AU2011315831B2 - Methods for inhibiting cell proliferation in EGFR-driven cancers - Google Patents

Methods for inhibiting cell proliferation in EGFR-driven cancers Download PDF

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Publication number
AU2011315831B2
AU2011315831B2 AU2011315831A AU2011315831A AU2011315831B2 AU 2011315831 B2 AU2011315831 B2 AU 2011315831B2 AU 2011315831 A AU2011315831 A AU 2011315831A AU 2011315831 A AU2011315831 A AU 2011315831A AU 2011315831 B2 AU2011315831 B2 AU 2011315831B2
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heterocyclic ring
atoms
substituted
alkyl
unsubstituted
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AU2011315831A1 (en
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David C. Dalgarno
Juan J. Miret
Victor M. Rivera
William C. Shakespeare
Xiaotian Zhu
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: ARIAD PHARMACEUTICALS, INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2011315831A 2010-10-14 2011-10-14 Methods for inhibiting cell proliferation in EGFR-driven cancers Active AU2011315831B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013203904A AU2013203904A1 (en) 2010-10-14 2013-04-11 Methods for inhibiting cell proliferation in EGFR-driven cancers

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39329110P 2010-10-14 2010-10-14
US61/393,291 2010-10-14
PCT/US2011/056457 WO2012051587A1 (en) 2010-10-14 2011-10-14 Methods for inhibiting cell proliferation in egfr-driven cancers

Related Child Applications (1)

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AU2013203904A Division AU2013203904A1 (en) 2010-10-14 2013-04-11 Methods for inhibiting cell proliferation in EGFR-driven cancers

Publications (2)

Publication Number Publication Date
AU2011315831A1 AU2011315831A1 (en) 2013-03-28
AU2011315831B2 true AU2011315831B2 (en) 2015-01-22

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AU2011315831A Active AU2011315831B2 (en) 2010-10-14 2011-10-14 Methods for inhibiting cell proliferation in EGFR-driven cancers

