JP5820476B2 - レフルノミドおよびマロノニトリラマイドの新規の使用 - Google Patents

レフルノミドおよびマロノニトリラマイドの新規の使用 Download PDF

Info

Publication number
JP5820476B2
JP5820476B2 JP2013525178A JP2013525178A JP5820476B2 JP 5820476 B2 JP5820476 B2 JP 5820476B2 JP 2013525178 A JP2013525178 A JP 2013525178A JP 2013525178 A JP2013525178 A JP 2013525178A JP 5820476 B2 JP5820476 B2 JP 5820476B2
Authority
JP
Japan
Prior art keywords
injury
spinal cord
present disclosure
syndrome
leflunomide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013525178A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013536209A (ja
JP2013536209A5 (cg-RX-API-DMAC10.html
Inventor
グイド クープマンズ
グイド クープマンズ
ビルギット ハッセ
ビルギット ハッセ
ステファン ミュルナー
ステファン ミュルナー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Algiax Pharmaceuticals GmbH
Original Assignee
Algiax Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algiax Pharmaceuticals GmbH filed Critical Algiax Pharmaceuticals GmbH
Publication of JP2013536209A publication Critical patent/JP2013536209A/ja
Publication of JP2013536209A5 publication Critical patent/JP2013536209A5/ja
Application granted granted Critical
Publication of JP5820476B2 publication Critical patent/JP5820476B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2013525178A 2010-08-24 2011-08-23 レフルノミドおよびマロノニトリラマイドの新規の使用 Active JP5820476B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37645310P 2010-08-24 2010-08-24
EP10008802 2010-08-24
EP10008802.0 2010-08-24
US61/376,453 2010-08-24
PCT/EP2011/004218 WO2012025217A1 (en) 2010-08-24 2011-08-23 Novel use of leflunomide and malononitrilamides

Publications (3)

Publication Number Publication Date
JP2013536209A JP2013536209A (ja) 2013-09-19
JP2013536209A5 JP2013536209A5 (cg-RX-API-DMAC10.html) 2014-08-21
JP5820476B2 true JP5820476B2 (ja) 2015-11-24

Family

ID=44587762

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013525178A Active JP5820476B2 (ja) 2010-08-24 2011-08-23 レフルノミドおよびマロノニトリラマイドの新規の使用

Country Status (7)

Country Link
US (1) US8957098B2 (cg-RX-API-DMAC10.html)
EP (1) EP2608782B1 (cg-RX-API-DMAC10.html)
JP (1) JP5820476B2 (cg-RX-API-DMAC10.html)
CN (1) CN103153295A (cg-RX-API-DMAC10.html)
DK (1) DK2608782T3 (cg-RX-API-DMAC10.html)
ES (1) ES2591355T3 (cg-RX-API-DMAC10.html)
WO (1) WO2012025217A1 (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE034890T2 (hu) * 2010-10-29 2018-03-28 Algiax Pharmaceuticals Gmbh Malononitrilaminok alkalmazása neuropathiás fájdalomban
ES2984690T3 (es) * 2020-06-26 2024-10-30 Algiax Pharmaceuticals Gmbh Composición de nanopartículas

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
AU649421B2 (en) 1990-05-18 1994-05-26 Sanofi-Aventis Deutschland Gmbh Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
ES2124800T3 (es) * 1993-01-08 1999-02-16 Hoechst Ag Empleo de leflunomida para la inhibicion de interleuquina 1 beta.
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6011051A (en) * 1996-07-31 2000-01-04 Hoechst Aktiengesellschaft Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
US6015557A (en) 1999-02-24 2000-01-18 Tobinick; Edward L. Tumor necrosis factor antagonists for the treatment of neurological disorders
GB0123571D0 (en) * 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
US6727272B1 (en) 2002-07-15 2004-04-27 Unitech Pharmaceuticals, Inc. Leflunomide analogs for treating rheumatoid arthritis
NZ589307A (en) 2008-04-29 2012-04-27 Pharnext Compositions comprising baclogen or terbinafine for treating alzheimer disease and related disorders through a modulation of angiogenesis
EP2314291A1 (en) * 2009-10-22 2011-04-27 Sanofi-Aventis Use of the combination of teriflunomide and glatiramer acetate for treating multiple sclerosis

Also Published As

Publication number Publication date
ES2591355T3 (es) 2016-11-28
CN103153295A (zh) 2013-06-12
US20130274301A1 (en) 2013-10-17
EP2608782A1 (en) 2013-07-03
US8957098B2 (en) 2015-02-17
EP2608782B1 (en) 2016-06-29
JP2013536209A (ja) 2013-09-19
DK2608782T3 (en) 2016-09-05
WO2012025217A1 (en) 2012-03-01

Similar Documents

Publication Publication Date Title
JP6257326B2 (ja) 神経因性疼痛におけるマロノニトリルアミドの使用
JP2008520731A (ja) 中枢神経系傷害を治療及び管理するための、免疫調節性化合物を使用した方法及び組成物
JP2007531770A (ja) 睡眠不全、及び疾患に伴う睡眠不全の治療、予防、又は管理の方法、及びそれに用いる組成物
JP2013536209A (ja) レフルノミドおよびマロノニトリラマイドの新規の使用
CN101309585A (zh) 使用pde4调节剂治疗和控制中枢神经系统损伤的方法和组合物
EP2685983B1 (en) Novel use of imidazotriazinones
KR20190067824A (ko) 아필리모드 조성물 및 이를 알츠하이머병 치료에 사용하기 위한 방법
CN110290788A (zh) 氨基甲酸酯化合物用于预防、缓解或治疗双相障碍的用途
JP2019516722A (ja) 三叉神経痛を予防又は治療する目的のためのカルバメート化合物の使用
EP2146713B1 (fr) Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo-4- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes craniens
US20140057978A1 (en) Novel use of benzofuranylsulfonates
WO2013156231A1 (en) Use of imidazotriazinones in neuropathic pain
WO2015166918A1 (ja) 耳鳴患者の治療用の薬剤
HK1111916A (en) Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
HK40015213A (en) Use of carbamate compounds for prevention, alleviation or treatment of bipolar disorder
WO2013156232A1 (en) Use of benzofuranylsulfonates in neuropathic pain
CA2942446A1 (en) Treatment of cognitive disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140630

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140630

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150414

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150611

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150929

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20151002

R150 Certificate of patent or registration of utility model

Ref document number: 5820476

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250