JP2016537338A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016537338A5 JP2016537338A5 JP2016528225A JP2016528225A JP2016537338A5 JP 2016537338 A5 JP2016537338 A5 JP 2016537338A5 JP 2016528225 A JP2016528225 A JP 2016528225A JP 2016528225 A JP2016528225 A JP 2016528225A JP 2016537338 A5 JP2016537338 A5 JP 2016537338A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- treatment
- group
- prodrug
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C([C@](CS1)NC1=O)=O Chemical compound *C([C@](CS1)NC1=O)=O 0.000 description 3
- YTZKOQUCBOVLHL-UHFFFAOYSA-N CC(C)(C)c1ccccc1 Chemical compound CC(C)(C)c1ccccc1 YTZKOQUCBOVLHL-UHFFFAOYSA-N 0.000 description 1
- LEAJWPFHMHVEKV-UHFFFAOYSA-N CCC(c(cccc1)c1OC)=O Chemical compound CCC(c(cccc1)c1OC)=O LEAJWPFHMHVEKV-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020069560A JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902052P | 2013-11-08 | 2013-11-08 | |
| US61/902,052 | 2013-11-08 | ||
| US201361902669P | 2013-11-11 | 2013-11-11 | |
| US61/902,669 | 2013-11-11 | ||
| PCT/US2014/064581 WO2015070034A1 (en) | 2013-11-08 | 2014-11-07 | Substituted n-acetyl-l-cysteine derivatives and related compounds |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017213633A Division JP6559756B2 (ja) | 2013-11-08 | 2017-11-06 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2020069560A Division JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537338A JP2016537338A (ja) | 2016-12-01 |
| JP2016537338A5 true JP2016537338A5 (cg-RX-API-DMAC10.html) | 2017-12-14 |
| JP6691044B2 JP6691044B2 (ja) | 2020-04-28 |
Family
ID=51952031
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528225A Expired - Fee Related JP6691044B2 (ja) | 2013-11-08 | 2014-11-07 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2017213633A Active JP6559756B2 (ja) | 2013-11-08 | 2017-11-06 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2020069560A Active JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2021156357A Active JP7170811B2 (ja) | 2013-11-08 | 2021-09-27 | 置換ｎ－アセチル－ｌ－システイン誘導体及び関連化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017213633A Active JP6559756B2 (ja) | 2013-11-08 | 2017-11-06 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2020069560A Active JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2021156357A Active JP7170811B2 (ja) | 2013-11-08 | 2021-09-27 | 置換ｎ－アセチル－ｌ－システイン誘導体及び関連化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US9630937B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3674297A1 (cg-RX-API-DMAC10.html) |
| JP (4) | JP6691044B2 (cg-RX-API-DMAC10.html) |
| AU (3) | AU2014346591B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2929655C (cg-RX-API-DMAC10.html) |
| DK (1) | DK3066089T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2765236T3 (cg-RX-API-DMAC10.html) |
| HU (1) | HUE048345T2 (cg-RX-API-DMAC10.html) |
| LT (1) | LT3066089T (cg-RX-API-DMAC10.html) |
| PL (1) | PL3066089T3 (cg-RX-API-DMAC10.html) |
| PT (1) | PT3066089T (cg-RX-API-DMAC10.html) |
| SI (1) | SI3066089T1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2015070034A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA201705288B (cg-RX-API-DMAC10.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2545033A4 (en) * | 2010-03-10 | 2013-08-21 | Promentis Pharm Inc | PROPIONIC ACIDS, PROPIONIC ACID ESTERS AND RELATED COMPOUNDS |
| US9630937B2 (en) * | 2013-11-08 | 2017-04-25 | Promentis Pharmaceuticals, Inc. | Substituted N-acetyl-L-cysteine derivatives and related compounds |
| WO2016192687A1 (en) * | 2015-06-05 | 2016-12-08 | China Medical University | New use of inhibitor of cystine-glutamate transporter |
