cc(P(C)(C)=O)ccc1Nc(nc1Nc2ccccc2)ncc1Cl LZAIDNSADNOUIN-UHFFFAOYSA-N 0.000 description 1
- GIKMWFAAEIACRF-UHFFFAOYSA-N Clc(c(Cl)n1)cnc1Cl Chemical compound Clc(c(Cl)n1)cnc1Cl GIKMWFAAEIACRF-UHFFFAOYSA-N 0.000 description 1
- IDRUEHMBFUJKAK-UHFFFAOYSA-N FC(c(c(Cl)n1)cnc1Cl)(F)F Chemical compound FC(c(c(Cl)n1)cnc1Cl)(F)F IDRUEHMBFUJKAK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39329110P | 2010-10-14 | 2010-10-14 | |
| US61/393,291 | 2010-10-14 | ||
| PCT/US2011/056457 WO2012051587A1 (en) | 2010-10-14 | 2011-10-14 | Methods for inhibiting cell proliferation in egfr-driven cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013539795A true JP2013539795A (ja) | 2013-10-28 |
| JP2013539795A5 JP2013539795A5 (enExample) | 2014-11-27 |
Family
ID=45938740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013534053A Pending JP2013539795A (ja) | 2010-10-14 | 2011-10-14 | Egfr発動性がんの細胞増殖の阻害方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140024620A1 (enExample) |
| EP (1) | EP2627179A4 (enExample) |
| JP (1) | JP2013539795A (enExample) |
| KR (1) | KR20130139999A (enExample) |
| CN (2) | CN103153064B (enExample) |
| AU (1) | AU2011315831B2 (enExample) |
| BR (1) | BR112013008816A2 (enExample) |
| CA (1) | CA2810900A1 (enExample) |
| EA (1) | EA201390550A1 (enExample) |
| IL (1) | IL225351A0 (enExample) |
| MX (1) | MX2013004086A (enExample) |
| WO (1) | WO2012051587A1 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017521436A (ja) * | 2014-07-04 | 2017-08-03 | チル ファーマシューティカル カンパニー リミテッド | スピロ環アリールリン酸化物及びアリールリン硫化物(spirocyclic aryl phosphorus oxide and aryl phosphorus sulfide) |
| WO2017200016A1 (ja) * | 2016-05-17 | 2017-11-23 | 公益財団法人がん研究会 | Egfr-tki耐性を獲得した肺癌の治療薬 |
| JP2020503271A (ja) * | 2016-11-30 | 2020-01-30 | アリアド ファーマシューティカルズ, インコーポレイテッド | 造血前駆体キナーゼ1(hpk1)阻害剤としてのアニリノピリミジンas |
| JP2020527151A (ja) * | 2017-07-19 | 2020-09-03 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. | Egfrキナーゼ阻害薬としてのアリールホスフィンオキシド |
| JP2021506942A (ja) * | 2017-12-21 | 2021-02-22 | 深▲チェン▼市塔吉瑞生物医薬有限公司Shenzhen TargetRx, Inc. | キナーゼ活性を阻害するためのジアニリノピリミジン系化合物 |
| JP2022517396A (ja) * | 2019-01-18 | 2022-03-08 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Egfr阻害剤の塩、結晶形及びその製造方法 |
| JP2023513333A (ja) * | 2020-02-14 | 2023-03-30 | 貝達薬業股▲ふん▼有限公司 | キノリニル基ホスフィンオキシド化合物、並びにその組成物及び使用 |
| JP2024502175A (ja) * | 2021-01-07 | 2024-01-17 | オンタリオ・インスティテュート・フォー・キャンサー・リサーチ(オーアイシーアール) | Nuakキナーゼの阻害剤としてのイソインドリノンアミノピリミジン化合物、その組成物及び使用 |
| JP2024511514A (ja) * | 2021-04-01 | 2024-03-13 | セラペックス カンパニー リミテッド | タンパク質キナーゼに対する阻害活性を有するピリミジン誘導体及びそれを含む治療用医薬組成物 |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105150B (zh) | 2008-05-21 | 2014-03-12 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| KR101884010B1 (ko) * | 2011-05-04 | 2018-07-31 | 어리어드 파마슈티칼스, 인코포레이티드 | Egfr-유도된 암의 세포 증식을 억제하는 화합물 |
| EP2844642B8 (en) * | 2012-05-05 | 2019-12-25 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
| CN102977104A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 2,4-二氯-7-氢-吡咯并(2,3)嘧啶的合成 |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| UA115388C2 (uk) * | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
