JP2013529611A5 - - Google Patents
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- Publication number
- JP2013529611A5 JP2013529611A5 JP2013515827A JP2013515827A JP2013529611A5 JP 2013529611 A5 JP2013529611 A5 JP 2013529611A5 JP 2013515827 A JP2013515827 A JP 2013515827A JP 2013515827 A JP2013515827 A JP 2013515827A JP 2013529611 A5 JP2013529611 A5 JP 2013529611A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- triazolo
- chlorophenyl
- ethylacetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 31
- 150000003839 salts Chemical class 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- -1 amino, hydroxyl Chemical group 0.000 claims 5
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 229940125763 bromodomain inhibitor Drugs 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- PJPRMRNFJZOFLA-FQEVSTJZSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-(1h-pyrazol-4-yl)-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C2=CNN=C2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 PJPRMRNFJZOFLA-FQEVSTJZSA-N 0.000 claims 1
- WMKQEPQCESYBNS-FQEVSTJZSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-(1h-pyrazol-5-yl)-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2NN=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 WMKQEPQCESYBNS-FQEVSTJZSA-N 0.000 claims 1
- HFCOQWDWESZNEW-DEOSSOPVSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-(2-methylphenyl)-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C(=CC=CC=2)C)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 HFCOQWDWESZNEW-DEOSSOPVSA-N 0.000 claims 1
- QKKNSYUKNJSTRL-NDEPHWFRSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-[3-(pyrrolidin-1-ylmethyl)phenyl]-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=C(CN3CCCC3)C=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 QKKNSYUKNJSTRL-NDEPHWFRSA-N 0.000 claims 1
- PILKZSVRGDSFDN-LJAQVGFWSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-[3-[(4-methylpiperazin-1-yl)methyl]phenyl]-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=C(CN3CCN(C)CC3)C=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 PILKZSVRGDSFDN-LJAQVGFWSA-N 0.000 claims 1
- UCHHERPHYGYXQM-NDEPHWFRSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-[4-(pyrrolidin-1-ylmethyl)phenyl]-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=CC(CN3CCCC3)=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 UCHHERPHYGYXQM-NDEPHWFRSA-N 0.000 claims 1
- DODSTUSXECRXBY-LJAQVGFWSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=CC(CN3CCN(C)CC3)=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 DODSTUSXECRXBY-LJAQVGFWSA-N 0.000 claims 1
- LBNZQYJSQFKTMP-QHCPKHFHSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=CC=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 LBNZQYJSQFKTMP-QHCPKHFHSA-N 0.000 claims 1
- MXNRKTOXHIEBKM-QFIPXVFZSA-N 2-[(4s)-6-(4-chlorophenyl)-1-methyl-8-pyridin-4-yl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=CN=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 MXNRKTOXHIEBKM-QFIPXVFZSA-N 0.000 claims 1
- SPAMVIHCDISFJZ-DEOSSOPVSA-N 2-[(4s)-6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=C(OC)C=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 SPAMVIHCDISFJZ-DEOSSOPVSA-N 0.000 claims 1
- DBNRUVQIPZTZFK-DEOSSOPVSA-N 2-[(4s)-6-(4-chlorophenyl)-8-(4-methoxyphenyl)-1-methyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=CC(OC)=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 DBNRUVQIPZTZFK-DEOSSOPVSA-N 0.000 claims 1
- JZVFVHUUEWVBPO-SANMLTNESA-N 2-[(4s)-6-(4-chlorophenyl)-8-[3-(ethylaminomethyl)phenyl]-1-methyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound CCNCC1=CC=CC(C=2C=C3C(N4C(C)=NN=C4[C@H](CC(=O)NCC)N=C3C=3C=CC(Cl)=CC=3)=CC=2)=C1 JZVFVHUUEWVBPO-SANMLTNESA-N 0.000 claims 1
- PHVGVVDKYSSPKA-SANMLTNESA-N 2-[(4s)-6-(4-chlorophenyl)-8-[4-(ethylaminomethyl)phenyl]-1-methyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound C1=CC(CNCC)=CC=C1C1=CC=C2N3C(C)=NN=C3[C@H](CC(=O)NCC)N=C(C=3C=CC(Cl)=CC=3)C2=C1 PHVGVVDKYSSPKA-SANMLTNESA-N 0.000 claims 1
