|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4475196A
(en)
|
1981-03-06 |
1984-10-02 |
Zor Clair G |
Instrument for locating faults in aircraft passenger reading light and attendant call control system
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4486194A
(en)
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
JPS6081397A
(ja)
|
1983-10-06 |
1985-05-09 |
荒川化学工業株式会社 |
中性抄紙方法
|
|
US4494880A
(en)
|
1984-03-14 |
1985-01-22 |
Su Wen Kuang |
Foldable clock dial
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
AU584417B2
(en)
|
1985-04-01 |
1989-05-25 |
Lonza Group Ag |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
NZ215865A
(en)
|
1985-04-22 |
1988-10-28 |
Commw Serum Lab Commission |
Method of determining the active site of a receptor-binding analogue
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
HU196394B
(en)
|
1986-06-27 |
1988-11-28 |
Richter Gedeon Vegyeszet |
Process for preparing 2-halogenated ergoline derivatives
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
SE461013B
(sv)
|
1988-02-11 |
1989-12-18 |
Christian Wesslau |
Farmaceutisk komposition verksam mot lungobstruktioner bestaaende av en betaadrenerg antagonist och ett tyroideahormon
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
US5272263A
(en)
|
1989-04-28 |
1993-12-21 |
Biogen, Inc. |
DNA sequences encoding vascular cell adhesion molecules (VCAMS)
|
|
US6307025B1
(en)
|
1989-04-28 |
2001-10-23 |
Biogen, Inc. |
VCAM fusion proteins and DNA coding therefor
|
|
US5217870A
(en)
|
1989-04-28 |
1993-06-08 |
Biogen, Inc. |
Monoclonal antibodies against CDX
|
|
US5260210A
(en)
|
1989-09-27 |
1993-11-09 |
Rubin Lee L |
Blood-brain barrier model
|
|
US6033665A
(en)
|
1989-09-27 |
2000-03-07 |
Elan Pharmaceuticals, Inc. |
Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5192746A
(en)
|
1990-07-09 |
1993-03-09 |
Tanabe Seiyaku Co., Ltd. |
Cyclic cell adhesion modulation compounds
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
GB9019812D0
(en)
|
1990-09-11 |
1990-10-24 |
Scotgen Ltd |
Novel antibodies for treatment and prevention of infection in animals and man
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
DK0626861T4
(da)
|
1992-01-13 |
2004-08-16 |
Biogen Inc |
Behandling af astma.
|
|
US5871734A
(en)
|
1992-01-13 |
1999-02-16 |
Biogen, Inc. |
Treatment for asthma with VLA-4 blocking agents
|
|
JPH07506566A
(ja)
|
1992-02-12 |
1995-07-20 |
バイオゲン インコーポレイテッド |
炎症性胃腸病の処置
|
|
US5932214A
(en)
|
1994-08-11 |
1999-08-03 |
Biogen, Inc. |
Treatment for inflammatory bowel disease with VLA-4 blockers
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
DK0670735T3
(da)
|
1992-11-13 |
1997-07-28 |
Univ Washington |
Perifisering af hæmotopoietiske stamceller.
|
|
DK0678122T3
(da)
|
1993-01-12 |
2000-03-06 |
Biogen Inc |
Rekombinante anti-VLA4 antistofmolekyler
|
|
WO1994017818A1
(en)
|
1993-02-08 |
1994-08-18 |
The Syntex-Synergen Neuroscience Joint Venture |
Methods for treating amyotrophic lateral sclerosis with cntf
|
|
WO1994017828A2
(en)
|
1993-02-09 |
1994-08-18 |
Biogen, Inc. |
Treatment for insulin dependent diabetes
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
US6432404B1
(en)
|
1993-12-23 |
2002-08-13 |
Icos Corporation |
Methods of inhibiting locomotor damage following spinal cord injury with α D-specific antibodies
|
|
US5840299A
(en)
*
|
1994-01-25 |
1998-11-24 |
Athena Neurosciences, Inc. |
Humanized antibodies against leukocyte adhesion molecule VLA-4
|
|
EP0804237B8
(en)
|
1994-01-25 |
2006-11-08 |
Elan Pharmaceuticals, Inc. |
Humanized antibodies against leukocyte adhesion molecule vla-4
|
|
US5672622A
(en)
|
1994-04-21 |
1997-09-30 |
Berlex Laboratories, Inc. |
