JP2013525469A5 - - Google Patents
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- Publication number
- JP2013525469A5 JP2013525469A5 JP2013508506A JP2013508506A JP2013525469A5 JP 2013525469 A5 JP2013525469 A5 JP 2013525469A5 JP 2013508506 A JP2013508506 A JP 2013508506A JP 2013508506 A JP2013508506 A JP 2013508506A JP 2013525469 A5 JP2013525469 A5 JP 2013525469A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- formula
- halogen
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 150000002367 halogens Chemical class 0.000 claims 18
- 239000012453 solvate Substances 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 8
- -1 trifluoromethoxy, phenoxy, cyclohexylmethyloxy, pyridylmethoxy, cinnamyloxy, naphthylmethoxy, phenoxymethyl Chemical group 0.000 claims 8
- 125000004953 trihalomethyl group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 4
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 4
- XXHKHLYABSAFDW-UHFFFAOYSA-N 5-amino-5-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]pentane-1,3-diol Chemical compound C1=C(Cl)C(C(CC(O)CCO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 XXHKHLYABSAFDW-UHFFFAOYSA-N 0.000 claims 4
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 4
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 2
- JZHXIFZZZFFZBQ-XMMPIXPASA-N [(2r)-2-amino-4-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=C(Cl)C(CC[C@](CO)(N)COP(O)(O)=O)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 JZHXIFZZZFFZBQ-XMMPIXPASA-N 0.000 claims 2
- JZHXIFZZZFFZBQ-DEOSSOPVSA-N [(2s)-2-amino-4-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=C(Cl)C(CC[C@@](CO)(N)COP(O)(O)=O)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 JZHXIFZZZFFZBQ-DEOSSOPVSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000006372 monohalo methyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 206010003671 Atrioventricular Block Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000003288 anthiarrhythmic effect Effects 0.000 claims 1
- 239000003416 antiarrhythmic agent Substances 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 230000002763 arrhythmic effect Effects 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000011221 initial treatment Methods 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 206010042772 syncope Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 0 **C(*)C(*)(*)N Chemical compound **C(*)C(*)(*)N 0.000 description 1
- JLFCVPLJWDRWDT-VWLOTQADSA-N C=P(O)(O)OC[C@](CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)N Chemical compound C=P(O)(O)OC[C@](CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)N JLFCVPLJWDRWDT-VWLOTQADSA-N 0.000 description 1
- NYPIIMZBDFKVOJ-RUZDIDTESA-N CP(O)(OC[C@@](CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)N)=O Chemical compound CP(O)(OC[C@@](CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)N)=O NYPIIMZBDFKVOJ-RUZDIDTESA-N 0.000 description 1
- IINUNQPYJGJCJI-UHFFFAOYSA-N NC(CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)CO Chemical compound NC(CCc(c(Cl)c1)ccc1Sc1cc(OCc2ccccc2)ccc1)(CO)CO IINUNQPYJGJCJI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10162082 | 2010-05-06 | ||
| EP10162082.1 | 2010-05-06 | ||
| PCT/EP2011/057210 WO2011138398A1 (en) | 2010-05-06 | 2011-05-05 | Dosage regimen of diaryl sulfide derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016081108A Division JP6290963B2 (ja) | 2010-05-06 | 2016-04-14 | ジアリールスルフィド誘導体の投与レジメン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013525469A JP2013525469A (ja) | 2013-06-20 |
| JP2013525469A5 true JP2013525469A5 (https=) | 2014-05-29 |
Family
ID=42236590
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508506A Withdrawn JP2013525469A (ja) | 2010-05-06 | 2011-05-05 | ジアリールスルフィド誘導体の投与レジメン |
| JP2016081108A Expired - Fee Related JP6290963B2 (ja) | 2010-05-06 | 2016-04-14 | ジアリールスルフィド誘導体の投与レジメン |
| JP2018020950A Active JP6615247B2 (ja) | 2010-05-06 | 2018-02-08 | ジアリールスルフィド誘導体の投与レジメン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016081108A Expired - Fee Related JP6290963B2 (ja) | 2010-05-06 | 2016-04-14 | ジアリールスルフィド誘導体の投与レジメン |
| JP2018020950A Active JP6615247B2 (ja) | 2010-05-06 | 2018-02-08 | ジアリールスルフィド誘導体の投与レジメン |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20130210924A1 (https=) |
| EP (1) | EP2566473B1 (https=) |
| JP (3) | JP2013525469A (https=) |
| KR (1) | KR20130098885A (https=) |
| CN (2) | CN102917698A (https=) |
| AU (1) | AU2011249789B2 (https=) |
| BR (1) | BR112012028248A2 (https=) |
| CA (1) | CA2794607A1 (https=) |
| EA (1) | EA201201515A1 (https=) |
| ES (1) | ES2562416T3 (https=) |
| MX (1) | MX2012012925A (https=) |
| WO (1) | WO2011138398A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI519539B (zh) * | 2010-12-21 | 2016-02-01 | Kyorin Seiyaku Kk | Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof |
| US20160000811A1 (en) | 2013-02-20 | 2016-01-07 | Novartis Ag | Treatment of graft versus host disease in transplant patients |
| EP4248958A3 (en) * | 2021-01-28 | 2024-01-03 | Priothera SAS | Methods of treatment with s1p receptor modulators |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1431275B1 (en) | 2001-09-27 | 2010-04-07 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivative, addition salt thereof, and immunosuppressant |
| MXPA04002679A (es) * | 2001-09-27 | 2004-07-30 | Kyorin Seiyaku Kk | Derivados de sulfuro de diarilo, sales de los mismos y agentes inmunosupresores que utilizan los mismos. |
| KR101003877B1 (ko) * | 2002-09-19 | 2010-12-30 | 교린 세이야꾸 가부시키 가이샤 | 아미노알코올 유도체와 그 부가염 및 면역 억제제 |
| US7456157B2 (en) | 2003-02-18 | 2008-11-25 | Kyorin Pharmaceutical Co., Ltd. | Aminophosphonic acid derivatives, addition salts thereof and S1P receptor modulators |
| CN1874996B (zh) | 2003-08-28 | 2011-05-18 | 诺瓦提斯公司 | 氨基丙醇衍生物 |
| CN101014329B (zh) * | 2004-07-16 | 2010-09-08 | 杏林制药株式会社 | 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物 |
| WO2006041015A1 (ja) * | 2004-10-12 | 2006-04-20 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| KR20140095109A (ko) * | 2004-11-29 | 2014-07-31 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 용법 |
| SI2295049T1 (sl) * | 2005-09-09 | 2015-03-31 | Novartis Ag | Zdravljenje avtoimunskih bolezni |
| HUE033168T2 (en) * | 2008-03-17 | 2017-11-28 | Actelion Pharmaceuticals Ltd | Dosage regimen for selective SIP1 receptor agonist |
| CN102119028A (zh) * | 2008-08-18 | 2011-07-06 | 诺瓦提斯公司 | 用于治疗脱髓鞘性周围神经病的氨基醇衍生物 |
| CN105213372A (zh) * | 2008-12-22 | 2016-01-06 | 诺华股份有限公司 | S1p受体激动剂的给药方案 |
| RS66784B9 (sr) * | 2008-12-22 | 2025-08-29 | Novartis Ag | Režim doziranјa agonista s1p receptora |
-
2011
- 2011-05-05 EP EP11720419.8A patent/EP2566473B1/en active Active
- 2011-05-05 CA CA2794607A patent/CA2794607A1/en not_active Abandoned
- 2011-05-05 BR BR112012028248A patent/BR112012028248A2/pt not_active IP Right Cessation
- 2011-05-05 ES ES11720419.8T patent/ES2562416T3/es active Active
- 2011-05-05 US US13/643,324 patent/US20130210924A1/en not_active Abandoned
- 2011-05-05 CN CN2011800227113A patent/CN102917698A/zh active Pending
- 2011-05-05 KR KR1020127031867A patent/KR20130098885A/ko not_active Withdrawn
- 2011-05-05 EA EA201201515A patent/EA201201515A1/ru unknown
- 2011-05-05 WO PCT/EP2011/057210 patent/WO2011138398A1/en not_active Ceased
- 2011-05-05 CN CN201610590854.9A patent/CN106309416A/zh active Pending
- 2011-05-05 AU AU2011249789A patent/AU2011249789B2/en not_active Expired - Fee Related
- 2011-05-05 MX MX2012012925A patent/MX2012012925A/es not_active Application Discontinuation
- 2011-05-05 JP JP2013508506A patent/JP2013525469A/ja not_active Withdrawn
-
2014
- 2014-07-28 US US14/341,891 patent/US20140336265A1/en not_active Abandoned
-
2016
- 2016-04-14 JP JP2016081108A patent/JP6290963B2/ja not_active Expired - Fee Related
- 2016-10-19 US US15/297,683 patent/US20170119702A1/en not_active Abandoned
-
2017
- 2017-12-07 US US15/834,482 patent/US20180161290A1/en not_active Abandoned
-
2018
- 2018-02-08 JP JP2018020950A patent/JP6615247B2/ja active Active
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