JP2013536257A5 - - Google Patents
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- Publication number
- JP2013536257A5 JP2013536257A5 JP2013526551A JP2013526551A JP2013536257A5 JP 2013536257 A5 JP2013536257 A5 JP 2013536257A5 JP 2013526551 A JP2013526551 A JP 2013526551A JP 2013526551 A JP2013526551 A JP 2013526551A JP 2013536257 A5 JP2013536257 A5 JP 2013536257A5
- Authority
- JP
- Japan
- Prior art keywords
- theobromine
- agent
- amount
- expectorant
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 claims 16
- 239000003172 expectorant agent Substances 0.000 claims 8
- 229960004559 theobromine Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 230000003419 expectorant effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010011224 Cough Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 230000000510 mucolytic effect Effects 0.000 claims 3
- 229940066491 mucolytics Drugs 0.000 claims 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims 3
- 239000006188 syrup Substances 0.000 claims 3
- 235000020357 syrup Nutrition 0.000 claims 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 2
- GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 claims 2
- 229960005174 ambroxol Drugs 0.000 claims 2
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical group NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 claims 2
- 239000001099 ammonium carbonate Substances 0.000 claims 2
- 229960003870 bromhexine Drugs 0.000 claims 2
- OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229960004399 carbocisteine Drugs 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 229940066493 expectorants Drugs 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 claims 2
- 239000007937 lozenge Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- -1 troche Substances 0.000 claims 2
- 229960004224 tyloxapol Drugs 0.000 claims 2
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims 2
- 229920001664 tyloxapol Polymers 0.000 claims 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims 1
- WHRZCXAVMTUTDD-UHFFFAOYSA-N 1h-furo[2,3-d]pyrimidin-2-one Chemical compound N1C(=O)N=C2OC=CC2=C1 WHRZCXAVMTUTDD-UHFFFAOYSA-N 0.000 claims 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims 1
- UNMYWSMUMWPJLR-UHFFFAOYSA-L Calcium iodide Chemical compound [Ca+2].[I-].[I-] UNMYWSMUMWPJLR-UHFFFAOYSA-L 0.000 claims 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- 235000006173 Larrea tridentata Nutrition 0.000 claims 1
- 244000073231 Larrea tridentata Species 0.000 claims 1
- XOGTZOOQQBDUSI-UHFFFAOYSA-M Mesna Chemical compound [Na+].[O-]S(=O)(=O)CCS XOGTZOOQQBDUSI-UHFFFAOYSA-M 0.000 claims 1
- 241000183666 Nepsera aquatica Species 0.000 claims 1
- YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical compound CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 claims 1
- 108010058907 Tiopronin Proteins 0.000 claims 1
- 241000219793 Trifolium Species 0.000 claims 1
- 229960004308 acetylcysteine Drugs 0.000 claims 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims 1
- 235000012501 ammonium carbonate Nutrition 0.000 claims 1
- 229940059913 ammonium carbonate Drugs 0.000 claims 1
- 235000019270 ammonium chloride Nutrition 0.000 claims 1
- 229960001040 ammonium chloride Drugs 0.000 claims 1
- 229960001283 antimony pentasulfide Drugs 0.000 claims 1
- PPKVREKQVQREQD-UHFFFAOYSA-N antimony pentasulfide Chemical compound S=[Sb](=S)S[Sb](=S)=S PPKVREKQVQREQD-UHFFFAOYSA-N 0.000 claims 1
- 229940046413 calcium iodide Drugs 0.000 claims 1
- 229910001640 calcium iodide Inorganic materials 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 229960002126 creosote Drugs 0.000 claims 1
- 229960001305 cysteine hydrochloride Drugs 0.000 claims 1