- USCJQEZHNLJYPQ-SANMLTNESA-N 2-[(4s)-6-(4-chlorophenyl)-8-[4-[(dimethylamino)methyl]phenyl]-1-methyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-n-ethylacetamide Chemical compound N([C@H](C1=NN=C(C)N1C1=CC=C(C=C11)C=2C=CC(CN(C)C)=CC=2)CC(=O)NCC)=C1C1=CC=C(Cl)C=C1 USCJQEZHNLJYPQ-SANMLTNESA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 150000001557 benzodiazepines Chemical class 0.000 claims 1
- 125000003310 benzodiazepinyl group Chemical group N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1010514.6A GB201010514D0 (en) | 2010-06-22 | 2010-06-22 | Novel compounds |
| GB1010514.6 | 2010-06-22 | ||
| GBGB1106801.2A GB201106801D0 (en) | 2011-04-21 | 2011-04-21 | Novel compounds |
| GB1106801.2 | 2011-04-21 | ||
| PCT/EP2011/060179 WO2011161031A1 (en) | 2010-06-22 | 2011-06-20 | Benzotriazolodiazepine compounds inhibitors of bromodomains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529611A JP2013529611A (ja) | 2013-07-22 |
| JP2013529611A5 true JP2013529611A5 (OSRAM) | 2014-06-05 |
| JP5844358B2 JP5844358B2 (ja) | 2016-01-13 |
Family
ID=44310320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515827A Expired - Fee Related JP5844358B2 (ja) | 2010-06-22 | 2011-06-20 | ベンゾトリアゾロジアゼピン化合物を含むブロモドメイン阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9085582B2 (OSRAM) |
| EP (1) | EP2585465B1 (OSRAM) |
| JP (1) | JP5844358B2 (OSRAM) |
| ES (1) | ES2526671T3 (OSRAM) |
| WO (1) | WO2011161031A1 (OSRAM) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| US8981083B2 (en) | 2010-05-14 | 2015-03-17 | Dana Farber Cancer Institute, Inc. | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
| US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| US9328117B2 (en) | 2011-06-17 | 2016-05-03 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2013027168A1 (en) | 2011-08-22 | 2013-02-28 | Pfizer Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| WO2013033270A2 (en) * | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same |
| WO2013033269A1 (en) * | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bioorthogonal monomers capable of dimerizing and targeting bromodomains and methods of using same |
| EP2785717B1 (en) | 2011-11-29 | 2016-01-13 | Novartis AG | Pyrazolopyrrolidine compounds |
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| US9365576B2 (en) | 2012-05-24 | 2016-06-14 | Novartis Ag | Pyrrolopyrrolidinone compounds |
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| US9663523B2 (en) * | 2012-09-28 | 2017-05-30 | Bayer Pharma Aktiengesellschaft | BET protein-inhibiting 5-aryltriazoleazepines |
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| JP2016513117A (ja) * | 2013-02-22 | 2016-05-12 | バイエル ファーマ アクチエンゲゼルシャフト | 過剰増殖性疾患を治療するためのｂｅｔタンパク質阻害剤としてのピロロ−およびピラゾロ−トリアゾロジアゼピン類 |
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| CN108440528A (zh) | 2013-03-12 | 2018-08-24 | 艾伯维公司 | 四环布罗莫结构域抑制剂 |
| WO2014159392A1 (en) | 2013-03-14 | 2014-10-02 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
| SG11201506924YA (en) | 2013-03-15 | 2015-09-29 | Incyte Corp | Tricyclic heterocycles as bet protein inhibitors |
| HK1217484A1 (zh) | 2013-04-26 | 2017-01-13 | 百济神州有限公司 | 取代的5-(3，5-二甲基异恶唑-4-基)二氢吲哚-2-酮类衍生物 |
| US8975417B2 (en) | 2013-05-27 | 2015-03-10 | Novartis Ag | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
| CN105209467B (zh) | 2013-05-27 | 2018-06-08 | 诺华股份有限公司 | 咪唑并吡咯烷酮衍生物及其在治疗疾病中的用途 |
| KR20160012195A (ko) | 2013-05-28 | 2016-02-02 | 노파르티스 아게 | Bet 억제제로서의 피라졸로-피롤리딘-4-온 유도체 및 질환의 치료에서의 그의 용도 |
| PT3004112T (pt) | 2013-05-28 | 2017-12-11 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona e sua utilização no tratamento de doença |
| AR096837A1 (es) | 2013-07-08 | 2016-02-03 | Incyte Corp | Heterociclos tricíclicos como inhibidores de proteínas bet |
| EP3024327B1 (en) * | 2013-07-25 | 2019-09-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| WO2015070020A2 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| EA029269B1 (ru) | 2013-11-21 | 2018-02-28 | Новартис Аг | Производные пирролопирролона и их применение для лечения заболеваний |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| GB201320994D0 (en) * | 2013-11-28 | 2014-01-15 | Univ Dundee | Enzyme function probes |
| WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| CN105940005A (zh) | 2014-01-31 | 2016-09-14 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| RU2016134947A (ru) | 2014-01-31 | 2018-03-01 | Дана-Фарбер Кансер Институт, Инк. | Производные диаминопиримидин бензолсульфона и их применение |
| US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| US9580430B2 (en) | 2014-02-28 | 2017-02-28 | The Regents Of The University Of Michigan | 9H-pyrimido[4,5-B]indoles and related analogs as BET bromodomain inhibitors |
| RU2722179C2 (ru) | 2014-02-28 | 2020-05-28 | Тэнша Терапеутикс, Инк. | Лечение состояний, ассоциированных с гиперинсулинемией |
| UA119870C2 (uk) | 2014-04-23 | 2019-08-27 | Інсайт Корпорейшн | 1H-ПІРОЛО[2,3-c]ПІРИДИН-7(6H)-ОНИ ТА ПІРАЗОЛО[3,4-c]ПІРИДИН-7(6H)-ОНИ ЯК ІНГІБІТОРИ БІЛКІВ BET |
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| CN113788818A (zh) | 2016-04-06 | 2021-12-14 | 密执安大学评议会 | Mdm2蛋白质降解剂 |
| US10759808B2 (en) | 2016-04-06 | 2020-09-01 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
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| WO2018052949A1 (en) | 2016-09-13 | 2018-03-22 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as bet protein degraders |
| WO2018052945A1 (en) | 2016-09-13 | 2018-03-22 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines as bet protein degraders |
| WO2018144789A1 (en) | 2017-02-03 | 2018-08-09 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as bet bromodomain inhibitors |
| WO2019055444A1 (en) | 2017-09-13 | 2019-03-21 | The Regents Of The University Of Michigan | DEGRADATION AGENTS OF BROMODOMAIN BET PROTEIN WITH CLEAR BINDERS |
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| DE3610848A1 (de) | 1986-04-01 | 1987-10-15 | Boehringer Ingelheim Kg | Neue 1,4-diazepine |
| MC1999A1 (fr) * | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| JP3239364B2 (ja) | 1991-10-11 | 2001-12-17 | ウェルファイド株式会社 | 骨粗鬆症治療薬およびジアゼピン化合物 |
| JPH06128257A (ja) | 1992-10-13 | 1994-05-10 | Yoshitomi Pharmaceut Ind Ltd | ピリドジアゼピン化合物 |
| CA2176020A1 (en) | 1993-11-22 | 1995-06-01 | John J. Baldwin | Benzodiazepines |
| WO1996016062A1 (en) | 1994-11-18 | 1996-05-30 | Japan Tobacco Inc. | Osteoporosis remedy and triazepine compound |
| IL127516A0 (en) | 1996-06-12 | 1999-10-28 | Japan Tobacco Inc | A cytokine production inhibitor |
| WO1998011111A1 (en) | 1996-09-13 | 1998-03-19 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienotriazolodiazepine compounds and medicinal uses thereof |
| JP4641526B2 (ja) | 2003-11-03 | 2011-03-02 | グラクソ グループ リミテッド | 流体分配デバイス |
| SG115845A1 (en) | 2004-03-31 | 2005-10-28 | Univ Singapore | Modulation of trip-br function and method of treating proliferative disorders |
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| EP2239264A4 (en) | 2007-12-28 | 2012-01-11 | Mitsubishi Tanabe Pharma Corp | ANTITUMORAL MEDIUM |
| GB0919431D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
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- 2011-06-20 JP JP2013515827A patent/JP5844358B2/ja not_active Expired - Fee Related
- 2011-06-20 WO PCT/EP2011/060179 patent/WO2011161031A1/en not_active Ceased
- 2011-06-20 ES ES11725769.1T patent/ES2526671T3/es active Active
- 2011-06-20 US US13/702,177 patent/US9085582B2/en not_active Expired - Fee Related
- 2011-06-20 EP EP11725769.1A patent/EP2585465B1/en not_active Not-in-force
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