JP2013533304A5 - - Google Patents
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- Publication number
- JP2013533304A5 JP2013533304A5 JP2013523659A JP2013523659A JP2013533304A5 JP 2013533304 A5 JP2013533304 A5 JP 2013533304A5 JP 2013523659 A JP2013523659 A JP 2013523659A JP 2013523659 A JP2013523659 A JP 2013523659A JP 2013533304 A5 JP2013533304 A5 JP 2013533304A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- lantibiotic
- type
- treatment
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 52
- 238000009472 formulation Methods 0.000 claims description 50
- 108010062877 Bacteriocins Proteins 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 235000014666 liquid concentrate Nutrition 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 125000005842 heteroatom Chemical group 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000000872 buffer Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- 208000035143 Bacterial infection Diseases 0.000 claims description 4
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 229960003085 meticillin Drugs 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 125000004043 oxo group Chemical group O=* 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims description 4
- 241000191967 Staphylococcus aureus Species 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000011859 microparticle Substances 0.000 claims description 3
- 235000000346 sugar Nutrition 0.000 claims description 3
- 150000008163 sugars Chemical class 0.000 claims description 3
- ICIJWOWQUHHETJ-UHFFFAOYSA-N (3,5-dichlorophenyl)methanamine Chemical compound NCC1=CC(Cl)=CC(Cl)=C1 ICIJWOWQUHHETJ-UHFFFAOYSA-N 0.000 claims description 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 2
- 108010053762 deoxyactagardine B Proteins 0.000 claims description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000008504 concentrate Nutrition 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 239000013020 final formulation Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 125000004404 heteroalkyl group Chemical group 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 description 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1013513.5A GB201013513D0 (en) | 2010-08-11 | 2010-08-11 | Formulations |
| GB1013513.5 | 2010-08-11 | ||
| PCT/GB2011/001191 WO2012020219A2 (en) | 2010-08-11 | 2011-08-09 | Formulations for infusion of type b lantibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533304A JP2013533304A (ja) | 2013-08-22 |
| JP2013533304A5 true JP2013533304A5 (https=) | 2014-09-18 |
| JP5865374B2 JP5865374B2 (ja) | 2016-02-17 |
Family
ID=42931511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523659A Expired - Fee Related JP5865374B2 (ja) | 2010-08-11 | 2011-08-09 | Ｂ型ランチビオティックの点滴用製剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9192569B2 (https=) |
| EP (1) | EP2603204A2 (https=) |
| JP (1) | JP5865374B2 (https=) |
| CN (1) | CN103108628B (https=) |
| CA (1) | CA2807206A1 (https=) |
| EA (1) | EA024344B1 (https=) |
| GB (1) | GB201013513D0 (https=) |
| MX (1) | MX2013001470A (https=) |
| WO (1) | WO2012020219A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4067368A1 (en) | 2016-06-01 | 2022-10-05 | Athira Pharma, Inc. | Compounds |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| CN109620979B (zh) * | 2018-12-29 | 2020-09-01 | 福建师范大学 | 低离子休克提高氨基糖苷类抗生素杀灭持留菌效率的方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1013513A (en) | 1963-03-25 | 1965-12-15 | Watney Combe Reid & Co Ltd | Improvements in and relating to hopping beer |
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| GB8507528D0 (en) | 1985-03-22 | 1985-05-01 | Lepetit Spa | Basis monocarboxyamide derivatives |
| US5304540A (en) | 1988-06-22 | 1994-04-19 | Applied Microbiology, Inc. | Pharmaceutical bacteriocin compositions and methods for using the same |
| IN167138B (https=) | 1988-08-17 | 1990-09-01 | Hoechst India | |
| GB8926639D0 (en) | 1989-11-24 | 1990-01-17 | Agricultural & Food Res | Delayed release formulations |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| IT1260505B (it) | 1992-06-01 | 1996-04-09 | Poli Ind Chimica Spa | Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon |
| IL107887A (en) | 1992-12-08 | 2003-07-06 | Ambi Inc | Stabilized lanthionine containing bacteriocin compositions |
| US5512269A (en) * | 1993-06-09 | 1996-04-30 | Burroughs Wellcome, Co. | Method of treating retained pulmonary secretions |