- 108010067396 dornase alfa Proteins 0.000 claims 1
- 229960002561 eprazinone Drugs 0.000 claims 1
- BSHWLCACYCVCJE-UHFFFAOYSA-N eprazinone Chemical compound C=1C=CC=CC=1C(OCC)CN(CC1)CCN1CC(C)C(=O)C1=CC=CC=C1 BSHWLCACYCVCJE-UHFFFAOYSA-N 0.000 claims 1
- 229960003262 erdosteine Drugs 0.000 claims 1
- QGFORSXNKQLDNO-UHFFFAOYSA-N erdosteine Chemical compound OC(=O)CSCC(=O)NC1CCSC1=O QGFORSXNKQLDNO-UHFFFAOYSA-N 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229960001867 guaiacol Drugs 0.000 claims 1
- IZYQCDNLUPLXOO-UHFFFAOYSA-N guaiacol benzoate Chemical compound COC1=CC=CC=C1OC(=O)C1=CC=CC=C1 IZYQCDNLUPLXOO-UHFFFAOYSA-N 0.000 claims 1
- 229950001828 guaiacol benzoate Drugs 0.000 claims 1
- 229950010370 guaiacol carbonate Drugs 0.000 claims 1
- ORUJFMPWKPVXLZ-UHFFFAOYSA-N guaiacol carbonate Chemical compound COC1=CC=CC=C1OC(=O)OC1=CC=CC=C1OC ORUJFMPWKPVXLZ-UHFFFAOYSA-N 0.000 claims 1
- 229950010751 guaiacol phosphate Drugs 0.000 claims 1
- ADBFDJQRBQZXAB-UHFFFAOYSA-N guaiacol phosphate Chemical compound COC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)OC)OC1=CC=CC=C1OC ADBFDJQRBQZXAB-UHFFFAOYSA-N 0.000 claims 1
- 229960002146 guaifenesin Drugs 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 229940071870 hydroiodic acid Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960004635 mesna Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- QFRKWSPTCBGLSU-UHFFFAOYSA-M potassium 4-hydroxy-3-methoxybenzene-1-sulfonate Chemical compound [K+].COC1=CC(S([O-])(=O)=O)=CC=C1O QFRKWSPTCBGLSU-UHFFFAOYSA-M 0.000 claims 1
- 229940069505 potassium guaiacolsulfonate Drugs 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- SDGNVCFTXNYEBL-UHFFFAOYSA-N propane-1,2,3-triol;hydroiodide Chemical compound I.OCC(O)CO SDGNVCFTXNYEBL-UHFFFAOYSA-N 0.000 claims 1
- 229940048730 senega Drugs 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 235000009518 sodium iodide Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 229960004402 tiopronin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1014391.5 | 2010-08-27 | ||
| GBGB1014391.5A GB201014391D0 (en) | 2010-08-27 | 2010-08-27 | Drug composition and its use in therapy |
| PCT/GB2011/051610 WO2012025761A1 (en) | 2010-08-27 | 2011-08-25 | Theobromine in combination with an expectorant or a mucolytic for use in therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016153321A Division JP2016196504A (ja) | 2010-08-27 | 2016-08-04 | 治療における使用のために去痰薬または粘液溶解薬と組み合わせたテオブロミン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013536257A JP2013536257A (ja) | 2013-09-19 |
| JP2013536257A5 true JP2013536257A5 (enExample) | 2014-10-09 |
Family
ID=43013412
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526551A Pending JP2013536257A (ja) | 2010-08-27 | 2011-08-25 | 治療における使用のために去痰薬または粘液溶解薬と組み合わせたテオブロミン |
| JP2016153321A Pending JP2016196504A (ja) | 2010-08-27 | 2016-08-04 | 治療における使用のために去痰薬または粘液溶解薬と組み合わせたテオブロミン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016153321A Pending JP2016196504A (ja) | 2010-08-27 | 2016-08-04 | 治療における使用のために去痰薬または粘液溶解薬と組み合わせたテオブロミン |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP2608847B1 (enExample) |
| JP (2) | JP2013536257A (enExample) |
| CN (1) | CN103189108B (enExample) |
| AU (1) | AU2011294905B2 (enExample) |
| BR (1) | BR112013004659A8 (enExample) |
| CA (1) | CA2809767A1 (enExample) |
| CO (1) | CO6700840A2 (enExample) |
| EA (1) | EA201390287A1 (enExample) |
| EC (1) | ECSP13012524A (enExample) |
| ES (1) | ES2672128T3 (enExample) |
| GB (1) | GB201014391D0 (enExample) |
| IL (1) | IL224953A (enExample) |
| MX (1) | MX343598B (enExample) |
| NZ (1) | NZ607670A (enExample) |
| PE (1) | PE20140013A1 (enExample) |
| PH (1) | PH12013500392A1 (enExample) |
| PL (1) | PL2608847T3 (enExample) |
| SG (1) | SG188322A1 (enExample) |
| UA (1) | UA112760C2 (enExample) |
| WO (1) | WO2012025761A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| GB201111485D0 (en) * | 2011-07-05 | 2011-08-17 | Biocopea Ltd | Drug composition and its use in therapy |
| US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| GB0910375D0 (en) | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
| JP2017527618A (ja) * | 2014-09-08 | 2017-09-21 | ゴッサム バイオファーマシューティカルズ，インコーポレイティド | 肺サルコイドーシスの治療方法 |
| WO2017043935A1 (ko) * | 2015-09-09 | 2017-03-16 | 한국생명공학연구원 | 소브레롤을 포함하는 근력 약화 관련 질환의 예방 또는 치료용 조성물 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9700654A2 (hu) | 1997-03-26 | 1999-09-28 | Dezső Korbonits | Teobromin tartalmú köhögéscsillapító készítmények |
| WO2000000212A1 (en) * | 1998-06-26 | 2000-01-06 | Nutracorp Scientific, Inc. | Promoting nitric oxide and cyclic gmp activity |
| JP2002193839A (ja) * | 2000-12-27 | 2002-07-10 | Meiji Seika Kaisha Ltd | ココア製剤 |
| JP2003055258A (ja) * | 2001-08-16 | 2003-02-26 | Rohto Pharmaceut Co Ltd | 安定化された組成物 |
| US7097859B2 (en) * | 2004-04-05 | 2006-08-29 | Hack Jacob C | Indium supplement compositions and methods therefor |
| US20060148837A1 (en) * | 2005-01-04 | 2006-07-06 | Everett Laboratories, Inc. | Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| GB2424185B (en) * | 2005-03-16 | 2009-12-30 | Atulkumar Sumanbhai Patel | A cough mixture |
| KR20080009994A (ko) * | 2006-07-25 | 2008-01-30 | 안국약품 주식회사 | 기침 치료용 조성물 |
| US20080085312A1 (en) * | 2006-10-04 | 2008-04-10 | Auriga Laboratories, Inc. | Multi-Phase Release Potassium Guaiacolsulfonate Compositions |
| US20080176955A1 (en) * | 2007-01-16 | 2008-07-24 | Victory Pharma, Inc. | Combined administration of benzonatate and guaifenesin |
| DE102007000521A1 (de) * | 2007-10-18 | 2009-04-23 | Renate Conrad | Hustenpräparat |
| GB201111485D0 (en) * | 2011-07-05 | 2011-08-17 | Biocopea Ltd | Drug composition and its use in therapy |
| GB0910375D0 (en) * | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
| EP2571499A1 (en) * | 2010-05-18 | 2013-03-27 | Mahmut Bilgic | Pharmaceutical composition comprising n- acetylcysteine and a xanthine |
-
2010
- 2010-08-27 GB GBGB1014391.5A patent/GB201014391D0/en not_active Ceased
-
2011
- 2011-08-25 AU AU2011294905A patent/AU2011294905B2/en not_active Ceased
- 2011-08-25 SG SG2013014816A patent/SG188322A1/en unknown
- 2011-08-25 PE PE2013000352A patent/PE20140013A1/es not_active Application Discontinuation
- 2011-08-25 PL PL11755105T patent/PL2608847T3/pl unknown
- 2011-08-25 EP EP11755105.1A patent/EP2608847B1/en not_active Not-in-force
- 2011-08-25 JP JP2013526551A patent/JP2013536257A/ja active Pending
- 2011-08-25 PH PH1/2013/500392A patent/PH12013500392A1/en unknown
- 2011-08-25 BR BR112013004659A patent/BR112013004659A8/pt not_active IP Right Cessation
- 2011-08-25 ES ES11755105.1T patent/ES2672128T3/es active Active
- 2011-08-25 NZ NZ607670A patent/NZ607670A/en not_active IP Right Cessation
- 2011-08-25 MX MX2013002334A patent/MX343598B/es active IP Right Grant
- 2011-08-25 WO PCT/GB2011/051610 patent/WO2012025761A1/en not_active Ceased
- 2011-08-25 UA UAA201303724A patent/UA112760C2/uk unknown
- 2011-08-25 EA EA201390287A patent/EA201390287A1/ru unknown
- 2011-08-25 CA CA2809767A patent/CA2809767A1/en not_active Abandoned
- 2011-08-25 CN CN201180052248.7A patent/CN103189108B/zh not_active Expired - Fee Related
-
2013
- 2013-02-27 IL IL224953A patent/IL224953A/en not_active IP Right Cessation
- 2013-03-22 CO CO13057476A patent/CO6700840A2/es unknown
- 2013-03-25 EC ECSP13012524 patent/ECSP13012524A/es unknown
-
2016
- 2016-08-04 JP JP2016153321A patent/JP2016196504A/ja active Pending
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