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Country Link
US (1) US20140024620A1 (enExample)
EP (1) EP2627179A4 (enExample)
JP (1) JP2013539795A (enExample)
KR (1) KR20130139999A (enExample)
CN (2) CN103153064B (enExample)
AU (1) AU2011315831B2 (enExample)
BR (1) BR112013008816A2 (enExample)
CA (1) CA2810900A1 (enExample)
EA (1) EA201390550A1 (enExample)
IL (1) IL225351A0 (enExample)
MX (1) MX2013004086A (enExample)
WO (1) WO2012051587A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102105150B (zh) 2008-05-21 2014-03-12 阿里亚德医药股份有限公司 用作激酶抑制剂的磷衍生物
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
KR101884010B1 (ko) * 2011-05-04 2018-07-31 어리어드 파마슈티칼스, 인코포레이티드 Egfr-유도된 암의 세포 증식을 억제하는 화합물
EP2844642B8 (en) * 2012-05-05 2019-12-25 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
US20150166591A1 (en) 2012-05-05 2015-06-18 Ariad Pharmaceuticals, Inc. Methods and compositions for raf kinase mediated diseases
CN102977104A (zh) * 2012-11-26 2013-03-20 盛世泰科生物医药技术(苏州)有限公司 2,4-二氯-7-氢-吡咯并（2,3）嘧啶的合成
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
UA115388C2 (uk) * 2013-11-21 2017-10-25 Пфайзер Інк. 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
CN104761544B (zh) * 2014-01-03 2019-03-15 北京轩义医药科技有限公司 Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂
US10300058B2 (en) 2014-04-18 2019-05-28 Xuanzhu Pharma Co., Ltd. Tyrosine kinase inhibitor and uses thereof
WO2016000581A1 (zh) * 2014-07-04 2016-01-07 南京明德新药研发股份有限公司 螺环芳基磷氧化物和芳基磷硫化物
CN106699810A (zh) * 2015-11-17 2017-05-24 清华大学 一种含氮杂环化合物及其制备方法与在抑制激酶活性中的应用
CN108350006B (zh) * 2015-11-27 2020-01-03 正大天晴药业集团股份有限公司 氘修饰的Brigatinib衍生物、含有该化合物的药物组合物及其用途
WO2017133663A1 (en) * 2016-02-03 2017-08-10 Shanghai Fochon Pharmaceutical Co., Ltd. Phosphorus containing compounds as protein kinase inhibitors
CN107098887B (zh) * 2016-02-22 2019-08-09 复旦大学 嘧啶类化合物
JP6911019B2 (ja) * 2016-05-17 2021-07-28 公益財団法人がん研究会 Ｅｇｆｒ−ｔｋｉ耐性を獲得した肺癌の治療薬
EP4001273A3 (en) 2016-08-29 2022-08-24 The Regents Of The University Of Michigan Aminopyrimidines as alk inhibitors
MA46942A (fr) * 2016-11-30 2021-05-05 Ariad Pharma Inc Anilinopyrimidines en tant qu'inhibiteurs de kinase 1 progénitrices hématopoïétiques (hpk1)
WO2018165145A1 (en) * 2017-03-08 2018-09-13 Ariad Pharmaceuticals, Inc. Pharmaceutical formulations comprising 5-chloro-n4-[2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl} pyrimidine-2,4-diamine
PH12020550034B1 (en) 2017-07-19 2024-05-22 Chia Tai Tianqing Pharmaceutical Group Co Ltd Aryl-phosphorus-oxygen compound as egfr kinase inhibitor
CA3074017A1 (en) * 2017-09-08 2019-03-14 The Regents Of The University Of Colorado, A Body Corporate Compounds, compositions and methods for treating or preventing her-driven drug-resistant cancers
JP7043098B2 (ja) * 2017-12-21 2022-03-29 深▲チェン▼市塔吉瑞生物医薬有限公司 キナーゼ活性を阻害するためのジアニリノピリミジン系化合物
CN110305161A (zh) * 2018-03-20 2019-10-08 暨南大学 2-氨基嘧啶类化合物及其应用
CN110467638A (zh) * 2018-05-09 2019-11-19 北京赛特明强医药科技有限公司 一种含有间氯苯胺类取代基的双氨基氯代嘧啶类化合物、制备方法及其应用
CN110467637B (zh) * 2018-05-09 2022-02-18 北京赛特明强医药科技有限公司 一种含有氧化膦类取代苯胺的双氨基氯代嘧啶类化合物、制备方法及其应用
CN110526941A (zh) * 2018-05-24 2019-12-03 北京赛特明强医药科技有限公司 一种含有间氯苯胺类取代基的吡咯并嘧啶类化合物、制备方法及其应用
CN111836819A (zh) * 2018-05-24 2020-10-27 北京赛特明强医药科技有限公司 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用
CN110835320A (zh) * 2018-08-15 2020-02-25 江苏奥赛康药业有限公司 二氨基嘧啶类化合物及其应用
US20220119431A1 (en) * 2019-01-18 2022-04-21 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Salt of egfr inhibitor, crystal form, and preparation method therefor
CN111825719A (zh) * 2019-04-15 2020-10-27 北京赛特明强医药科技有限公司 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用
WO2020216371A1 (zh) * 2019-04-26 2020-10-29 江苏先声药业有限公司 Egfr抑制剂及其应用
WO2020253862A1 (zh) * 2019-06-21 2020-12-24 上海翰森生物医药科技有限公司 含氮芳基磷氧化物类衍生物、其制备方法和应用
US11529350B2 (en) 2019-07-03 2022-12-20 Sumitomo Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof
CN114430740B (zh) * 2019-07-26 2023-12-29 贝达药业股份有限公司 Egfr抑制剂、组合物及其制备方法
CN114430739A (zh) * 2019-07-26 2022-05-03 贝达药业股份有限公司 Egfr抑制剂、组合物及其制备方法
CN112538072B (zh) * 2019-09-21 2024-02-06 齐鲁制药有限公司 氨基嘧啶类egfr抑制剂
WO2021057882A1 (zh) * 2019-09-26 2021-04-01 贝达药业股份有限公司 Egfr抑制剂、组合物及其制备方法
WO2021073498A1 (zh) * 2019-10-17 2021-04-22 贝达药业股份有限公司 Egfr抑制剂、组合物及其制备方法