Treatment of multiple sclerosis
|
|
SE504751C2
(sv)
|
1994-06-30 |
1997-04-21 |
Lars Fredriksson |
Kopplingslänk
|
|
US5498156A
(en)
|
1994-09-02 |
1996-03-12 |
Ipsco Enterprises Inc. |
Dual-purpose guide and drum cleaner for Steckel mill coiler furnace
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
DE19541844C1
(de)
|
1995-11-09 |
1997-07-24 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung
|
|
DK0929578T3
(da)
|
1996-02-09 |
2003-08-25 |
Abbott Lab Bermuda Ltd |
Humane antistoffer, der binder human TNFalfa
|
|
SG124234A1
(en)
|
1996-07-25 |
2006-08-30 |
Biogen Idec Inc |
Cell adhesion inhibitors
|
|
US7361331B2
(en)
|
1996-10-18 |
2008-04-22 |
Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food |
Plant bioreactors
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US6890526B2
(en)
|
1997-05-06 |
2005-05-10 |
Vanderbilt University |
Methods and reagents for the treatment of multiple sclerosis
|
|
JP2001512138A
(ja)
|
1997-07-31 |
2001-08-21 |
エラン・ファーマシューティカルズ・インコーポレーテッド |
Ｖｌａ−４が介在する白血球付着を阻害するベンジル化合物
|
|
US6153653A
(en)
|
1997-11-26 |
2000-11-28 |
Protarga, Inc. |
Choline compositions and uses thereof
|
|
JP2001527040A
(ja)
|
1997-12-30 |
2001-12-25 |
バイオアブソーバブル コンセプツ，インコーポレイティド |
神経系の脳血管性疾患を治療、抑制及び防止するためのテトラサイクリン及び／又はテトラサイクリン誘導体
|
|
HUP0102255A3
(en)
|
1998-05-28 |
2001-12-28 |
Biogen Idec Ma Inc Cambridge |
Vla-4 inhibitor omepupa-v, pharmaceutical compositions comprising thereof and their use
|
|
US7232830B2
(en)
|
1998-06-26 |
2007-06-19 |
Elaine A Delack |
Method for treatment of neurodegenerative diseases and effects of aging
|
|
EP2065050A1
(en)
*
|
1998-09-14 |
2009-06-03 |
Board of Regents, The University of Texas System |
Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
|
|
US6355623B2
(en)
|
1998-09-24 |
2002-03-12 |
Hopital-Sainte-Justine |
Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage
|
|
DE19853487A1
(de)
|
1998-11-19 |
2000-05-25 |
Fumapharm Ag Muri |
Verwendung von Dialkylfumaraten
|
|
JP2002538167A
(ja)
|
1999-03-03 |
2002-11-12 |
バイオジェン インコーポレイテッド |
脂質の代謝および貯蔵を調節する方法
|
|
AU2446801A
(en)
|
1999-12-23 |
2001-07-03 |
Ancile Pharmaceuticals, Inc. |
Treatment for inflammatory bowel disease (ibd) and related conditions
|
|
AU2001233034A1
(en)
|
2000-01-27 |
2001-08-07 |
American Cyanamid Company |
Method for preparing alpha-sulfonyl hydroxamic acid derivatives
|
|
AU2001245899B2
(en)
|
2000-03-31 |
2006-06-15 |
The Scripps Research Institute |
Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
|
|
US8288322B2
(en)
|
2000-04-17 |
2012-10-16 |
Dyax Corp. |
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
|
|
US6537243B1
(en)
|
2000-10-12 |
2003-03-25 |
Abbott Laboratories |
Device and method for obtaining interstitial fluid from a patient for diagnostic tests
|
|
EP1401484A1
(en)
|
2001-06-11 |
2004-03-31 |
Transition Therapeutics Inc. |
Combination therapies using vitamin b12 and interferon for treatment of viral, proliferative and inflammatory diseases
|
|
CA2860702C
(en)
|
2001-12-17 |
2019-02-26 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
|
|
US20040203031A1
(en)
|
2002-04-03 |
2004-10-14 |
University Of Pennsylvania |
Methods for determining drug responsiveness
|
|
AU2003211063A1
(en)
|
2002-02-15 |
2003-09-09 |
Cornell Research Foundation, Inc. |
Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells
|
|
PL215263B1
(pl)
|
2002-02-25 |
2013-11-29 |
Elan Pharm Inc |
Kompozycja do przewleklego leczenia patologicznego zapalenia i zastosowanie natalizumabu lub jego immunologicznie aktywnego fragmentu do wytwarzania leku
|
|
AU2003217912A1
(en)
*
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
WO2004029207A2
(en)
|
2002-09-27 |
