DK2608782T3 - New use of leflunomide malononitrilamider - Google Patents
New use of leflunomide malononitrilamider Download PDFInfo
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- DK2608782T3 DK2608782T3 DK11754832.1T DK11754832T DK2608782T3 DK 2608782 T3 DK2608782 T3 DK 2608782T3 DK 11754832 T DK11754832 T DK 11754832T DK 2608782 T3 DK2608782 T3 DK 2608782T3
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/275—Nitriles; Isonitriles
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| US37645310P | 2010-08-24 | 2010-08-24 | |
| EP10008802 | 2010-08-24 | ||
| PCT/EP2011/004218 WO2012025217A1 (en) | 2010-08-24 | 2011-08-23 | Novel use of leflunomide and malononitrilamides |
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| DK2608782T3 true DK2608782T3 (en) | 2016-09-05 |
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| HUE034890T2 (hu) * | 2010-10-29 | 2018-03-28 | Algiax Pharmaceuticals Gmbh | Malononitrilaminok alkalmazása neuropathiás fájdalomban |
| ES2984690T3 (es) * | 2020-06-26 | 2024-10-30 | Algiax Pharmaceuticals Gmbh | Composición de nanopartículas |
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| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| AU649421B2 (en) | 1990-05-18 | 1994-05-26 | Sanofi-Aventis Deutschland Gmbh | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| ES2124800T3 (es) * | 1993-01-08 | 1999-02-16 | Hoechst Ag | Empleo de leflunomida para la inhibicion de interleuquina 1 beta. |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US6011051A (en) * | 1996-07-31 | 2000-01-04 | Hoechst Aktiengesellschaft | Use of isoxazole and crotonamide derivatives for the modulation of apoptosis |
| US6015557A (en) | 1999-02-24 | 2000-01-18 | Tobinick; Edward L. | Tumor necrosis factor antagonists for the treatment of neurological disorders |
| GB0123571D0 (en) * | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| US6727272B1 (en) | 2002-07-15 | 2004-04-27 | Unitech Pharmaceuticals, Inc. | Leflunomide analogs for treating rheumatoid arthritis |
| NZ589307A (en) | 2008-04-29 | 2012-04-27 | Pharnext | Compositions comprising baclogen or terbinafine for treating alzheimer disease and related disorders through a modulation of angiogenesis |
| EP2314291A1 (en) * | 2009-10-22 | 2011-04-27 | Sanofi-Aventis | Use of the combination of teriflunomide and glatiramer acetate for treating multiple sclerosis |
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|---|---|
| ES2591355T3 (es) | 2016-11-28 |
| CN103153295A (zh) | 2013-06-12 |
| US20130274301A1 (en) | 2013-10-17 |
| EP2608782A1 (en) | 2013-07-03 |
| US8957098B2 (en) | 2015-02-17 |
| EP2608782B1 (en) | 2016-06-29 |
| JP2013536209A (ja) | 2013-09-19 |
| JP5820476B2 (ja) | 2015-11-24 |
| WO2012025217A1 (en) | 2012-03-01 |
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