JP2013534217A5 - - Google Patents
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- Publication number
- JP2013534217A5 JP2013534217A5 JP2013521934A JP2013521934A JP2013534217A5 JP 2013534217 A5 JP2013534217 A5 JP 2013534217A5 JP 2013521934 A JP2013521934 A JP 2013521934A JP 2013521934 A JP2013521934 A JP 2013521934A JP 2013534217 A5 JP2013534217 A5 JP 2013534217A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- variant
- antibody
- nacl
- hcl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36914810P | 2010-07-30 | 2010-07-30 | |
| US61/369,148 | 2010-07-30 | ||
| PCT/US2011/045524 WO2012015912A1 (en) | 2010-07-30 | 2011-07-27 | Method for purifying active polypeptides or immunocojugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534217A JP2013534217A (ja) | 2013-09-02 |
| JP2013534217A5 true JP2013534217A5 (enExample) | 2014-09-18 |
| JP6061853B2 JP6061853B2 (ja) | 2017-01-18 |
Family
ID=45530485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013521934A Expired - Fee Related JP6061853B2 (ja) | 2010-07-30 | 2011-07-27 | 活性ポリペプチドまたは免疫複合体の精製方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US9580461B2 (enExample) |
| EP (3) | EP3797847A1 (enExample) |
| JP (1) | JP6061853B2 (enExample) |
| CN (1) | CN103079666B (enExample) |
| BR (1) | BR112013002334A2 (enExample) |
| CA (1) | CA2806314C (enExample) |
| DK (1) | DK3434346T3 (enExample) |
| ES (2) | ES2678204T3 (enExample) |
| HU (2) | HUE051702T2 (enExample) |
| LT (2) | LT3434346T (enExample) |
| MX (1) | MX342920B (enExample) |
| NO (1) | NO2021030I1 (enExample) |
| PL (1) | PL3434346T3 (enExample) |
| PT (1) | PT3434346T (enExample) |
| SG (3) | SG187587A1 (enExample) |
| WO (1) | WO2012015912A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
| BR112013002334A2 (pt) | 2010-07-30 | 2016-05-24 | Medimmune Llc | método para purificar polipeptídeos ou imunoconjugados ativos. |
| CA2815342A1 (en) * | 2010-10-20 | 2012-04-26 | Medimmune, Llc | Methods for processing inclusion bodies |
| SG11201407809QA (en) | 2012-05-31 | 2014-12-30 | Agency Science Tech & Res | Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities |
| CN105007937B (zh) * | 2012-12-20 | 2019-11-19 | 米迪缪尼有限公司 | 生产免疫偶联物的方法 |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| KR101531479B1 (ko) * | 2014-11-21 | 2015-06-26 | 세원셀론텍(주) | 의료용 재료로 사용하기 위한 고농도 콜라겐 제조방법 |
| EP3280444B1 (en) * | 2015-04-10 | 2024-05-08 | Adimab, LLC | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| JP7217700B2 (ja) | 2016-09-13 | 2023-02-03 | アラーガン、インコーポレイテッド | 安定化非タンパク質クロストリジウム毒素組成物 |
| WO2018075357A1 (en) * | 2016-10-17 | 2018-04-26 | Duke University | PRODUCTION OF IMMUNOTOXIN D2C7-(scdsFv)-PE38KDEL |
| WO2018092885A1 (ja) | 2016-11-18 | 2018-05-24 | アステラス製薬株式会社 | 新規な抗ヒトＭＵＣ１抗体Ｆａｂフラグメント |
| WO2018187388A1 (en) * | 2017-04-04 | 2018-10-11 | Scarab Genomics, Llc | Improved purification of crm 197 from bacteria |
| TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| US20200239575A1 (en) * | 2017-10-06 | 2020-07-30 | University Of Utah Research Foundation | A fusion protein for targeted therapy of autoimmune disease |
| WO2019071150A1 (en) * | 2017-10-06 | 2019-04-11 | University Of Utah Research Foundation | FUSION PROTEIN FOR TARGETED THERAPY OF AUTOIMMUNE DISEASE |
| US12202908B2 (en) | 2018-05-17 | 2025-01-21 | Astellas Pharma Inc. | Complex having anti-human MUC1 antibody Fab fragment, peptide linker and/or ligand |
| MX2021004146A (es) | 2018-10-10 | 2021-06-08 | Astellas Pharma Inc | Composicion farmaceutica que contiene complejo de fragmento fab de anticuerpo antihumano con sitio marcado. |
| US12514927B2 (en) | 2019-10-30 | 2026-01-06 | Duke University | Immunotherapy with combination therapy comprising an immunotoxin |
| IL295143B2 (en) | 2020-02-13 | 2026-02-01 | Hoffmann La Roche | A method for determining the loading state of AAV particles using nuclear magnetic resonance relaxometry |
| EP4175969A4 (en) * | 2020-07-01 | 2024-07-24 | Medimmune, LLC | DETERGENT AND METHOD FOR PURIFYING A BIOTHERAPY AGENT |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3060165A (en) | 1962-10-23 | Preparation of toxic ricin | ||
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5079163A (en) | 1985-03-29 | 1992-01-07 | Cetus Corporation | Recombinant ricin toxin fragments |
| US4689401A (en) | 1986-03-06 | 1987-08-25 | Cetus Corporation | Method of recovering microbially produced recombinant ricin toxin a chain |
| US4892827A (en) | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| JP2665827B2 (ja) | 1990-05-11 | 1997-10-22 | アメリカ合衆国 | 低―動物毒性と高殺細胞活性の改良シュードモナス外毒素 |
| US5608039A (en) | 1990-10-12 | 1997-03-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Single chain B3 antibody fusion proteins and their uses |
| CA2136724A1 (en) | 1992-06-18 | 1993-12-23 | Ira H. Pastan | Recombinant pseudomonas exotoxin with increased activity |
| WO1998041641A1 (en) | 1997-03-20 | 1998-09-24 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors |
| US6296843B1 (en) | 1998-04-03 | 2001-10-02 | The Penn State Research Foundation | Mutagenized IL 13-based chimeric molecules |
| US7355012B2 (en) * | 2001-09-26 | 2008-04-08 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mutated anti-CD22 antibodies with increased affinity to CD22-expressing leukemia cells |
| WO2003051926A2 (en) * | 2001-12-14 | 2003-06-26 | Friedrich-Alexander-Universitaet Erlangen-Nuernberg | Anti-cd7 immunotoxin as fusion protein |
| JP2004089182A (ja) * | 2002-06-24 | 2004-03-25 | Takeda Chem Ind Ltd | がんの予防・治療剤 |
| PT1543038T (pt) * | 2002-09-11 | 2017-07-07 | Genentech Inc | Purificação de proteína |
| DE602004027291D1 (de) * | 2003-11-25 | 2010-07-01 | Us Gov Health & Human Serv | Mutierte anti-cd22-antikörper und immunkonjugate |
| US20080125363A1 (en) | 2004-12-14 | 2008-05-29 | Enzon Pharmaceuticals Inc. | Polymer-Linked Pseudomonas Exotoxin Immunotoxin |
| ATE524489T1 (de) | 2005-07-29 | 2011-09-15 | Us Gov Health & Human Serv | Mutierte pseudomonas-exotoxine mit reduzierter antigenität |
| WO2008039761A2 (en) * | 2006-09-25 | 2008-04-03 | Medimmune, Llc. | Stabilized antibody formulations and uses thereof |
| CN101541345A (zh) * | 2006-09-25 | 2009-09-23 | 米迪缪尼有限公司 | 稳定化的抗体制剂和其应用 |
| DK2197903T3 (en) | 2007-09-04 | 2015-01-05 | Us Gov Health & Human Serv | Deletions in Domain II from Pseudomonas exotoxin A that reduce non-specific TOXICITY |
| US20110250199A1 (en) * | 2008-06-04 | 2011-10-13 | The Government of the United States of America as represented by the Secretary of the Department.... | Immunotoxins and uses thereof |
| CA2737597C (en) * | 2008-10-16 | 2017-03-14 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof |
| BR112013002334A2 (pt) | 2010-07-30 | 2016-05-24 | Medimmune Llc | método para purificar polipeptídeos ou imunoconjugados ativos. |
-
2011
- 2011-07-27 BR BR112013002334A patent/BR112013002334A2/pt not_active IP Right Cessation
- 2011-07-27 US US13/813,083 patent/US9580461B2/en not_active Expired - Fee Related
- 2011-07-27 CA CA2806314A patent/CA2806314C/en active Active
- 2011-07-27 ES ES11813105.1T patent/ES2678204T3/es active Active
- 2011-07-27 PL PL18174165T patent/PL3434346T3/pl unknown
- 2011-07-27 EP EP20192591.4A patent/EP3797847A1/en not_active Withdrawn
- 2011-07-27 DK DK18174165.3T patent/DK3434346T3/da active
- 2011-07-27 SG SG2013005228A patent/SG187587A1/en unknown
- 2011-07-27 EP EP18174165.3A patent/EP3434346B1/en active Active
- 2011-07-27 SG SG10202009967TA patent/SG10202009967TA/en unknown
- 2011-07-27 MX MX2013001044A patent/MX342920B/es active IP Right Grant
- 2011-07-27 WO PCT/US2011/045524 patent/WO2012015912A1/en not_active Ceased
- 2011-07-27 ES ES18174165T patent/ES2836447T3/es active Active
- 2011-07-27 JP JP2013521934A patent/JP6061853B2/ja not_active Expired - Fee Related
- 2011-07-27 EP EP11813105.1A patent/EP2613857B1/en active Active
- 2011-07-27 CN CN201180037262.XA patent/CN103079666B/zh not_active Expired - Fee Related
- 2011-07-27 LT LTEP18174165.3T patent/LT3434346T/lt unknown
- 2011-07-27 HU HUE18174165A patent/HUE051702T2/hu unknown
- 2011-07-27 PT PT181741653T patent/PT3434346T/pt unknown
- 2011-07-27 SG SG10201506030RA patent/SG10201506030RA/en unknown
-
2017
- 2017-02-03 US US15/423,928 patent/US10072083B2/en active Active
-
2018
- 2018-09-07 US US16/124,441 patent/US10556955B2/en not_active Expired - Fee Related
-
2020
- 2020-02-10 US US16/786,634 patent/US11136396B2/en not_active Expired - Fee Related
-
2021
- 2021-07-14 HU HUS2100027C patent/HUS2100027I1/hu unknown
- 2021-07-15 NO NO2021030C patent/NO2021030I1/no unknown
- 2021-07-29 LT LTPA2021517C patent/LTPA2021517I1/lt unknown
- 2021-09-02 US US17/465,092 patent/US20210395370A1/en not_active Abandoned
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