| CN104761544B (zh) * | 2014-01-03 | 2019-03-15 | 北京轩义医药科技有限公司 | Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 |
| US10300058B2 (en) | 2014-04-18 | 2019-05-28 | Xuanzhu Pharma Co., Ltd. | Tyrosine kinase inhibitor and uses thereof |
| CN106699810A (zh) * | 2015-11-17 | 2017-05-24 | 清华大学 | 一种含氮杂环化合物及其制备方法与在抑制激酶活性中的应用 |
| CN108350006B (zh) * | 2015-11-27 | 2020-01-03 | 正大天晴药业集团股份有限公司 | 氘修饰的Brigatinib衍生物、含有该化合物的药物组合物及其用途 |
| WO2017133663A1 (en) * | 2016-02-03 | 2017-08-10 | Shanghai Fochon Pharmaceutical Co., Ltd. | Phosphorus containing compounds as protein kinase inhibitors |
| CN107098887B (zh) * | 2016-02-22 | 2019-08-09 | 复旦大学 | 嘧啶类化合物 |
| EP4001273A3 (en) | 2016-08-29 | 2022-08-24 | The Regents Of The University Of Michigan | Aminopyrimidines as alk inhibitors |
| WO2018165145A1 (en) * | 2017-03-08 | 2018-09-13 | Ariad Pharmaceuticals, Inc. | Pharmaceutical formulations comprising 5-chloro-n4-[2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl} pyrimidine-2,4-diamine |
| CA3074017A1 (en) * | 2017-09-08 | 2019-03-14 | The Regents Of The University Of Colorado, A Body Corporate | Compounds, compositions and methods for treating or preventing her-driven drug-resistant cancers |
| CN110305161A (zh) * | 2018-03-20 | 2019-10-08 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
| CN110467638A (zh) * | 2018-05-09 | 2019-11-19 | 北京赛特明强医药科技有限公司 | 一种含有间氯苯胺类取代基的双氨基氯代嘧啶类化合物、制备方法及其应用 |
| CN110467637B (zh) * | 2018-05-09 | 2022-02-18 | 北京赛特明强医药科技有限公司 | 一种含有氧化膦类取代苯胺的双氨基氯代嘧啶类化合物、制备方法及其应用 |
| CN110526941A (zh) * | 2018-05-24 | 2019-12-03 | 北京赛特明强医药科技有限公司 | 一种含有间氯苯胺类取代基的吡咯并嘧啶类化合物、制备方法及其应用 |
| CN111836819A (zh) * | 2018-05-24 | 2020-10-27 | 北京赛特明强医药科技有限公司 | 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 |
| CN110835320A (zh) * | 2018-08-15 | 2020-02-25 | 江苏奥赛康药业有限公司 | 二氨基嘧啶类化合物及其应用 |
| CN111825719A (zh) * | 2019-04-15 | 2020-10-27 | 北京赛特明强医药科技有限公司 | 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 |
| WO2020216371A1 (zh) * | 2019-04-26 | 2020-10-29 | 江苏先声药业有限公司 | Egfr抑制剂及其应用 |
| WO2020253862A1 (zh) * | 2019-06-21 | 2020-12-24 | 上海翰森生物医药科技有限公司 | 含氮芳基磷氧化物类衍生物、其制备方法和应用 |
| US11529350B2 (en) | 2019-07-03 | 2022-12-20 | Sumitomo Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof |
| CN114430740B (zh) * | 2019-07-26 | 2023-12-29 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| CN114430739A (zh) * | 2019-07-26 | 2022-05-03 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| CN112538072B (zh) * | 2019-09-21 | 2024-02-06 | 齐鲁制药有限公司 | 氨基嘧啶类egfr抑制剂 |
| WO2021057882A1 (zh) * | 2019-09-26 | 2021-04-01 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| WO2021073498A1 (zh) * | 2019-10-17 | 2021-04-22 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
| WO2021098883A1 (zh) * | 2019-11-21 | 2021-05-27 | 浙江同源康医药股份有限公司 | 用作egfr激酶抑制剂的化合物及其应用 |
| WO2021104441A1 (zh) * | 2019-11-29 | 2021-06-03 | 江苏先声药业有限公司 | 作为egfr激酶抑制剂的多芳基化合物 |
| US20230158157A1 (en) * | 2020-02-25 | 2023-05-25 | Dana-Farber Cancer Institute, Inc. | Potent and selective degraders of alk |
