JP2013536209A5 - - Google Patents
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- Publication number
- JP2013536209A5 JP2013536209A5 JP2013525178A JP2013525178A JP2013536209A5 JP 2013536209 A5 JP2013536209 A5 JP 2013536209A5 JP 2013525178 A JP2013525178 A JP 2013525178A JP 2013525178 A JP2013525178 A JP 2013525178A JP 2013536209 A5 JP2013536209 A5 JP 2013536209A5
- Authority
- JP
- Japan
- Prior art keywords
- spinal cord
- injury
- syndrome
- stereoisomer
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003169 central nervous system Anatomy 0.000 claims 9
- 208000020431 spinal cord injury Diseases 0.000 claims 9
- 208000001738 Nervous System Trauma Diseases 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 210000000278 spinal cord Anatomy 0.000 claims 6
- 208000034656 Contusions Diseases 0.000 claims 5
- 230000009519 contusion Effects 0.000 claims 5
- 208000000202 Diffuse Axonal Injury Diseases 0.000 claims 4
- 206010019196 Head injury Diseases 0.000 claims 4
- 206010037714 Quadriplegia Diseases 0.000 claims 4
- 206010041549 Spinal cord compression Diseases 0.000 claims 4
- 208000029028 brain injury Diseases 0.000 claims 4
- 230000009521 diffuse axonal injury Effects 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 206010052346 Brain contusion Diseases 0.000 claims 2
- 208000006569 Central Cord Syndrome Diseases 0.000 claims 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 2
- 206010010254 Concussion Diseases 0.000 claims 2
- 206010053778 Conus medullaris syndrome Diseases 0.000 claims 2
- 206010015769 Extradural haematoma Diseases 0.000 claims 2
- 206010033892 Paraplegia Diseases 0.000 claims 2
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims 2
- 208000002667 Subdural Hematoma Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 206010007821 cauda equina syndrome Diseases 0.000 claims 2
- 230000006835 compression Effects 0.000 claims 2
- 238000007906 compression Methods 0.000 claims 2
- 230000009514 concussion Effects 0.000 claims 2
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 1
- 229960000681 leflunomide Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37645310P | 2010-08-24 | 2010-08-24 | |
| EP10008802 | 2010-08-24 | ||
| EP10008802.0 | 2010-08-24 | ||
| US61/376,453 | 2010-08-24 | ||
| PCT/EP2011/004218 WO2012025217A1 (en) | 2010-08-24 | 2011-08-23 | Novel use of leflunomide and malononitrilamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536209A JP2013536209A (ja) | 2013-09-19 |
| JP2013536209A5 true JP2013536209A5 (cg-RX-API-DMAC10.html) | 2014-08-21 |
| JP5820476B2 JP5820476B2 (ja) | 2015-11-24 |
Family
ID=44587762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013525178A Active JP5820476B2 (ja) | 2010-08-24 | 2011-08-23 | レフルノミドおよびマロノニトリラマイドの新規の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8957098B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2608782B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5820476B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN103153295A (cg-RX-API-DMAC10.html) |
| DK (1) | DK2608782T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2591355T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2012025217A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE034890T2 (hu) * | 2010-10-29 | 2018-03-28 | Algiax Pharmaceuticals Gmbh | Malononitrilaminok alkalmazása neuropathiás fájdalomban |
| ES2984690T3 (es) * | 2020-06-26 | 2024-10-30 | Algiax Pharmaceuticals Gmbh | Composición de nanopartículas |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| AU649421B2 (en) | 1990-05-18 | 1994-05-26 | Sanofi-Aventis Deutschland Gmbh | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| ES2124800T3 (es) * | 1993-01-08 | 1999-02-16 | Hoechst Ag | Empleo de leflunomida para la inhibicion de interleuquina 1 beta. |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US6011051A (en) * | 1996-07-31 | 2000-01-04 | Hoechst Aktiengesellschaft | Use of isoxazole and crotonamide derivatives for the modulation of apoptosis |
| US6015557A (en) | 1999-02-24 | 2000-01-18 | Tobinick; Edward L. | Tumor necrosis factor antagonists for the treatment of neurological disorders |
| GB0123571D0 (en) * | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| US6727272B1 (en) | 2002-07-15 | 2004-04-27 | Unitech Pharmaceuticals, Inc. | Leflunomide analogs for treating rheumatoid arthritis |
| NZ589307A (en) | 2008-04-29 | 2012-04-27 | Pharnext | Compositions comprising baclogen or terbinafine for treating alzheimer disease and related disorders through a modulation of angiogenesis |
| EP2314291A1 (en) * | 2009-10-22 | 2011-04-27 | Sanofi-Aventis | Use of the combination of teriflunomide and glatiramer acetate for treating multiple sclerosis |
-
2011
- 2011-08-23 WO PCT/EP2011/004218 patent/WO2012025217A1/en not_active Ceased
- 2011-08-23 DK DK11754832.1T patent/DK2608782T3/en active
- 2011-08-23 CN CN201180040827XA patent/CN103153295A/zh active Pending
- 2011-08-23 EP EP11754832.1A patent/EP2608782B1/en active Active
- 2011-08-23 ES ES11754832.1T patent/ES2591355T3/es active Active
- 2011-08-23 JP JP2013525178A patent/JP5820476B2/ja active Active
- 2011-08-23 US US13/817,800 patent/US8957098B2/en active Active
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