| WO2018107040A1 (en) * | 2016-12-09 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | 1-(2-fluorophenyl)-n-[1-(2-fluoro-4-pyridyl)pyrazol-3-yl]cyclopropanecarboxamide, its solid forms and pharmaceutical uses thereof |
| US20180251431A1 (en) * | 2016-12-09 | 2018-09-06 | Vertex Pharmaceuticals Incorporated | 1,3-substituted pyrazole compounds useful for reduction of very long chain fatty acid levels |
| US20190177295A1 (en) * | 2017-12-08 | 2019-06-13 | Vertex Pharmaceuticals Incorporated | Process for the preparation of a 1,3-disubstituted pyrazole compound |
| US20240425857A1 (en) | 2021-10-29 | 2024-12-26 | Vib Vzw | Means and Methods for Chronic Wound Healing |
| CN116535998B (zh) * | 2023-06-20 | 2024-05-17 | 安徽省阳明达新材料科技有限公司 | 一种热熔复合石材玻璃耐热eva胶片的制备方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1493697A1 (de) * | 1965-02-25 | 1969-11-20 | Hoechst Ag | Verfahren zur Spaltung von Thiolestern aromatischer Carbonsaeuren |
| IT1194117B (it) | 1981-11-20 | 1988-09-14 | Isnardi Pietro & C Spa | Derivati salicilici di n-acetilcisteina |
| CN85107378A (zh) | 1984-09-13 | 1987-03-18 | 陶氏化学公司 | 从原煤中回收有用煤的起泡剂组合物和泡沫浮选方法 |
| US5637616A (en) | 1993-06-18 | 1997-06-10 | Arcturus Pharmaceutical Corporation | Method for treating diseases mediated by proteases |
| WO1995017900A1 (en) | 1993-12-30 | 1995-07-06 | Arcturus Pharmaceutical Corporation | Methods for the treatment of the central nervous system or eye involving pathogenic oxidation pathways |
| AU2825295A (en) | 1994-06-13 | 1996-01-05 | Arcturus Pharmaceutical Corporation | Method for the treatment, prevention or minimization of hair loss |
| JP3608021B2 (ja) * | 1996-09-05 | 2005-01-05 | 参天製薬株式会社 | 新規含硫黄アミノ酸誘導体 |
| KR19990078146A (ko) | 1998-03-24 | 1999-10-25 | 마키노 아라타 | 프로필렌계 수지 조성물 및 이를 사용한 연신필름 |
| JP2002519341A (ja) * | 1998-06-29 | 2002-07-02 | パーカー ヒューズ インスティテュート | 強力な抗がん剤としてのアルキルケトン類 |
| AU6314200A (en) * | 1999-07-26 | 2001-02-13 | Toray Industries, Inc. | Carboxylic acid derivatives and adhesion molecule inhibitors containing the sameas the active ingredient |
| JP4684553B2 (ja) | 2001-09-27 | 2011-05-18 | ザ メンタル ヘルス リサーチ インスティチュート オブ ビクトリア | 生理学的過程の調節およびこれに有用な薬剤 |
| US7887833B2 (en) | 2001-12-04 | 2011-02-15 | Ben-Gurion University Of The Negev Research And Development Authority | Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting |
| CN1233629C (zh) | 2002-11-22 | 2005-12-28 | 贵州省中国科学院天然产物化学重点实验室 | 具有神经营养作用的硫酯类化合物及其它的合成方法和应用 |
| FR2856592B1 (fr) | 2003-06-27 | 2008-04-25 | Oreal | Composition cosmetique a base de percuseur(s) de radical thiyl pour la deformation permanente des fibres keratiniques |
| US8993627B2 (en) | 2005-04-21 | 2015-03-31 | Sentient Lifesciences, Inc. | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress |
| RU2007143040A (ru) | 2005-04-21 | 2009-05-27 | Гленн А. ГОЛДШТЕЙН (US) | Амид n-ацетилцистеина (амид nac) в лечении заболеваний и состояний, связанных с окислительным стрессом |
| US20090258917A1 (en) | 2005-10-12 | 2009-10-15 | Benjamin Pelcman | Benzoxazoles Useful in the Treatment of Inflammation |
| JP2010505844A (ja) * | 2006-10-03 | 2010-02-25 | ガレオン・フアーマシユーチカルズ・インコーポレーテツド | Ｓ−ニトロソチオール化合物および関連誘導体 |
| US7829709B1 (en) | 2007-08-10 | 2010-11-09 | Marquette University | Cysteine prodrugs to treat schizophrenia and drug addiction |
| US8173809B2 (en) | 2008-02-07 | 2012-05-08 | Marquette University | Cysteine and cystine prodrugs to treat schizophrenia and reduce drug cravings |
| JP5658137B2 (ja) | 2008-04-16 | 2015-01-21 | マーケット ユニバーシティー | 統合失調症又は薬物渇望治療用医薬組成物 |
| CN102316730A (zh) | 2008-05-09 | 2012-01-11 | 天雅瑞药业有限公司 | 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释 |
| JP2012520342A (ja) | 2009-03-16 | 2012-09-06 | ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ | 代謝障害を処置するのに有用な抗炎症剤および抗酸化剤のコンジュゲート |