2004-04-08 |
Xencor Inc. |
Optimized fc variants and methods for their generation
|
|
EP3064215A1
(en)
|
2002-10-16 |
2016-09-07 |
Samuel F. Hunter |
Method for treatment of demyelinating central nervous system disease
|
|
DE60331101D1
(de)
|
2002-11-22 |
2010-03-11 |
Chugai Pharmaceutical Co Ltd |
Antikörper gegen geschädigtes gewebe
|
|
CA2514125A1
(en)
|
2003-01-24 |
2004-08-12 |
Elan Pharmaceuticals, Inc. |
Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
|
|
RU2358763C2
(ru)
|
2003-02-10 |
2009-06-20 |
Элан Фармасьютикалз, Инк. |
Композиции иммуноглобулина и способ их получения
|
|
US20050074443A1
(en)
|
2003-10-03 |
2005-04-07 |
Treadwell Benjamin V. |
Methods of attenuating autoimmune disease and compositions useful therefor
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
|
MY162179A
(en)
|
2004-04-01 |
2017-05-31 |
Elan Pharm Inc |
Steroid sparing agents and methods of using same
|
|
BRPI0508762A
(pt)
|
2004-04-16 |
2007-08-14 |
Genentech Inc |
método de aumento do esgotamento de células b em mamìferos, método de aumento da eficácia do esgotamento de células b, método de tratamento de malignidade ou neoplasma de células b, método de alìvio de disfunção autoimunológica regulada por células b, método de esgotamento das células b e composição
|
|
CA2478458A1
(en)
|
2004-08-20 |
2006-02-20 |
Michael Panzara |
Treatment of pediatric multiple sclerosis
|
|
RS52213B
(sr)
|
2004-09-03 |
2012-10-31 |
Genentech, Inc. |
Humanizovani anti-beta7 antagonisti i njihove primene
|
|
CN103169965A
(zh)
|
2004-11-19 |
2013-06-26 |
比奥根艾迪克Ma公司 |
治疗多发性硬化
|
|
EP1833509A4
(en)
|
2004-12-03 |
2008-12-03 |
Biogen Idec Inc |
DELAYING OR PREVENTING THE APPEARANCE OF MULTIPLE SCLEROSIS
|
|
CA2600929A1
(en)
*
|
2005-03-04 |
2006-09-14 |
Biogen Idec Ma Inc. |
Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues
|
|
AU2006254772B2
(en)
|
2005-06-09 |
2011-06-02 |
Ucb Pharma S.A. |
2,6 quinolinyl derivatives, processes for preparing them and their use as medicament
|
|
WO2007008943A2
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc. |
Optimized anti-ep-cam antibodies
|
|
MX2008014793A
(es)
|
2006-05-25 |
2008-12-02 |
Biogen Idec Inc |
Metodos para tratar la apoplejia.
|
|
EP2053961A4
(en)
|
2006-08-09 |
2013-05-01 |
Biogen Idec Inc |
METHOD FOR DISPENSING A MEDICAMENT
|
|
US8771689B2
(en)
|
2006-12-11 |
2014-07-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Alpha B-crystallin as a therapy for ischemia or inflammation
|
|
US8931218B2
(en)
|
2007-04-19 |
2015-01-13 |
Oldcastle Building Products, Inc. |
Modular brick or block outdoor structures
|
|
MX2009012343A
(es)
|
2007-05-14 |
2010-02-10 |
Biogen Idec Inc |
Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello.
|
|
EP2170390B1
(en)
|
2007-06-14 |
2018-11-07 |
Biogen MA Inc. |
Natalizumab antibody formulations
|
|
WO2008157282A1
(en)
|
2007-06-18 |
2008-12-24 |
Genentech, Inc. |
Biological markers predictive of rheumatoid arthritis response to b-cell antagonists
|
|
DE102007049542A1
(de)
|
2007-10-16 |
2009-04-23 |
Neue Magnetodyn Gmbh |
Implantierbare Vorrichtung, System zum Erzeugen lokalisierter elektromagnetischer Felder im Bereich eines Implantats und Spulenanordnung
|
|
EP2050462A1
(en)
|
2007-10-18 |
2009-04-22 |
PAION Deutschland GmbH |
Improved treatment of stroke patients
|
|
SMT202000306T1
(it)
*
|
2010-04-16 |
2020-07-08 |
Biogen Ma Inc |
Anticorpi anti-vla-4
|
|
CA2850885A1
(en)
|
2011-10-17 |
2013-04-25 |
Westfaelische Wilhelms-Universitaet Muenster |
Assessment of pml risk and methods based thereon
|
|
US12037398B2
(en)
*
|
2018-06-04 |
2024-07-16 |
Biogen Ma Inc. |
Anti-VLA-4 antibodies having reduced effector function
|