| EP4129996A4 (en) * | 2020-03-23 | 2023-07-12 | Qilu Pharmaceutical Co., Ltd. | Novel aminopyrimidine egfr inhibitor |
| CN111777592B (zh) * | 2020-06-22 | 2021-06-18 | 温州医科大学 | 一种n4-(2,5-二甲氧基苯基)-嘧啶二胺类靶向ddr1抑制剂及其制备和应用 |
| CN116710444A (zh) * | 2020-10-30 | 2023-09-05 | 缆图药品公司 | 嘧啶化合物、组合物及其医药应用 |
| US20240051945A1 (en) * | 2020-10-30 | 2024-02-15 | Blueprint Medicines Corporation | Pyrimidine compounds, compositions, and medicinal applications thereof |
| CN116685583A (zh) * | 2020-10-30 | 2023-09-01 | 缆图药品公司 | 嘧啶化合物、组合物及其医药应用 |
| JP2023549074A (ja) * | 2020-10-30 | 2023-11-22 | ブループリント メディシンズ コーポレイション | ピリミジン化合物、組成物、及びその医薬用途 |
| CN116234556A (zh) * | 2020-12-18 | 2023-06-06 | 江苏豪森药业集团有限公司 | 一种芳基磷氧化物类衍生物自由碱的晶型及其制备方法和应用 |
| CA3204383A1 (en) * | 2021-01-07 | 2022-07-14 | Rima AL-AWAR | Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof |
| TW202237597A (zh) * | 2021-03-19 | 2022-10-01 | 大陸商上海齊魯製藥研究中心有限公司 | 新型egfr降解劑 |
| WO2022199589A1 (zh) * | 2021-03-23 | 2022-09-29 | 南京明德新药研发有限公司 | 嘧啶衍生物 |
| CN117222637A (zh) * | 2021-04-30 | 2023-12-12 | 百济神州有限公司 | Egfr降解剂和相关使用方法 |
| WO2022227032A1 (en) * | 2021-04-30 | 2022-11-03 | Beigene (Beijing) Co., Ltd. | Egfr degraders and associated methods of use |
| CN115677772B (zh) * | 2021-07-30 | 2023-08-18 | 浙江大学智能创新药物研究院 | 一种用于egfr激酶抑制剂的化合物、组合物及其应用 |
| WO2024005516A1 (ko) * | 2022-06-28 | 2024-01-04 | 보로노이 주식회사 | 헤테로아릴 유도체 화합물 및 이의 용도 |
| CN115260234A (zh) * | 2022-07-01 | 2022-11-01 | 江苏医药职业学院 | 一种2-氨基-4-氨基芳基磷氧基嘧啶化合物及其制备方法与应用 |
| CN116284001B (zh) * | 2023-01-30 | 2025-06-06 | 中国药科大学 | Dclk1抑制剂、制备方法、药物组合物和应用 |
| CN117187271B (zh) * | 2023-03-07 | 2024-08-27 | 艾博生物科技(上海)有限公司 | 编码激活性EGFR突变肽的免疫调节治疗mRNA组合物 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004517925A (ja) * | 2000-12-21 | 2004-06-17 | グラクソ グループ リミテッド | 血管新生制御剤としてのピリミジンアミン |
| WO2008039359A2 (en) * | 2006-09-25 | 2008-04-03 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidine kinase inhibitors |
| WO2009008371A1 (ja) * | 2007-07-06 | 2009-01-15 | Astellas Pharma Inc. | ジ(アリールアミノ)アリール化合物 |
| JP2009514876A (ja) * | 2005-11-03 | 2009-04-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼのための化合物および組成物 |
| WO2009109605A1 (en) * | 2008-03-05 | 2009-09-11 | Novartis Ag | Use of pyrimidine derivatives for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members |
| WO2009126515A1 (en) * | 2008-04-07 | 2009-10-15 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2009143389A1 (en) * | 2008-05-21 | 2009-11-26 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| WO2009158571A1 (en) * | 2008-06-27 | 2009-12-30 | Avila Therapeutics And Uses Thereof | Heteroaryl compounds and uses thereof |
| US20100016296A1 (en) * | 2007-10-19 | 2010-01-21 | Avila Therapeutics, Inc. | Heteroaryl compounds and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| WO2011162515A2 (en) * | 2010-06-23 | 2011-12-29 | Hanmi Holdings Co. , Ltd. | Novel fused pyrimidine derivatives for inhd3ition of tyrosine kinase activity |
| US9238629B2 (en) * | 2010-11-01 | 2016-01-19 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP2637502B1 (en) * | 2010-11-10 | 2018-01-10 | Celgene CAR LLC | Mutant-selective egfr inhibitors and uses thereof |
-
2011
- 2011-10-14 EP EP11833524.9A patent/EP2627179A4/en not_active Withdrawn
- 2011-10-14 CA CA2810900A patent/CA2810900A1/en not_active Abandoned
- 2011-10-14 MX MX2013004086A patent/MX2013004086A/es not_active Application Discontinuation
- 2011-10-14 BR BR112013008816A patent/BR112013008816A2/pt not_active IP Right Cessation
- 2011-10-14 CN CN201180049813.4A patent/CN103153064B/zh active Active
- 2011-10-14 KR KR1020137012320A patent/KR20130139999A/ko not_active Withdrawn
- 2011-10-14 CN CN201510102987.2A patent/CN104814970A/zh active Pending
- 2011-10-14 EA EA201390550A patent/EA201390550A1/ru unknown
- 2011-10-14 JP JP2013534053A patent/JP2013539795A/ja active Pending
- 2011-10-14 US US13/878,744 patent/US20140024620A1/en not_active Abandoned
- 2011-10-14 AU AU2011315831A patent/AU2011315831B2/en active Active
- 2011-10-14 WO PCT/US2011/056457 patent/WO2012051587A1/en not_active Ceased
-
2013
- 2013-03-20 IL IL225351A patent/IL225351A0/en unknown
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004517925A (ja) * | 2000-12-21 | 2004-06-17 | グラクソ グループ リミテッド | 血管新生制御剤としてのピリミジンアミン |
| JP2009514876A (ja) * | 2005-11-03 | 2009-04-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼのための化合物および組成物 |
| WO2008039359A2 (en) * | 2006-09-25 | 2008-04-03 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidine kinase inhibitors |
| WO2009008371A1 (ja) * | 2007-07-06 | 2009-01-15 | Astellas Pharma Inc. | ジ(アリールアミノ)アリール化合物 |
| US20100016296A1 (en) * | 2007-10-19 | 2010-01-21 | Avila Therapeutics, Inc. | Heteroaryl compounds and uses thereof |
| WO2009109605A1 (en) * | 2008-03-05 | 2009-09-11 | Novartis Ag | Use of pyrimidine derivatives for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members |
| WO2009126515A1 (en) * | 2008-04-07 | 2009-10-15 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2009143389A1 (en) * | 2008-05-21 | 2009-11-26 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| WO2009158571A1 (en) * | 2008-06-27 | 2009-12-30 | Avila Therapeutics And Uses Thereof | Heteroaryl compounds and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| CANCER RESEARCH, 2010, VOL.70(4), P.1625-1634, JPN6015034350, ISSN: 0003143105 * |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017521436A (ja) * | 2014-07-04 | 2017-08-03 | チル ファーマシューティカル カンパニー リミテッド | スピロ環アリールリン酸化物及びアリールリン硫化物(spirocyclic aryl phosphorus oxide and aryl phosphorus sulfide) |
| WO2017200016A1 (ja) * | 2016-05-17 | 2017-11-23 | 公益財団法人がん研究会 | Egfr-tki耐性を獲得した肺癌の治療薬 |
| JPWO2017200016A1 (ja) * | 2016-05-17 | 2019-04-04 | 公益財団法人がん研究会 | Egfr−tki耐性を獲得した肺癌の治療薬 |
| US10813933B2 (en) | 2016-05-17 | 2020-10-27 | Japanese Foundation For Cancer Research | Therapeutic agent for lung cancer that has acquired EGFR-TKI resistance |
| US11419871B2 (en) | 2016-05-17 | 2022-08-23 | Japanese Foundation For Cancer Research | Therapeutic agent for lung cancer that has acquired EGFR-TKI resistance |
| JP7025426B2 (ja) | 2016-11-30 | 2022-02-24 | アリアド ファーマシューティカルズ, インコーポレイテッド | 造血前駆体キナーゼ1(hpk1)阻害剤としてのアニリノピリミジンas |