| CA2787784A1 (en) | 2010-01-29 | 2011-08-04 | Dana-Farber Cancer Institute, Inc. | Small molecules for the modulation of mcl-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders |
| EP2545033A4 (en) | 2010-03-10 | 2013-08-21 | Promentis Pharm Inc | PROPIONIC ACIDS, PROPIONIC ACID ESTERS AND RELATED COMPOUNDS |
| WO2012033235A1 (ko) | 2010-09-06 | 2012-03-15 | 서울대학교 산학협력단 | Ｎ-아세틸-ｌ-시스테인 또는 이의 유도체를 포함하는 불안 장애 치료용 약학 조성물 |
| EP2638005A4 (en) * | 2010-11-12 | 2015-04-01 | Promentis Pharm Inc | S-T-BUTYL-CYSTONE-PROTECTED DI-PEPTIDE ANALOGS AND ASSOCIATED COMPOUNDS |
| US20120122793A1 (en) | 2010-11-12 | 2012-05-17 | Promentis Pharmaceuticals, Inc. | S-Protected Cysteine Analogs and Related Compounds |
| EP2665742B1 (en) | 2011-01-20 | 2016-04-20 | Oneday - Biotech And Pharma Ltd. | Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof |
| US9457014B2 (en) * | 2011-07-28 | 2016-10-04 | Promentis Pharmaceuticals, Inc. | Cysteine prodrugs |
| WO2014209412A1 (en) | 2013-06-29 | 2014-12-31 | Viva Pharmaceutical, Inc. | N-acetyl l-cysteine chelates and methods for making and using the same |
| US20150038586A1 (en) | 2013-07-10 | 2015-02-05 | Sentient Lifesciences, Inc. | Use of n-acetylcysteine amide in the treatment of penetrating head injury |
| US20150133558A1 (en) | 2013-10-15 | 2015-05-14 | Glenn A. Goldstein | Use of n-acetylcysteine amide for decreasing intracranial pressure |
| US9630937B2 (en) * | 2013-11-08 | 2017-04-25 | Promentis Pharmaceuticals, Inc. | Substituted N-acetyl-L-cysteine derivatives and related compounds |
| WO2015112724A1 (en) | 2014-01-24 | 2015-07-30 | Brighton Biotech, Inc. | Naca for the treatment of chronic or acute cognitive dysfunction |
| WO2015112715A1 (en) | 2014-01-24 | 2015-07-30 | Brighton Biotech, Inc. | Naca for the treatment of chronic or low impact brian trauma |
-
2014
- 2014-11-07 US US14/535,855 patent/US9630937B2/en active Active
- 2014-11-07 PT PT148027717T patent/PT3066089T/pt unknown
- 2014-11-07 EP EP19207221.3A patent/EP3674297A1/en not_active Withdrawn
- 2014-11-07 JP JP2016528225A patent/JP6691044B2/ja not_active Expired - Fee Related
- 2014-11-07 EP EP14802771.7A patent/EP3066089B1/en active Active
- 2014-11-07 DK DK14802771.7T patent/DK3066089T3/da active
- 2014-11-07 ES ES14802771T patent/ES2765236T3/es active Active
- 2014-11-07 AU AU2014346591A patent/AU2014346591B2/en not_active Ceased
- 2014-11-07 HU HUE14802771A patent/HUE048345T2/hu unknown
- 2014-11-07 LT LTEP14802771.7T patent/LT3066089T/lt unknown
- 2014-11-07 WO PCT/US2014/064581 patent/WO2015070034A1/en not_active Ceased
- 2014-11-07 SI SI201431469T patent/SI3066089T1/sl unknown
- 2014-11-07 US US14/535,953 patent/US9012674B1/en active Active
- 2014-11-07 CA CA2929655A patent/CA2929655C/en active Active
- 2014-11-07 PL PL14802771T patent/PL3066089T3/pl unknown
-
2017
- 2017-03-15 US US15/459,840 patent/US10112897B2/en active Active
- 2017-04-07 US US15/481,728 patent/US10358414B2/en active Active
- 2017-08-04 ZA ZA2017/05288A patent/ZA201705288B/en unknown
- 2017-11-06 JP JP2017213633A patent/JP6559756B2/ja active Active
-
2018
- 2018-12-21 AU AU2018282446A patent/AU2018282446B2/en not_active Ceased
-
2019
- 2019-06-17 US US16/443,793 patent/US10961187B2/en active Active
-
2020
- 2020-04-08 JP JP2020069560A patent/JP6952825B2/ja active Active
- 2020-10-21 AU AU2020257084A patent/AU2020257084A1/en not_active Abandoned
-
2021
- 2021-03-29 US US17/216,285 patent/US20210395194A1/en not_active Abandoned
- 2021-09-27 JP JP2021156357A patent/JP7170811B2/ja active Active
-
2023
- 2023-10-17 US US18/488,215 patent/US20240059649A1/en active Pending