JP2013534462A - 血液濾過に適した膜 - Google Patents
血液濾過に適した膜 Download PDFInfo
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- JP2013534462A JP2013534462A JP2013512864A JP2013512864A JP2013534462A JP 2013534462 A JP2013534462 A JP 2013534462A JP 2013512864 A JP2013512864 A JP 2013512864A JP 2013512864 A JP2013512864 A JP 2013512864A JP 2013534462 A JP2013534462 A JP 2013534462A
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Abstract
Description
a)層の少なくとも1つは、ポリマーナノファイバーから製造されるナノウェブであり、
b)ナノウェブの平均流量細孔径は50nm〜5μmの範囲であり、
c)ナノファイバーの数平均直径は100〜600nmの範囲であり、
d)ナノウェブの目付は1〜20g/m2の範囲であり、
e)ナノウェブの空隙率は60〜95%の範囲であり、
f)層の少なくとも1つは支持層であり、
g)ナノウェブは親水性である。
−一連の紡糸ノズルを備える紡糸口金と捕集装置との間、または別々の電極と捕集機との間に高電圧を印加する工程、
−ポリマーと溶媒を含むポリマー溶液流を紡糸口金に供給する工程、
を含み、
−それにより、ポリマー溶液が、紡糸口金から紡糸ノズルを通して吐出され、高電圧の影響下で帯電した噴流に変化し、
−それにより、噴流が捕集機もしくは支持層上に堆積する、または捕集機もしくは支持層により捕集され、
−それにより、捕集機もしくは支持層上に堆積するまたは捕集機もしくは支持層により捕集される前またはその間に、噴流中のポリマーが凝固し、それによりナノファイバーが形成される。
標準的な重合方法により製造されたポリアミド−4,6からナノウェブを製造した。ナノウェブは、ギ酸と酢酸の混合物に溶解したポリアミド−4,6の溶液を使用し、本明細書に記載のエレクトロスピニングを使用して製造した。混合物は、ギ酸40wt%と酢酸60wt%とからなった。ギ酸は、メルク(Merck)から入手した(Proanalyse、98〜100%)。酢酸もメルクから入手した(99+%)。
本発明の膜構造の性能を試験するために、本膜構造および従来技術の血液分離フィルター(比較)を血液分離試験に使用した。血液分離試験では、健常被験者の鮮血20μlを膜構造の上面および比較フィルターの上面に付着させた。比較フィルターは、ポールコーポレーション(Pall Corporation)製の市販のフィルターであった。フィルターは、Pall Vivid GFフィルターとして販売されている。
表1に、膜構造(本発明のものと比較例の両方)に使用される材料の説明を記載し、
表2に、膜構造の性質を記載し、
表3に、血液分離試験の結果を記載する。
比較例Bは、不織支持材:Novatexx 2597(Freudenberg Filtration Technologies KGから市販されている)である。
実施例1、2、3および4は全て、比較例BのNovatexx 2597不織支持体上に電気紡糸されているPA−4,6ナノウェブ膜構造である。実施例1〜4は、平均流量細孔径が異なる。更なる詳細については表1を参照されたい。
表1の結果から、本発明の材料(実施例1〜4)を使用すると、従来技術の材料(比較例1)より浸出物が減少することを明確に推論できる。さらに、表2から、本発明の膜構造のデッドボリュームは、従来技術の材料のものよりずっと少ないと結論付けることができる。表3から、本発明の膜構造では、血液分離時間がずっと短縮されると結論付けることができる。さらに、本発明の膜では、従来技術の材料と比較して、血液1μl当たり生成される血漿量が多くなる。
Claims (15)
- 複数の層を含む膜構造であって、
−前記層の少なくとも1つがポリマーナノファイバーから製造されたナノウェブであり、
−前記ナノウェブの平均流量細孔径が50nm〜5μmの範囲であり、
−前記ナノファイバーの数平均直径が100〜600nmの範囲であり、
−前記ナノウェブの目付が1〜20g/m2の範囲であり、
−前記ナノウェブの空隙率が60〜95%の範囲であり、
−前記層の少なくとも1つが支持層であり、
−前記ナノウェブが親水性である、
膜構造。 - 前記ナノファイバーが脂肪族ポリアミド、その混合物およびコポリアミド、好ましくはポリアミド−6、ポリアミド−6,6、ポリアミド−4,6、これらのコポリアミドおよび/または混合物から製造される、請求項1に記載の膜構造。