| EP0700998B1 (en) | 1994-09-12 | 2003-11-26 | Aventis Pharma Deutschland GmbH | Recombinant mersacidin and a method for production |
| CN1138560C (zh) | 1995-06-23 | 2004-02-18 | Ambi股份有限公司 | 控制对抗生素耐药的革兰氏阳性细菌的方法和治疗感染的方法 |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US5958873A (en) | 1997-06-09 | 1999-09-28 | University Of Cincinnati | Oral formulation for treatment of bacteria-induced diseases of the colon |
| US5985823A (en) | 1997-06-09 | 1999-11-16 | Ambi Inc. | Method for the treatment of diarrheal disease and for eliminating particular bacterial populations from the colon |
| DE19745583A1 (de) | 1997-10-15 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben |
| US6569830B1 (en) | 1999-03-05 | 2003-05-27 | Ambi, Inc. | Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains |
| JP2004501191A (ja) | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| ATE273695T1 (de) | 2000-06-28 | 2004-09-15 | Smithkline Beecham Plc | Nassvermahlung |
| GB0110432D0 (en) | 2001-04-27 | 2001-06-20 | Plant Bioscience Ltd | Lantibiotic production |
| WO2002103010A1 (en) | 2001-06-14 | 2002-12-27 | Plant Bioscience Limited | Methods and materials for targeted gene disruption in actinomycete bacteria |
| US6861236B2 (en) | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
| JP2006502713A (ja) | 2002-10-10 | 2006-01-26 | モリケム メディシンズ， インコーポレイテッド | デュラマイシンをコードする核酸 |
| MXPA05004121A (es) * | 2002-10-18 | 2006-02-17 | Molichem Medicines Inc | Metodos para tratar la enfermedad de ojo reseco con lantibioticos. |
| US7351687B2 (en) | 2003-07-18 | 2008-04-01 | Vicuron Pharmaceuticals, Inc. | Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof |
| ES2281808T3 (es) | 2003-07-18 | 2007-10-01 | Vicuron Pharmaceuticals, Inc. | Antibiotico 107891, sus factores a1 y a2, composiciones y sales farmaceuticamente aceptables y uso del mismo. |
| US20050271650A1 (en) | 2004-02-17 | 2005-12-08 | Cellmatrix, Inc. | Method and composition for angiogenesis inhibition |
| GB0406870D0 (en) | 2004-03-26 | 2004-04-28 | Novacta Biosystems Ltd | Improvements relating to the production of lantibiotics |
| JP2009509519A (ja) | 2005-09-27 | 2009-03-12 | ノヴァクタ バイオシステムズ リミティッド | ランチビオティックメルサシジンの変種およびそれらの使用 |
| GB0600928D0 (en) * | 2006-01-17 | 2006-02-22 | Novacta Biosystems Ltd | Improvements relating to lantibiotics |
| KR20120038021A (ko) | 2006-10-27 | 2012-04-20 | 화이자 프로덕츠 인코포레이티드 | 하이드록시프로필 메틸 셀룰로스 경질 캡슐 및 이의 제조 방법 |
| CA2690267A1 (en) | 2007-06-12 | 2008-12-18 | The University Of British Columbia | Small cationic antimicrobial peptides |
| GB0714030D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| GB0714029D0 (en) | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | Lantibiotic-based compounds having antimicrobial activity |
| WO2010058238A1 (en) | 2008-11-24 | 2010-05-27 | Sentinella Pharmaceuticals, Inc. ("Sentinella") | Lantibiotic carboxyamide derivatives with enhanced antibacterial activity |
| SI2387580T1 (sl) | 2009-01-14 | 2014-11-28 | Novacta Biosystems Limited | Deoksiaktagardinski derivati |
| GB0900599D0 (en) | 2009-01-14 | 2009-02-18 | Novacta Biosystems Ltd | Treatment |
| MX2011008043A (es) | 2009-02-04 | 2011-08-17 | Novacta Biosystems Ltd | Derivados de actagardina. |
| JP5852966B2 (ja) * | 2010-02-02 | 2016-02-03 | ノヴァクタ バイオシステムズ リミティッド | ランチビオティックの塩 |
| GB201001688D0 (en) | 2010-02-02 | 2010-03-17 | Novacta Biosystems Ltd | Compounds |
| US20130171252A1 (en) | 2010-07-14 | 2013-07-04 | Novacta Biosystems Limited | Formulation Comprising a Type B Lantibiotic |
-
2010
- 2010-08-11 GB GBGB1013513.5A patent/GB201013513D0/en not_active Ceased
-
2011
- 2011-08-09 US US13/816,063 patent/US9192569B2/en not_active Expired - Fee Related
- 2011-08-09 CN CN201180038723.5A patent/CN103108628B/zh not_active Expired - Fee Related
- 2011-08-09 CA CA2807206A patent/CA2807206A1/en not_active Abandoned
- 2011-08-09 EA EA201291463A patent/EA024344B1/ru not_active IP Right Cessation
- 2011-08-09 JP JP2013523659A patent/JP5865374B2/ja not_active Expired - Fee Related
- 2011-08-09 EP EP11749878.2A patent/EP2603204A2/en not_active Withdrawn
- 2011-08-09 MX MX2013001470A patent/MX2013001470A/es not_active Application Discontinuation
- 2011-08-09 WO PCT/GB2011/001191 patent/WO2012020219A2/en not_active Ceased
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