| JP2020503271A (ja) * | 2016-11-30 | 2020-01-30 | アリアド ファーマシューティカルズ, インコーポレイテッド | 造血前駆体キナーゼ1(hpk1)阻害剤としてのアニリノピリミジンas |
| JP2020527151A (ja) * | 2017-07-19 | 2020-09-03 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. | Egfrキナーゼ阻害薬としてのアリールホスフィンオキシド |
| JP7233410B2 (ja) | 2017-07-19 | 2023-03-06 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Egfrキナーゼ阻害薬としてのアリールホスフィンオキシド |
| US11254696B2 (en) | 2017-12-21 | 2022-02-22 | Shenzhen Targetrx, Inc. | Dianilinopyrimidine compound for inhibiting kinase activity |
| JP7043098B2 (ja) | 2017-12-21 | 2022-03-29 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | キナーゼ活性を阻害するためのジアニリノピリミジン系化合物 |
| JP2021506942A (ja) * | 2017-12-21 | 2021-02-22 | 深▲チェン▼市塔吉瑞生物医薬有限公司Shenzhen TargetRx, Inc. | キナーゼ活性を阻害するためのジアニリノピリミジン系化合物 |
| JP2022517396A (ja) * | 2019-01-18 | 2022-03-08 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Egfr阻害剤の塩、結晶形及びその製造方法 |
| JP2023513333A (ja) * | 2020-02-14 | 2023-03-30 | 貝達薬業股▲ふん▼有限公司 | キノリニル基ホスフィンオキシド化合物、並びにその組成物及び使用 |
| JP2024502175A (ja) * | 2021-01-07 | 2024-01-17 | オンタリオ・インスティテュート・フォー・キャンサー・リサーチ(オーアイシーアール) | Nuakキナーゼの阻害剤としてのイソインドリノンアミノピリミジン化合物、その組成物及び使用 |
| JP2024511514A (ja) * | 2021-04-01 | 2024-03-13 | セラペックス カンパニー リミテッド | タンパク質キナーゼに対する阻害活性を有するピリミジン誘導体及びそれを含む治療用医薬組成物 |
| JP7737117B2 (ja) | 2021-04-01 | 2025-09-10 | セラペックス カンパニー リミテッド | タンパク質キナーゼに対する阻害活性を有するピリミジン誘導体及びそれを含む治療用医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013004086A (es) | 2013-07-05 |
| WO2012051587A1 (en) | 2012-04-19 |
| EP2627179A4 (en) | 2014-04-02 |
| US20140024620A1 (en) | 2014-01-23 |
| CN103153064B (zh) | 2015-04-22 |
| AU2011315831A1 (en) | 2013-03-28 |
| KR20130139999A (ko) | 2013-12-23 |
| EA201390550A1 (ru) | 2013-08-30 |
| AU2011315831B2 (en) | 2015-01-22 |
| EP2627179A1 (en) | 2013-08-21 |
| BR112013008816A2 (pt) | 2016-06-28 |
| CN103153064A (zh) | 2013-06-12 |
| IL225351A0 (en) | 2013-06-27 |
| CN104814970A (zh) | 2015-08-05 |
| CA2810900A1 (en) | 2012-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2011315831B2 (en) | Methods for inhibiting cell proliferation in EGFR-driven cancers | |
| JP5999177B2 (ja) | Egfr発動性がんの細胞増殖阻害用化合物 | |
| JP6469567B2 (ja) | Egfr発動性がんの細胞増殖阻害用化合物 | |
| KR102072869B1 (ko) | Fgfr 키나제 조절제로서의 퀴놀린 | |
| KR102134204B1 (ko) | 신규 화합물 | |
| RU2648818C2 (ru) | Ингибитор ret | |
| CN104011052B (zh) | 化合物 | |
| CN106029646B (zh) | 嘧啶‑2,4‑二胺衍生物和含有该衍生物作为活性成分的抗癌药物组合物 | |
| US9611283B1 (en) | Methods for inhibiting cell proliferation in ALK-driven cancers | |
| WO2020027083A1 (ja) | キナゾリン化合物を有効成分とする医薬組成物 | |
| MX2014014110A (es) | Pteridinas como inhibidores del receptor del factor de crecimiento de fribroblasto (fgfr). | |
| TW200529846A (en) | 3-quinolinecarbonitrile protein kinase inhibitors | |
| AU2013203904A1 (en) | Methods for inhibiting cell proliferation in EGFR-driven cancers | |
| EP2844642B1 (en) | Compounds for inhibiting cell proliferation in egfr-driven cancers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141007 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141007 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150901 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160405 |