JP2013533230A5 - - Google Patents
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- Publication number
- JP2013533230A5 JP2013533230A5 JP2013513755A JP2013513755A JP2013533230A5 JP 2013533230 A5 JP2013533230 A5 JP 2013533230A5 JP 2013513755 A JP2013513755 A JP 2013513755A JP 2013513755 A JP2013513755 A JP 2013513755A JP 2013533230 A5 JP2013533230 A5 JP 2013533230A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- buprenorphine
- flowable composition
- prodrug
- thermoplastic polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 33
- 230000009969 flowable effect Effects 0.000 claims 18
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 13
- 229960001736 buprenorphine Drugs 0.000 claims 13
- 239000002207 metabolite Substances 0.000 claims 13
- 229940002612 prodrug Drugs 0.000 claims 13
- 239000000651 prodrug Substances 0.000 claims 13
- 229920001169 thermoplastic Polymers 0.000 claims 12
- 239000007788 liquid Substances 0.000 claims 10
- 239000007943 implant Substances 0.000 claims 9
- 210000001124 body fluid Anatomy 0.000 claims 5
- 239000010839 body fluid Substances 0.000 claims 5
- 229920000728 polyester Polymers 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 239000012736 aqueous medium Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 208000026251 Opioid-Related disease Diseases 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 210000000476 body water Anatomy 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 150000001991 dicarboxylic acids Chemical class 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 150000003951 lactams Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 201000005040 opiate dependence Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 239000003361 porogen Substances 0.000 claims 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1009549.5 | 2010-06-08 | ||
| GB1009549.5A GB2481018B (en) | 2010-06-08 | 2010-06-08 | Injectable flowable composition comprising buprenorphine |
| PCT/GB2011/051057 WO2011154724A2 (en) | 2010-06-08 | 2011-06-06 | Compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016110259A Division JP6251774B2 (ja) | 2010-06-08 | 2016-06-01 | 組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533230A JP2013533230A (ja) | 2013-08-22 |
| JP2013533230A5 true JP2013533230A5 (enExample) | 2014-07-24 |
| JP5986072B2 JP5986072B2 (ja) | 2016-09-06 |
Family
ID=42471306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513755A Expired - Fee Related JP5986072B2 (ja) | 2010-06-08 | 2011-06-06 | 組成物 |
| JP2016110259A Active JP6251774B2 (ja) | 2010-06-08 | 2016-06-01 | 組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016110259A Active JP6251774B2 (ja) | 2010-06-08 | 2016-06-01 | 組成物 |
Country Status (32)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8470359B2 (en) | 2000-11-13 | 2013-06-25 | Qlt Usa, Inc. | Sustained release polymer |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| GB2481018B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| WO2013126552A1 (en) * | 2012-02-21 | 2013-08-29 | Auburn University | Buprenorphine nanoparticle composition and methods thereof |
| ES2716570T3 (es) | 2012-04-17 | 2019-06-13 | Purdue Pharma Lp | Sistemas y procedimientos para tratar o prevenir una respuesta farmacodinámica adversa inducida por opioides |
| AU2013294915C1 (en) | 2012-07-26 | 2019-11-21 | Camurus Ab | Opioid formulations |
| ES2837803T3 (es) * | 2012-07-26 | 2021-07-01 | Camurus Ab | Formulaciones de opioides |
| EP2931253A1 (en) * | 2012-12-13 | 2015-10-21 | Heron Therapeutics, Inc. | Pharmaceutical composition comprising antiemetic compounds and polyorthoester |
| US9636308B2 (en) | 2013-03-15 | 2017-05-02 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| US9592227B2 (en) * | 2013-03-15 | 2017-03-14 | Heron Therapeutics, Inc. | Compositions of a polyorthoester and an aprotic solvent |
| US9393211B2 (en) | 2013-03-15 | 2016-07-19 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
| GB201404139D0 (en) * | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| EP3509601A1 (en) | 2014-04-21 | 2019-07-17 | Heron Therapeutics, Inc. | A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam |
| JP6723162B2 (ja) * | 2014-04-21 | 2020-07-15 | ヘロン セラピューティクス， インコーポレイテッドＨｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ポリオルトエステルおよび有機酸添加剤の組成物 |
| US9801945B2 (en) | 2014-04-21 | 2017-10-31 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| CN106535886A (zh) | 2014-04-21 | 2017-03-22 | 赫伦治疗有限公司 | 长效聚合物输送系统 |
| AU2015253417B2 (en) | 2014-04-28 | 2020-02-20 | Dimerx, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
| GB201419091D0 (en) * | 2014-10-27 | 2014-12-10 | Camurus Ab | Formulations |
| US20160128997A1 (en) * | 2014-11-07 | 2016-05-12 | Indivior Uk Limited | Sustained-release buprenorphine formulations |
| US10786515B2 (en) | 2015-08-03 | 2020-09-29 | Tolmar International Limited | Liquid polymer delivery system for extended administration of drugs |
