JP2013530937A5 - - Google Patents

Info

Publication number

JP2013530937A5

JP2013530937A5 JP2013508502A JP2013508502A JP2013530937A5 JP 2013530937 A5 JP2013530937 A5 JP 2013530937A5 JP 2013508502 A JP2013508502 A JP 2013508502A JP 2013508502 A JP2013508502 A JP 2013508502A JP 2013530937 A5 JP2013530937 A5 JP 2013530937A5

Authority

JP

Japan

Prior art keywords

alkyl

alkoxy

halogen

phenyl

formula

Prior art date

2011-05-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 28
• 125000003545 alkoxy group Chemical group 0.000 claims 18
• 229910052736 halogen Inorganic materials 0.000 claims 18
• 150000002367 halogens Chemical class 0.000 claims 18
• 150000003839 salts Chemical class 0.000 claims 17
• 239000012453 solvate Substances 0.000 claims 15
• -1 trifluoromethoxy, phenoxy, cyclohexylmethyloxy, pyridylmethoxy, cinnamyloxy, naphthylmethoxy, phenoxymethyl Chemical group 0.000 claims 12
• 150000001875 compounds Chemical class 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
• 229910052799 carbon Inorganic materials 0.000 claims 8
• 125000004953 trihalomethyl group Chemical group 0.000 claims 8
• 125000004414 alkyl thio group Chemical group 0.000 claims 6
• 125000003710 aryl alkyl group Chemical group 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• 150000004677 hydrates Chemical class 0.000 claims 6
• 229910052760 oxygen Inorganic materials 0.000 claims 6
• 229910052717 sulfur Inorganic materials 0.000 claims 6
• 238000011282 treatment Methods 0.000 claims 6
• 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 4
• 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
• 125000004849 alkoxymethyl group Chemical group 0.000 claims 4
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims 4
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 4
• 206010025135 lupus erythematosus Diseases 0.000 claims 4
• 230000002265 prevention Effects 0.000 claims 4
• XXHKHLYABSAFDW-UHFFFAOYSA-N 5-amino-5-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]pentane-1,3-diol Chemical compound C1=C(Cl)C(C(CC(O)CCO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 XXHKHLYABSAFDW-UHFFFAOYSA-N 0.000 claims 3
• 241000023320 Luma <angiosperm> Species 0.000 claims 3
• 208000004921 cutaneous lupus erythematosus Diseases 0.000 claims 3
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims 3
• 208000024891 symptom Diseases 0.000 claims 3
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 2
• 125000002252 acyl group Chemical group 0.000 claims 2
• 230000002411 adverse Effects 0.000 claims 2
• 125000001931 aliphatic group Chemical group 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 125000006372 monohalo methyl group Chemical group 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
• 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
• 208000006926 Discoid Lupus Erythematosus Diseases 0.000 claims 1
• JZHXIFZZZFFZBQ-XMMPIXPASA-N [(2r)-2-amino-4-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=C(Cl)C(CC[C@](CO)(N)COP(O)(O)=O)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 JZHXIFZZZFFZBQ-XMMPIXPASA-N 0.000 claims 1
• JZHXIFZZZFFZBQ-DEOSSOPVSA-N [(2s)-2-amino-4-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=C(Cl)C(CC[C@@](CO)(N)COP(O)(O)=O)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 JZHXIFZZZFFZBQ-DEOSSOPVSA-N 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 208000011830 chronic cutaneous lupus erythematosus Diseases 0.000 claims 1
• 230000001969 hypertrophic effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 206010057887 neonatal lupus erythematosus Diseases 0.000 claims 1
• 230000001613 neoplastic effect Effects 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 238000011519 second-line treatment Methods 0.000 claims 1
• 208000011834 subacute cutaneous lupus erythematosus Diseases 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• IINUNQPYJGJCJI-UHFFFAOYSA-N NC(CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)CO Chemical compound NC(CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)CO IINUNQPYJGJCJI-UHFFFAOYSA-N 0.000 description 1