- 前記支持材が親水性である、請求項1または2に記載の膜構造。
- 前記ナノファイバーがコーティングされており、好ましくは防汚コーティングでコーティングされている、請求項1〜3のいずれか1項に記載の膜構造。
- 前記防汚コーティングが生物防汚コーティングである、請求項1〜4のいずれか1項に記載の膜構造。
- 前記支持層が微孔質層である、請求項1〜5のいずれか1項に記載の膜構造。
- 前記微孔質層が超高分子量ポリエチレンから製造され、好ましくは防汚コーティングされた超高分子量ポリエチレンから製造されている、請求項6に記載の膜構造。
- 前記膜構造の層の少なくとも1つがコーティングされている、請求項1〜7のいずれか1項に記載の膜構造。
- 前記膜構造の層の少なくとも1つが(生物)防汚コーティングでコーティングされている、請求項8に記載の膜構造。
- 前記支持層が前記膜構造の上側にあり、前記ナノウェブが前記構造の下側にある、請求項1〜9のいずれか1項に記載の膜構造。
- 請求項1〜10のいずれか1項に記載の膜構造を備える膜カセット。
- 請求項1〜10のいずれか1項に記載の膜構造または請求項11に記載の膜カセットを備えるデバイス。
- 血液濾過のための、請求項1〜10のいずれか1項に記載の膜構造、請求項11に記載の膜カセット、または請求項12に記載のデバイスの使用。
- 次の用途:ガス−ガス濾過、高温ガス濾過、粒子濾過、液体濾過(精密濾過、限外濾過、ナノ濾過、逆浸透など)のような分子分離および濾過;排水浄化、油および燃料濾過;医薬成分および機能性食品成分を含む放出制御用途;浸透抽出、浸透気化および接触器用途;酵素の固定化、および加湿器、薬物送達;(産業用)ワイプ、手術用ガウンおよびドレープ、創傷ドレッシング、組織工学、保護衣、触媒担体、および様々なコーティングのいずれか1つのための、請求項1〜10のいずれか1項に記載の膜構造、請求項11に記載の膜カセット、または請求項12に記載のデバイスの使用。
- 診断デバイスにおける、請求項1〜10のいずれか1項に記載の膜構造、請求項11に記載の膜カセット、または請求項12に記載のデバイスの使用。
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JP2012520761A (ja) | 2009-03-19 | 2012-09-10 | イー・エム・デイー・ミリポア・コーポレイシヨン | ナノ繊維濾過媒体を用いる、流体資料からの微生物の除去 |
US20120145632A1 (en) * | 2009-07-15 | 2012-06-14 | Konraad Albert Louise Hector Dullaert | Electrospinning of polyamide nanofibers |
US9623352B2 (en) | 2010-08-10 | 2017-04-18 | Emd Millipore Corporation | Method for retrovirus removal |
US10668308B2 (en) | 2010-08-31 | 2020-06-02 | Crosstex International, Inc. | Filter mask having one or more malleable stiffening members |
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Also Published As
Publication number | Publication date |
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KR20130112849A (ko) | 2013-10-14 |
WO2011151314A1 (en) | 2011-12-08 |
TW201201899A (en) | 2012-01-16 |
CA2800857A1 (en) | 2011-12-08 |
EP2576031A1 (en) | 2013-04-10 |
TWI517898B (zh) | 2016-01-21 |
CN102917777B (zh) | 2016-05-11 |
US20130256230A1 (en) | 2013-10-03 |
EA201201622A1 (ru) | 2013-05-30 |
CN102917777A (zh) | 2013-02-06 |
IL223280A0 (en) | 2013-02-03 |
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