| AU2016355236C1 (en) | 2015-11-16 | 2022-09-22 | Medincell | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
| PL3512518T3 (pl) * | 2016-09-13 | 2023-03-27 | Alar Pharmaceuticals Inc. | Preparaty buprenorfiny o przedłużonym uwalnianiu |
| US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
| NZ760033A (en) | 2017-06-16 | 2023-02-24 | Indivior Uk Ltd | Methods to treat opioid use disorder |
| WO2019144079A1 (en) | 2018-01-22 | 2019-07-25 | Yuhua Li | Pharmaceutical composition for sustained release delivery of buprenorphine |
| TWI838372B (zh) | 2018-05-11 | 2024-04-11 | 昱展新藥生技股份有限公司 | 丁基原啡因衍生物之長效注射劑型及結晶型 |
| WO2020077235A1 (en) | 2018-10-11 | 2020-04-16 | Indivior Uk Limited | Buprenorphine to treat respiratory depression |
| US12403291B2 (en) * | 2019-08-30 | 2025-09-02 | Intersect Ent, Inc. | Submucosal bioresorbable drug eluting platform |
| CN118831057A (zh) * | 2023-04-25 | 2024-10-25 | 深圳善康医药科技股份有限公司 | 丁丙诺啡植入剂及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| EP1125577B1 (en) | 1994-04-08 | 2006-02-15 | QLT USA, Inc. | Liquid drug delivery compositions |
| US20030211157A1 (en) * | 1996-05-06 | 2003-11-13 | Simon David Lew | Semi-sol delivery blend for water soluble molecules |
| US6143314A (en) * | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
| US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| PT2561860T (pt) * | 2002-05-31 | 2018-05-08 | Titan Pharmaceuticals Inc | Dispositivo polimérico implantável para a libertação prolongada de buprenorfina |
| US7368126B2 (en) * | 2002-11-06 | 2008-05-06 | Guohua Chen | Controlled release depot formulations |
| WO2004081196A2 (en) * | 2003-03-11 | 2004-09-23 | Qlt Usa Inc. | Formulations for cell- schedule dependent anticancer agents |
| CA2582374A1 (en) * | 2004-10-04 | 2006-04-20 | Qlt Usa, Inc. | Ocular delivery of polymeric delivery formulations |
| EP1824460B1 (en) * | 2004-11-10 | 2014-12-24 | Tolmar Therapeutics, Inc. | A stabilized polymeric delivery system |
| EP3202814B1 (en) | 2007-02-15 | 2019-10-16 | Tolmar Therapeutics, Inc. | Low burst poly-(lactide/glycolide) and methods to produce polymers |
| US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
| GB2481018B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
-
2010
- 2010-06-08 GB GB1009549.5A patent/GB2481018B/en active Active
- 2010-06-08 GB GB1413064.5A patent/GB2513267B/en active Active
-
2011
- 2011-06-06 HR HRP20180118TT patent/HRP20180118T1/hr unknown
- 2011-06-06 DK DK17205986.7T patent/DK3360538T3/da active
- 2011-06-06 DK DK11728037.0T patent/DK2579874T3/da active
- 2011-06-06 PL PL11728037T patent/PL2579874T3/pl unknown
- 2011-06-06 NO NO11728037A patent/NO2579874T3/no unknown
- 2011-06-06 SI SI201131401T patent/SI2579874T1/en unknown
- 2011-06-06 EP EP17205986.7A patent/EP3360538B1/en active Active
- 2011-06-06 WO PCT/GB2011/051057 patent/WO2011154724A2/en not_active Ceased
- 2011-06-06 EP EP11728037.0A patent/EP2579874B1/en active Active
- 2011-06-06 BR BR112012031290A patent/BR112012031290A2/pt not_active Application Discontinuation
- 2011-06-06 JP JP2013513755A patent/JP5986072B2/ja not_active Expired - Fee Related
- 2011-06-06 PT PT117280370T patent/PT2579874T/pt unknown
- 2011-06-06 LT LTEP11728037.0T patent/LT2579874T/lt unknown
- 2011-06-06 MX MX2012014335A patent/MX339209B/es active IP Right Grant
- 2011-06-06 SM SM20180038T patent/SMT201800038T1/it unknown
- 2011-06-06 AU AU2011263478A patent/AU2011263478B2/en active Active
- 2011-06-06 US US13/703,013 patent/US8921387B2/en active Active
- 2011-06-06 HU HUE11728037A patent/HUE038275T2/hu unknown
- 2011-06-06 CA CA2801676A patent/CA2801676C/en active Active
- 2011-06-06 RS RS20180068A patent/RS56820B1/sr unknown
- 2011-06-06 KR KR1020127032282A patent/KR101865689B1/ko not_active Expired - Fee Related
- 2011-06-06 ES ES11728037.0T patent/ES2656938T3/es active Active
- 2011-06-06 CN CN201180039223.3A patent/CN103079544B/zh not_active Expired - Fee Related
- 2011-06-06 RU RU2012157244A patent/RU2607498C2/ru not_active IP Right Cessation
- 2011-06-06 EP EP23150636.1A patent/EP4218720A1/en active Pending
- 2011-06-06 SG SG2012089652A patent/SG186200A1/en unknown
- 2011-06-06 NZ NZ604026A patent/NZ604026A/en unknown
- 2011-06-06 FI FIEP17205986.7T patent/FI3360538T3/fi active
- 2011-06-06 MY MYPI2012005274A patent/MY171625A/en unknown
- 2011-06-06 ES ES17205986T patent/ES2939612T3/es active Active
-
2012
- 2012-12-06 ZA ZA2012/09233A patent/ZA201209233B/en unknown
- 2012-12-06 IL IL223488A patent/IL223488A/en active IP Right Grant
- 2012-12-07 CL CL2012003462A patent/CL2012003462A1/es unknown
-
2013
- 2013-01-04 CO CO13001795A patent/CO6670529A2/es unknown
-
2016
- 2016-06-01 JP JP2016110259A patent/JP6251774B2/ja active Active
-
2017
- 2017-09-11 IL IL254417A patent/IL254417A0/en unknown
-
2018
- 2018-01-24 CY CY181100098T patent/CY1120761T1/el unknown
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