PE20130612A1 - Tratamiento de enfermedades autoinmunes - Google Patents

Tratamiento de enfermedades autoinmunes

Info

Publication number
PE20130612A1
PE20130612A1 PE2012002122A PE2012002122A PE20130612A1 PE 20130612 A1 PE20130612 A1 PE 20130612A1 PE 2012002122 A PE2012002122 A PE 2012002122A PE 2012002122 A PE2012002122 A PE 2012002122A PE 20130612 A1 PE20130612 A1 PE 20130612A1
Authority
PE
Peru
Prior art keywords
halogen
alkyl
treatment
benzyloxy
phenyl
Prior art date
Application number
PE2012002122A
Other languages
English (en)
Inventor
Peter Gergely
Erik Wallstroem
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42199281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130612(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20130612A1 publication Critical patent/PE20130612A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/30—Sulfides having the sulfur atom of at least one thio group bound to two carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES HALOGENO, TRIHALOGENOMETILO, OH, ALQUILO C1-C7, TRIFLUOROMETOXI, ENTRE OTROS; R2 ES H, HALOGENO, ALCOXI C1-C4, FENETILO, BENCILOXI, ENTRE OTROS; R3 ES H, HALOGENO, CF3, ALQUILO C1-C7, FENILO, ENTRE OTROS; R4 Y R5 SON CADA UNO H , UN RESIDUO DE FORMULA (a); R8 Y R9 SON CADA UNO H O ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO POR HALOGENO; n ES UN ENTERO DE 1 - 4; X ES O, SO, S, SO2. SON COMPUESTOS PREFERIDOS: 2-AMINO-2-[4-(3-BENCILOXIFENILTIO)-2-CLOROFENIL] ETIL-PROPANO-1,3-DIOL; ESTER MONO-{(S)-2-AMINO-4-[4-(3-BENCILOXI-FENILSULFANIL)-2-CLORO-FENIL]-2-HIDROXIMETIL-BUTILICO} DEL ACIDO FOSFORICO; ENTRE OTROS. DICHO COMPUESTO ES UN INMUNOSUPRESOR BIEN TOLERADO Y CON UN PERFIL DE SEGURIDAD FAVORABLE UTIL EN EL TRATAMIENTO DE LUPUS ERITEMATOSO SUBCUTANEO AGUDO.
PE2012002122A 2010-05-06 2011-05-05 Tratamiento de enfermedades autoinmunes PE20130612A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10162079 2010-05-06

Publications (1)

Publication Number Publication Date
PE20130612A1 true PE20130612A1 (es) 2013-06-06

Family

ID=42199281

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012002122A PE20130612A1 (es) 2010-05-06 2011-05-05 Tratamiento de enfermedades autoinmunes

Country Status (23)

Country Link
US (1) US20130172297A1 (es)
EP (1) EP2566470A1 (es)
JP (1) JP2013530937A (es)
KR (1) KR20130066630A (es)
CN (1) CN102869353A (es)
AU (1) AU2011249784B2 (es)
BR (1) BR112012028190A2 (es)
CA (1) CA2795394A1 (es)
CL (1) CL2012003091A1 (es)
CR (1) CR20120566A (es)
CU (1) CU20120154A7 (es)
EA (1) EA201201514A1 (es)
EC (1) ECSP12012312A (es)
IL (1) IL222690A0 (es)
MA (1) MA34285B1 (es)
MX (1) MX2012012926A (es)
NZ (1) NZ603999A (es)
PE (1) PE20130612A1 (es)
SG (1) SG185746A1 (es)
TN (1) TN2012000509A1 (es)
TW (1) TW201201814A (es)
WO (1) WO2011138393A1 (es)
ZA (1) ZA201207710B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI519539B (zh) 2010-12-21 2016-02-01 Kyorin Seiyaku Kk Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof
US9289494B2 (en) 2013-11-20 2016-03-22 RestorTears, LLC Method of treating ocular disorders with compounds found in Harderian gland secretions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1431275B1 (en) * 2001-09-27 2010-04-07 Kyorin Pharmaceutical Co., Ltd. Diaryl ether derivative, addition salt thereof, and immunosuppressant
CN1329372C (zh) 2001-09-27 2007-08-01 杏林制药株式会社 二芳基硫醚衍生物及其加成盐和免疫抑制剂
MXPA05003080A (es) 2002-09-19 2005-06-15 Kyorin Seiyaku Kk Derivado de amino alcohol, sales de los mismos y agentes inmunosupresores.
KR101005171B1 (ko) * 2003-02-18 2011-01-04 교린 세이야꾸 가부시키 가이샤 아미노포스폰산 유도체와 그 부가염 및 ｓ1ｐ 수용체조절제
DE602004029355D1 (de) * 2003-05-26 2010-11-11 Takeda Pharmaceutical Sulfopyrrolderivate
CA2535704C (en) 2003-08-28 2012-12-11 Novartis Ag Aminopropanol derivatives
DK1723138T3 (da) * 2004-02-11 2010-08-23 Basilea Pharmaceutica Ag Substituerede benzimidazoler og deres anvendelse til at inducere apoptose
JPWO2006041015A1 (ja) * 2004-10-12 2008-05-15 杏林製薬株式会社 アミノアルコール誘導体とその付加塩及び免疫抑制剤
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
PT2295049E (pt) * 2005-09-09 2015-03-02 Novartis Ag Tratamento de doenças auto-imunes

Also Published As

Publication number Publication date
SG185746A1 (en) 2013-01-30
NZ603999A (en) 2014-06-27
JP2013530937A (ja) 2013-08-01
AU2011249784B2 (en) 2014-03-06
TW201201814A (en) 2012-01-16
KR20130066630A (ko) 2013-06-20
ECSP12012312A (es) 2012-12-28
EA201201514A1 (ru) 2013-05-30
TN2012000509A1 (en) 2014-04-01
EP2566470A1 (en) 2013-03-13
CR20120566A (es) 2013-01-09
AU2011249784A1 (en) 2012-12-20
CU20120154A7 (es) 2013-03-27
MA34285B1 (fr) 2013-06-01
US20130172297A1 (en) 2013-07-04
WO2011138393A1 (en) 2011-11-10
IL222690A0 (en) 2012-12-31
BR112012028190A2 (pt) 2016-08-02
CL2012003091A1 (es) 2013-03-22
ZA201207710B (en) 2013-06-26
CA2795394A1 (en) 2011-11-10
MX2012012926A (es) 2012-12-17
CN102869353A (zh) 2013-01-09

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal