EA201201515A1 - Схема приема производных диарилсульфидов - Google Patents
Схема приема производных диарилсульфидовInfo
- Publication number
- EA201201515A1 EA201201515A1 EA201201515A EA201201515A EA201201515A1 EA 201201515 A1 EA201201515 A1 EA 201201515A1 EA 201201515 A EA201201515 A EA 201201515A EA 201201515 A EA201201515 A EA 201201515A EA 201201515 A1 EA201201515 A1 EA 201201515A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- halogen
- phenyl
- trihalomethyl
- alkoxy
- Prior art date
Links
- -1 DIARYL SULFIDES Chemical class 0.000 title abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10162082 | 2010-05-06 | ||
| PCT/EP2011/057210 WO2011138398A1 (en) | 2010-05-06 | 2011-05-05 | Dosage regimen of diaryl sulfide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201201515A1 true EA201201515A1 (ru) | 2013-08-30 |
Family
ID=42236590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201201515A EA201201515A1 (ru) | 2010-05-06 | 2011-05-05 | Схема приема производных диарилсульфидов |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20130210924A1 (https=) |
| EP (1) | EP2566473B1 (https=) |
| JP (3) | JP2013525469A (https=) |
| KR (1) | KR20130098885A (https=) |
| CN (2) | CN106309416A (https=) |
| AU (1) | AU2011249789B2 (https=) |
| BR (1) | BR112012028248A2 (https=) |
| CA (1) | CA2794607A1 (https=) |
| EA (1) | EA201201515A1 (https=) |
| ES (1) | ES2562416T3 (https=) |
| MX (1) | MX2012012925A (https=) |
| WO (1) | WO2011138398A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI519539B (zh) * | 2010-12-21 | 2016-02-01 | Kyorin Seiyaku Kk | Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof |
| BR112015019197A2 (pt) | 2013-02-20 | 2017-07-18 | Kyorin Seiyaku Kk | tratamento de doença de enxerto versus hospedeiro em pacientes transplantados |
| AU2022214268A1 (en) * | 2021-01-28 | 2023-07-27 | Priothera Limited | Methods of treatment with s1p receptor modulators |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2461212C (en) * | 2001-09-27 | 2010-08-17 | Kyorin Pharmaceutical Co., Ltd. | Diaryl sulfide derivatives, salts thereof and immunosuppressive agents using the same |
| DE60235900D1 (de) | 2001-09-27 | 2010-05-20 | Kyorin Seiyaku Kk | Osuppressivum |
| JP4571497B2 (ja) * | 2002-09-19 | 2010-10-27 | 杏林製薬株式会社 | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| BRPI0407658A (pt) | 2003-02-18 | 2006-02-21 | Kyorin Seiyaku Kk | derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico |
| ATE449069T1 (de) | 2003-08-28 | 2009-12-15 | Novartis Pharma Gmbh | Aminopropanolderivate |
| US7781617B2 (en) * | 2004-07-16 | 2010-08-24 | Kyorin Pharmaceutical Co., Ltd | Effective use method of medicaments and method of preventing expression of side effect |
| WO2006041015A1 (ja) * | 2004-10-12 | 2006-04-20 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| KR20070085465A (ko) * | 2004-11-29 | 2007-08-27 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 용법 |
| ES2529724T3 (es) * | 2005-09-09 | 2015-02-25 | Novartis Ag | Tratamiento de enfermedades autoinmunes |
| PL2278960T5 (pl) * | 2008-03-17 | 2020-06-29 | Actelion Pharmaceuticals Ltd. | Schemat dawkowania dla selektywnego agonisty receptora sip1 |
| WO2010020609A1 (en) * | 2008-08-18 | 2010-02-25 | Novartis Ag | Amino alcohol derivatives for the treatment of demyelinating peripheral neuropathies |
| JP5657565B2 (ja) * | 2008-12-22 | 2015-01-21 | ノバルティス アーゲー | Ｓ１ｐ受容体アゴニストの投与レジメン |
| TW201028143A (en) * | 2008-12-22 | 2010-08-01 | Novartis Ag | Dosage regimen for a S1P receptor agonist |
-
2011
- 2011-05-05 BR BR112012028248A patent/BR112012028248A2/pt not_active IP Right Cessation
- 2011-05-05 AU AU2011249789A patent/AU2011249789B2/en not_active Expired - Fee Related
- 2011-05-05 CN CN201610590854.9A patent/CN106309416A/zh active Pending
- 2011-05-05 MX MX2012012925A patent/MX2012012925A/es not_active Application Discontinuation
- 2011-05-05 EP EP11720419.8A patent/EP2566473B1/en active Active
- 2011-05-05 JP JP2013508506A patent/JP2013525469A/ja not_active Withdrawn
- 2011-05-05 CN CN2011800227113A patent/CN102917698A/zh active Pending
- 2011-05-05 ES ES11720419.8T patent/ES2562416T3/es active Active
- 2011-05-05 CA CA2794607A patent/CA2794607A1/en not_active Abandoned
- 2011-05-05 WO PCT/EP2011/057210 patent/WO2011138398A1/en not_active Ceased
- 2011-05-05 KR KR1020127031867A patent/KR20130098885A/ko not_active Withdrawn
- 2011-05-05 EA EA201201515A patent/EA201201515A1/ru unknown
- 2011-05-05 US US13/643,324 patent/US20130210924A1/en not_active Abandoned
-
2014
- 2014-07-28 US US14/341,891 patent/US20140336265A1/en not_active Abandoned
-
2016
- 2016-04-14 JP JP2016081108A patent/JP6290963B2/ja not_active Expired - Fee Related
- 2016-10-19 US US15/297,683 patent/US20170119702A1/en not_active Abandoned
-
2017
- 2017-12-07 US US15/834,482 patent/US20180161290A1/en not_active Abandoned
-
2018
- 2018-02-08 JP JP2018020950A patent/JP6615247B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011138398A1 (en) | 2011-11-10 |
| AU2011249789B2 (en) | 2015-03-19 |
| US20170119702A1 (en) | 2017-05-04 |
| US20130210924A1 (en) | 2013-08-15 |
| JP6290963B2 (ja) | 2018-03-07 |
| CA2794607A1 (en) | 2011-11-10 |
| US20140336265A1 (en) | 2014-11-13 |
| MX2012012925A (es) | 2012-12-17 |
| BR112012028248A2 (pt) | 2016-08-02 |
| EP2566473B1 (en) | 2016-01-06 |
| JP2016183159A (ja) | 2016-10-20 |
| JP2018100280A (ja) | 2018-06-28 |
| ES2562416T3 (es) | 2016-03-04 |
| CN102917698A (zh) | 2013-02-06 |
| CN106309416A (zh) | 2017-01-11 |
| JP2013525469A (ja) | 2013-06-20 |
| KR20130098885A (ko) | 2013-09-05 |
| AU2011249789A1 (en) | 2012-12-13 |
| JP6615247B2 (ja) | 2019-12-04 |
| EP2566473A1 (en) | 2013-03-13 |
| US20180161290A1 (en) | 2018-06-14 |
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