WO2021098883A1 (zh) * 2019-11-21 2021-05-27 浙江同源康医药股份有限公司 用作egfr激酶抑制剂的化合物及其应用
WO2021104441A1 (zh) * 2019-11-29 2021-06-03 江苏先声药业有限公司 作为egfr激酶抑制剂的多芳基化合物
CA3167899A1 (en) * 2020-02-14 2021-08-19 Xiangyong LIU Quinolyl phosphine oxide compound, and composition and application thereof
US20230158157A1 (en) * 2020-02-25 2023-05-25 Dana-Farber Cancer Institute, Inc. Potent and selective degraders of alk
EP4129996A4 (en) * 2020-03-23 2023-07-12 Qilu Pharmaceutical Co., Ltd. Novel aminopyrimidine egfr inhibitor
CN111777592B (zh) * 2020-06-22 2021-06-18 温州医科大学 一种n4-(2,5-二甲氧基苯基)-嘧啶二胺类靶向ddr1抑制剂及其制备和应用
CN116710444A (zh) * 2020-10-30 2023-09-05 缆图药品公司 嘧啶化合物、组合物及其医药应用
US20240051945A1 (en) * 2020-10-30 2024-02-15 Blueprint Medicines Corporation Pyrimidine compounds, compositions, and medicinal applications thereof
CN116685583A (zh) * 2020-10-30 2023-09-01 缆图药品公司 嘧啶化合物、组合物及其医药应用
JP2023549074A (ja) * 2020-10-30 2023-11-22 ブループリント メディシンズ コーポレイション ピリミジン化合物、組成物、及びその医薬用途
CN116234556A (zh) * 2020-12-18 2023-06-06 江苏豪森药业集团有限公司 一种芳基磷氧化物类衍生物自由碱的晶型及其制备方法和应用
JP2024502175A (ja) * 2021-01-07 2024-01-17 オンタリオ・インスティテュート・フォー・キャンサー・リサーチ（オーアイシーアール） Ｎｕａｋキナーゼの阻害剤としてのイソインドリノンアミノピリミジン化合物、その組成物及び使用
CA3204383A1 (en) * 2021-01-07 2022-07-14 Rima AL-AWAR Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof
TW202237597A (zh) * 2021-03-19 2022-10-01 大陸商上海齊魯製藥研究中心有限公司 新型egfr降解劑
WO2022199589A1 (zh) * 2021-03-23 2022-09-29 南京明德新药研发有限公司 嘧啶衍生物
MX2023010016A (es) * 2021-04-01 2023-09-07 Therapex Co Ltd Derivado de pirimidina con actividad inhibidora contra las proteina cinasas y composicion farmaceutica terapeutica que incluye el mismo.
CN117222637A (zh) * 2021-04-30 2023-12-12 百济神州有限公司 Egfr降解剂和相关使用方法
WO2022227032A1 (en) * 2021-04-30 2022-11-03 Beigene (Beijing) Co., Ltd. Egfr degraders and associated methods of use
CN115677772B (zh) * 2021-07-30 2023-08-18 浙江大学智能创新药物研究院 一种用于egfr激酶抑制剂的化合物、组合物及其应用
WO2024005516A1 (ko) * 2022-06-28 2024-01-04 보로노이 주식회사 헤테로아릴 유도체 화합물 및 이의 용도
CN115260234A (zh) * 2022-07-01 2022-11-01 江苏医药职业学院 一种2-氨基-4-氨基芳基磷氧基嘧啶化合物及其制备方法与应用
CN116284001B (zh) * 2023-01-30 2025-06-06 中国药科大学 Dclk1抑制剂、制备方法、药物组合物和应用
CN117187271B (zh) * 2023-03-07 2024-08-27 艾博生物科技(上海)有限公司 编码激活性EGFR突变肽的免疫调节治疗mRNA组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009126515A1 (en) * 2008-04-07 2009-10-15 Irm Llc Compounds and compositions as protein kinase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100847169B1 (ko) * 2000-12-21 2008-07-17 글락소 그룹 리미티드 혈관형성 조절제로서의 피리미딘아민
WO2007056151A2 (en) * 2005-11-03 2007-05-18 Irm Llc Protein kinase inhbitors
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US8314234B2 (en) * 2006-09-25 2012-11-20 Janssen Pharmaceutica N.V. Bicyclic pyrimidine kinase inhibitors
TWI389893B (zh) * 2007-07-06 2013-03-21 Astellas Pharma Inc 二（芳胺基）芳基化合物
US7989465B2 (en) * 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
US20110033453A1 (en) * 2008-03-05 2011-02-10 Carlos Garcia-Echeverria Use of pyrimidine derivatives for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
CN102105150B (zh) * 2008-05-21 2014-03-12 阿里亚德医药股份有限公司 用作激酶抑制剂的磷衍生物
NZ624345A (en) * 2008-06-27 2016-07-29 Celgene Avilomics Res Inc 2,4-disubstituted pyrimidines useful as kinase inhibitors
WO2011162515A2 (en) * 2010-06-23 2011-12-29 Hanmi Holdings Co. , Ltd. Novel fused pyrimidine derivatives for inhd3ition of tyrosine kinase activity
US9238629B2 (en) * 2010-11-01 2016-01-19 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP2637502B1 (en) * 2010-11-10 2018-01-10 Celgene CAR LLC Mutant-selective egfr inhibitors and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009126515A1 (en) * 2008-04-07 2009-10-15 Irm Llc Compounds and compositions as protein kinase inhibitors

Also Published As

Publication number Publication date
MX2013004086A (es) 2013-07-05
WO2012051587A1 (en) 2012-04-19
EP2627179A4 (en) 2014-04-02
US20140024620A1 (en) 2014-01-23
CN103153064B (zh) 2015-04-22
AU2011315831A1 (en) 2013-03-28
KR20130139999A (ko) 2013-12-23
EA201390550A1 (ru) 2013-08-30
EP2627179A1 (en) 2013-08-21
BR112013008816A2 (pt) 2016-06-28
JP2013539795A (ja) 2013-10-28
CN103153064A (zh) 2013-06-12
IL225351A0 (en) 2013-06-27
CN104814970A (zh) 2015-08-05
CA2810900A1 (en) 2012-04-19

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